Severe Obesity in Type 2 Diabetes Causes Impaired Glucose Metabolism in Muscle Cells

Article title: Impaired glucose partitioning in primary myotubes from severely obese women with type 2 diabetes

Authors: Kai Zou, Kristen Turner, Donghai Zheng, J. Matthew Hinkley, Benjamin A. Kugler, Pamela J. Hornby, James M. Lenhard, Terry E. Jones, Walter J. Pories, G. Lynis Dohm, Joseph A. Houmard

From the authors: “The present data indicates that myotubes derived from severely obese women with [type 2 diabetes] display a phenotype of dysregulated intramyocellular glucose metabolism in a manner that partitions glucose towards non-oxidized glycolysis.” 

This study is highlighted as one of November’s “best of the best” as part of the American Physiological Society’s APSselect program.