Hevolution Foundation: Transforming Healthspan Science with Unprecedented $400M Funding Surge

Hevolution Foundation, a global nonprofit organization that provides grants and early-stage investments to incentivize research and entrepreneurship in healthspan science, has committed over $400 million to healthspan sciences within the past 21 months, positioning the Foundation as the world’s largest philanthropic funder of geroscience.

Icahn School of Medicine at Mount Sinai Awarded $21 Million NIH Grant to Advance Understanding of Aging-Related Hormone

Researchers at the Icahn School of Medicine at Mount Sinai have been awarded a $21 million grant from the National Institute on Aging (NIA) of the National Institutes of Health (NIH), to further advance understanding of an aging-related hormone known as follicle-stimulating hormone (FSH), including its potential role in obesity, osteoporosis, and Alzheimer’s disease.

Subtle cognitive decline precedes end to driving for older adults

Even slight cognitive changes can affect an older person’s decision to stop driving, according to a new study by researchers at Washington University School of Medicine in St. Louis. The findings suggest that routine cognitive testing — in particular, the kind of screening designed to pick up the earliest, most subtle decline — could help older adults and their physicians make decisions about driving that maximizes safety while preserving independence as long as possible.

‘Good’ Fat Metabolism Changes Tied to Estrogen Loss, Not Necessarily to Aging

Brown fat metabolism decreases in older men and women, but the decrease in women is not necessarily tied to age, according to new research. The first-of-its-kind study is published ahead of print in the American Journal of Physiology-Endocrinology and Metabolism and has been chosen as an APSselect article for May.

Synchronisation between the central circadian clock and the circadian clocks of tissues preserves their functioning and prevents ageing

• Two complementary research articles, published simultaneously in the journals Science and Cell Stem Cell by a team of scientists from the UPF and IRB Barcelona, reveal that central and peripheral circadian clocks coordinate to regulate the daily activity of skin and muscles.
• The coordination between the two clocks (central and peripheral) guarantees 50% of the circadian functions of tissues, including vital processes such as the cell cycle, DNA repair, mitochondrial activity, and metabolism.
• Synchronisation between the central brain clock and peripheral ones prevents premature muscle ageing and improves muscle function, suggesting new strategies to tackle age-related decline through circadian rhythm modulation.

Early Alzheimer’s Detection with Artificial Intelligence

“AI-driven neuroimaging techniques have the potential to improve prediction models for Alzheimer’s progression and facilitate personalized treatment strategies,” says Domenico Praticò, MD, the Scott Richards North Star Foundation Chair for Alzheimer’s Research, Professor in the Departments of Pharmacology and Microbiology, and Director of the Alzheimer’s Center at Temple (ACT), at the Lewis Katz School of Medicine at Temple University (LKSOM).

Study Reveals How Obesity Could Accelerate Aging in the Brain

A new study conducted in mice traces how obesity and a high-fat diet may accelerate aging in the blood vessels that supply blood to the brain. The work is being presented this week at the American Physiology Summit, the flagship annual meeting of the American Physiological Society.

Intermittent Fasting May Help Preserve Intestinal Health as We Age

A study in mice found that intermittent fasting brought benefits beyond weight loss, suggesting it could help the body better process glucose and reduce age-related declines in intestinal function. Researchers will present their work this week at the American Physiology Summit.

L-Nutra Unveils Groundbreaking Research on Fasting Mimicking Diets (FMDs) and Reduced Biological Age Score

L-Nutra Inc., a leading nutrition technology company developing evidence-based Nutrition for Longevity and Nutrition as Medicine programs, is excited to announce the release of a groundbreaking longevity and healthy aging study published in Nature Communications, a prestigious Nature portfolio journal.

Yoga provides unique cognitive benefits to older women at risk of Alzheimer’s disease, study finds

A new UCLA Health study found Kundalini yoga provided several benefits to cognition and memory for older women at risk of developing Alzheimer’s disease including restoring neural pathways, preventing brain matter decline and reversing aging and inflammation-associated biomarkers – improvements not seen in a group who received standard memory training exercises.

Army of specialized T cells may trigger asthma attacks in older men

LA JOLLA, CA—Scientists from La Jolla Institute for Immunology (LJI) and The University of Southampton, UK, have uncovered a group of immune cells that may drive severe asthma. These cells, called cytotoxic CD4+ tissue-resident memory T cells, gather in the lungs and appear to possess the molecular weaponry to cause the most harm in men who developed asthma later in life.

Older Adults Show Greater Increase in Body Temperature in Simulated Heatwave Than Previously Reported

Under conditions designed to better mirror real-world conditions, a new study finds that adults 65 and older are affected more by heatwave-like temperatures than previously reported. The study included intermittent bouts of light activity and was published in the Journal of Applied Physiology.

How can we preserve our cognitive health as we age?

National Healthy Aging Month (September) is underway. Professor Liz Stine-Morrow, a researcher at the Beckman Institute for Advanced Science and Technology at the University of Illinois Urbana-Champaign, studies the conditions and strategies that augment cognitive health and make us effective…

Maintaining Stable Weight Increases Longevity Among Older Women

UC San Diego Herbert Wertheim School of Public Health and Human Longevity Science researchers investigated the associations of weight changes later in life with exceptional longevity and found that women who maintained their body weight after age 60 were more likely to reach exceptional longevity.