Cedars-Sinai July Research Highlights

A roundup of the latest medical discoveries and faculty news at Cedars-Sinai.

Solving the climate crisis requires collaboration between natural and social scientists

Now that the world has experienced its hottest day in history, it is more urgent than ever for natural and social scientists to work together to address the climate crisis and keep global temperature increases below 2°C. To this end, an international group of esteemed researchers recently published an innovative research paper that highlights the importance of integrating knowledge from natural and social sciences to inform about effective climate change policies and practice.

Heart Checkups Advised for Kids Who Play Sports

Key Takeaways:Sudden cardiac arrest is a leading cause of death among young athletes.Pre-participation heart screenings are advised for athletes ages 12 and above.Cardiac tests can detect 99% of abnormalities.Heart defects don’t prohibit kids from playing sports.The fact that sudden cardiac arrest is a leading cause of death in young athletes seems illogical, provoking an obvious question: “That’s the point,” says Children’s Hospital Los Angeles cardiologist Paul Kantor, MBBCh, MSc, FRCPC.

New research highlights risks of selective adaptation in extreme coral habitats

Resilient corals, often referred to as ‘super corals’, have recently been seen as potential saviours in the face of climate change and its detrimental effects on coral reefs. Now, a team of scientists is working to better understand these corals in order to develop strategies to protect fragile ecosystems such as the Great Barrier Reef.

GW Expert: Rise in Burn Injuries During Extreme Heat Wave in the U.S.

Hospitals and burn centers in the Southwest United States are reporting an increase in burn injuries from touching everyday surfaces that are baking under record temperatures. According to The Wall Street Journal, burn centers are treating people who touch hot door…

St. Croix: Radio Astronomy in the Caribbean

Although the location of St. Croix is perfect for a VLBA antenna, the island poses significant challenges for using and maintaining a radio antenna. The St. Croix dish is located on the eastern side of the island, almost at sea level. So it is constantly bombarded by salt air, ocean rains, and even the occasional tropical storm.

Research to Prevent Blindness and Association of University Professors of Ophthalmology Announce 2024 Recipient of RPB David F. Weeks Award for Outstanding Vision Research

Patricia Ann D’Amore, PhD, MBA, has been selected as the 2024 RPB David F. Weeks Award for Outstanding Vision Research (Weeks Award). Dr. D’Amore will receive her award and deliver a presentation during the AUPO 2024 Annual Meeting in Austin, Texas in February.

American Society of Nephrology Applauds Senate Passage of the Securing the U.S. Organ Procurement and Transplantation Act (S. 1668)

The United States Senate unanimously passed the Securing the U.S. Organ Procurement Transplantation Network (OPTN) Act (S. 1668), following House passage earlier this week, marking a new era for the United States transplant system.

Mitochondrial Changes Linked to High Blood Pressure in Pregnancy

A new study provides evidence for the possibility that mitochondrial dysregulation could be a contributing factor in the development of hypertensive disorders of pregnancy. The study is published in Physiological Genomics. It was chosen as an APSselect article for July.

CHOP and Penn Medicine Researchers Develop “In Vivo” RNA-based Gene Editing Model for Blood Disorders

In a step forward in the development of genetic medicines, researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body. If translated into the clinic, this approach could expand access and reduce the cost of gene therapies for blood disorders, many of which currently require patients receive chemotherapy and a stem cell transplant. The findings were published today in the journal Science.

First Ochsner Health Medical School Scholarship Recipient Matches into Residency Program in the Gulf South

Xavier and Ochsner are thrilled to announce that the first Ochsner Health Medical School Scholarship recipient, 2019 Xavier alumna Sarah Bertrand, MD, has graduated from Louisiana State University Health- Shreveport School of Medicine (LSUHS School of Medicine) and is entering a residency in the Gulf South. Ochsner and Xavier also this year awarded the fifth annual Ochsner Health Medical School Scholarship for LSUHS School of Medicine to Van Smith III, a 2023 graduate of Xavier.

Study Shows Mitochondrial Transplantation Effective in Reversing Damage to Kidneys and Kidney Cells

According to the National Kidney Foundation, more than 100,000 Americans are waiting for a kidney transplant, and the demand for donated kidneys far exceeds the supply. In fact, only 25,498 kidney transplants were performed in 2022, and kidney disease impacts 37 million people in the U.S. But a new preclinical study, led by scientists at Wake Forest University School of Medicine, shows that a new technology called mitochondrial transplantation holds promise as a potential therapy that could change the kidney transplant landscape.

Yale Scientists Identify Immune Cells Critical for Immunologic Memory for Melanoma

Immune-checkpoint inhibitors have become the standard of care for patients with advanced melanoma to improve survival, but only some patients respond to this immunotherapy and have long-term benefits. The lack of a long-lasting response, researchers say, is related to failure of antitumor immunologic memory. Treatment options for advanced melanoma are limited for patients who do not respond to this type of therapy.

UV disinfection in the treatment management of SARS-CoV-2 Omicron variants

The global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its new variants has created a need for effective disinfection technologies to protect against harmful pathogens. While vaccines offer some protection, their effectiveness against future variants is uncertain. Therefore, additional strategies are important during the pre-vaccine stage.

Transcription Factors Contribute to Subtypes of Colorectal Cancers

New research in colorectal cancers directed by investigators at the Johns Hopkins Kimmel Cancer Center suggests that expression of transcription factors — proteins that help turn specific genes on or off by binding to nearby DNA — may play a central role in the degree of DNA methylation across the genome, contributing to the development of different subtypes of these cancers. Methylation is a process in which certain chemical groups attach to areas of DNA that guide genes’ on/off switches.

Research Corporation for Science Advancement (RCSA) chooses Symplectic Grant Tracker to manage funding for innovative scientific research

The Research Corporation for Science Advancement (RCSA) has chosen Symplectic Grant Tracker from Digital Science’s suite of flagship products to advance its aims of providing catalytic funding for innovative scientific research.

New research reveals historic migration’s link to present-day implicit racial bias

Roughly six million Black people moved away from the American South during the Great Migration between 1910 and 1970, hoping to escape racial violence and discrimination while pursuing economic and educational opportunities. Now, research has uncovered a link between this historic event with present-day inequalities and implicit biases.

Investigators Identify Translation Gaps in Instrument That Measures Nursing Practice Environment

Two decades ago, the Practice Environment Scale of the Nursing Work Index was published to measure the nursing practice environment. Although the instrument’s use has resulted in advances in science and quality improvement efforts, its potential may be limited by the availability and quality of translations into different languages.