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UrduArticle title: Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism Authors: Fangyi Liu, Xiao Wang, Hua Geng, Heng-Fu Bu, Peng Wang, Isabelle G. De Plaen, Hong Yang, Jiaming Qian, Xiao-Di Tan From the authors: “Our study provides…
Category: Research Alert
Wet T-Shirt Provides Effective Cooling for Older Adults during Heat Waves
Article title: Keeping older individuals cool in hot and moderately humid conditions: wetted clothing with and without an electric fan Authors: Matthew N. Cramer, Mu Huang, Gilbert Moralez, Craig G. Crandall From the authors: “These findings suggest that wearing a water-soaked T-shirt…
COVID-19 ONE HEALTH TELE NEWS CONFERENCE
Day: Thursday, April 2 Time: 8am EDT Please register for News Conference: The World Needs to Triage Now on Stopping the Next Zoonotic Pandemic on Apr 2, 2020 8:00 AM EDT at: https://attendee.gotowebinar.com/register/6563219508106471694 After registering, you will receive a confirmation…
WHAT MEDIA ARE ASKING ABOUT COVID-19
WHAT MEDIA ARE ASKING ABOUT COVID-19 In communities throughout the nation, the 12,000 members of the Infectious Diseases Society of America are working nonstop to control the spread of the novel coronavirus and care for people who become seriously ill.…
Coronavirus’ Binding Action May Also Cause Kidney Damage and Infertility; Researchers Consider Potential Treatment Paths
Article title: COVID-19 infection and mortality – A physiologist’s perspective enlightening clinical features and plausible interventional strategies Authors: Zaid A. Abassi, Karl Skorecki, Samuel Noam Heyman, Safa Kinaneh, Zaher Armaly From the authors: “Cleavage of the S-glycoprotein by furin and its…
What Every Colorectal Surgeon Should Know About Telemedicine
In the context of the coronavirus outbreak and COVID-19 epidemic, healthcare professionals are turning to telemedicine to continue serving their patients. DCR Journal provides information for everyone, not just colorectal surgeons. See the update here. Original post https://alertarticles.info
Wearable Technology in the Perioperative Period: Predicting Risk of Postoperative Complications in Patients Undergoing Elective Colorectal Surgery
There is significant room for improvement in baseline preoperative activity levels of patients undergoing colorectal surgery, and poor activity is associated with increased postoperative complications.
Stopping the Spread of COVID-19
Coronavirus disease 2019 (COVID-19) is the infectious disease caused by a novel coronavirus. What Is COVID-19? COVID-19 is a respiratory infection caused by the virus SARS-CoV-2, which was recently discovered after an outbreak began in Wuhan, China, in…
Digestive Symptoms Are Prominent Among COVID-19 Patients Reveals Study in The American Journal of Gastroenterology
The American Journal of Gastroenterology published today a new study that reveals digestive symptoms, including diarrhea, are common in COVID-19 patients. The study comes from the Wuhan Medical Treatment Expert Group for COVID-19 in China. Nearly half of COVID-19 patients…
Applying Deep Learning to Automate UAV‐Based Detection of Scatterable Landmines
Recent advances in unmanned‐aerial‐vehicle‐ (UAV‐) based remote sensing utilizing lightweight multispectral and thermal infrared sensors allow for rapid wide‐area landmine contamination detection and mapping surveys. We present results of a study focused on developing and testing an automated technique of…
Care for Critically Ill Patients With COVID-19
Initial reports suggest that COVID-19 is associated with severe disease that requires intensive care in approximately 5% of proven infections.1 Given how common the disease is becoming, as in prior major severe acute respiratory infection outbreaks—SARS (severe acute respiratory syndrome), MERS…
Embargoed: Forthcoming Report To Examine Alzheimer’s and Other Dementias in U.S.
The Alzheimer’s Association will issue the 2020 Alzheimer’s Diseases Facts and Figures Report on March 11, 2020. The new report will highlight the latest disease-related statistics for America’s 6th leading cause of death for those 65+, including prevalence, incidence, mortality, costs of care and impact on caregivers both nationally, as well as state by state data, for both 2020 and future projections. This new report will feature findings from a first-of-its-kind, comprehensive survey of primary care physicians (PCPs) and medical school residents which examines the medical profession’s readiness to meet future care needs for the growing number of people living with Alzheimer’s and other dementias. Information and report findings are under strict embargo until Wednesday, March 11, 2020.
Using LinkedIn Could Hinder People’s Ability to Find a Job
Social media, especially the networking and employment site LinkedIn, has transformed the job search process, with an estimated 75% of job searchers using the platform to find a job and most recruiters using it to find applicants, but is that…
Time of day differences in neural reward responsiveness in children
The Reward Positivity (∆RewP) event-related potential (ERP), generally quantified as the difference between neural responsiveness to monetary gains (RewP-Gain) and losses (RewP-Loss) is commonly used as an index of neural reward responsiveness. Despite the popularity of this ERP component in…
Lack of Motivation the Most Central Domain for Successful Treatment of Schizophrenia Symptoms
A recent conceptual development in schizophrenia is to view its manifestations as interactive networks rather than individual symptoms. Negative symptoms, which are associated with poor functional outcome and reduced rates of recovery, represent a critical need in schizophrenia therapeutics. MIN101…
Study Finds ‘Far-Reaching’ Impact from Affordable Care Act
[Embargoed to March 2, 2020 @ 4 p.m. (ET). ] By 2008, when President Obama was first elected, the rate of uninsurance in the U.S. had been steadily deteriorating: nearly 56 million Americans reported they had no health insurance for…
Ion Pump in Kidneys Controls Blood Volume, Blood Pressure in Pregnancy
Article title: H,K-ATPase type 2 regulates gestational extracellular compartment expansion and blood pressure in mice Authors: Christine Walter, Chloé Rafael, Samia Lasaad, Stéphanie Baron, Amel Salhi, Gilles Crambert From the authors:”In this study, we observed that the H,K-ATPase type 2…
Heat Therapy Promotes Blood Vessel Development, Enhances Muscle Strength without Affecting Mitochondria
Article title: Effects of repeated local heat therapy on skeletal muscle structure and function in humans Authors: Kyoungrae Kim, Blake A. Reid, Caitlin A. Casey, Brooke E. Bender, Bohyun Ro, Qifan Song, Adam J. Trewin, Aaron C. Petersen, Shihuan Kuang, Timothy…
Enzyme + Mitochondrial Signaling May Contribute to Pulmonary Hypertension in Newborns
Article title: PKCβ and reactive oxygen species mediate enhanced pulmonary vasoconstrictor reactivity following chronic hypoxia in neonatal rats Authors: Joshua R. Sheak, Simin Yan, Laura Weise-Cross, Rosstin Ahmadian, Benjimen R. Walker, Nikki L. Jernigan From the authors: “This research demonstrates a novel…
Researchers Identify Mechanisms That Regulate Dynamics of Non-static Junctional Sarcoplasmic Reticulum in Heart Cells
Article title: Junctional sarcoplasmic reticulum motility in adult mouse ventricular myocytes Authors: Benjamin M. Drum, Can Yuan, Ana De La Mata, Nathan Grainger, L. Fernando Santana From the authors: “Our findings suggest a novel mechanism of [excitation-contraction (EC)] coupling regulation.…
Loss of Enzyme in Fat Tissue Leads to Improved Insulin Sensitivity in Liver
Article title: DPP4 deletion in adipose tissue improves hepatic insulin sensitivity in diet-induced obesity Authors: Tania Romacho, Henrike Sell, Ira Indrakusuma, Diana Roehrborn, Tamara R. Castañeda, Tomas Jelenik, Daniel Markgraf, Sonja Hartwig, Jürgen Weiß, Hadi Al-Hasani, Michael Roden, Jürgen Eckel…
Spinal Fluid Sodium May Play Role in Blood Pressure Management
Article title: Elevated cerebrospinal fluid sodium in hypertensive human subjects with a family history of Alzheimer’s disease Authors: Lucas A. C. Souza, Fatima Trebak, Veena Kumar, Ryousuke Satou, Patrick G. Kehoe, Wei Yang, Whitney Wharton, Yumei Feng Earley From the authors: “Our…
Reduced Response to Odors May Be Common in People with Autism
Article title: Decreased amplitude and reliability of odor-evoked responses in two mouse models of autism Authors: Matthew A. Geramita, Jing A. Wen, Matthew D. Rannals, and Nathaniel N. Urban From the authors: “Here we show that two mouse models of autism,…
Kidney Clock Gene Plays Role in Regulating Blood Pressure in Male Mice
Article title: Loss of circadian gene Bmal1 in the collecting duct lowers blood pressure in male, but not female, mice Authors: Dingguo Zhang, Chunhua Jin, Ijeoma E. Obi, Megan K. Rhoads, Reham H. Soliman, Randee S. Sedaka, John Miller Allan, Binli…
Amino Acid Supplement + Radiation for Cancer = A Dangerous Mix for Some
Article title: Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome Authors: Isabelle R. Miousse, Laura E. Ewing, Charles M. Skinner, Rupak Pathak, Sarita Garg, Kristy R. Kutanzi, Stepan Melnyk, Martin Hauer-Jensen, Igor Koturbash From the authors: “This study demonstrates that dietary…
General Anesthetic Exposure During Adolescence Might Contribute to Developing Alcohol Use Disorder
BINGHAMTON, N.Y. – General anesthetic exposure during adolescence may be an environmental risk factor contributing to an enhanced susceptibility to developing alcohol use disorders, according to researchers at Binghamton University, State University of New York. Adolescent alcohol abuse can lead…
Engineers develop skin rejuvenation method using stem cells
BINGHAMTON, NY — Vesicles derived from human stem cells can be used to rejuvenate skin, according to a research team including faculty at Binghamton University, State University of New York. The use of stem cell-derived extracellular vesicles (EVs) as a cell-free…
Using Social Media to Understand the Vaccine Debate in China
THE SITUATIONVaccine acceptance is a crucial public health issue, which has been exacerbated by the use of social media to spread content expressing vaccine hesitancy. Studies have shown that social media can provide new information regarding the dynamics of vaccine…
MTU Crew Goes BIG for NASA’s Lunar Projects
NASA’s BIG Idea Challenge funds eight university teams to work on lunar payloads and study the Moon’s darkest reaches. A student team at Michigan Technological University takes their rover technology to the “dark side”. Not for evil — the polar craters…
Bioelectrocatalysis uses cellular processes for chemical synthesis
Greener and more efficient chemical catalysts are right within our cells. Catalysts are key components of the chemical reactions that produce chemicals, biofuels and other materials. Catalysts are active in cellular processes too—certain enzymes, when connected to electrodes, can carry…
Investigating Medicaid Expansion’s Association With Insurance Status, Diagnosis, Treatment Among Patients With Cancer
Investigating Medicaid Expansion’s Association With Insurance Status, Diagnosis, Treatment Among Patients With Cancer JAMA Network OpenOriginal Investigation Association of Medicaid Expansion Under the Affordable Care Act With Insurance Status, Cancer Stage, and Timely Treatment Among Patients With Breast, Colon, and…
Coronavirus – study finds methods for preventing global disease spread through airports
As coronavirus spreads across the globe via infected air travelers, authorities are looking for ways to contain the outbreak and avoid a pandemic. This study, published in Risk Analysis, analyzes the impact of implementing disease mitigation strategies at airports across the globe. The study finds that increasing traveler engagement with proper hand-hygiene at all airports has the potential to reduce the risk of a potential pandemic by 24-69 percent. The researchers also identify ten critical airports, central to the air-transportation network. If hand-washing mitigation strategies are implemented in just these ten locations, the pandemic risk can drop by up to 37 percent.
Drug to Improve Fetal Growth May Impair Baby’s Postnatal Blood Pressure, Sugar Levels
Article title: Antenatal sildenafil citrate treatment increases offspring blood pressure in the placental-specific Igf2 knockout mouse model of FGR Authors: J. Renshall, E. C. Cottrell, E. Cowley, C. P. Sibley, P. N. Baker, E. B. Thorstensen, S. L. Greenwood, M. Wareing, M.…
Drug-induced Cystitis May Increases Brain Inflammation, Causes Depression in Rats
Article title: Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats Authors: Nathan A. Hirshman, Francis M. Hughes Jr., Huixia Jin, William T. Harrison, Simon W. White, Isabelle Doan, Shelby N. Harper, Patrick D.…
Growth Factor Receptor-bound Protein Plays Role in Muscle Cell Insulin Signaling
Article title: Role of Grb10 in mTORC1-dependent regulation of insulin signaling and action in human skeletal muscle cells Authors: Ashlin M. Edick, Olivia Auclair, Sergio A. Burgos From the authors: “Based on these findings, we propose that mTORC1 controls PI3K/Akt…
Changes in Muscle Nerve Activity in Type 2 Diabetes May Increase Heart Disease Risk
Article title: Augmented pressor and sympathoexcitatory responses to the onset of isometric handgrip in patients with type 2 diabetes Authors: Jennifer R. Vranish, Seth W. Holwerda, Jasdeep Kaur, Paul J. Fadel From the authors: “[Type 2 diabetes] is associated with…
Nicotine Boosts Production of Inflammation-causing Hormones, Worsens Kidney Disease
Article title: COX-2 derived prostaglandins as mediators of the deleterious effects of nicotine in chronic kidney disease Authors: Sunil Rangarajan, Gabriel Rezonzew, Phillip Chumley, Huma Fatima, Mikhail Golovko, Wenguang Feng, Ping Hua, Edgar A. Jaimes From the authors: “In these studies,…
Scientists Find Links Between Digestive Processing Time, Stool Consistency and Gut Microbiome Composition
Article title: Distal colonic transit is linked to gut microbiota diversity and microbial fermentation in humans with slow colonic transit Authors: Mattea Müller, Gerben D.A. Hermes, Emanuel E. Canfora, Hauke Smidt, Ad A.M. Masclee, Erwin G. Zoetendal, Ellen E. Blaak From…
Study Explores Alternative Treatments for Small Fiber Neuropathy Mutation
Article title: The small fiber neuropathy NaV1.7 I228M mutation: impaired neurite integrity via bioenergetic and mitotoxic mechanisms, and protection by dexpramipexole Authors: Seong IL Lee, Janneke G.J. Hoeijmakers, Catharina G. Faber, Ingemar. S. J. Merkies, Giuseppe Lauria, Stephen G. Waxman…
Lifelong Exercise Influences Muscle Size, Function, Fat Tissue in Older Adults
Article title: Skeletal muscle size, function and adiposity with lifelong aerobic exercise Authors: Toby L. Chambers, Timothy R. Burnett, Ulrika Raue, Gary A. Lee, W. Holmes Finch, Bruce M. Graham, Todd A. Trappe, Scott W. Trappe From the authors: “This is…
Researchers Identify Molecule Cluster That Improves Mucus Hydration in Cystic Fibrosis
Article title: Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia Authors: Catharina van Heusden, Brian Button, Wayne H. Anderson, Agathe Ceppe, Lisa C. Morton, Wanda K. O’Neal, Hong Dang, Neil E. Alexis, Scott H.…
Study Highlights Importance of Cellular Substrates and Physical Environment as Determinants to Cell Migration
Article title: Bioenergetics underlying single cell migration on aligned nanofiber scaffolds Authors: Abinash Padhi, Alexander H. Thomson, Justin B. Perry, Grace N. Davis, Ryan P. McMillan, Sandra Loesgen, Elizabeth N. Kaweesa, Rakesh Kapania, Amrinder S. Nain, David A. Brown From…
New Guideline Aims to Transform Evaluation and Care of Children and Adolescents with ADHD
The Journal of Developmental & Behavioral Pediatrics is releasing a groundbreaking guideline for the diagnosis and care of attention-deficit/hyperactivity disorders in children and youth in a supplement to its February 2020 issue. The Society for Developmental and Behavior Pediatrics Clinical…
First Ancient DNA from West and Central Africa Illuminates Deep Human Past
An international team led by Harvard Medical School scientists has produced the first genome-wide ancient human DNA sequences from west and central Africa.
Introducing “Health Years in Total:” A Novel Framework for Valuing Health Outcomes in Cost-Effectiveness Analyses
Lawrenceville, NJ, USA—January 21, 2020—Value in Health, the official journal of ISPOR—the professional society for health economics and outcomes research, announced today the publication of an article introducing a new framework for valuing health outcomes in cost-effectiveness analyses. This new…
Implementing Grand Strategy Toward China
“China wants to replace the United States as the strongest and most influential power in Asia and beyond,” warns Council on Foreign Relations (CFR) Henry A. Kissinger Senior Fellow for U.S. Foreign Policy Robert D. Blackwill. “Washington should launch an all-out…
Preparing for the Next Foreign Policy Crisis
Overview Managing foreign policy crises has become a recurring challenge for U.S. presidents. Since the end of the Cold War, there have been one hundred twenty occasions in which a threatening development overseas triggered a period of intense, high-level deliberation…
Dengue new vaccine performs well in large trial, but safety remains key concern
News wise on Dengue related news. An experimental dengue vaccine has shown promising early results in a large, multicountry trial, but critical questions remain about its effectiveness and safety. Still unclear, for example, is whether the vaccine—which had an efficacy…
UMD studies green infrastructure to manage more intense stormwater with climate change
UMD researchers are connecting climate change to urban and suburban stormwater management, with the ultimate goal of increasing resiliency to major storm events. With models not only predicting more rain, but an increased frequency of particularly intense and destructive storms
Wild Camels Not so Wild
Each year, WCS scientists author or co-author nearly 300 peer-reviewed studies and papers. “WCS 3 Sentence Science” is a regular tip-sheet – in bite sized helpings – of some of this published work. 1. Researchers investigated male lineages of both wild and…