Enzyme + Mitochondrial Signaling May Contribute to Pulmonary Hypertension in Newborns

Article title: PKCβ and reactive oxygen species mediate enhanced pulmonary vasoconstrictor reactivity following chronic hypoxia in neonatal rats

Authors: Joshua R. Sheak, Simin Yan, Laura Weise-Cross, Rosstin Ahmadian, Benjimen R. Walker, Nikki L. Jernigan

From the authors: “This research demonstrates a novel contribution of [protein kinase C beta type] and mitochondrial reactive oxygen species signaling to increased pulmonary vasoconstrictor reactivity in chronically hypoxic neonates. The results provide a potential mechanism by which chronic hypoxia increases both basal and agonist-induced pulmonary arterial smooth muscle tone, which may contribute to neonatal pulmonary hypertension.”

This study is highlighted as one of March’s “best of the best” as part of the American Physiological Society’s APSselect program.

 

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