Reduced Response to Odors May Be Common in People with Autism

Article title: Decreased amplitude and reliability of odor-evoked responses in two mouse models of autism

Authors: Matthew A. Geramita, Jing A. Wen, Matthew D. Rannals, and Nathaniel N. Urban

From the authors: “Here we show that two mouse models of autism, Cntnap2- and Shank3- deficient mice, display reduced odor-evoked response amplitudes and reliability. These data suggest that altered sensory evoked responses may constitute a circuit phenotype in [autism spectrum disorders].”

This study is highlighted as one of March’s “best of the best” as part of the American Physiological Society’s APSselect program.

 

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