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UrduArticle title: Chemogenetic activation of intracardiac cholinergic neurons improves cardiac function in pressure overload-induced heart failure Authors: Jhansi Dyavanapalli, Aloysius James Hora, Joan B. Escobar, John Schloen, Mary Kate Dwyer, Jeannette Rodriguez, Christopher F. Spurney, Matthew W. Kay From the authors: “The…
Category: Research Alert
Study Explores Possible Candidates for Vaccine Treatment for Liver Cancer
Article title: Experimental analysis of T cell epitopes for designing liver cancer vaccine predicted by system-level immunoinformatics approach Authors: Syed Aun Muhammad, Sidra Zafar, Samana Zahra Rizvi, Imran Imran, Fahad Munir, Muhammad Babar Jamshed, Amjad Ali, Xiaogang Wu, Numan Shahid,…
Researchers Discover a Novel Potassium Channel Activator Which Acts as a Potential Anticonvulsant
Corresponding Authors: Paul A. Slesinger, PhD, Lillian and Henry M. Stratton Professor of Neuroscience, Director, Center for Neurotechnology & Behavior, Icahn School of Medicine at Mount Sinai, New York (lead) Avner Schlessinger, PhD, Associate Professor, Department of Pharmacological Sciences, Associate…
Lesbian, gay and bisexual youth keep praying, but quit church as they reach adulthood
Many churches are unwelcoming to sexual minorities, which may lead lesbian, gay and bisexual Americans to retreat from religiton. This study investigates the trajectories of religion change for sexual minorities and other emerging adults, using two longitudinal data sources to…
UNC Researcher Leads National Survey on Mental Health Impact of COVID-19 Pandemic
CHAPEL HILL, NC – The findings of a nationwide survey assessing the effects of the COVID-19 pandemic on the emotional wellbeing of the U.S. adult population have been released online. The survey was a collaboration between UNC School of Medicine…
Research shows COVID-19 is an independent risk factor for acute ischemic stroke.
Corresponding Author: Puneet Belani, MD, Assistant Professor at Icahn School of Medicine at Mount Sinai Hospital, Department of Radiology, Neuroradiology. Bottom Line: COVID-19 infection is significantly associated with strokes, and patients with COVID-19 should undergo more aggressive monitoring for stroke.…
Researchers create a tool for better anticipation of preterm birth
Premature birth is a major global health challenge and the leading cause of death in children under 5. In order to predict premature birth, it necessary to know the gestational age of a baby, which isn’t easy. Even if a…
Machine Learning Has a Flaw. It’s Gullible
Potential biases that limit the effectiveness of machine learning process technologies and the scope for human capital to be complementary in reducing such biases is explored by Rajshree Agarwal and Evan Starr at the University of Maryland’s Robert H. Smith…
Monoclonal Antibody Restores T-Cell Ability to Kill Cancer
A new class of anticancer agents can restore the ability of cytotoxic T lymphocytes (CTLs) to infiltrate the tumor and kill target cells in patients with metastatic non-small cell lung cancer (mNSCLC).
Researchers Identify Rare Cantú Syndrome as Genetic Form of Heart Failure
“The mechanism of high-output cardiac hypertrophy arising from potassium channel gain-of-function in Cantú syndrome,” published ahead of print in the journal Function, identifies the rare disorder Cantú syndrome as a genetic type of heart failure distinct from other forms of…
Spanish in the 2016 U.S. presidential election
This study analyzes discourse in and about Spanish by presidential hopefuls and their prospective running mates leading up to the 2016 United States presidential election. I utilize Irvine and Gal’s (2000) framework of semiotic processes to reveal how Democratic and…
Strainoptronics: A New Way to Control Photons
SUMMARYResearchers discovered a new way to engineer optoelectronic devices by stretching a two-dimensional material on top of a silicon photonic platform. Using this method, coined strainoptronics by a team led by George Washington University professor Volker Sorger, the researchers demonstrated…
Clinical Trial Looks at Antiseptic Nasal Spray and Gargle to Prevent COVID-19 Infections
As the COVID-19 pandemic continues, researchers at the University of Kentucky are exploring the use of an antiseptic nasal spray and gargle to prevent transmission and infection of the virus among healthcare workers and non-COVID patients. The PIIPPI trial, which stands for Povidone-Iodine Intranasal for Prophylaxis…
Two Widely-Used Drugs for Erectile Dysfunction Could Be Repurposed to Treat Osteoporosis
Why the Research Is Interesting: Osteoporosis is a global public health problem that affects almost 200 million people worldwide. Erectile dysfunction is the most common male sexual dysfunction in the aging population, with more than 70% of men over the…
Early screening of Seattle-area pregnant women shows low infection rate for COVID-19
Screening all pregnant women who delivered at UW Medicine facilities during the height of the covid pandemic in Washington state showed that remarkably few tested positive for the virus without symptoms, a new report shows.
Mortality of Mechanically Ventilated COVID-19 Patients Is Lower than Previously Reported Reveals Study in Critical Care Medicine
June 4, 2020 – An online first study published in Critical Care Medicine indicates the actual mortality rate of adults with critical illness from COVID-19 is less than what was previously reported. Compared to earlier reports of a 50 percent…
Study shows how to achieve optimal treatment and improve outcomes for rare cancer patients
(Baltimore, MD) — The Institute for Cancer Care at Mercy Medical Center is pleased to announce the publication of an in-depth analysis on appendiceal goblet cell carcinomas managed with CRS/HIPEC (Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy) in the Annals of Surgical Oncology. These very rare…
Expression of Certain Genes May Affect Vulnerability to Post-Traumatic Stress Disorder
Highlights In a recent study, genes were predicted to be expressed at different levels in the tissues of individuals with PTSD compared with those without PTSD. Individuals with PTSD tended to have a lower expression of a gene called SNRNP35…
UNC Researchers Collaborate on Project to Study Pandemic’s Impact on People with Eating Disorders
CHAPEL HILL, NC – When the COVID-19 pandemic led to mandatory stay at home orders and physical distancing efforts, UNC School of Medicine’s Cynthia Bulik, PhD, Distinguished Professor of Eating Disorders, and Christine Peat, PhD, assistant professor of psychiatry, took…
Newly Discovered Hormone Could Play Important Role in Adjusting Thirst Levels
Article title: A novel regulator of thirst behavior: phoenixin Authors: Christopher J. Haddock, Gislaine Almeida-Pereira, Lauren M. Stein, Gina L. C. Yosten, Willis K. Samson From the authors: “These actions, together with the stimulatory action of [phoenixin] on vasopressin secretion, suggest that…
Zinc Transporter Gene Mutation May Play Role in Lactation Performance
Article title: A common genetic variant in zinc transporter ZnT2 (Thr288Ser) is present in women with low milk volume and alters lysosome function and cell energetics Authors: Olivia C. Rivera, Donna T. Geddes, Shiran Barber-Zucker, Raz Zarivach, Annie Gagnon, David I. Soybel,…
Study Explores Experience, Processing of Multi-site Touch
Article title: Principles of tactile search over the body Authors: Elizabeth J. Halfen, John F. Magnotti, Md. Shoaibur Rahman, Jeffrey M. Yau From the authors: “Establishing how multi-site touch is experienced and processed may be important for the study and treatment of…
Study Suggests Low-carbohydrate, High-fat Diet Protects against Obesity
Article title: Dietary carbohydrates modulate metabolic and β-cell adaptation to high-fat diet-induced obesity Authors: Tracy K. Her, William S. Lagakos, Matthew R. Brown, Nathan K. LeBrasseur, Kuntol Rakshit, Aleksey V. Matveyenko From the authors: “These studies support the hypothesis that low carbohydrate/high…
High Levels of Follicle Simulating Hormone May Lead to Increased Muscle Loss in Late Perimenopause
Article title: Appendicular lean mass is lower in late compared with early perimenopausal women: potential role of FSH Authors: Young-Min Park, Catherine M. Jankowski, Cemal Ozemek, Kerry L. Hildreth, Wendy M. Kohrt, Kerrie L. Moreau From the authors: “Our data suggest that the…
Mouse Study Looks at Role of Transmembrane Transporter in Duchenne Muscular Dystrophy
Article title: Isoform-specific Na,K-ATPase and membrane cholesterol remodeling in motor endplates in distinct mouse models of myodystrophy Authors: Violetta V. Kravtsova, Elena V. Bouzinova, Alexander V. Chibalin, Vladimir V. Matchkov, Igor I. Krivoi From the authors: “Altogether, the α2 Na,K-ATPase and…
Lack of Sodium Channel Component Protects against Diet-induced Artery Stiffening
Article title: Western diet induces renal artery endothelial stiffening that is dependent on the epithelial Na+ channel Authors: Yuxin Xiong, Annayya R. Aroor, Francisco I. Ramirez-Perez, Guanghong Jia, Javad Habibi, Camila Manrique-Acevedo, Guido Lastra, Donqqing Chen, Vincent G. DeMarco, Luis A.…
Compound in Red Wine, Grape Juice May Limit Inflammation in Cystic Fibrosis
Article title: Resveratrol restores intracellular transport in cystic fibrosis epithelial cells Authors: Binyu Lu, Deborah A. Corey, Thomas J. Kelley From the authors: “Though further studies are necessary, the ability of resveratrol to reverse [cystic fibrosis] cellular phenotypes in a manner not…
Renal Circadian Clock Gene Plays Sex-specific Role in Blood Pressure, Sodium Storage
Article title: Differences in renal BMAL1 contribution to sodium homeostasis and blood pressure control in male and female mice Authors: Ryan Crislip, Lauren Grace Douma, Sarah Howland Masten, Kit-Yan Cheng, I. Jeanette Lynch, Jermaine G. Johnston, Dominique Barral, Krystal B. Glasford,…
Low-intensity Exercise with Blood Flow Restriction May Improve Muscle Health
Article title: Blood flow restriction exercise stimulates mobilization of hematopoietic stem/progenitor cells and increases the circulating ACE2 levels in healthy adults Authors: Shrinidh Joshi, Sean Mahoney, Jesmin Jahan, Logan Pitts, Kyle J. Hackney, Yagna P.R. Jarajapu From the authors: “This study…
Study Explores Role of Extracellular Vesicles in Tissue Repair after Heart Attack
Article title: CDC-derived extracellular vesicles reprogram inflammatory macrophages to an arginase 1-dependent pro-angiogenic phenotype Authors: Kyle I. Mentkowski, Asma Mursleen, Jonathan D. Snitzer, Lindsey M. Euscher, Jennifer K. Lang From the authors: “Our study was designed to gain mechanistic insight into the…
New Discovery May Lead to Effective and Natural Treatment for Parkinson’s Disease
Summary: Investigators have identified two molecules naturally produced by the body that stimulate the production of dopamine, the molecule that is in short supply in the brains of patients with Parkinson’s disease. Highlights: – The Nurr1 protein maintains thehealth of neurons…
Virus transmission between individuals via a surgical smoke plume
Electrosurgery uses energy to destroy tissue creating a gaseous byproduct referred to as surgical smoke or plume. This smoke can contain viable cells and viruses; specifically, human papillomavirus has been demonstrated in this smoke. Human papillomavirus in smoke does pose…
Are Gastrointestinal Symptoms Specific for COVID-19 Infection? A Prospective Case-Control Study from the United States
“To our knowledge, this is the first prospective case-control study of GI symptoms in COVID-19 patients. We found a high prevalence of GI symptoms (74%) in COVID-19 patients, with the most common GI symptoms being anorexia (53%) and diarrhea (50%). However,…
New remdesivir trial at UIC tests drug in combination with baricitinib
The University of Illinois at Chicago is enrolling patients in a second clinical trial to study the drug remdesivir as a treatment for COVID-19. Funded by the National Institute of Allergy and Infectious Disease (NIAID), this international randomized, placebo-controlled clinical trial will…
Study Explores Mitochondrial-directed Therapy for Carbon Monoxide Poisoning
Article title: Ex vivo use of cell-permeable succinate prodrug attenuates mitochondrial dysfunction in blood cells obtained from carbon monoxide poisoned individuals Authors: Shawn Owiredu, Abhay Ranganathan, David M. Eckmann, Frances S. Shofer, Kevin Hardy, David S. Lambert, Matthew Kelly, David H. Jang…
WHAT THE UNITED STATES AND OTHER COUNTRIES CAN EXPECT BASED ON THE ITALIAN EXPERIENCE
Italy got hit as first among Western countries, and the Italian experience may represent an opportunity for the United States and other countries to put in place timely measures to decrease the potentially devastating effect of the healthcare crisis on…
Leading the Way in Innovative Research for COVID-19 Patients
Leading the Way in Innovative Research for COVID-19 Patients As the COVID-19 pandemic continues, there is great interest in studying treatment and prevention approaches for the disease. Cleveland Clinic is participating in a number of research projects related to COVID-19.…
Parkinson’s Disease: Exploring Motives for Long-Term Adherence to a Group Exercise Program
Abstract Purpose The aim of this study was to explore why people with Parkinson’s disease maintained attendance at a community group exercise program. Design Qualitative design was used for this study. Methods A purposive sample was used to recruit participants. Interviews with individual and focus groups collected narrative data that were interpreted using content…
Penn State cancer research center joins pandemic fight
UNIVERSITY PARK, Pa. — The Penn State Center for Structural Oncology (CSO) is shifting some of its focus from fighting cancer to fighting COVID-19, with three projects. The CSO’s director, Deborah Kelly, Lloyd & Dottie Foehr Huck Chair in Molecular Biophysics…
Protease-activated Receptor Blockage May Be Treatment Option for Diabetes-related Kidney Disease
Article title: Dual blockade of protease-activated receptor 1 and 2 additively ameliorates diabetic kidney disease Authors: Shohei Mitsui, Yuji Oe, Akiyo Sekimoto, Emiko Sato, Yamato Hashizume, Shu Yamakage, Satoshi Kumakura, Hiroshi Sato, Sadayoshi Ito, Nobuyuki Takahashi From the authors: “These findings suggest that…
Scientists Explore Mechanism that Regulates Protein Levels, Controls Fluid Transport in Intestines
Article title: SNX27 regulates DRA activity and mediates its direct recycling by PDZ-interaction in early endosomes at the apical pole of Caco2 cells Authors: Karen Bannert, Peggy Berlin, Johannes Reiner, Heiko Lemcke, Robert David, Robby Engelmann, Georg Lamprecht From the authors:“The results…
Diabetes Drug May Protect Breastfed Sons from Future Metabolic Disorder
Article title: Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner Authors: Zach Carlson, Hannah Hafner, Molly Mulcahy, Kaylie Bullock, Allen Zhu, Dave Bridges, Ernesto Bernal-Mizrachi, Brigid Gregg From the authors: “Future…
Sugary Sodas Linked to Increased Risk of Chronic Kidney Disease
Article title: High-fructose corn syrup-sweetened soft drink consumption increases vascular resistance in the kidneys at rest and during sympathetic activation Authors: Christopher L. Chapman, Tigran Grigoryan, Nicole T. Vargas, Emma L. Reed, Paul J. Kueck, Leonard D. Pietrafesa, Adam C. Bloomfield,…
New Xenometabolite Contributes to Exercise-induced Changes in Blood, Muscle Tissue Composition
Article title: Identification and regulation of xenometabolite derivatives cis- and trans-3,4-methylene-heptanoylcarnitine in plasma and skeletal muscle of exercising humans Authors: Hany F. Sobhi, Xinjie Zhao, Peter Plomgaard, Miriam Hoene, Jakob S. Hansen, Benedikt Karus, Andreas M. Niess, Hans U. Häring, Rainer Lehmann,…
Veterans with Traumatic Brain Injury Have Higher Sugar Levels in Brain
Article title: Increased myoinositol in the anterior cingulate cortex of veterans with a history of traumatic brain injury: a proton magnetic resonance spectroscopy study Authors: Chandni Sheth, Andrew P. Prescot, Margaret Legarreta, Perry F. Renshaw, Erin McGlade, Deborah Yurgelun-Todd From the…
Researchers Identify Enzyme in Mice that May Contribute to Age-related Heart Disease
Article title: Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging Authors: Melissa Lieu, Christopher J. Traynham, Claudio de Lucia, Jessica Pfleger, Michela Piedepalumbo, Rajika Roy, Jennifer Petovic, Gavin Landesberg, Steven…
Spinal Cord Contributes to Post-injury Walking Recovery in Cats
Article title: Recovery of locomotion in cats after severe contusion of the low thoracic spinal cord Authors: Hugo Delivet-Mongrain, Melvin Dea, Jean-Pierre Gossard, Serge Rossignol From the authors: “The main findings of this study show that after a very large damage following…
Helicobacter Pylori Bacteria Lowers Enzyme Levels to Cause Gastric Injury
Article title: Helicobacter pylori infection impairs chaperone-assisted maturation of Na,K-ATPase in gastric epithelium Authors: Elizabeth A. Marcus, Elmira Tokhtaeva, Jossue L. Jimenez, Yi Wen, Bita V. Naini, Ashley N. Heard, Samuel Kim, Joseph Capri, Whitaker Cohn, Julian P. Whitelegge, Olga Vagin…
Study Explores Temperature Regulation in Extreme and Humidity during Emergency Rescue
Article title: Human thermoregulation during prolonged exposure to warm and extremely humid environments expected to occur in disabled submarine scenarios Authors: Zachary J. Schlader, Blair D. Johnson, Riana R. Pryor, Jocelyn Stooks, Brian M. Clemency, David Hostler From the authors: “These data…
Mental health in children on home confinement in COVID-19 outbreak in China
What The Study Did: This study investigates the depression and anxiety of children in China’s Hubei province during the coronavirus disease 2019 (COVID-19) lockdown. Authors: Ranran Song, Ph.D., M.S., of the Huazhong University of Science and Technology in Wuhan, China, is the…