Researchers Identify Molecule Cluster That Improves Mucus Hydration in Cystic Fibrosis

Article title: Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia

Authors: Catharina van Heusden, Brian Button, Wayne H. Anderson, Agathe Ceppe, Lisa C. Morton, Wanda K. O’Neal, Hong Dang, Neil E. Alexis, Scott H. Donaldson, Holger Stephan, Richard C. Boucher, Eduardo R. Lazarowski

From the authors: “We have identified polyoxometalates that markedly reduce the hydrolysis of ATP by airway epithelial cells and inflamed [cystic fibrosis] sputum.” 

This study is highlighted as one of February’s “best of the best” as part of the American Physiological Society’s APSselect program.

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