Groundbreaking LLNL and BridgeBio Oncology Therapeutics collaboration announces start of human trials for supercomputing-discovered cancer drug

In a substantial milestone for supercomputing-aided drug design, Lawrence Livermore National Laboratory (LLNL) and BridgeBio Oncology Therapeutics (BridgeBio) today announced clinical trials have begun for a first-in-class medication that targets specific genetic mutations implicated in many types of cancer.

Rensselaer Researchers Upend Theory About the Formation of the Milky Way Galaxy

Rensselaer Polytechnic Institute’s Heidi Jo Newberg, Ph.D., professor of astronomy; Tom Donlon, Ph.D., a visiting researcher at Rensselaer and a postdoctoral researcher at the University of Alabama; and their team have recently published research that reveals a shocking discovery about the history of our universe: the Milky Way Galaxy’s last major collision occurred billions of years later than previously thought.

Citrus saviors: discovering the genetic defense against Huanglongbing disease

A recent study has pinpointed two key enzymes in Citrus sinensis that play a crucial role in the plant’s defense mechanism against the Asian citrus psyllid (ACP), a vector for the lethal huanglongbing (HLB) disease. This research offers a promising lead in the battle against a disease that has caused significant losses in the citrus industry.

Vigorous Exercise May Preserve Cognition in High-Risk Patients With Hypertension

People with high blood pressure have a higher risk of cognitive impairment, including dementia, but a new study from researchers at Wake Forest University School of Medicine suggests that engaging in vigorous physical activity more than once a week can lower that risk.

Flower power: genetic insights into the Chrysanthemum’s architectural elegance

Researchers have made significant strides in understanding the genetic factors that shape the Chrysanthemum lavandulifolium’s inflorescence, with a particular focus on the cla-miR164-NO APICAL MERISTEM (ClNAM) gene’s regulatory functions. This study provides a foundation for advancements in the targeted breeding and genetic enhancement of this species.

How a protein component of nuclear pore complexes regulates development of blood cells and may contribute to myeloid disorders

Nuclear pore complexes (NPCs) are channels composed of multiple proteins that ferry molecules in and out of the nucleus, regulating many critical cellular functions, such as gene expression, chromatin organization and RNA processes that influence cell survival, proliferation, and differentiation.

Drug Used to Treat Eczema May Provide Relief for Patients with Intensely Itchy Skin Diseases

Clinical Trial Finds Oral Medication Significantly Reduced Prurigo Nodularis and Chronic Pruritus of Unknown Origin Symptoms A drug approved to treat eczema provided significant improvement in the symptoms of patients with severe itching diseases that currently have no targeted treatments, according to a new study published in JAMA Dermatology.

MD Anderson Research Highlights for June 5, 2024

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.

Largest-ever antibiotic discovery effort uses AI to uncover potential cures in microbial dark matter

Almost a century ago, the discovery of antibiotics like penicillin revolutionized medicine by harnessing the natural bacteria-killing abilities of microbes. Today, a new study co-led by researchers at the Perelman School of Medicine at the University of Pennsylvania suggests that natural-product antibiotic discovery is about to accelerate into a new era, powered by artificial intelligence (AI).

Injury Prediction Rule Could Decrease Radiographic Imaging Exposure in Children, Study Shows

In a study published today in The Lancet Child & Adolescent Health, researchers in the Pediatric Emergency Care Applied Research Network (PECARN) created a highly accurate cervical spine injury prediction rule. When applied, the rule decreases the use of CT by more than 50% without missing clinically significant injuries or increasing normal X-ray use.

When mothers and children talk about problems, environment matters

Talking to their parents about daily stressors can help adolescents deal with their problems. This is particularly important during the transition to middle school, when youth often are faced with new peer and academic challenges. But does it matter where these conversations take place? That’s the topic of a new study from the University of Illinois Urbana-Champaign.

Study Reveals Billion-Dollar Toll of Domestic Violence in California

A comprehensive new study by Tulane University’s Newcomb Institute and the University of California San Diego School of Global Policy and Strategy has quantified the staggering economic impact of intimate partner violence in California, revealing billions in costs that deeply affect survivors, communities and taxpayers across the state.

How tumor stiffness alters immune cell behavior to escape destruction

Researchers at Sanford Burnham Prebys, with collaborators, illuminate how the fibrotic tumor microenvironment creates an inhospitable milieu for anti-tumor immunity, not just by creating a physical barrier but through metabolic changes that suppress the anti-tumor function of responding immune cells.

Canisius University experts dissect impact of President Biden’s executive order and its broader socio-political context

In response to President Joe Biden’s announcement today, Tuesday, June 4, limiting the border crossing of asylum-seekers,  Canisius University professors Richard Reitsma, PhD and Shyam Sriram, PhD, are available to provide expert commentary.  Both bring a wealth of expertise to…

An anti-inflammatory curbs spread of fungi causing serious blood infections

Study finds that mesalamine, a common anti-inflammatory drug, can fight the fungus Candida albicans in the gut, potentially preventing the risk of invasive candidiasis in patients with blood cancers.

Wayne State University partners with Great Lakes Water Authority to help train water pipeline managers of the future

The Great Lakes Water Authority (GLWA) has partnered with Wayne State University to develop its Workforce Development and Pipe Management Program, which will help recruit, teach and graduate the next generation of water pipeline managers. The two-year program will begin July 1, 2024, and will be supported by a contract totaling more than $480,000.

FAU and Mainstreet Research Poll of Battleground States Highlights Partisan Divide on Top Issues, Trump Conviction

A new poll of voters in Pennsylvania, Michigan and Wisconsin, often considered battleground states, highlights the partisan divide on important issues and on the legal case against former U.S. President Donald Trump.