Researchers from Roswell Park Comprehensive Cancer Center will present compelling findings showcasing significant benefits of resistance training for patients with multiple myeloma, in a talk at the 66th American Society of Hematology (ASH) Annual Meeting. The study, led by Jens Hillengass, MD, PhD, and Janine Joseph, MS, MBA, presents new evidence documenting that targeted exercise regimens can alleviate fatigue, improve sleep and reduce pain, offering new hope for enhancing quality of life in cancer care.
Year: 2024
Roswell Park Experts Report Insights on CAR T for Follicular Lymphoma, KEYNOTE-667 Combo in Hodgkin Lymphoma
The results of two important lymphoma studies led by experts at Roswell Park Comprehensive Cancer Center will be presented during oral abstract sessions this morning at the 66th annual meeting of the American Society of Hematology (ASH) in San Diego, California. Lymphoma is a type of blood cancer that causes white blood cells called lymphocytes to grow out of control and behave abnormally.
ASH 2024: Antibody Shows Encouraging Results for Treating High-risk Follicular Lymphoma and Marginal Zone Lymphoma
ASH 2024 Presentations: Two clinical trials testing the antibody loncastuximab tesirine (Zynlonta) showed encouraging results in patients with high-risk forms of two blood cancers – follicular lymphoma and marginal zone lymphoma.
Preclinical Study Shows Targeted Drug Strengthens the Power of CAR T-Cell Therapy in Two Pediatric Leukemias
A preclinical study led by a faculty member at Roswell Park Comprehensive Cancer Center shows that gilteritinib (brand name Xospata), a targeted cancer treatment, can strengthen chimeric antigen receptor (CAR) T-cell immunotherapy in two high-risk pediatric leukemias that have poor survival rates — FLT3-mutated acute myeloid leukemia (AML) and KMT2A-rearranged acute lymphoblastic leukemia (ALL). Lisa Niswander, MD, PhD, Assistant Professor of Oncology in the Department of Pediatric Oncology, will deliver the results this afternoon in an oral abstract session at the 66th annual meeting of the American Society of Hematology (ASH) in San Diego, California.
Roswell Park Study Reveals How Venetoclax Boosts Immune Response to CAR T for Chronic Lymphocytic Leukemia
Research out of Roswell Park Comprehensive Cancer Center has shed light on how the drug venetoclax (brand name Venclexta) works synergistically with CAR T-cell immunotherapy to combat chronic lymphocytic leukemia (CLL), the most common type of leukemia in the U.S. Matthew Cortese, MD, MPH, Assistant Professor of Oncology in Roswell Park’s departments of Medicine and Cancer Genetics & Genomics, is first author of the study, which he will present during an oral abstract session today at the 66th annual meeting of the American Society of Hematology (ASH) in San Diego, California.
Keto diet metabolite may power up CAR T cells to kill cancer
A simple dietary supplement may provide a new approach to boost CAR T cell function, according to a study from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine’s Abramson Cancer Center, presented at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition (Abstract 4).
New Research from Children’s Hospital of Philadelphia to Transform Standard of Care Across the Globe for Newly Diagnosed Children with B-cell Acute Lymphoblastic Leukemia
Researchers at Children’s Hospital of Philadelphia (CHOP) and the Children’s Oncology Group (COG) announced the results of a Phase 3 study that demonstrated adding the bi-specific T-cell engager, blinatumomab, to chemotherapy for newly diagnosed National Cancer Institute (NCI) standard risk (SR) B-cell acute lymphoblastic leukemia (B-ALL) pediatric patients significantly improves survival outcomes. The results were published today in the New England Journal of Medicine and will be presented during the plenary session at the 66th American Society of Hematology (ASH) Annual Meeting & Exposition in San Diego on December 8.
Thawing Permafrost Reveals Complex Microbiome–Metabolite Interplay
Research led by a multi-institutional study found that microbes interact with sulfur- and nitrogen-rich compounds, possibly from mosses in bogs. This interaction appears to contribute to greenhouse gas production.
CSUF Among Top 5 National Institutions for Bachelor’s Degrees to Latinx Students
Cal State Fullerton ranked No. 4 in the nation among four-year schools for the total number of bachelor’s degrees awarded to Latinx students in both Hispanic Outlook in Higher Education’s 2024 “Top 100 Colleges and Universities for Hispanics” and Diverse: Issues In Higher Education’s 2024 “Top 100 Degree Producers” rankings.
Illinois research illuminates signal transduction mechanisms in Cys-loop receptors
University of Illinois researchers discovered a key factor responsible for facilitating signal transduction in Cys-loop receptors, providing insight into a longstanding question in the field of ion-channel physiology and contributing to rational drug design.
How Caregivers of People With Dementia Can Navigate the Holidays
Although the holiday season brings joy to many, it may mean added stress for those supporting a family member with memory loss. Mary-Catherine Lundquist, the program director of Care2Caregivers, a peer counseling helpline (800-424-2494) for caregivers of individuals with Alzheimer’s disease and related memory disorders operated by Rutgers Behavioral Health Care, discusses how families can make the most of the season.
Navigating the holiday season: MSU experts can comment
It’s the most wonderful time of the year, right? Not necessarily. We all know that the holidays can cause stress and angst as we cook, shop, entertain and spend time with family and friends we may not see often. Michigan State University experts offer suggestions on navigating the holiday — from the economy and food prices to religion and spirituality to health and relationships.
Sacrificing Sleep During the Holiday Season
A new survey from the American Academy of Sleep Medicine reveals that more than half of Americans (55%) say they are extremely or somewhat tired during the holiday season.
Expert Available to Talk about South Korea’s Martial Law Updates
George A. Lopez is the Rev. Theodore M. Hesburgh, C.S.C., Professor Emeritus of Peace Studies at the Kroc Institute for International Peace Studies in the Keough School of Global Affairs at the University of Notre Dame, and a former member of the UN Panel of Experts…
Researchers are Going to Map Cells Crucial to Child Respiratory Health and Disease
A research project co-led by researchers at the UNC School of Medicine and colleagues, will create an atlas of the cells in the nasal and oral cavities, throat, and lower airways of pediatric populations in unprecedented detail.
VUMC to study the effect of breathing tube size on breathing, speaking, swallowing
Vanderbilt University Medical Center has been approved for $7 million in research funding by the Patient-Centered Outcomes Research Institute (PCORI) to study the effect of breathing tube size on breathing, speaking and swallowing after critical illness.
Calculation Sharpens Imaging of Protons’ Insides
Nuclear scientists used a new theoretical approach to calculate a value essential for unraveling the three-dimensional motion of quarks within a proton. The researchers obtained a significantly more accurate picture of these internal building blocks’ transverse motion. The work will aid in calculations of 3D motion of quarks and gluons in future collider experiments.
Dark Energy Camera Spies the Outskirts of the Swirling Southern Pinwheel Galaxy
Twelve million light-years away lies the galactic masterpiece Messier 83, also known as the Southern Pinwheel Galaxy. Its swirling spiral arms display a high rate of star formation and have been host to six observed supernovae. This image was captured with the Department of Energy-fabricated Dark Energy Camera, mounted on the U.S. National Science Foundation Víctor M. Blanco 4-meter Telescope at Cerro Tololo Inter-American Observatory in Chile, a Program of NSF NOIRLab.
Cerro Tololo registra un tesoro cósmico de estrellas nacientes y supernovas exclusivo de los cielos del Sur
A 12 millones de años luz se encuentra la joya galáctica Messier 83, conocida también como la Galaxia del Molinillo Austral. Sus brazos espirales muestran una elevada tasa de formación estelar y además ya se han registrado seis supernovas observadas en ella. Esta detallada imagen se obtuvo en Chile con la Cámara de Energía Oscura del Departamento de Energía de los Estados Unidos, que se encuentra montada en el Telescopio de 4 metros Víctor M. Blanco, en Cerro Tololo, un Programa de NOIRLab de NSF.
Three Sanford Burnham Prebys faculty members ranked among the world’s most influential scientists
Three faculty members at Sanford Burnham Prebys are among the most influential scientists worldwide in the 2024 rankings by the Institute for Scientific Information at Clarivate.
NCCN Hosts Patient Advocacy Summit on Improving Access to Accurate Health Information
NCCN hosts a Patient Advocacy Summit bringing together leading experts to promote strategies and best practices for improving cancer care, focused on practice and policy solutions for sharing accurate, evidence-based health information with patients and caregivers.
UAlbany Chemists Develop Color-Changing Test for Rapid Salmonella Detection
UAlbany researchers have developed a new method for fast-acting salmonella detection. The test employs a paper strip that changes color in the presence of the bacterial genome, enabling quick, easy and inexpensive screening for salmonella in food products.
American Society of Anesthesiologists’ Statement Regarding Anthem’s Policy Reversal on Anesthesia Care Payment
The American Society of Anesthesiologists (ASA) is pleased that Anthem has reversed course on its deeply flawed policy proposal to no longer pay for anesthesia care if the surgery or procedure goes beyond an arbitrary, Anthem-set time limit, regardless of how long the surgical procedure actually takes.
Notre Dame’s Pulte Institute joins global consortium using research to end poverty
The United States Agency for International Development (USAID) has awarded $75 million to a consortium of leading global institutions, including the Pulte Institute for Global Development at the University of Notre Dame’s Keough School of Global Affairs, to enhance the effectiveness of poverty alleviation programs through research.
Grandma is “Still There”
It’s a challenge to celebrate the holiday season with loved ones who have dementia. But Stephen Post, PhD, a bioethicist, has a message that could change your focus when visiting these loved ones this season: There are powerful lucid moments that occur with the deeply forgetful. Hold onto them. It’s worth the time.
Researchers develop new shape-changing polymer
A team of scientists has created a new shape-changing polymer that could transform how future soft materials are constructed.
Record-low Antarctic sea ice can be explained and forecast months out by patterns in winds
University of Washington researchers show that the all-time record low in winter sea ice extent in 2023 can be explained by warm Southern Ocean conditions and patterns in the winds that circled Antarctica months earlier, allowing forecasts for sea ice coverage around the South Pole to be generated six or more months in advance. This could support regional and global weather and climate models.
Scientists urged to pull the plug on ‘bathtub modeling’ of flood risk
Recent decades have seen a rapid surge in damages and disruptions caused by flooding. In a commentary article published today in the American Geophysical Union journal Earth’s Future, researchers at the University of California, Irvine and the University of Bristol in the United Kingdom – the latter also executives of U.
Expert Available: French Politics & Trump’s Upcoming Visit
French President Emmanuel Macron has promised he will announce a new prime minister in the coming days. Meanwhile, U.S. President-elect Donald Trump is traveling to Paris this weekend. …
Pup play: Behind the sexual fetish, a caring community
A research project sheds light on the body image benefits of pup play, a role play in which people pretend to be dogs.
Chula Implements New Strategy, Launches Siam Square Walking Street for All, Showcasing Abilities of Special Needs People
Prof. Dr. Wilert Puriwat, President of Chulalongkorn University, led a team of staff from Property Management of Chulalongkorn University (PMCU) and Five for All Foundation in opening Siam Square Walking Street for All. Siam Square was transformed into a walking street for all for the first time. The project kickstarted with 2 days of performances by disabled performers who showcased their various talents, engaging with the public through activities such as music, sports, dance, and fashion shows. The event also featured products and services by people with disabilities all over Siam Square.
Physical climate change exposure and firms’ adaptation strategy
Abstract Research Summary This article examines whether and how firms adapt to physical exposures to climate change. I build a novel dataset that compiles information on the adaptation strategies of publicly traded companies around the globe and merge it with…
Echo ‘Our’ Voice? The influences of team members on the voice behavior of focal employees
Abstract This study investigates the social processes that underpin the influences of team members’ voice behavior on the voice behavior of other individual members. The tests of the hypotheses, using survey data from 342 full-time employees working in 74 project…
Getting a grip on health norms
A groundbreaking study led by the University of South Australia and conducted in collaboration with 140 authors across the globe, has created the world’s largest and most geographically comprehensive international norms for handgrip strength, enabling global peer-comparison, health screening and surveillance across the adult lifespan.
Tackling tough cancers: the dual-targeted attack on metastatic colorectal cancer
Scientists are making waves with a novel therapy for metastatic colorectal cancer (mCRC) that combines two powerful antibodies—one targeting epidermal growth factor receptor (EGFR), the other programmed cell death 1 (PD-1). This dual treatment aims to supercharge the immune system, showing early signs of improving survival and response rates. For patients with no other treatment options, this breakthrough offers a glimmer of hope, potentially changing the trajectory of their fight against cancer.
Toward an improved causal test of network effects: Does alliance network position enhance firm innovation?
Abstract Research Summary Assessing whether network position causes firm outcomes is difficult because networks result from firms’ strategic choices. To address this issue, we develop a research design that separates self-driven network change from other-driven change. Because other-driven change suppresses…
100 Vision-Saving Procedures and Counting: Q&A With Retinal Gene Therapy Expert Dr. Aaron Nagiel
His newly treated patients might show significant improvements on their eye chart tests, but Aaron Nagiel, MD, PhD, will tell you that the truest signs of visual progress come through the texts he receives from parents days, weeks, and months after their child’s treatment.There’s no shortage of stories: A toddler truly animals at the zoo for the first time.
Living in a Disadvantaged Neighborhood Linked to Higher Blood Pressure and Lower Cognition
New research from Wake Forest University School of Medicine suggests that living in a disadvantaged neighborhood is associated with higher blood pressure and lower cognitive scores, even among people who do not have an existing diagnosis of mild cognitive impairment.
New study: Peer-brokered sales central to illegal drug trade
The thought of illegal drug sales evokes images of deals done on shady street corners. But a new study from Case Western Reserve University exposes a critical but underreported element of the illegal drug market: so-called “peer-brokered” sales. Peer-brokered sales, in which people buy drugs for others within their social circles and take a cut—either as a share of the drugs or money by inflating the price—play a widespread and vital role in the distribution of illegal substances, according to the new study.
Developing highly efficient recovery materials for precious ‘rare earth metals’ and improving resource circulation for digital infrastructure
Dr. Jae-Woo Choi and his team at the Center for Water Cycle Research at the Korea Institute of Science and Technology (KIST) recently announced the development of a fiber-based recovery material that can recover rare earth metals such as neodymium (Nd) and dysprosium (Dy) with high efficiency. The new material is expected to contribute to solving rare earth supply and industrial stability issues by recovering and recycling rare earth metals (neodymium-iron-boron (Nd-Fe-B)) that are mainly used in third-generation permanent magnets, which are essential components in the electric vehicle, hybrid vehicle drive motors, wind power, robotics, and aerospace industries.
Entrepreneurs who take funding from close family and friends are more likely to pursue lower-risk growth options
Entrepreneurs often lack resources and funding needed to launch a venture and reach out to family and friends for initial support. But is it always good for a startup when individuals close to the founder are asked if they want to “be on the ground floor of something good?” New research from three Indiana University Kelley School of Business professors finds that such close ties to investors can lead founders to make more conservative venture growth decisions and make them more hesitant to take risks.
Qualitas Welcomes Three New Partners in Southeastern Massachusetts, Expanding Expertise and Access to Exceptional Dental Care
Qualitas Dental Partners is proud to announce the addition of three distinguished partners to its esteemed network, underscoring its commitment to delivering outstanding dental care to communities in southern New England
Study sheds light on evolving views of gender integration within the U.S. military
In a new study of current and former U.S. soldiers, researchers at the University of California, Irvine and Queen’s University found that those deployed to Afghanistan in mixed-gender units were more likely to view gender integration positively than all-male units.
2025 economic outlook amid presidential transition: MSU experts can comment
The economy was the top issue for voters in the 2024 presidential election with many Americans feeling the pinch of higher gas and food prices. From foreign conflict in the Middle East to port workers striking for collective bargaining efforts, as well as voters approving minimum wage raises in several states, the U.S. economy continues to lead in many headlines. That said, economists and experts at Michigan State University are available to comment on the economic forecast for the coming year, speaking specifically to the potential implications of tariffs, the stock market, automotive issues and electric vehicles, food prices and agriculture, and education.
Controlling cancer cells’ gluttony for glutamine
Researchers at the NCI-Designated Cancer Center at Sanford Burnham Prebys describe two enzymes newly identified for their roles in regulating macropinocytosis, a process cancer cells use to snatch extra nutrients from the jelly-like substance between cells. This allows tumors to fuel their growth even when they consume more energy and other resources than they can acquire from nearby blood vessels.
Analyzing multiple mammograms improves breast cancer risk prediction
A new method of analyzing mammograms — developed by researchers at WashU Medicine — identified individuals at high risk of developing breast cancer more accurately than the standard, questionnaire-based method did. The new method, powered by artificial intelligence, could help diagnose cancer earlier and guide recommendations for earlier screening, additional imaging or risk-reducing medications.
5 Trends That Are Changing Pediatric Epilepsy Care
Epilepsy is the most common pediatric brain disorder, affecting nearly half a million children in the U.S. And yet, only about 1% of patients who should be seen at a comprehensive epilepsy center are ever referred to this care.That’s a devastating statistic, especially for children—whose uncontrolled seizures can sometimes lead to irreversible developmental deficits.
Earthquake seismology expert, Dr. Stephen Gao, available for comment on California earthquake
Dr. Stephen Gao is available for comment related to the science behind the recent earthquake in California.
Seven researchers named to Battelle Distinguished Inventor cadre
Seven scientists affiliated with the Department of Energy’s Oak Ridge National Laboratory have been named Battelle Distinguished Inventors in recognition of being granted 14 or more United States patents. Since Battelle began managing ORNL in 2000, 104 ORNL researchers have reached this milestone.
Media Advisory: Virginia Tech expert explains NOAA forecast for mild winter in mid-Atlantic region
Drew Ellis, a professor in the Department of Geography and an expert in climate science, explains the National Oceanic and Atmospheric Administration’s winter outlook, which predicts a mild winter for the mid-Atlantic region of the United States.