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UrduArticle title: Diabetes causes NLRP3-dependent barrier dysfunction in mice with detrusor overactivity but not underactivity Authors: Michael R. Odom, Francis M. Hughes Jr., Huixia Jin, J. Todd Purves From the authors: “This is the first study to demonstrate that NLRP3-mediated…
Tag: Physiology
Biological Sex, Heart Disease Risk Factors Can Influence Relationship between Cardiorespiratory Fitness Level and Brain Blood Flow
Article title: Influence of sex and presence of cardiovascular risk factors on relations between cardiorespiratory fitness and cerebrovascular hemodynamics Authors: Wesley K. Lefferts, Cynthia M. Weiner, Sara E. Mascone, Jacqueline A. Augustine, Kevin S. Heffernan, Elizabeth C. Lefferts From the…
Changing Hormone Levels Post-menopause Leads to Vascular Impairment in Female Mice
Article title: Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice Authors: Jade A. Blackwell, Josiane F. Silva, Emma M. Louis, Andrea Savu, Tally M. Largent-Milnes, Heddwen L. Brooks, Paulo W. Pires From the authors: “Together, our data…
Researchers ID a Protein that Could Help Stop Cancerous Tumor Development
Article title: Decorin evokes reversible mitochondrial depolarization in carcinoma and vascular endothelial cells Authors: Thomas Neill, Christopher Xie, Renato V. Iozzo From the authors: “In conclusion, we have delineated a molecular axis focused on delivering prodepolarization signals to the mitochondrial…
New Research on Neuronal Response to Calcium Imaging Aid Interpretation of Data without Electrophysiology Recordings
Article title: Simultaneous whole-cell patch-clamp and calcium imaging on myenteric neurons Authors: Zhiling Li, Werend Boesmans, Youcef Kazwiny, Marlene M. Hao, Pieter Vanden Berghe From the authors: “Our findings will help in the interpretation of calcium imaging data without the…
Substance in Urine May Help Determine Asthma Severity
Article title: Urinary total conjugated 3-bromotyrosine, asthma severity and exacerbation risk Authors: Zeneng Wang, Weiling Xu, Suzy A. A. Comhair, Xiaoming Fu, Zhili Shao, Rebecca Bearden, Joe G. Zein, Eugene R. Bleecker, Mario Castro, Loren C. Denlinger, John V. Fahy,…
Math Model Shows Climate Change Puts Rainforest Animal’s Survival in Jeopardy
A South American marsupial with ties to an ancient line of animals may go extinct in the next half-century due to warming temperatures. Researchers from the Universidad Austral de Chile will present a mathematical model of the monito del monte’s survival predictions this week at the American Physiological Society (APS) Intersociety Meeting in Comparative Physiology: From Organism to Omics in an Uncertain World conference in San Diego.
It’s Not the Heat, It’s the Humidity: Water Loss Hurts Bees Most in the Desert
Digger bees lose large amounts of water during flight, which compromises their activity period and survival in the desert heat. Researchers from Arizona State University will present their work this week at the American Physiological Society (APS) Intersociety Meeting in Comparative Physiology: From Organism to Omics in an Uncertain World conference in San Diego.
Activity ‘Snacks’ Following Meals May Help Maintain Muscle Mass
Interrupting prolonged sitting with periodic activity “snacks” may help maintain muscle mass and quality, according to a new study by researchers at the University of Toronto.
Reduced Expression of Extracellular Matrix Protein May Ease Markers of Sclerosis-associated Lung Disease
Article title: Fibronectin-EDA accumulates via reduced ubiquitination downstream of toll-like receptor 9 activation in SSc-ILD fibroblasts Authors: Ferhan Tuncer, Melissa Bulik, John Villandre, Travis Lear, Yanwen Chen, Beyza Tuncer, Daniel J. Kass, Eleanor Valenzi, Christina Morse, John Sembrat II, Robert…
Researchers Identify Potential New Therapeutic Target for Polycystic Kidney Disease
Article title: The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease Authors: Shirin V. Sundar, Julie Xia Zhou, Brenda S. Magenheimer, Gail A. Reif, Darren P. Wallace, Gunda I. Georg, Sudhakar R. Jakkaraj, Joseph S. Tash, Alan S.L.…
Inspiratory Capacity Important Marker for Disease Outcomes in COPD
Article title: Physiological predictors of morbidity and mortality in COPD: the relative importance of reduced inspiratory capacity and inspiratory muscle strength Authors: Devin B. Phillips, Matthew D. James, Conor D. O’Donnell, Sandra G. Vincent, Katherine A. Webb, Juan P. de-Torres,…
Absence of Protein Signaling Pathway in Mice Is Associated with Defects in Intestinal Tissue Development
Article title: Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa Authors: Stamatia Papoutsopoulou, Joseph Tang, Ahmed H. Elramli, Jonathan M. Williams, Nitika Gupta, Felix I. Ikuomola, Raheleh Sheibani-Tezerji, Mohammad T. Alam, Juan…
Blocking Estrogen in Breast Cancer May Affect Blood Pressure, Kidney Health
Article title: Aromatase inhibition increases blood pressure and markers of renal injury in female rats Authors: Rawan N. Almutlaq, Annie E. Newell-Fugate, Louise C. Evans, Huma Fatima, Eman Y. Gohar From the authors: “The present findings demonstrate that systemic anastrozole…
Sex Differences in Aging Include Varied Gene Expression, Splicing Changes
Article title: Proteogenomics reveals sex-biased aging genes and coordinated splicing in cardiac aging Authors: Yu Han, Sara A. Wennersten, Julianna M. Wright, R. W. Ludwig, Edward Lau, Maggie P. Y. Lam From the authors: “In summary, this study shows that…
Loss of Transport Protein Function Contributes to Chronic Intestinal Inflammation
Article title: Loss of NKCC1 function increases epithelial tight junction permeability by upregulating claudin-2 expression Authors: Rainelli Koumangoye, Parker Penny, Eric Delpire From the authors: “We speculate that the upregulation of claudin-2, if confirmed in vivo, by increasing pore permeability…
Researchers Present New Mathematical Model for Studying Kidney Cells
Rockville, Md. (September 13, 2022)—Research published ahead of print in the journal Function presents a new mathematical model using opossum kidney cells to study the endocytic capacity of proximal tubule cells in the kidneys. The specialized cells in the proximal…
Researchers Explore Role of Plasma Membrane Pump in Calcium Signaling
Rockville, Md. (September 1, 2022)—Research published ahead of print in the journal Function suggests the plasma membrane Ca2+ ATPase (PMCA) pump helps regulate cytosolic calcium signaling. Cytosolic calcium is found within the cells’ intracellular fluid—the cytosol is one such liquid—and…
APS Launches New Center for Physiology Education
The American Physiological Society (APS) today launched the Center for Physiology Education, an online headquarters for physiology educators to gather, collaborate, engage and learn.
Diaphragm Muscle Fiber Mitochondria Adapt to Varying Levels of Activity
Article title: Mitochondrial adaptations to inactivity in diaphragm muscle fibers Authors: Alyssa D. Brown, Matthew J. Fogarty, Leah A. Davis, Debanjali Dasgupta, Carlos B. Mantilla, Gary C. Sieck From the authors: “Type I and IIa [diaphragm muscle] fibers were far…
Virtual Model Predicts Body Temperature for Hot and Cold States, May Aid Injury Prevention
Article title: A 3D virtual human model for simulating heat and cold stress Authors: Tushar Gulati, Rajeev Hatwar, Ginu Unnikrishnan, Jose E. Rubio, Jaques Reifman From the authors: “Our 3D thermoregulatory virtual human model consistently predicted the body’s thermal state…
Researchers ID Low Immune Cell Responsiveness and High Level of Proteins as Features of COVID-19 Severity
Article title: Chemokines, soluble PD-L1 and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness Authors: Eric D. Morrell, Pavan K. Bhatraju, Neha A. Sathe, Jonathan Lawson, Linzee Mabrey, Sarah E. Holton, Scott R. Presnell, Alice Wiedeman, Carolina Acosta-Vega,…
Intestinal Abnormalities in People with Posttraumatic Stress Disorder Don’t Improve Even When PTSD Symptoms Abate
Article title: Abnormal intestinal milieu in post-traumatic stress disorder is not impacted by treatment that improves symptoms Authors: Robin M. Voigt, Alyson K. Zalta, Shohreh Raeisi, Lijuan Zhang, J. Mark Brown, Christopher B. Forsyth, Randy A. Boley, Philip Held, Mark…
Men Performing Heavy Resistance Exercise Have Disruptions to Gene Expression in Muscles
Article title: Human skeletal muscle acetylcholine receptor gene expression in elderly males performing heavy resistance exercise Authors: Casper Soendenbroe, Mette F. Heisterberg, Peter Schjerling, Michael Kjaer, Jesper L. Andersen, Abigail L. Mackey From the authors: “Taken together, the results demonstrate…
Heart of Aging Female Mice Produce More Collagen than Males, Develops More Scarring
Article title: Sex-specific phenotypes in the aging mouse heart and consequences for chronic fibrosis Authors: Aude Angelini, Jesus Ortiz-Urbina, JoAnn Trial, Anilkumar K. Reddy, Anna Malovannaya, Antrix Jain, Mark L. Entman, George E. Taffet, Katarzyna A. Cieslik From the authors:…
Peptide Treatment May Improve High White Blood Cell Count Associated with Smoking
Article title: Recombinant human β-defensin 2 delivery improves smoking-associated lung neutrophilia and bacterial exacerbation Authors: Nadia Milad, Marie Pineault, Gabrielle Bouffard, Michaël Maranda-Robitaille, Ariane Lechasseur, Marie-Josée Beaulieu, Sophie Aubin, Benjamin A. H. Jensen, Mathieu C. Morissette From the authors: This…
Exercise + Sauna = Better Cardiovascular Function
New research suggests that adding a regular 15-minute sauna to an exercise routine may improve cardiovascular risk factors more than exercise alone. The study is the first randomized controlled trial to explore the long-term combination of exercise and sauna bathing in a non-clinical population. It is published ahead of print in the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.
Researchers Suggest Continued Heart and Lung Monitoring after COVID-19 for People with Highly Physical Jobs
Article title: The effect of medium-term recovery status after COVID-19 illness on cardiopulmonary exercise capacity in a physically active adult population Authors: Peter Ladlow, Oliver O’Sullivan, Alexander N. Bennett, Robert Barker-Davies, Andrew Houston, Rebecca Chamley, Samantha May, Daniel Mills, Dominic…
Omicron Variant of COVID-19 Does Not Cause Long-term Vascular Damage in Vaccinated Young Adults
Article title: Impact of breakthrough COVID-19 cases during the Omicron wave on vascular health and cardiac autonomic function in young adults Authors: Rachel J. Skow, Damsara Nandadeva, Ann-Katrin Grotle, Brandi Y. Stephens, Alexis N. Wright Paul J. Fadel From the…
Metabolomic Profiles Differ in Children Born to People with and without Obesity
Article title: Metabolomic signatures of low- and high-adiposity neonates differ based on maternal BMI Authors: Begum Aydogan Mathyk, Brian D. Piccolo, Fernanda Alvarado, Kartik Shankar, Perrie O’Tierney-Ginn From the authors: “Using untargeted metabolomics in 100 newborns, we found that cord…
Study of Body Weight-associated Genes in Rats May Inform Regulation of Obesity in Humans
Article title: Transcriptome-wide analyses of adipose tissue in outbred rats reveal genetic regulatory mechanisms relevant for human obesity Authors: Wesley L. Crouse, Swapan K. Das, Thu Le, Gregory Keele, Katie Holl, Osborne Seshie, Ann L. Craddock, Neeraj K. Sharma, Mary…
Selective Autophagy Process Protects Heart Muscle Cells from Death
Article title: Chaperone-mediated autophagy protects cardiomyocytes against hypoxic cell death Authors: Rajeshwary Ghosh, Jennifer Jason Gillaspie, Kenneth S. Campbell, J. David Symons, Sihem Boudina, James Scott Pattison From the authors: “In summary, the present study demonstrated the importance of [chaperone-mediated…
Flozin Drugs Lower Salt-Induced Hypertension, Maintain Circadian Rhythm in Rats
Article title: SGLT2 inhibition effect on salt-induced hypertension, RAAS and Na+ transport in Dahl SS rats Authors: Olha Kravtsova, Ruslan Bohovyk, Vladislav Levchenko, Oleg Palygin, Christine A. Klemens, Timo Rieg, Alexander Staruschenko From the authors: “The main findings of the…
Skin and Oral Microbiota Contribute to Blood Pressure Regulation
Article title: Beyond the gastrointestinal tract: oral and sex-specific skin microbiota are associated with hypertension in rats with genetic disparities Authors: Xue Mei, Blair Mell, Xi Cheng, Ji-Youn Yeo, Tao Yang, Nathaline Chiu, Bina Joe From the authors: “In conclusion,…
Common Prebiotic Fiber Mitigates Harm of High-salt Diet in Rats
New research in rats finds a diet high in the fiber inulin offered a protective effect against the damage of a high-salt diet. The research will be presented this week at the American Physiological Society and American Society for Nephrology Control of Renal Function in Health and Disease conference
Past Kidney Disease May Increase Preeclampsia Risk, Impair Blood Vessel Health during Pregnancy
A history of kidney problems may put people at a higher risk for impaired blood vessel function, which could lead to high blood pressure, preterm labor and other adverse outcomes, according to the results of a study in rats. The researchers will present their work this week at the American Physiological Society (APS) and American Society for Nephrology Control of Renal Function in Health and Disease conference in Charlottesville, Virginia.
Vitamin D Supplements May Offset Bone Loss Caused by Diabetes Drug
Vitamin D supplementation may help offset damaging bone loss that occurs in some people who take canagliflozin, a commonly prescribed diabetes drug. Researchers will present their work this week at the American Physiological Society (APS) and American Society for Nephrology Control of Renal Function in Health and Disease conference in Charlottesville, Virginia.
Giving Students Frequent Quizzes May Help Bridge Achievement Gap in Physiology
Frequent small stakes assessments may help marginalized students bridge an achievement gap in physiology education, according to research that will be presented this week at the American Physiological Society (APS) Institute on Teaching and Learning in Madison, Wisconsin.
Interactive Discussion Boards May Clarify Confusing Concepts in Advanced-level Physiology Courses
Using an online, interactive discussion board helped increase student understanding and engagement in a large enrollment course, according to new research from The Ohio State University College of Nursing. Physiology educator-researchers will present their findings this week at the American Physiological Society (APS) Institute on Teaching and Learning in Madison, Wisconsin.
Physiology Educators to Discuss Inclusive Teaching, Mentoring and Assessment at the APS Institute for Teaching and Learning
Physiology educators will gather in Madison, Wisconsin, June 21–24, 2022, for the American Physiological Society (APS) Institute on Teaching and Learning (ITL). The interactive multiday workshop will engage educators in sessions focused on the latest research and best practices in teaching, learning and assessment.
Artificial Intelligence Analyzes Gut Microbiota of Fish to Detect Waters Compromised by Climate Change
Article title: Gut microbiota of wild fish as reporters of compromised aquatic environments sleuthed through machine learning Authors: John W. Turner Jr., Xi Cheng, Nilanjana Saferin, Ji-Youn Yeo, Tao Yang Bina Joe From the authors: “Overall, this study represents the…
Researchers Find New Microvascular Regulation Role for Protein-coupled Receptor
Article title: Control of coronary vascular resistance by eicosanoids via a novel GPCR Authors: Nabil J. Alkayed, Zhiping Cao, Zu Yuan Qian, Shanthi Nagarajan, Xuehong Liu, Jonathan W. Nelson, Fuchun Xie, Bingbing Li, Wei Fan, Lijuan Liu, Marjorie R. Grafe,…
Acid Reflux in People with Barrett’s Esophagus May Change Cells to Cause Cancer
Article title: A human Barrett’s esophagus organoid system reveals epithelial-mesenchymal plasticity induced by acid and bile salts Authors: Qiuyang Zhang, Ajay Bansal, Kerry B. Dunbar, Yan Chang, Jianning Zhang, Uthra Balaji, Jinghua Gu, Xi Zhang, Eitan Podgaetz, Zui Pan, Stuart…
Calcium Signaling Plays Important Role in Regulating Bone Formation
Article title: Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation Authors: Abu Shufian Ishtiaq Ahmed, Matilda H. C. Sheng, Kin-Hing William Lau, Sean M. Wilson, Daniel Wongwarawat, Xiaolei Tang, Mahdis Ghahramanpouri,…
Anxiety Drug Increases Blood Pressure Variability in Young Adults
Article title: Potentiation of GABAergic synaptic transmission by diazepam acutely increases resting beat-to-beat blood pressure variability in young adults Authors: André L. Teixeira, Massimo Nardone, Milena Samora, Igor A. Fernandes, Plinio S. Ramos, Jeann L. Sabino-Carvalho, Djalma R. Ricardo, Philip…
Kidney Stone Formation Linked to Polycystic Kidney Disease in Mice
Article title: Kidney stone formation in a novel murine model of polycystic kidney disease Authors: Heather A.L. Riddle, Shiqin Zhang, Feng Qian, James C. Williams Jr., Jason R. Stubbs, Peter Stanley N. Rowe, Stephen C. Parnell From the authors: “Our…
Blocking Endothelin Receptors May Help People with Obesity Burn Calories, Reduce Heart Disease Risk
Article title: Dual endothelin receptor antagonism increases resting energy expenditure in people with increased adiposity Authors: Cassandra C. Derella, Anson M. Blanks, Andy Nguyen, Jacob Looney, Matthew A. Tucker, Jinhee Jeong, Paula Rodriguez-Miguelez, Jeffrey Thomas, Matthew Lyon, David M. Pollock,…
Temperature Plays a Role in Brain Activity Related to Episodic Memory and Planning
Article title: Brain temperature affects quantitative features of hippocampal sharp wave ripples Authors: Peter C. Petersen, Mihály Vöröslakos, György Buzsáki From the authors: “Here, we show that features of hippocampal ripples, including the rate of occurrence, peak frequency, and duration…
Breakthrough Omicron COVID-19 Variant Cases Don’t Impair Vascular Health Post-infection in Young Otherwise Healthy Adults
New research finds vaccinated young adults who were diagnosed with COVID-19 during the “omicron wave” of late 2021 and early 2022 did not have lasting vascular impairment after active infection. The first-of-its-kind study is published ahead of print in the American Journal of Physiology-Heart and Circulatory Physiology.
Brain Activity May Play Role in Childhood Trauma Victims’ Heart Disease Risk
Rockville, Md. (June 1, 2022)—Research published ahead of print in the journal Function suggests that reduced activity in one area of the brain may play in role in how adults who experienced adverse childhood events (ACEs) have a greater risk…