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UrduA research team from the UC Davis Comprehensive Cancer Center has identified a crucial epitope (a protein section that can activate the larger protein) on the CD95 receptor that can cause cells to die.
Tag: Cell Death
St. Jude finds NLRP12 as a new drug target for infection, inflammation and hemolytic diseases
Scientists at St. Jude Children’s Research Hospital found key “on” switch, NLRP12, for innate immune cell death in diseases that cause red blood cells to rupture, which can lead to inflammation and multi-organ failure.
Researchers Leverage Cell Self-Destruction to Treat Brain Tumors
Dominique Higgins, MD, PhD, an assistant professor in the Department of Neurosurgery, and a team of researchers at Columbia University have found that glioblastoma tumor cells are particularly sensitive to ferroptosis – a type of cell death that can be triggered by removing certain amino acids from the diet.
New cell death mechanism could offer novel cancer treatment strategies
A study from researchers at The University of Texas MD Anderson Cancer Center, published today in Nature Cell Biology, details a previously unexplained type of cell death called disulfidptosis that could open the door for novel cancer therapeutic strategies.
Selective Autophagy Process Protects Heart Muscle Cells from Death
Article title: Chaperone-mediated autophagy protects cardiomyocytes against hypoxic cell death Authors: Rajeshwary Ghosh, Jennifer Jason Gillaspie, Kenneth S. Campbell, J. David Symons, Sihem Boudina, James Scott Pattison From the authors: “In summary, the present study demonstrated the importance of [chaperone-mediated…
Newly Identified Aspect of Cell Death May Impact the Future of Fighting Diseases
Researchers have unmasked a component of the cell death process that could play a vital role in a better infection-fighting strategy.
Newly Discovered Lipid Prevents Cell Death
Programmed cell death is an important tool that an organism uses to keep itself healthy. When a cell does not function as it should, various stress reactions are activated.
Computer-based Modeling Identifies how Cell Death Is Regulated in Ischemic Kidney Injury
Article title: T95 nucleophosmin phosphorylation as a novel mediator and marker of regulated cell death in acute kidney injury Authors: Zhiyong Wang, Mostafa Belghasem, Erdjan Salih, Joel Henderson, Chinaemere Igwebuike, Andrea Havasi, Steven C. Borkan From the authors: “In this…
New Drug Reduces Stroke Damage in Mice
Mice that received an injection of a new experimental drug, TAT-DP-2, after a stroke had smaller areas of damage, and their long-term neurological function was better than that of untreated animals.
An ion channel senses cell swelling and helps cells to choose a response
New research from Washington University in St. Louis offers clues about how mechanosensitive ion channels in the plant’s cells respond to swelling by inducing cell death – potentially to protect the rest of the plant.
A direct protein-to-protein binding couples cell survival to cell proliferation
The regulators of apoptosis watch over cell replication and the decision to enter the cell cycle. Researchers now show a direct link between the protein MCL1 — a member of the BCL2 protein family known as the gatekeepers of apoptosis — and the cell-cycle checkpoint protein P18.
Breaking the dogma: Key cell death regulator has more than one way to get the job done
Scientists at St. Jude Children’s Research Hospital have discovered a new way that the molecule RIPK1 leads to cell death in infected, damaged or unwanted cells showing that more than one mechanism can trigger the process. The findings appeared online today in the Journal of Experimental Medicine.