English
Arabic
Chinese (Simplified)
Dutch
Esperanto
French
German
Greek
Italian
Japanese
Korean
Portuguese
Russian
Spanish
UrduThe Dementia Care Study (D-CARE) has found that health system and community-based dementia programs are no better than routine care in reducing caregiver strain or managing patient behaviors, but do improve caregivers’ confidence in their ability to manage challenges and access…
Tag: Alzheimer’s Disease
Neurocode Study Highlights Superior Performance of ALZpath pTau217 Assay in Alzheimer’s Diagnosis
Neurocode USA Inc, a leading clinical laboratory specializing in blood biomarkers for Alzheimer’s disease (AD) diagnosis, is pleased to announce the publication of a groundbreaking new study comparing the performance of two prominent pTau217 assays: the ALZpath assay and the Fujirebio assay.
Decoding the influence of mitochondrial Ca2+ regulation on neurodegenerative disease progression
Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death. Mitochondrial Ca2+ (Ca2+mito) plays a dual role in physiological processes like ATP production and pathophysiological events, including cell death and cancer. The balance of Ca2+ uptake and efflux, mediated by mitochondrial transporters and mitochondria-endoplasmic reticulum contact sites (MERCS), is essential for maintaining Ca2+mito homeostasis. This review summarizes current insights into mitochondrial Ca2+ regulation, its roles in physiology and neurodegenerative diseases, and explores therapeutic strategies targeting Ca2+ homeostasis, including innovative drug delivery systems and calcium-modulating agents.
FAU’s Randy D. Blakely, Ph.D., Honored as a Prestigious ASPET Fellow
Randy D. Blakely, Ph.D., has been named a Fellow of the American Society for Pharmacology and Experimental Therapeutics (ASPET). Designation as an ASPET Fellow recognizes leaders in the field for their exceptional contributions to pharmacological research, education, mentorship and leadership.
Grandma is “Still There”
It’s a challenge to celebrate the holiday season with loved ones who have dementia. But Stephen Post, PhD, a bioethicist, has a message that could change your focus when visiting these loved ones this season: There are powerful lucid moments that occur with the deeply forgetful. Hold onto them. It’s worth the time.
Living in a Disadvantaged Neighborhood Linked to Higher Blood Pressure and Lower Cognition
New research from Wake Forest University School of Medicine suggests that living in a disadvantaged neighborhood is associated with higher blood pressure and lower cognitive scores, even among people who do not have an existing diagnosis of mild cognitive impairment.
New pathways for Alzheimer’s prevention
A new study from the University of Delaware will look at Alzheimer’s disease (AD) and examine how changes in arterial stiffness and brain tissue in midlife adults could contribute to cognitive decline. The study aims to pinpoint early risk factors and explore preventive interventions.
Superspreader fibrils caught in the act
In dementia diseases such as Alzheimer’s, incorrectly folded proteins accumulate in the brain. Empa researchers have now resolved a particularly active species of protein fibrils with unprecedented precision. The formation of potentially toxic molecules on the surface of protein fibrils was studied from early to late stages spanning over a period of hours.
Popular diabetes and weight-loss drug may reduce risk of Alzheimer’s disease
Researchers at the Case Western Reserve School of Medicine have found that semaglutide may lower the risk of Alzheimer’s disease in people with type 2 diabetes (T2D).
Only Two Weeks Remain Until the ASHG 2024 Annual Meeting
The American Society of Human Genetics (ASHG) Annual Meeting will bring together the largest gathering of human geneticists in the world in Denver, Colorado on November 5-9.
Brain Blood Flow Resistance More Common in Older Adults with Cognitive Problems
Older adults with mild cognitive impairment showed greater resistance to brain blood flow compared to those without cognitive impediments.
RPI Alzheimer’s Disease Research Program Gets Multimillion-Dollar Boost
Rensselaer Polytechnic Institute (RPI) has been awarded two grants by the National Institute on Aging (NIA) to train graduate students on Alzheimer’s disease (AD) research and commercialization. NIA is one of the National Institutes of Health in the U.S. Department of Health and Human Services and is the primary federal agency supporting and conducting AD research.
Smaller vial size for Alzheimer’s drug could save Medicare hundreds of millions per year
Medicare could save up to 74% of the money lost from discarded Alzheimer’s drug lecanemab by the simple introduction of a new vial size that would reduce the amount of unused medication that is thrown away.
Non-invasive eye test for multiple diseases to advance under $4.8M NIH award
Researchers at the IU School of Optometry and IU Luddy School of Informatics, Computing and Engineering will advance next-generation technology that uses a simple eye scan to assist in the early detection of conditions such as Alzheimer’s disease, diabetes and heart disease.
Newly discovered genetic marker could pave the way for future Alzheimer’s disease therapeutics
Researchers have identified a new genetic marker that could play a role in the development of Alzheimer’s disease and lead to novel therapeutic targets and diagnostic tools for the disease.
Extra Virgin Olive Oil May Preserve Cognitive Function in Down Syndrome
Researchers working with the Alzheimer’s Center at Temple (ACT) recently investigated the effect of extra virgin olive oil (EVOO) on brain health and memory to determine if consumption of extra virgin olive oil, the main component of the Mediterranean diet, can delay cognitive decline in people with Down Syndrome (DS).
Brain network study reveals clues about dementia’s behavior changes
Dementia doesn’t just erode memory – it also changes behavior and mental health. A new study shows the brain’s salience network and tau protein may be involved.
Key mechanisms in asymptomatic Alzheimer’s disease brains may protect against cognitive decline
Researchers are studying the brains of a subset of people with asymptomatic Alzheimer’s disease who, despite having amyloid plaque and tau buildup postmortem, experienced no diagnosable dementia symptoms while they were living.
Clinical Trial Shows Synthetic Cannabis Reduces Agitation in Alzheimer’s Disease
In a study led by the Johns Hopkins University School of Medicine and Tufts University School of Medicine, researchers show that a pill form of the drug dronabinol, an FDA-approved synthetic version of marijuana’s main ingredient, THC, reduces agitation in patients with Alzheimer’s by an average of 30%.
New Study: Neuroscientists Spark Shelter-Seeking Response by Reactivating Memory Circuit
Using a sophisticated brain-imaging system, neuroscientists at Johns Hopkins Medicine say they have successfully reactivated a specific memory circuit in mice, causing them to seek out shelter when no shelter is actually present.
Researchers close in on understanding possible cause of Alzheimer’s disease
The National Institutes of Health (NIH) has awarded a four-year, $3.3 million grant to Case Western Reserve University researchers to investigate the potential involvement of specific brain proteins in the pathogenesis of Alzheimer’s disease.
New Brain Cell Cleaner: Astrocytes Raise Possibility of Alzheimer’s Disease Treatment
A research team led by Dr. Hoon Ryu from the Korea Institute of Science and Technology (KIST) has uncovered a new mechanism involving astrocytes for treating Alzheimer’s disease (AD) and proposed a novel therapeutic target.
Study Finds Certain MS Therapies May Not Slow Disability Progression
In people with primary progressive multiple sclerosis (MS), a new study has found no difference in the amount of time before disability worsened between people taking certain medications and those not receiving treatment. The study is published in the September 25, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Penny for Your Thoughts? Master Copper Regulator Discovery May Offer Alzheimer’s Clues
A groundbreaking study using a tiny roundworm could pave the way for new treatments for neurodegenerative disorders. Researchers have linked the worm gene swip-10 to copper regulation – a vital element for brain health found in everyday items like wiring and cookware. Understanding the roles of swip-10 and MBLAC1, a protein involved in processing cellular materials, could lead to the development of effective medications and opens new avenues for advancing brain disease treatments.
New Study Shows that Chronic Neurodegeneration can be Prevented after Traumatic Brain Injury
Violent blows or jolts to the head can cause traumatic brain injury (TBI), and there are currently about five million people in the U.S. living with chronic neurodegeneration and related impairments due to TBI.
Multiple sclerosis appears to protect against Alzheimer’s disease
A collaborative investigation among WashU Medicine experts in Alzheimer’s disease and multiple sclerosis (MS) finds evidence that MS patients are less likely to have amyloid plaques, a hallmark of Alzheimer’s disease, than adults without MS.
New research led by UTHealth Houston sheds light on the behavioral and psychological symptoms of Alzheimer’s disease and related dementias
A study offering insights into understanding and managing the behavioral and psychological symptoms of Alzheimer’s disease and related dementias led by a team of UTHealth Houston researchers has been published in Alzheimer’s & Dementia, the journal of the Alzheimer’s Association.
Do People with High Blood Pressure Have a Higher Risk of Alzheimer’s Disease?
People 60 and older with untreated high blood pressure may have an increased risk of Alzheimer’s disease compared to both people who have been or are being treated for high blood pressure as well as people without the chronic condition. The new research, a meta-analysis, is published in the August 14, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. These results do not prove that untreated high blood pressure causes Alzheimer’s disease, they only show an association.
Low magnesium levels increase disease risk, new study shows
A new Australian study has identified why a diet rich in magnesium is so important for our health, reducing the risk of DNA damage and chronic degenerative disorders.
Molecule restores cognition, memory in Alzheimer’s disease model mice
In a new study, a molecule identified and synthesized by UCLA Health researchers was shown to restore cognitive functions in mice with symptoms of Alzheimer’s disease by effectively jumpstarting the brain’s memory circuitry.
Can targeted therapies be applied to patients with Alzheimer’s?
University of Utah researchers discover potential treatments that target amyloid beta plaques on the brain that lead to dementia in patients with Alzheimer’s disease.
Researchers receive 9.5 million grant to study relationship between polyphenol intake, Alzheimer’s prevention, and the brain-gut-microbiome system
UCLA Health researchers, in collaboration with researchers from the Republic of Ireland and Northern Ireland, have received $9.5 million award from the National Institutes of Health (NIH) with support from European funding agencies — The Science Foundation Ireland (SFI) and the Public Health Agency Health & Social Care (HSC) — to study the effects of polyphenols on cognitive health and the brain-gut microbiome system.
Blood Test Shows Accuracy for Diagnosing Alzheimer’s Disease
A new study shows a type of blood test can determine if a patient has Alzheimer’s Disease with about 90 percent accuracy. According to the study, most of the time the blood test correctly identifies if patients with memory loss…
Aging-related genomic culprit found in Alzheimer’s disease
Researchers at Washington University School of Medicine in St. Louis have developed a way to study aged neurons in the lab without a brain biopsy, allowing them to accurately model the effects of aging in the development of late-onset Alzheimer’s disease.
New dementia prevention & care report: Two Univ. of Michigan experts available to comment
Two University of Michigan experts whose work is cited in a landmark new Lancet Commission report on dementia prevention and care are available to comment. They’re especially able to comment on the 14 risk factors that the commission says people…
Mejora de la imagenología de la enfermedad de Alzheimer con sensores fluorescentes
Ahora investigadores deACS Central Science demuestran una forma de empaquetar sensores fluorescentes para facilitar su paso a través de la barrera hematoencefálica en ratones, lo que permite mejorar la obtención de imagenología cerebral. Con un mayor desarrollo, la tecnología podría contribuir a avanzar en el diagnóstico y el tratamiento de la enfermedad de Alzheimer.
Improving Alzheimer’s disease imaging — with fluorescent sensors
Now, researchers in ACS Central Science demonstrate a way of packaging fluorescent sensors for easy passage across the blood-brain barrier in mice, allowing for improved brain imaging. With further development, the technology could help advance Alzheimer’s disease diagnosis and treatment.
Accuracy of diagnostic blood tests for Alzheimer’s disease varies
A head-to-head comparison of six commercially available blood tests for Alzheimer’s disease led by researchers at Washington University School of Medicine in St. Louis reveals that two are accurate enough to replace brain scans and spinal taps in some patients with cognitive impairments.
LANGaware awarded Patient Engagement Solutions agreement with Premier, Inc. for Early Detection of Cognitive and Behavioral Health Diseases
LANGaware, a pioneering AI-driven healthcare technology company, has been awarded a national group purchasing agreement for Patient Engagement Solutions with Premier, Inc.
Mayo Clinic scientists define new type of memory loss in older adults
Researchers at Mayo Clinic have established new criteria for a memory-loss syndrome in older adults that specifically impacts the brain’s limbic system. It can often be mistaken for Alzheimer’s disease.
Brain inflammation triggers muscle weakness after infections
Research from Washington University School of Medicine in St. Louis reveals how brain inflammation triggers extreme muscle weakness across several diseases, including viral infection, bacterial infection and Alzheimer’s disease. The study, in fruit flies and mice, also identified ways to block this process, which could have implications for treating or preventing the muscle wasting sometimes associated with inflammatory diseases, including bacterial infections, Alzheimer’s disease and long COVID.
Advocate Health champions health equity through new, innovative dementia care model
Advocate Health has been selected by the Centers for Medicare and Medicaid Services (CMS) to participate in the Guiding an Improved Dementia Experience (GUIDE) Model. Following years of neurocognitive disorders research pioneered by Advocate Health’s academic core, Wake Forest University School of Medicine, patients across the health system’s footprint will now benefit from the GUIDE Model’s new standardized approach to care for patients with dementia and their caregivers.
UAlbany Chemist Available to Discuss Eli Lilly Alzheimer’s Drug
ALBANY, N.Y. (July 9, 2024) — Last week, the Food and Drug Administration (FDA) approved a new Alzheimer’s medication developed by Eli Lilly that has shown in clinical trials to moderately delay the progression of memory and cognitive decline in…
Expert available: FDA approval of new Alzheimer’s drug, Kisunla
Aaron Burberry, Assistant Professor, Department of Pathology, School of Medicine https://case.edu/medicine/pathology/faculty/aaron-burberry
Expert available: FDA approval of Alzheimer’s disease drug, donanemab
The FDA approved a new Alzheimer’s disease treatment today called donanemab (brand name Kisunla), after it was reviewed and recommended by an advisory panel earlier this year. Sanjeev Vaishnavi, MD, PhD, an assistant professor of neurology at Penn Medicine, is…
New research identifies biomarkers that link alcohol use disorder and Alzheimer disease
Researchers agree that alcohol use can produce global and regional tissue volume changes in the brain, and that excessive alcohol use is associated with dementia and cognitive decline. A new study has examined the relationship between Alzheimer disease – the most common type of dementia – and alcohol use disorder (AUD), discovering biomarkers that link the two.
UC San Diego Receives $5M to Support Geriatrics Workforce Enhancement Program
The San Diego Imperial Geriatric Education Center has received renewed funding from the Health Resources and Services Administration, allowing the center to relocate to UC San Diego.
‘Fit2Drive’ Transforms Assessing Older Drivers with Cognitive Decline
With the help of an evidence-based calculator called “Fit2Drive,” researchers have made it easy to administer and evaluate an in-office test to predict an older individual’s probability of passing an on-road driving test. Based upon brief, easily administered cognitive tests, Fit2Drive provides an objective estimation of the ability to drive for those with cognitive concerns. Results show that the Fit2Drive algorithm demonstrated a strong 91.5% predictive accuracy.
Rensselaer Professor Receives $3.7 Million Grant for Alzheimer’s Disease Research
Chunyu Wang, M.D., Ph.D., professor of biological sciences and chemistry and chemical biology at Rensselaer Polytechnic Institute, has been awarded a five-year grant of more than $3.7 million by the National Institutes of Health’s National Institute on Aging to study Apolipoprotein E (ApoE) isoform interactions with heparan sulfate (HS) in Alzheimer’s disease (AD).
Icahn School of Medicine at Mount Sinai Awarded $21 Million NIH Grant to Advance Understanding of Aging-Related Hormone
Researchers at the Icahn School of Medicine at Mount Sinai have been awarded a $21 million grant from the National Institute on Aging (NIA) of the National Institutes of Health (NIH), to further advance understanding of an aging-related hormone known as follicle-stimulating hormone (FSH), including its potential role in obesity, osteoporosis, and Alzheimer’s disease.