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UrduNew York, NY – Researchers from the Icahn School of Medicine at Mount Sinai have found that most COVID-19 patients have persistent antibodies to the SARS-CoV-2 virus at levels that are correlated with neutralization of the virus more than…
Tag: SARS-CoV-2
Antibodies to SARS-CoV-2 Remain Stable, or Even Increase, Seven Months After Infection
The levels of IgG antibodies against SARS-CoV-2 Spike protein remain stable, or even increase, seven months after infection, according to a follow-up study in a cohort of healthcare workers coordinated by the Barcelona Institute for Global Health (ISGlobal), an institution supported by “la Caixa” Foundation, in collaboration with the Hospital Clinic of Barcelona.
Rethinking Remdesivir
UC San Diego researchers modify remdesivir, creating oral version that can be taken earlier in COVID-19 diagnoses. In cell and animal studies, revised drug proved effective and safe.
No Particular Risk of Infection of SARS-CoV-2 From Cash
How long do coronaviruses remain infectious on banknotes and coins? Is it possible to become infected through contact with cash?
UAH’s Baudry Lab part of half-million-dollar efforts to target COVID with drug therapies
Two different strategies to discover and perfect pharmaceuticals active against the COVID-19 virus have attracted a half million dollars in research funding to support five institutions, including the Baudry Lab at The University of Alabama in Huntsville (UAH).
Highly Potent, Stable Nanobodies Stop SARS-CoV-2
Göttingen researchers have developed mini-antibodies that efficiently block the coronavirus SARS-CoV-2 and its dangerous new variants.
利用人工智能筛选3000万种针对SARS-CoV-2的候选药物
妙佑医疗国际(Mayo Clinic)的研究人员和合作者利用计算机模拟和人工智能(AI)来筛选3000万种候选药物，这些药物有可能阻断导致COVID-19的SARS-CoV-2病毒。在一篇发表在《Biomolecules》上的论文中，研究人员阐述了他们如何加速药物发现，从而为开展进一步的研究确定最有希望的目标。他们的最终目的是寻找治疗COVID-19的新方法。
What if We Could Give Viruses a One-Two Punch?
Researchers at Stanford and Berkeley Lab’s Molecular Foundry have developed virus-killing molecules called peptoids. The technology could make possible an emerging category of antiviral drugs that could treat everything from herpes and COVID-19 to the common cold.
A rapid method to quantify antibodies against SARS-CoV-2
Scientists have developed a rapid, highly accurate test to detect antibodies against the spike protein of SARS-CoV-2 in human serum, opening a new avenue for understanding the full extent of the pandemic and evaluating the effectiveness of vaccines.
Scientists repurpose cancer and seizure medications to aid in the fight against COVID-19
Two teams of researchers using the Advanced Photon Source identified existing drugs — one used to treat cancer, the other an anti-seizure medication — that may work as treatments for COVID-19.
Usando a inteligência artificial para fazer a triagem de 30 milhões de possíveis medicamentos contra o SARS-CoV-2
Os pesquisadores e colaboradores da Mayo Clinic usaram a simulação em computadores e inteligência artificial (AI) para fazer a triagem virtual de 30 milhões de possíveis medicamentos que podem bloquear o SARS-CoV-2, o vírus que causa a COVID-19.
Imaging Test May Predict Patients Most at Risk of Some Heart Complications from COVID-19
Researchers at Johns Hopkins Medicine have shown that a type of echocardiogram, a common test to evaluate whether a person’s heart is pumping properly, may be useful in predicting which patients with COVID-19 are most at risk of developing atrial fibrillation — an irregular heartbeat that can increase a person’s risk for heart failure and stroke, among other heart issues. The new findings, published online May 30 in the Journal of the American Society of Echocardiography, also suggest that patients with COVID-19 who go on to develop atrial fibrillation more commonly have elevated levels of heart-related proteins called troponin and NT-proBNP in blood test samples.
Cutting out the proteins that give SARS-CoV-2 its power
Researchers at Texas Biomedical Research Institute (Texas Biomed) have narrowed down the proteins enabling SARS-CoV-2 to cause disease. Using advanced genetic engineering techniques developed at Texas Biomed, they systematically deleted the genetic code for five of the virus’s accessory proteins, one at a time, to see how each one affected the virus’s ability to spread and cause illness. The research was published online this month in the Journal of Virology.
UC San Diego Health Adopts SMART Health Card for Digital Vaccine Records
UC San Diego Health is now offering a verifiable digital vaccine record to its patients who have or will receive a COVID-19 vaccine. These secure online records, otherwise known as a SMART health card, can be accessed directly from the MyUCSDChart patient portal.
Study confirms the low likelihood that SARS-CoV-2 on hospital surfaces is infectious
A new study confirms the low likelihood that coronavirus contamination on hospital surfaces is infectious. The study is the original report on recovering near-complete SARS-CoV-2 genome sequences directly from surface swabs.
Virus that causes COVID-19 can find alternate route to infect cells
The virus that causes COVID-19 normally gets inside cells by attaching to a protein called ACE2. Researchers at Washington University School of Medicine in St. Louis have found that a single mutation confers the ability to enter cells through another route, which may threaten the effectiveness of COVID-19 vaccines and therapeutics designed to block the standard route of entry.
Had COVID-19? One vaccine dose enough; boosters for all, study says
A new study in ACS Nano supports increasing evidence that people who had COVID-19 need only one vaccine dose, and that boosters could be necessary for everyone in the future.
Engineering nanobodies as lifesavers when SARS-CoV-2 variants attack
Scientists are pursuing a new strategy in the protracted fight against the SARS-CoV-2 virus by engineering nanobodies that can neutralize virus variants in two different ways.
COVID-19 dual-antibody therapies effective against variants in animal study
A study from Washington University School of Medicine in St. Louis suggests that many, but not all, COVID-19 therapies made from combinations of two antibodies are effective against a wide range of virus variants, and that combination therapies appear to prevent the emergence of drug resistance.
Biophysical study sheds light on potentially druggable process of SARS-CoV-2 replication
This study investigates how the nucleocapsid protein, or N protein, of the SARS-CoV-2 virus packages the viral genome.
SARS-CoV-2 Worldwide Replication Drives Rapid Rise and Selection of Mutations
The number of COVID-19 variants is growing rapidly, so much that the scale and scope of mutation may pose a threat to the continuing successful use of the current vaccines and therapies. The findings, by an international team that includes University of California researchers, are being published in the June edition of the peer-reviewed journal EMBO Molecular Medicine. The pace of variation of the SARS-CoV-2 virus strains makes plain the threat that rapidly evolving new strains might give rise to escape variants, capable of limiting the efficacy of vaccines, therapies, and diagnostic tests.
Rapid exclusion of COVID-19 infection using AI, EKG technology
Artificial intelligence (AI) may offer a way to accurately determine that a person is not infected with COVID-19. An international retrospective study finds that infection with SARS-CoV-2, the virus that causes COVID-19, creates subtle electrical changes in the heart. An AI-enhanced EKG can detect these changes and potentially be used as a rapid, reliable COVID-19 screening test to rule out COVID-19 infection.
For Transplant Recipients, Third Time May Be the Charm for Better COVID Vaccine Protection
In a study published today in the Annals of Internal Medicine, Johns Hopkins Medicine researchers say they believe that, for the first time, there is evidence to show that three doses of vaccine increase antibody levels against SARS-CoV-2 — the virus that causes COVID 19 — more than the standard two-dose regimen for people who have received solid organ transplants.
AI Predicts How Patients with Viral Infections, Including COVID-19, Will Fare
UC San Diego School of Medicine researchers discovered gene expression patterns associated with pandemic viral infections, providing a map to help define patients’ immune responses, measure disease severity, predict outcomes and test therapies — for current and future pandemics.
SARS-CoV-2 Detectable — Though Likely Not Transmissible — on Hospital Surfaces
UC San Diego School of Medicine researchers discovered that SARS-CoV-2, or at least its genetic signature, abounds on hospital surfaces, often co-locating with one particular type of bacteria.
Story Tips from Johns Hopkins Experts on COVID-19
NEWS STORIES IN THIS ISSUE:
-Physician and Musician: Johns Hopkins Doctor Brings Passion for Music to Medicine During Pandemic
-Rapid, At-Home Blood Test Could Confirm COVID-19 Vaccination in Minutes
-What to Expect and Prepare for As You Return to Regular Health Care Appointments
-Study Suggests Sudden Hearing Loss Not Associated with COVID-19 Vaccination
-Vaccination May Not Rid COVID-19 Risk for Those with Rheumatic, Musculoskeletal Diseases
Cross Border Effort to Vaccinate 10,000 Maquiladora Workers
A coalition of six U.S. subsidiary companies have sponsored a COVID-19 mobile clinic to vaccinate 10,000 maquiladora workers employed in Baja California, Mexico. UC San Diego Health is vaccinating about 1,500 workers daily.
Will COVID-19 Eventually Become Just a Seasonal Nuisance?
Within the next decade, the novel coronavirus responsible for COVID-19 could become little more than a nuisance, causing no more than common cold-like coughs and sniffles. That possible future is predicted by mathematical models that incorporate lessons learned from the current pandemic on how our body’s immunity changes over time. Scientists at the University of Utah carried out the research, now published in the journal Viruses.
Comprehensive Mount Sinai Study Shows Direct Evidence That COVID-19 Can Infect Cells in Eye
Study Has Implications for Preventive Measures to Slow Spread of Virus
Dental procedures during pandemic are no riskier than a drink of water
A new study’s findings dispel the misconception that patients and providers are at high risk of catching COVID-19 at the dentist’s office.
With “herd immunity” unlikely, antivirals will play key role in COVID-19 management
According to The New York Times, the prospects for reaching “herd immunity” in the fight against COVID-19 are increasingly dim. Subsequently, the virus “will most likely become a manageable threat that will continue to circulate in the United States for…
Organ Transplant Recipients Remain Vulnerable to Covid-19 Even After Second Vaccine Dose
In a study published today in the Journal of the American Medical Association (JAMA), Johns Hopkins Medicine researchers show that although two doses of a vaccine against SARS-CoV-2 — the virus that causes COVID 19 — confers some protection for people who have received solid organ transplants, it’s still not enough to enable them to dispense with masks, physical distancing and other safety measures.
Rutgers Engineers Developing Rapid Breathalyzer Test for COVID-19
New Brunswick, N.J. (April 30, 2021) – Rutgers University–New Brunswick engineering professors Edward P. DeMauro, German Drazer, Hao Lin and Mehdi Javanmard are available for interviews on their work to develop a new type of fast-acting COVID-19 sensor that detects the presence…
How SARS-CoV-2 Hijacks Human Cells to Evade Immune System
UC San Diego School of Medicine researchers discovered one way in which SARS-CoV-2 hijacks human cell machinery to blunt the immune response, allowing it to establish infection, replicate and cause disease.
Hepatitis C Drugs Multiply Effect of COVID-19 Antiviral Remdesivir
When combined with drugs currently used to treat hepatitis C, the antiviral remdesivir is 10 times more effective in treating cells infected with SARS-CoV-2, the virus that causes COVID-19.
New rapid COVID-19 test the result of university-industry partnership
A partnership between UC Davis and Maurice J. Gallagher, Jr., chairman and CEO of Allegiant Travel Company, has led to a 20-minute COVID-19 test. The method pairs a mass spectrometer with a powerful machine-learning platform to detect SARS-CoV-2 in nasal swabs. A recent study published in Nature Scientific Reports shows the test to be 98.3% accurate for positive COVID-19 tests and 96% for negative tests.
UT Southwestern Identifies First Reported Brazil Variant of SARS-CoV-2 in North Texas
DALLAS – April 24, 2021 – UT Southwestern Medical Center scientists have identified the first cases of the Brazilian variant of COVID-19 infection in North Texas using next-generation sequencing technologies along with PCR testing.
Story Tips from Johns Hopkins Experts on COVID-19
NEWS STORIES IN THIS ISSUE:
PREGNANT AFTER THE FIRST DOSE OF COVID-19 VACCINE — NOW WHAT?
STUDY SHOWS VACCINES MAY PROTECT AGAINST NEW COVID-19 STRAINS … AND MAYBE THE COMMON COLD
EXPANDED DASHBOARD TOOL RANKS ACCESSIBILITY OF STATE VACCINE WEBSITES
Rutgers Expert Available to Discuss Spring Allergy Season in N.J.
New Brunswick, N.J. (April 20, 2021) – Rutgers University–New Brunswick allergy specialist Leonard Bielory is available for interviews on the spring allergy season in New Jersey. “One can expect a brisk allergy season this year since we had a lot…
Pandemic Eviction Bans Found to Protect Entire Communities from COVID-19 Spread
A new study led by researchers at Johns Hopkins and the University of Pennsylvania uses computer modeling to suggest that eviction bans authorized during the COVID-19 pandemic reduced the infection rate and not only protected those who would have lost their housing but also entire communities from the spread of infections.
Simulations reveal how dominant SARS-CoV-2 strain binds to host, succumbs to antibodies
Large-scale supercomputer simulations at the atomic level show that the dominant G form variant of the COVID-19-causing virus is more infectious partly because of its greater ability to readily bind to its target host receptor in the body, compared to other variants.
Study of More Than 3,000 Members of the US Marine Corps. Reveals Past COVID-19 Infection Does Not Fully Protect Young People Against Reinfection
Although antibodies induced by SARS-CoV-2 infection are largely protective, they do not completely protect against reinfection in young people, as evidenced through a longitudinal, prospective study of more than 3,000 young, healthy members of the US Marines Corps conducted by researchers at the Icahn School of Medicine at Mount Sinai and the Naval Medical Research Center, published April 15 in The Lancet Respiratory Medicine.
Experimental Therapy for Parasitic Heart Disease May Also Help Stop COVID-19
UC San Diego researchers found that the chemical inhibitor K777 reduces the coronavirus’ ability to infect cell lines by blocking human enzyme cathepsin L; clinical trials are underway.
How Well do COVID-19 Vaccines Work Over the Longer Term?
UC San Diego students will participate in nationwide clinical trial to assess if COVID-19 vaccination prevents infection and reduces risk of transmission.
Houston Methodist study reveals COVID-19 UK variant cases doubling weekly in Houston
Houston Methodist infectious disease pathologists have discovered new COVID-19 cases caused by the SARS-CoV-2 UK B.1.1.7 variant are doubling weekly. By mid-March the number increased sharply to 648 cases from 305 just a week earlier. The findings come from the latest batch of 8,857 virus genomes sequenced from patients with positive COVID-19 tests in the first two months of 2021, representing 94% of Houston Methodist cases.
Globally Accessible Therapy Is Found to Protect Against Lethal Inflammation from COVID-19 in Animal Models
Mount Sinai researchers have found that a widely available and inexpensive drug targeting inflammatory genes has reduced morbidity and mortality in mice infected with SARS-CoV-2, the virus that causes COVID-19.
UCLA to lead CDC-funded study testing effectiveness of vaccines on health workers
Researchers will study vaccinated and non-vaccinated health workers who get tested for the virus after experiencing common COVID-19 symptoms like fever, cough or a loss of sense of taste or smell. They will compare the incidence of positive tests and severity of illness in those who test positive.
Aerosol modeling detects SARS-CoV-2 infectious dose, droplets
Fluid mechanics-based transport modeling in the human respiratory tract and research data were used to determine which droplet sizes are most like to reach the dominant infection site and the number of virus particles needed to trigger infection.
Though Risk is Minuscule, Infection after COVID-19 Vaccination is Possible
Investigators from UC San Diego and UCLA report COVID-19 infection rates for a cohort of health care workers previously vaccinated for the novel coronavirus. Risk of infection is minuscule, but exists.
Novel Coronavirus Circulated Undetected Months before First COVID-19 Cases in Wuhan, China
Using molecular dating tools and epidemiological simulations, researchers at UC San Diego School of Medicine estimate that the SARS-CoV-2 virus likely circulated undetected for two months before the first human cases of COVID-19 were described in Wuhan, China in late-December 2019.