Johns Hopkins researchers have received $35 million in funding from the U.S. Department of Defense (DOD) Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND), on behalf of the Defense Health Agency, for two nationwide clinical trials to test the effectiveness of a convalescent blood plasma outpatient treatment. The treatment is a transfusion of a blood product from COVID-19 survivors that contains antibodies that may help the patient’s immune system fight the virus.
Tag: Clinical Trial
Study Suggests New Approach to Improve Radiation Therapy Resistance in Glioblastoma
Laboratory research paves the way for a clinical trial to see if an FDA-approved drug used to prevent organ transplant rejection can work against glioblastoma, a type of aggressive brain tumor.
Single-shot COVID-19 vaccine protects non-human primates
A leading COVID-19 vaccine candidate developed at Beth Israel Deaconess Medical Center creates the groundwork for a newly launched COVID-19 vaccine clinical trial
Cancer Research Institute and The Mark Foundation for Cancer Research Launch Collaboration to Evaluate Liquid Biopsy for More Accurate and Rapid Assessment of Lung Cancer Patient Response to Immunotherapy
The Cancer Research Institute (CRI) and The Mark Foundation for Cancer Research have launched a clinical trial that aims to demonstrate the utility of a novel, ultra-sensitive biomarker-directed blood test, or liquid biopsy, in assessing cancer patient responses to immunotherapy.
Baylor Scott & White Research Institute Expands Efforts in the Fight Against COVID-19
As the global response to the SARS-COV-2 virus that causes COVID-19 approaches 200 days, Baylor Scott & White Research Institute, the research and development arm of Baylor Scott & White Health, is accelerating its pace of bringing clinical trials online.
Baylor Scott & White Research Institute continues to mobilize staff and resources, including components needed to integrate critical patient-safety measures at every participating site within the Baylor Scott & White system for industry sponsored drug trials, investigator-initiated drug trials and research studies, and observational and data studies designed to help increase knowledge around case trends, viral epidemiology, and care best practices.
Excellent Research Results for CAR-T Cell Therapy Against Hodgkin Lymphoma
CAR-T cell therapy, which attacks cancer cells using a person’s reprogrammed immune cells, has been used to treat Hodgkin lymphoma with remarkable success for the first time, according to the results of an early phase clinical trial.
UC Davis Health tests monoclonal antibodies as potential COVID-19 treatment
Timothy Albertson has received a BARDA grant to lead a new clinical trial at UC Davis Health. The trial evaluates the efficacy, safety and tolerability of an antibody cocktail in hospitalized adult patients with COVID-19.
NCCN Explores Adoption of Biosimilars in Oncology in Collaboration with Pfizer
National Comprehensive Cancer Network issues Request for Proposals (RFP) for projects that develop and validate enduring approaches to improve the safe, effective, and efficient adoption of biosimilars in oncology.
Keck Medicine of USC enrolling patients as part of international clinical trial to study antiviral drug as treatment for COVID-19
Keck Medicine of USC physicians are enrolling patients as part of an international clinical trial to evaluate the safety and efficacy of an antiviral drug, DAS181, as a possible treatment for hospitalized patients with severe COVID-19.
UTHealth joins study of blood pressure medication’s effect on improving COVID-19 outcomes
An interventional therapy aimed at improving survival chances and reducing the need for critical care treatment due to COVID-19 is being investigated by physicians at The University of Texas Health Science Center at Houston (UTHealth). The clinical trial is underway at Memorial Hermann and Harris Health System’s Lyndon B. Johnson Hospital.
Mount Sinai Health System, Emergent BioSolutions, and ImmunoTek Bio Centers Form Collaboration to Develop Emergent’s COVID-19 Hyperimmune Globulin (COVID-HIG) Product Candidate with U.S. Department of Defense Funding
Mount Sinai and Emergent to conduct clinical trials to evaluate COVID-HIG for post-exposure prophylaxis of COVID-19 in front-line health care workers and to support a potential Expanded Access Program for military personnel with funding from the U.S. Department of Defense
– ImmunoTek to extend operating license and provide training to Mount Sinai to establish onsite plasma collection to support production of COVID-HIG
UTHealth joins trial of arthritis drug’s effect on COVID-19-induced cytokine storm
A drug is being studied for its effectiveness in treating a type of severe immune overreaction seen in patients with COVID-19-induced pneumonia by researchers at The University of Texas Health Science Center at Houston (UTHealth). The clinical trial is enrolling patients at Harris Health System’s Lyndon B. Johnson Hospital.
Early clinical trial supports tumor cell–based vaccine for mantle cell lymphoma
A phase I/II clinical trial by researchers at Stanford University suggests that vaccines prepared from a patient’s own tumor cells may prevent the incurable blood cancer mantle cell lymphoma (MCL) from returning after treatment. The study, which will be published June 19 in the Journal of Experimental Medicine (JEM), reveals that the vaccines are a safe and effective way to induce the body’s immune system to attack any tumor cells that could cause disease relapse.
Rutgers Expert Available to Discuss Steroid Drug Dexamethasone Reducing COVID-19 Deaths
Rutgers scholar Fredric Wondisford is available to discuss how dexamethasone can be used to treat critically ill COVID-19 patients following a study in the United Kingdom that found the steroid drug reduced the number of deaths. “The preliminary results from…
COVID-19 Clinical Trial of Immune Therapy Open at Mount Sinai, Made Possible by Philanthropic Donation
Mount Sinai Health System is beginning the first clinical trial in the New York metropolitan region of an immune-boosting therapy in COVID-19 patients.
MD Anderson and Philips collaborate to facilitate personalized oncology treatments and clinical trial matching based on genomic markers
MD Anderson and Philips today announced a collaboration to aid oncologists around the world to personalize therapy based on their patients’ genomic profiles, with the aim of improving patient care.
COVID-19 vaccine to be tested in UIC clinical trial
The University of Illinois at Chicago will soon test a vaccine for COVID-19. Expected to launch July 9, the trial — a phase 3 clinical study — will test the efficacy of a vaccine developed by biotech company Moderna.
Assessing Data Integrity in Times of COVID
Rutgers Cancer Institute expert discusses guarding data integrity for the first remdesivir double-blind placebo-controlled clinical trial addressing treatment for COVID-19.
$1M Gift Speeds COVID-19 Testing and Tracking at UC San Diego
A $1M gift from the John and Mary Tu Foundation is accelerating the efforts of UC San Diego translational research virologist Davey Smith to increase the number of people tested for COVID-19, as well as develop new ways to track and treat the virus. Smith and his team are studying how the disease spreads to better inform contact tracing, as well as leading clinical trials to test new drugs for treatment of COVID-19.
University of Miami Coronavirus Study Targets Possible Sexual Transmission
Men who tested positive for COVID-19 are now being enrolled in a unique study led by the University of Miami Miller School of Medicine to determine the interaction of the virus with semen.
Montefiore and Einstein Test a New Drug Combination to Conquer COVID-19
Montefiore Health System and Albert Einstein College of Medicine have begun the next stage of the Adaptive COVID-19 Treatment Trial (ACTT), to evaluate treatment options for people hospitalized with severe COVID-19 infection. The new iteration of the trial, known as ACTT 2, is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
UCLA launches clinical trial to help reduce severity of COVID-19 illness in men
UCLA researchers have launched a new clinical trial that uses a hormone suppresser commonly used to treat men with prostate cancer to help improve clinical outcomes for men infected with COVID-19.
ACTG Launches Clinical Trial Testing Treatment for COVID-19
The AIDS Clinical Trials Group (ACTG) has initiated a clinical trial to evaluate whether the drug combination hydroxychloroquine and azithromycin can prevent hospitalization and death from COVID-19.
Robbins Family Awards Honor Exemplary Service In Nursing at Memorial Sloan Kettering
As we celebrate National Nurses Week, Memorial Sloan Kettering Cancer Center (MSK) and The Robbins Family Foundation recognize seven distinguished nursing staff members for their exemplary service. Each member of this select group is being honored with the inaugural 2020 Robbins Family Award for Nursing Excellence.
Memorial Sloan Kettering Awards & Appointments
Memorial Sloan Kettering Cancer Center (MSK) announces the following awards and appointments.
KU Cancer Center pivots to protect patients and trial participants amidst pandemic
The University of Kansas Cancer Center is helping fight the pandemic in numerous ways.
SINK COVID-19 study: Can common drugs offer 2-step approach to combat deadly virus?
Researchers at Beaumont Health have begun enrolling patients in a new clinical study aimed at treating COVID-19 patients with two common drugs.
Rutgers Expert Available to Discuss Remdesivir as Possible Treatment for COVID-19
A Rutgers University expert who is leading a series of Remdesivir trials for people with COVID-19 is available to discuss the drug as a possible treatment as well as preliminary positive results from the trials. “As seen in a news…
Can the antimalarial drug hydroxychloroquine prevent infection with COVID-19?
UCLA is one of seven sites participating in a clinical trial investigating whether hydroxychloroquine, a commonly used anti-malarial and autoimmune drug, can prevent infection with COVID-19.
University of Iowa virology research helps facilitate new clinical trial for COVID-19
Research by University of Iowa virologist Wendy Maury, has helped facilitate the launch of a new clinical trial in the United Kingdom of a drug that might help treat patients with COVID-19.
Clinical Trial Begins to See if Convalescent Plasma Can Treat COVID-1
Montefiore Health System, Albert Einstein College of Medicine and NYU Langone have launched a new clinical trial to study if convalescent plasma—taken from people who have recovered from COVID-19—is effective in treating the disease.
Trial of Highly Touted Drug Begins at Montefiore and Einstein
Researchers at Montefiore Health System and Albert Einstein College of Medicine have begun testing the drug hydroxychloroquine for the treatment of COVID-19, as part of a nationwide trial sponsored by the National Heart, Lung, and Blood Institute (NHLBI).
Research and innovation as an essential function amid the COVID-19 pandemic
Necessity being the mother of invention, Houston Methodist clinicians, researchers and staff have collaborated on a number of clinical device and research innovations in response to COVID-19. Houston Methodist Academic Institute leadership has continually emphasized translational research in new technologies.
Mount Sinai Researchers Collaborate with GenScript to Develop a COVID-19 Antibody to Treat Sick Patients
The highly targeted antibody may block the coronaviruses’ ability to enter human lung cells
The PALM Trial honored with the Society for Clinical Trials’ prestigious David Sackett Trial of the Year Award for 2020
Each year since 2008, SCT has awarded the David Sackett Trial of the Year Award to a randomized, controlled trial published (either electronically or in print) in the previous calendar year. The 2020 recipient is Pamoja Tulinde Maisha (PALM [“Together Save Lives”] in the Kiswahili language) trial.
How Do Commonly Used Blood Pressure Medications Affect Outcomes Among Patients with COVID-19?
A new international trial will evaluate whether the use of medications to treat high blood pressure affect outcomes among patients who are prescribed the medication and hospitalized with COVID-19. Investigators will examine whether ACEI or ARBs help to mitigate complications or lead to worse outcomes.
UNC Health Workers Called to Join National PCORnet® Study to Fight COVID-19
The Healthcare Worker Exposure Response & Outcomes (HERO) Registry launched this week, inviting U.S. health care workers to share clinical and life experiences in order to understand the perspectives and problems faced by those on the COVID-19 pandemic front lines.
University of Kansas Medical Center to participate in clinical trial of hydroxychloroquine in health care workers
KU Medical Center is one of 60 sites across the nation that will be participating in this clinical trial, led by the Duke Clinical Research Institute.
UChicago Medicine begins clinical trial to explore convalescent plasma transfusions for COVID-19 patients
The University of Chicago Medicine is launching a clinical trial to study whether blood plasma from people who have recovered from COVID-19 can be used to treat patients who are still in the hospital with severe disease symptoms.
Two Major COVID-19 Clinical Trials Launched to Determine Effectiveness and Safety of Drugs in Treating Coronavirus
Researchers from Intermountain Healthcare and University of Utah Health in Salt Lake City have launched two vital clinical trials to test the effectiveness and safety of two drugs – hydroxychloroquine (HCQ) and azithromycin – to treat patients with COVID-19.
Robot designed to simplify blood draws
Bioengineers have created a blood-drawing robot that performed as well or better than technicians. The device could increase blood draw success from difficult- to-find veins and allow healthcare workers more time to treat patients.
Clinical trial launches to evaluate antimalarial drugs for COVID-19 treatment
Washington University School of Medicine in St. Louis is launching a clinical trial for patients hospitalized with COVID-19 at Barnes-Jewish Hospital. The trial will investigate the effectiveness of different combinations of the antimalarial drugs chloroquine and hydroxychloroquine and the antibiotic azithromycin in treating ill patients infected with the novel coronavirus.
UCLA clinical trial tests anti-viral drug remdesivir and other therapies against COVID-19
UCLA Health is one of 75 sites around the globe participating in a clinical trial sponsored by the National Institutes of Health to test the effectiveness of a candidate anti-viral drug against COVID-19.
Trial for Potential Coronavirus Treatment is Underway at Montefiore and Einstein
Montefiore Health System and Albert Einstein College of Medicine has joined a clinical trial to evaluate the experimental drug remdesivir to treat people who are hospitalized with severe COVID-19 infection.
UH to launch clinical trial in the fight to protect clinicians against COVID-19
University Hospitals announced it will lead a clinical trial that involves the administration of an investigational drug, ARMS-I, to its caregivers working on the frontlines of the COVID-19 pandemic. The trial, named the ARMS-I COVID Study, is designed to assess whether the drug helps prevent airborne transmission of coronavirus and whether it reduces the symptoms of healthcare providers who have tested positive for the virus.
Immunotherapy effective in metastatic prostate cancers with specific markers of immune activation
A subset of patients with metastatic prostate cancer and specific markers of immune activity responded well to treatment with immune checkpoint inhibitors, according to results of a Phase II trial.
Solving a medical mystery and changing CDC screenings for COVID-19
UC Davis Health physicians and medical staff who treated the first case of community transmission of COVID-19 in the U.S. provide a detailed case study of her condition and the medical steps and challenges they experienced before arriving at a diagnosis and treatment.
New blood test can detect wide range of cancers, now available to at risk individuals in clinical study at Dana-Farber
In a study involving thousands of participants, a new blood test detected more than 50 types of cancer as well as their location within the body with a high degree of accuracy, according to an international team of researchers led by Dana-Farber Cancer Institute and the Mayo Clinic.
St. Jude experimental anti-malarial drug shows promise in first clinical trial
Malaria is a leading killer of children worldwide, and new drugs are needed. New research reports encouraging early clinical results with a new compound.
UC Davis launches two clinical studies to treat COVID-19
UC Davis Health has two clinical trials underway for hospitalized patients with severe COVID-19, the disease caused by the novel coronavirus, SARS-CoV-2.