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UrduThe UK Markey Cancer Center will be the first site worldwide to initiate a cancer clinical trial that evaluates its anti-cancer activity in humans using ArtemiLife™ Inc. coffee products, which are made using the leaves of the Artemisia annua plant.
Tag: Clinical Trial
Case Western Reserve awarded $3 million National Cancer Institute grant to apply AI to immunotherapy in lung cancer patients
Medical researchers from Case Western Reserve University, New York University (NYU), and University Hospitals have been awarded a five-year, $3 million National Cancer Institute grant to develop and apply artificial intelligence (AI) tools for predicting which lung cancer patients will respond to immunotherapy.
Repurposing Tocilizumab in Scleroderma Patients May Prevent Early Lung Disease
A phase 3 clinical trial finds an anti-inflammatory drug used in rheumatoid arthritis can preserve lung function in patients with systemic sclerosis.
UCLA team receives $6 million from NIH to explore new pancreatic cancer therapies
A team of researchers from the UCLA Jonsson Comprehensive Cancer Center has been awarded two research grants totaling $6 million from the National Institutes of Health to identify new ways to treat pancreatic cancer.
First targeted therapy for children with achondroplasia shows persistent height gain for up to two years
Children with achondroplasia, the most common form of disproportionate short stature, grow taller with trends in improved body proportions after two years of daily vosoritide treatment, a new study analysis finds. Results of the industry-sponsored study will be presented at ENDO 2021, the Endocrine Society’s annual meeting.
Semaglutide reduces excess body fat in people with obesity
In adults with obesity or overweight, weekly treatment with the glucagon-like peptide 1 (GLP1) receptor agonist semaglutide leads to reduced excess body fat and increased lean body mass, according to an industry-sponsored study presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.
Study suggests high vitamin D levels may protect against COVID-19, especially for Black people
A new research study at the University of Chicago Medicine has found that when it comes to COVID-19, having vitamin D levels above those traditionally considered sufficient may lower the risk of infection, especially for Black people.
Three-Drug Therapy for Most Common Genetic Cause of Cystic Fibrosis Found Safe and Effective in 6-11-Year-Olds
An international, open-label Phase 3 study, co-led by Susanna McColley, MD, from Ann & Robert H. Lurie Children’s Hospital of Chicago, found that a regimen of three drugs (elexacaftor/tezacaftor/ivacaftor) that targets the genetic cause of cystic fibrosis was safe and effective in 6-11-year-olds with at least one copy of F508del mutation in the CFTR gene, which is estimated to represent almost 90 percent of the cystic fibrosis population in the United States.
CAR T-cell therapy generates lasting remissions in patients with multiple myeloma
In a major advance in the treatment of multiple myeloma, a CAR T-cell therapy has generated deep, sustained remissions in patients who had relapsed from several previous therapies, an international clinical trial has found.
First-in-Human Clinical Trial to Assess Gene Therapy for Alzheimer’s Disease
UC San Diego researchers have launched a first-in-human Phase I clinical trial to assess the safety and efficacy of a gene therapy to deliver a key protein into the brains of persons with Alzheimer’s disease or Mild Cognitive Impairment, a condition that often precedes full-blown dementia.
New recommendations aim to eliminate racial bias in myeloma trials
Recommendations designed to address the under-representation of African Americans in clinical trials for multiple myeloma (MM), a blood cancer that is twice as deadly in this demographic as in whites.
Study Discovers Safe, Effective Oral Treatment for Uterine Fibroids
A University of Chicago Medicine researcher working with an international team of scientists has developed a daily oral combination therapy that is reliable, safe and effective for long-term treatment of uterine fibroids.
Medication Keeps More Patients with ANCA-Associated Vasculitis in Remission Than Steroids
Avacopan, which targets a receptor that attracts the cells that cause inflammation, was shown to be more effective at keeping patients in remission for a year than prednisone
Researchers Studying Wearable Device to Help Detect COVID-19 Upon Infection
University of Miami Miller School of Medicine researchers are recruiting health care workers to study whether a wearable device, a wristwatch, can capture real time data that can be used to alert wearers of subtle physiological changes that may indicate they have become infected with COVID-19.
Fetal Surgery for Spina Bifida Leads to Better Mobility in School-Age Children
Adding to a growing body of research affirming the benefits of fetal surgery for spina bifida, new findings show prenatal repair of the spinal column confers physical gains that extend into childhood. The researchers found that children who had undergone fetal surgery for myelomeningocele, the most severe form of spina bifida, were more likely than those who received postnatal repair to walk independently, go up and down stairs, and perform self-care tasks like using a fork, washing hands and brushing teeth. They also had stronger leg muscles and walked faster than children who had their spina bifida surgery after birth.
Peginterferon-lambda shows strong antiviral action to accelerate clearance of COVID-19
A clinical study led by Dr. Jordan Feld, a liver specialist at Toronto Centre for Liver Disease, University Health Network (UHN), showed an experimental antiviral drug can significantly speed up recovery for COVID-19 outpatients – patients who do not need to be hospitalized. This could become an important intervention to treat infected patients and help curb community spread, while COVID-19 vaccines are rolled out this year.
Fecal Transplant Turns Cancer Immunotherapy Non-Responders into Responders
A phase II clinical trial shows that changing the gut microbiome through fecal transplant can transform cancer patients who never responded to immunotherapy into patients who do.
Recruiting Starts at University of Miami Health System for NIH Study of COVID-19 Immunity
The University of Miami Health System is one of five sites nationally and the only one in the Southeast U.S. chosen to participate in a National Institute of Allergy and Infectious Diseases (NIAID) study looking at people who have had COVID-19 or have had a COVID-19 vaccine to examine the durability and robustness of participants’ antibody and T-cell responses to the virus.
Dynamic, personalized treatment approach may improve outcomes in gastroesophageal cancers
A phase 2 clinical trial providing personalized treatments based on the genetic profile of metastatic tumors in gastroesophageal cancers has found that using customized treatment approaches, and adapting them over time as tumors become resistant, led to higher rates of survival compared to historical controls.
Modified pain management strategy reduces opioid exposure to trauma patients, study shows
A pain management regimen comprised mostly of over-the-counter medication reduced opioid exposure in trauma patients while achieving equal levels of pain control, according to a new study by physician-researchers at UTHealth.
Researchers Help Pioneer New Era in Prostate Cancer Active Surveillance
Sylvester Comprehensive Cancer Center researchers are looking at ways to combine imaging and biomarkers to predict prostate cancer progression more accurately.
Crystal Denlinger Named Chief Scientific Officer for National Comprehensive Cancer Network
The National Comprehensive Cancer Network (NCCN) announces Crystal S. Denlinger, MD, FACP, as incoming Senior Vice President, Chief Scientific Officer. Dr. Denlinger will help to steer strategic direction for the nonprofit as well as oversee the NCCN Oncology Research Program (ORP).
University of Miami Miller School of Medicine Leads Groundbreaking Trial for COVID -19 Treatment
University of Miami Miller School of Medicine researchers led a unique and groundbreaking randomized controlled trial showing umbilical cord derived mesenchymal stem cell infusions safely reduce risk of death and quicken time to recovery for the severest COVID-19 patients, according to results published in STEM CELLS Translational Medicine in January 2021.
“This is how we can help” – Couple shares their story as COVID-19 clinical trial participants
“I don’t feel so great,” my husband, Brandon, said to me one Saturday afternoon – the last thing I wanted to hear after spending the last seven months tuned into COVID-19 media coverage. Knowing a few of his co-workers had recently tested positive for the virus, we didn’t wait to secure an appointment for a rapid test. When he called me an hour later to tell me he has tested positive, my heart sank.
Research News Tip Sheet: Story Ideas From Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Tuesday.
University of Utah to speed process of bringing new therapeutics to patients
The Huntsman Cancer Institute, College of Pharmacy and PIVOT Center have partnered to establish the University of Utah Therapeutic Accelerator Hub. The new Accelerator will provide resources and expertise to researchers to support the process of translating research discoveries into innovative clinical applications.
Ovarian Cancer Screening Study Focuses on Early Detection in Women at Low Risk
Atlantic Health System is enrolling women in a landmark study that uses a simple blood test for the CA-125 protein to screen women who are at low risk for ovarian cancer. The purpose of the clinical trial is to help determine whether this test can catch ovarian cancer early in women who would not normally be screened for it. Atlantic Health System hospitals are the only centers in the New York metro region to participate in the study, and have the third highest enrollment numbers in the nation.
University Hospitals Announces its Participation in Novel Clinical Trial Testing Multiple Therapeutics to Treat COVID-19
ACTIV-2 will evaluate the safety and efficacy of investigational treatments for adults who have COVID-19, but do not require hospitalization. ACTIV-2 is a randomized, blinded, controlled study that tests a variety of new agents against placebo. This approach allows promising investigational agents to be added and removed over the course of the study.
Combo-Drug Treatment for Type 2 Diabetes Remains Effective After Two Years
Patients whose Type 2 diabetes is not controlled with metformin can benefit long-term from a two-drug combination treatment that also reduces weight.
Woman recovering from COVID-19 shares experience as monoclonal antibody clinical trial participant
When Christina Loville tested positive for the coronavirus, she was terrified. She decided to channel her fear into researching COVID-19 treatments, where she discovered a local clinical trial led by experts at The University of Texas Health Science Center at Houston (UTHealth).
Clinical trial shows experimental drug safely slows progression of diabetic kidney disease
Patients with diabetic kidney disease can potentially be treated with a new investigational medication that may slow the progress of their illness without harmful side effects to their hearts, according to the results of a global clinical trial announced Friday.
For toddlers with autism, more intervention hours are not necessarily better
Two prominent early intervention models for toddlers with autism show a very similar impact, whether delivered at 15-hours or 25-hours per week intensities, a study led by UC Davis MIND Institute researchers has found.
UH Cleveland Medical Center enrolls first patient at the site for an AAV gene therapy trial treating OTC deficiency
A patient at UH Cleveland Medical Center received an AAV8-mediated gene transfer of human Ornithine Transcarbamylase. The infusion was well tolerated and patient was discharged without issue. The gene therapy is part of an international, multi-site trial sponsored by Ultragenyx Pharmaceutical Inc.
Back Pain with Sciatica More Likely to Improve with Immediate Physical Therapy
For people who experience back pain with sciatica, meaning their pain radiates into their leg, it may be worthwhile to start physical therapy right away, according to new research reported in Annals of Internal Medicine. That approach is different from the initial advice doctors often give patients with back pain, which is to try to remain active and give their symptoms time to subside before considering treatment like physical therapy.
Baylor Scott & White Health Enrolls First Patients in the World in Trial for Inhaled Remdesivir
Earlier this month, Baylor Scott & White Research Institute enrolled the first four patients in the world on Gilead’s new clinical trial involving an investigational inhaled solution of remdesivir (NCT04539262). This is Gilead’s first trial in COVID-19 patients examining the safety and efficacy of an inhaled solution of the drug in an outpatient setting. The study of an inhaled solution asks whether this mode of delivery can help reduce the amount of virus from the airways earlier.
Clinical trial to assess rehabilitation treatment for infants and toddlers after stroke
In the first of its kind for the tiniest stroke survivors, researchers at The University of Texas Health Science Center at Houston (UTHealth) will lead a stroke rehabilitation clinical trial in the state of Texas through a multi-institutional NIH StrokeNet initiative.
Rutgers Experts Explore Questions, Concerns Over COVID-19 Vaccine Trials
As researchers race to develop a COVID-19 vaccine, a Rutgers infectious disease expert and a Rutgers bioethicist discuss how clinical trials work, the ethics of developing and distributing a vaccine, safety and efficacy in clinical trials and what a successful vaccine may mean.
Study reveals racial disparities in clinical trial recruitment and points to strategies to achieve more inclusive clinical research
In a new study published in the journal Clinical Trials, researchers led by Stephen Juraschek, MD, PhD, Assistant Professor of Medicine at Beth Israel Deaconess Medical Center (BIDMC) compared four electronic-based recruitment methods and four traditional recruitment methods to determine how different strategies may impact enrollment of groups traditionally under-represented in the medical literature.
.@UChicagoMedicine experts can discuss #Tocilizumab research; Drug may reduce need for ventilators in #COVID19 pneumonia
Roche made news today as research showed its drug (tocilizumab) reduced patients’ need for ventilators for those with COVID-19-associated pneumonia. A University of Chicago Medicine team has done separate, independent research on tocilizumab and found similar results in their own phase II trial.…
Young Houston woman recovers from COVID-19 after participation in two UTHealth clinical trials
Heba Hajjar, 23, recovered from COVID-19 after participating in two clinical trials while in the ICU.
UChicago Medicine begins clinical trial testing the efficacy of antibody against SARS-CoV-2
The University of Chicago Medicine is launching a clinical trial to examine the potential of an antibody against the SARS-CoV-2 spike protein for treating COVID-19, the disease caused by the novel coronavirus.
UT Southwestern Announces Open Enrollment For At-Home COLCORONA Clinical Trial
DALLAS, Aug. 19, 2020 – UT Southwestern Medical Center is the first facility in Dallas and the surrounding region to participate in the international COLCORONA trial. This study is evaluating the therapeutic benefit of colchicine as a treatment to prevent complications and death related to severe cases of COVID-19. Recently diagnosed patients or individuals who are showing symptoms and have a household member diagnosed with COVID-19 over the age of 40 and from Dallas and the surrounding areas can enroll in this free, at-home clinical trial.
Clinical trials for potential COVID-19 vaccines need to include a more diverse roster of participants
Those who lead clinical trials for potential COVID-19 vaccines need to include more minorities. According to Marjorie A. Speers, executive director of non-profit Clinical Research Pathways and a former CDC official, Black and Latino patients are vastly under-represented in most…
Researchers pivot from studying cancer and cystic fibrosis to launch trial of drug to fight COVID-19
The University of Kansas Medical Center announced today a trial exploring a drug intended to fight the cytokine storm common in COVID-19.
Combination therapy significantly improves survival outcomes for patients with acute myeloid leukemia
A combination regimen of venetoclax and azacitidine was safe and improved overall survival (OS) over azacitidine alone in certain patients with acute myeloid leukemia (AML), according to the Phase III VIALE-A trial led by The University of Texas MD Anderson Cancer Center.
Young nearsighted kids benefit from bifocal contact lenses, study shows
Bifocal contact lenses aren’t just for aging eyes anymore. In nearsighted kids as young as 7 years old, multifocal contact lenses with a heavy dose of added reading power can dramatically slow further progression of myopia, new research has found.
First Patients in NIH ACTIV-3 Clinical Trial Enroll in Dallas
On Wednesday in Dallas, just one day after the initiative was launched by the National Institutes of Health (NIH), Baylor Scott & White Research Institute enrolled the first patient in the world for the ACTIV-3 clinical trial. A second patient was enrolled the following day.
Important Dementia Studies Continuing at UK Despite Ongoing COVID-19 Pandemic
The COVID-19 pandemic brought many things to a screeching halt and continues to impact our daily lives. However, important research at the University of Kentucky’s Sanders-Brown Center on Aging (SBCoA) is continuing under extreme caution and deep dedication.
A monumental study in the field of dementia research is set to get underway in the coming weeks at UK.
Johns Hopkins Receives $35 Million in Funding from Department of Defense for Covid-19 Blood Plasma Trials
Johns Hopkins researchers have received $35 million in funding from the U.S. Department of Defense (DOD) Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND), on behalf of the Defense Health Agency, for two nationwide clinical trials to test the effectiveness of a convalescent blood plasma outpatient treatment. The treatment is a transfusion of a blood product from COVID-19 survivors that contains antibodies that may help the patient’s immune system fight the virus.
Study Suggests New Approach to Improve Radiation Therapy Resistance in Glioblastoma
Laboratory research paves the way for a clinical trial to see if an FDA-approved drug used to prevent organ transplant rejection can work against glioblastoma, a type of aggressive brain tumor.