Tag: Dexamethasone

How Does Glucocorticoid Therapy Affect the Developing Cardiovascular System During Pregnancy?

sarah JonasResearch Results

Glucocorticoid therapy is widely used during pregnancies at risk of premature delivery to promote fetal lung maturation. While it is an effective treatment, it can also trigger heart and blood vessel problems. New research published in The FASEB Journal uncovers the mechanisms behind the cardiovascular-related effects of the most commonly used glucocorticoids, Dexamethasone (Dex) and Betamethasone (Beta).

Triple-drug therapy for post-transplant management of multiple myeloma

sarah JonasResearch Results

Promising results from an ongoing clinical trial a three-drug treatment may improve survival in patients with newly diagnosed multiple myeloma who have undergone preliminary treatment followed by a stem cell transplant.

Genetically Engineered Nanoparticle Delivers Dexamethasone Directly to Inflamed Lungs

sarah JonasResearch Results

Nanoengineers at the University of California San Diego have developed immune cell-mimicking nanoparticles that target inflammation in the lungs and deliver drugs directly where they’re needed. As a proof of concept, the researchers filled the nanoparticles with the drug dexamethasone and administered them to mice with inflamed lung tissue. Inflammation was completely treated in mice given the nanoparticles, at a drug concentration where standard delivery methods did not have any efficacy.

Early Corticosteroid Treatment of Bacterial Meningitis, Along with Antibiotics, Leads to Full Recovery in Shortest Time

sarah JonasResearch Results

Treating bacterial meningitis early with dexamethasone, a corticosteroid hormone that is effective at reducing inflammation, along with antibiotics, leads to full recovery in the shortest time, according to a recently published case report by researchers from Hackensack Meridian Jersey Shore University Medical Center and the Cleveland Clinic.

Remdesivir for COVID-19: FDA Approved but Still Unproven

sarah JonasResearch Results

In a review of evidence from the most reliable data from randomized trials to find likely small-to-moderate effects of remdesivir, researchers say that totality of evidence compiled before the WHO trial results justifies compassionate use of remdesivir for severely ill patients. A smaller trial in China showed significantly decreased mean recovery time but no suggestion of a mortality benefit. ACTT-1 found the same mean recovery time and a suggestion of a mortality benefit that did not achieve statistical significance.

Could the time of day impact the effectiveness of COVID-19 treatment?

sarah JonasResearch Results

For months, experts have warned against the use of anti-inflammatory medications, such as ibuprofen, to treat COVID-19 symptoms. But could the timing of when this drug is taken play a role in its effectiveness?

Common Blood Test Identifies Benefits and Risks of Steroid Treatment in COVID-19 Patients

sarah JonasResearch Results

A new study led by Albert Einstein College of Medicine and Montefiore Health System confirms the findings of the large scale British trial of steroid use for COVID-19 patients and advances the research by answering several key questions: Which patients are most likely to benefit from steroid therapy? Could some of them be harmed? Can other formulations of steroids substitute for the agent studied in the British trial? The research was published today in the Journal of Hospital Medicine.