Orthopedic surgery patients do fine without opioid painkillers

Study results showed that by prescribing a combination of three non-opioid painkillers to patients, researchers successfully reduced approximately tenfold the amounts of opioids consumed over a six-week post-operative period, without altering their pain levels.

Co-principal investigator Olufemi Ayeni and his team gleaned their results by enrolling 193 patients between March 2021 and March 2022 from three Hamilton hospitals including HHS’ McMaster University Medical Centre and Hamilton General Hospital, and St. Joseph’s Healthcare Hamilton.

The patients were randomly assigned to either a control group of 98 receiving standard opioid-based painkillers or an opioid-free group (93) receiving a combination therapy of naproxen, acetaminophen and pantoprazole and a patient educational infographic. The opioid-free group did have access to opioid medication if required for pain. Each patient undergoing outpatient knee or shoulder arthroscopic surgery was monitored for six weeks

Robert Wood Johnson University Hospital Earns National Accreditation from the Commission on Cancer of the American College of Surgeons

The Commission on Cancer (CoC), a quality program of the American College of Surgeons (ACS), has granted Three-Year Accreditation to the cancer program at Robert Wood Johnson University Hospital (RWJUH), an RWJBarnabas Health Facility, in partnership with Rutgers Cancer Institute of New Jersey, the state’s only National Cancer Institute-designated Comprehensive Cancer Center.

The Path to a Practical Nursing Career in Louisiana Can Now Start in High School

New Orleans high school students interested in nursing careers will soon have a free, three-year path to becoming Licensed Practical Nurses (LPN) starting in 11th grade. The new pilot LPN apprenticeship program was developed by New Orleans Career Center (NOCC), Delgado Charity School of Nursing and Ochsner Health. Recruiting for a pilot cohort will begin in January for 20 seats. It is the only program of its kind in New Orleans.

Why women may be more susceptible to Alzheimer’s disease

Case Western Reserve University researchers have identified a mechanism in brain tissue that may explain why women are more vulnerable to Alzheimer’s disease—a finding that they say could help lead to new medicines to treat the disease. The researchers found that the female brain shows higher expression of a certain enzyme compared to males, resulting in greater accumulation of a protein called tau.

Helping companies improve energy efficiency through high performance computing

The U.S. Department of Energy (DOE) has awarded DOE’s Argonne National Laboratory with $600,000 in federal funding to work on two new projects that will advance cutting edge manufacturing and clean energy technologies.

New algorithms help four-legged robots run in the wild

A new system of algorithms developed by UC San Diego engineers enables four-legged robots to walk and run on challenging terrain while avoiding both static and moving obstacles. The work brings researchers a step closer to building robots that can perform search and rescue missions or collect information in places that are too dangerous or difficult for humans.

Endocrine Society experts recommend individualized approach to use of telehealth

Following rapid growth during the COVID-19 pandemic, telehealth visits are expected to remain an important part of endocrine care, according to a new Endocrine Society policy perspective published in The Journal of Clinical Endocrinology & Metabolism.

Becoming Sober – A ‘Voice’ for Mothers Navigating the Child Welfare System

Stigmatized and ignored, pregnant women and mothers with substance use disorders often are voiceless. Researchers used documentary photography as platform to enable mothers in recovery to be heard. Results reveal a shared perception. For mothers with a substance use disorder involved with the child welfare system it is easy to fail and hard to succeed. The emotional jeopardy of child welfare system interactions was described by the mothers to result in feelings of defeat and an increased vulnerability to reoccurrence of substance use.

Study Provides Further Evidence That Immune Cell Dysregulation is a Driver of COVID-19 Severity Study Provides Further Evidence That Immune Cell Dysregulation is a Driver of COVID-19 Severity

In one of the largest single-center COVID-19 cohort studies to date, researchers at the Icahn School of Medicine at Mount Sinai, using samples collected during the peak of the pandemic in New York City, have identified a key driver of COVID-19 disease severity.

Radiation oncology research and clinical trial results to be featured at ASTRO’s Annual Meeting in San Antonio

The American Society for Radiation Oncology (ASTRO) announced today the 10 studies that will be highlighted in the 2022 ASTRO Annual Meeting press program. Researchers will discuss their findings in two news briefings to be held October 24 and 25 in the Henry B. Gonzalez Convention Center in San Antonio and via live webcast. Reporters can register for the meeting at astro.org/annualmeetingpress.

AIP Congratulates 2022 Nobel Prize Winners in Physics

The 2022 Nobel Prize in physics was awarded to Alain Aspect, John F. Clauser, and Anton Zeilinger “for experiments with entangled photons, establishing the violation of Bell inequalities and pioneering quantum information science.” To help journalists and the public understand the context of this work, AIP is compiling a Nobel Prize resources page featuring relevant scientific papers and articles, quotes from experts, photos, multimedia, and other resources.

Reduced Expression of Extracellular Matrix Protein May Ease Markers of Sclerosis-associated Lung Disease

Article title: Fibronectin-EDA accumulates via reduced ubiquitination downstream of toll-like receptor 9 activation in SSc-ILD fibroblasts Authors: Ferhan Tuncer, Melissa Bulik, John Villandre, Travis Lear, Yanwen Chen, Beyza Tuncer, Daniel J. Kass, Eleanor Valenzi, Christina Morse, John Sembrat II, Robert…

Absence of Protein Signaling Pathway in Mice Is Associated with Defects in Intestinal Tissue Development

Article title: Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa Authors: Stamatia Papoutsopoulou, Joseph Tang, Ahmed H. Elramli, Jonathan M. Williams, Nitika Gupta, Felix I. Ikuomola, Raheleh Sheibani-Tezerji, Mohammad T. Alam, Juan…

Game Changers in Fighting Climate Change: Refuels Are Suitable for Everyday Use

Synthetic fuels produced from renewable sources, so-called refuels, are deemed potential game changers in fighting climate change. Refuels promise to reduce CO2 emissions by up to 90% compared to conventional fuels and they allow for the continued use of existing vehicle fleets with combustion engines and of the refueling infrastructure, from fuel production to transport to sales. Researchers of Karlsruhe Institute of Technology (KIT) carried out extensive fleet tests in a large-scale project with industry partners and proved that refuels can be used in all vehicles and produced in large quantities in the foreseeable future. The results of the research project “reFuels – Rethinking Fuels” were presented on Monday, September 19, in Karlsruhe.

SGLT2 inhibitors and GLP1 receptor antagonists improve type-2 diabetes outcomes, but are not cost effective

A cost-effectiveness study of sodium–glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP1) receptor agonists has found that the use of these medications as first-line treatment for type-2 diabetes would improve outcomes, but their costs would need to decrease by at least 70 percent to be cost-effective. The study is published in Annals of Internal Medicine.

History of nation’s first gender-affirming surgery clinic offers both a lesson and cautionary tale 

An essay about the creation and subsequent closure of the nation’s first gender-affirming surgery (GAS) clinic in the United States offers a unique history lesson about and cautionary tale for physicians treating transgender persons in the face of both existing institutional transphobia and renewed cultural backlash. The piece is published in Annals of Internal Medicine.

Incidence of Myocarditis/Pericarditis Following mRNA COVID-19 Vaccination Among Children and Younger Adults in the United States

In this population-based surveillance, the authors found that myocarditis/pericarditis 0 to 7 days after mRNA vaccination in persons aged 5 to 39 years occurred in approximately 1 in 200,000 doses after the first dose and 1 in 30,000 doses after second dose of the primary series, and 1 in 50,000 doses after the first booster. The incidence varied markedly by age and sex, however, with a disproportionate number of cases occurring in male persons, notably among adolescents after dose 2 and first boosters.

Rural health education center in Illinois gets $6.5M

UIC’s College of Medicine Rockford will receive nearly $6.5 million over the next five years to fund the Illinois Area Health Education Centers Network program. The network seeks to address the critical health workforce needs in rural and underserved communities in Illinois by providing access to training and education opportunities.

Spilling the Secrets of Quantum Entanglement

Scientists recently tested the ability of three techniques called entanglement witnesses to accurately identify pairs of entangled magnetic particles. Of the three, quantum Fisher information (QFI) performed best, routinely locating entanglement in complex materials. This work is the most thorough examination of QFI’s capabilities to date and is the first to apply QFI to massive solid materials.

Alzheimer’s and Dementia: The Journal of the Alzheimer’s Association announces UK’s Donna Wilcock as new editor-in-chief

The Alzheimer’s Association welcomes the University of Kentucky’s Donna M. Wilcock, Ph.D., as the new editor-in-chief of Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.Since its inception in 2005, Alzheimer’s & Dementia has sought to bridge the knowledge gaps that separate traditional fields of dementia research by rapidly disseminating new findings and acting as a forum for articles covering clinical investigations and basic, social and behavioral research.