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UrduA new Iowa State University study details the structure of a critical enzyme present in SARS-CoV-2, the coronavirus that causes COVID-19. This enzyme removes nucleoside antiviral medications from the virus’s RNA, rendering many treatments ineffective. Scientists could use data uncovered in the new study to find ways to inhibit the enzyme, possibly leading to more effective treatments.
Month: August 2021
New Study Finds Emperor Penguins Increasingly Threatened by Climate Change
Woods Hole, MA (August 3, 2021) – A new study published today in Global Change Biology provides valuable new data that highlights how species extinction risk is accelerating due to rapid climate change and an increase in extreme climate events, such as glacial calving and sea ice loss. The study, led by Stephanie Jenouvrier, associate scientist, and seabird ecologist at Woods Hole Oceanographic Institution, and co-authored by an international team of scientists, policy experts, ecologists, and climate scientists, provided pivotal research and projections tailored for use by the U.S Fish & Wildlife Service (USFWS). Their work proposed that emperor penguins be listed as threatened under the Endangered Species Act and this week, USFWS submitted that listing proposal.
Bringing discoveries to light: X-ray science at Argonne
The Advanced Photon Source allows an intricate view of everything from proteins to nuclear fuel. With a planned upgrade, it will become even more powerful.
Emperor penguins, increasingly under siege by climate change, Proposed as threatened species under Endangered Species Act
Today, the U. S Fish and Wildlife Service (USFWS) announced a proposal to list the emperor penguin as a threatened species under the Endangered Species Act (ESA) based on evidence that the animal’s sea ice habitat is shrinking and is likely to continue to do so over the next several decades. Proposing a listing of threatened means the animal is at risk of becoming an endangered species–in danger of extinction–in the foreseeable future if its habitat continues to be destroyed or adversely changed.
Susan Joseph appointed as Executive Director of FinTech at Cornell University
Fintech at Cornell, an initiative of the Cornell SC Johnson College of Business, is pleased to announce the appointment of Susan Joseph as Executive Director. Joseph will represent the initiative at all levels, in collaboration with faculty director Will Cong, Associate Professor of Finance & Rudd Family Professor of Management at the Samuel Curtis Johnson Graduate School of Management.
Mayo Clinic in Florida recognized as Center of Excellence for Antimicrobial Stewardship
Mayo Clinic in Florida has been recognized as an Antimicrobial Stewardship Center of Excellence by the Infectious Diseases Society of America (IDSA) ― the only hospital in North Florida to hold that designation. This designation recognizes Mayo Clinic’s optimal antimicrobial use and ongoing efforts to combat antimicrobial resistance.
Penn Nursing Offering Free Online Transitional Care Course to Clinicians
Penn Nursing is offering a free course on transitional care, “Advancing High Quality Care: The Transitional Care Model”. The course – being offered for free now through December 31, 2021 – is designed for nurses and other health care professionals seeking to improve care systems through application of the Transitional Care Model (TCM). TCM is proven in multiple NIH funded clinical trials to improve the health outcomes of older adults coping with complex care needs while reducing health care costs. This introductory learning opportunity connects clinicians and clinical leaders with the evidence to advance meaningful and measurable change in their organizations and communities. Click here to learn more and register. Use code ASPIRE21TCM (case sensitive) to access the course for free.
Is reducing opioids for pain patients linked to higher rates of overdose and mental health crisis?
A UC Davis Health study published in JAMA found a 68% increase in overdose events and a doubling of mental health crises among patients who were on stable opioid therapy but saw their doses tapered.
Nanotech device can detect risk for serious complication during pregnancy
Researchers from UCLA and Cedars-Sinai have developed a new way to detect a potentially life-threatening condition that can occur during pregnancy.
The condition, placenta accreta spectrum disorder, occurs when the placenta grows too deeply into the uterine wall and fails to detach from the uterus after childbirth. It can lead to significant blood loss during pregnancy and delivery, requiring blood transfusions and intensive care, and it can result in serious illness and infection and can even be fatal for the mother. The condition occurs in less than 0.5% of pregnancies.
Artificial Stomach Reveals Fluid Dynamics of Food Digestion
Scientists have extensively studied how gastric juices in the stomach break down ingested food and other substances. However, less is known about how complex flow patterns and mechanical stresses in the stomach contribute to digestion. Researchers built a prototype of an artificial antrum to present a deeper understanding of how physical forces influence food digestion based on fluid dynamics. In Physics of Fluids, they reveal a classifying effect based on the breakup of liquid drops combined with transport phenomena.
Does Visual Feedback of Our Tongues Help in Speech Motor Learning?
When we speak, we use our auditory and somatosensory systems to monitor the results of the movements of our tongue or lips. Since we cannot typically see our own faces and tongues while we speak, however, the potential role of visual feedback has remained less clear. In the Journal of the Acoustical Society of America, researchers explore how readily speakers will integrate visual information about their tongue movements during a speech motor learning task.
Experimental Model of Ovarian Cancer Shows Effect of Healthy Cell Arrangement in Metastasis
A key element to slowing metastasis in ovarian cancer is understanding the mechanisms of how tumor cells invade tissues. In APL Bioengineering, biophysics researchers explain how microscopic defects in how healthy cells line up can alter how easily ovarian cancer cells invade tissue. Using an experimental model, the group found that disruptions in the normal cellular layout, called topological defects, affect the rate of tumor cell invasion.
Study Yields Tiny Targets for Healing Human Memory
Cedars-Sinai researchers have identified a set of brain cells that, when affected by epilepsy, cause memory impairment in patients with a particular type of the disorder called temporal lobe epilepsy (TLE).
Johns Hopkins Bloomberg School of Public Health Appoints M. Daniele Fallin as New Bloomberg Centennial Professor
Johns Hopkins Bloomberg School of Public Health has appointed Margaret Daniele (Dani) Fallin, PhD, as a Bloomberg Centennial Professor.
Same Berkeley MBA without the commute
UC Berkeley’s Haas School of Business announced a new flexible online option for its top-ranked, part-time Evening & Weekend MBA Program. The new Flex option offers the same curriculum and faculty and the same Berkeley Haas MBA degree in a highly customized and flexible online and on-campus format.
Study shows users banned from social platforms go elsewhere with increased toxicity
Users banned from social platforms go elsewhere with increased toxicity, according to a new study featuring researchers from Binghamton University, State University of New York.
Statins may improve survival for triple-negative breast cancer patients
A study led by researchers from The University of Texas MD Anderson Cancer Center found a significant association between cholesterol-lowering drugs commonly known as statins and survival rates of triple-negative breast cancer patients. Since statins are low in cost, easy to access and produce minimal side effects, this could have an important impact on outcomes for this aggressive disease.
The George Washington University Partners with Student Defense, Columbia University to Launch Higher Education Research Initiative
Today the George Washington University, along with Student Defense and Columbia University, launched the Postsecondary Equity & Economics Research (PEER) Project.
Congress of Neurological Surgeons selects Wolters Kluwer as its publisher
Wolters Kluwer, Health announced a multi-year agreement reestablishing its collaboration with the Congress of Neurological Surgeons (CNS), the leading organization dedicated to advancing neurosurgery through education and innovation. Beginning in January 2022, Wolters Kluwer will publish three medical specialty journals from CNS’s portfolio including its flagship publication Neurosurgery, one of the most highly cited neurosurgery journals in the world.
Moffitt Researchers Show Beta-Cutaneous HPV May Be Predictor of Squamous Cell Carcinoma
In a new article published online ahead of print in the journal Cancer Research, Moffitt Cancer Center researchers demonstrate a link between the presence of cutaneous human papillomavirus and the incidence of squamous cell carcinomas and identify key characteristics of infection that may contribute to development of the disease.
Johns Hopkins Study: Anti-Parasitic Drug Slows Pancreatic Cancer in Mice
As the third-most lethal cancer in the United States, with only a 1% five-year survival rate for people with its most aggressive form, pancreatic cancer has long been a target of researchers who search for ways to slow or stop its growth and spread. Now, a team of Johns Hopkins Medicine researchers have found that an anti-parasitic drug prevents pancreatic cancer’s initiation, progression and metastasis in genetically engineered mice.
Implant shows extreme promise for regenerating bone
Its powers may not rival Wolverine’s, but a regenerative implant engineered by researchers at the University of Nebraska Medical Center and University of Nebraska–Lincoln could help repair bone-deep damage following physical trauma, surgery or osteoporosis.
RegeneratOR Workforce Development Receives NSF Award
With the recent announcement of the RegeneratOR Test Bed to support regenerative medicine start up companies, the Wake Forest Institute for Regenerative Medicine (WFIRM) and the RegenMed Development Organization (RemDO) are embarking on the next step – to help create the future workforce.
Novel Therapy Shows Promise for Lung Cancer Patients with Rare EGFR Mutation
Moffitt Cancer Center is part of a multinational, early phase clinical trial evaluating a new targeted therapy for patients with metastatic or unresectable non-small cell lung cancer who have a specific genetic mutation: EGFR Ex20Ins. New expanded data from the trial was published in the Journal of Clinical Oncology.
Integrate disciplines to conserve biodiversity
Innovation arises through the transfer of research results into practiceValuable research results threaten to gather dust in university libraries if they are not put into practice. While transdisciplinary research seems to become increasingly important in sciences, funding programs and media, there are still many misunderstandings to be clarified.
Prestressed plasters for old buildings
The technology of stabilizing concrete structures with carbon fiber-reinforced polymers, thus helping them to last longer, was developed decades ago; among others at Empa. Today, researchers in Dübendorf are working on a new variant with prestressed lamellas – with good prospects for practical application.
What’s Killing Coral Reefs in Florida is Also Killing Them in Belize
Only 17 percent of live coral cover remains on fore-reefs in Belize. A study finds new evidence that nitrogen enrichment from land-based sources like agriculture run-off and sewage, are significantly driving macroalgal blooms to increase on the Belize Barrier Reef and causing massive decline in hard coral cover. With only 2 percent of hard coral cover remaining in the Florida Keys National Marine Sanctuary, it’s too late to save that reef, but there’s still hope for the Belize Barrier Reef.
DSW Joins the On Our Sleeves® Movement for Children’s Mental Health
DSW has joined the On Our Sleeves® movement, committing to a national in-store campaign. Between Aug. 1-Oct. 31, DSW customers will have the option to round-up their purchase, or donate $1, $3, $5 or an additional amount of their choice during checkout at approximately 500 stores.
Weight Loss May Not Resolve Obesity-related Airway Dysfunction
Article title: Obese adipose tissue modulates proinflammatory responses of mouse airway epithelial cells Authors: Jennifer L. Ather, Katherine E. Van Der Vliet, Madeleine M. Mank, Leah F. Reed, Anne E. Dixon, Matthew E. Poynter From the authors: “A novel finding from…
Chronic Pulmonary Hypertension Alters Chloride Homeostasis in Pulmonary Artery Smooth Muscle Cells
Article title: Increased intracellular Cl- concentrations in pulmonary arterial myocytes associated with chronic hypoxic pulmonary hypertension Authors: Hui Sun, Omkar Paudel, James S. K. Sham From the authors: “This study characterizes for the first time the expression profile of [chloride]…
Mouse Model of COVID-19–induced Lung Injury May Aid Development of Coronavirus Treatments
Article title: The SARS-CoV-2 spike protein subunit 1 induces COVID-19–like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells Authors: Ruben Colunga Biancatelli, Pavel Solopov, Elizabeth R. Sharlow, John S. Lazo, Paul Ellis Marik, John…
Intracellular pH, Oxygen Consumption Rate Study Raises Questions about Limiting Metabolic Programming in Cancer Cells
Article title: Ethyl isopropyl amiloride decreases oxidative phosphorylation and increases mitochondrial fusion in clonal untransformed and cancer cells Authors: Sagar S. Manoli, Kyle Kisor, Bradley A. Webb, Diane L. Barber From the authors: “Our findings that a lower [intracellular pH (pHi)]…
Chronic Alcohol Consumption Inhibits Intestinal Absorption of Vitamin B7, May Lead to Deficiency
Article title: Effect of chronic alcohol exposure on gut vitamin B7 uptake: involvement of epigenetic mechanisms and effect of alcohol metabolites Authors: Kalidas Ramamoorthy, Subrata Sabui, Padmanabhan Srinivasan, Saleh Al-Juburi, Quang Pham, Brian D. Chu, Rita D. Simoes, James M.…
Intrauterine Growth Restriction in Rats Causes Long-term Increases in Offspring’s Blood Pressure, Impairs Renal Artery Vascular Tone
Article title: Vascular tone regulation in renal interlobar arteries of male rats is dysfunctional after intrauterine growth restriction Authors: Jenny Voggel, Lubomir Lubomirov, Felix Lechner, Gregor Fink, Eva Nüsken, Maria Wohlfarth, Gabriele Pfitzer, Kija Shah-Hosseini, Martin Hellmich, Miguel A. Alejandre…
Rat Model of Preeclampsia Gives new Insight into Immunological Changes during Pregnancy
Article title: Immunological comparison of pregnant Dahl salt-sensitive and Sprague-Dawley rats commonly used to model characteristics of preeclampsia Authors: Erin B. Taylor, Eric M. George, Michael J. Ryan, Michael R. Garrett, Jennifer M. Sasser From the authors: “The current study…
Icahn School of Medicine at Mount Sinai and Meharry Medical College Announce Partnership to Address Racism in Basic Sciences and Medicine
The Icahn School of Medicine at Mount Sinai (Icahn Mount Sinai) and Meharry Medical College in Nashville, Tennessee, today announced they have entered into an agreement that will address racism and bias in the basic sciences and introduce greater diversity and inclusion.
Lack of DUSP5 Protein Leads to Pulmonary Hypertension and Heart Enlargement in Mice
Article title: DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy Authors: Bradley S. Ferguson, Sara A. Wennersten, Kimberly M. Demos-Davies, Marcello Rubino, Emma L. Robinson, Maria A. Cavasin, Matthew S. Stratton, Andrew M. Kidger, Tianjing…
Heparin-based Blood Purification Protects Baboon Kidneys in Severe Pneumonia, Sepsis
Article title: Heparin-based blood purification attenuates organ injury in baboons with S. pneumoniae pneumonia Authors: Lingye Chen, Bryan D. Kraft, Victor L. Roggli, Zachary R. Healy, Christopher W. Woods, Ephraim L. Tsalik, Geoffrey S. Ginsburg, David M. Murdoch, Hagir B.…
Potential biomarker found for lung disease in scleroderma patients
Researchers have discovered a protein that may predict disease severity for scleroderma-associated interstitial lung disease, the leading cause of death for patients with the rare autoimmune condition. Higher circulating levels of the CTRP9 were associated with more severe lung disease, while low levels were associated with preserved function.
Low-fiber Diet May Lead to Gut Infection Even if You’re Not Overweight
Diet, more than body mass, may play a role in the risk for gut infection, and eating more fiber could be the key to prevention. The study is published ahead of print in the American Journal of Physiology-Endocrinology and Metabolism.
Giraffes are as socially complex as elephants, study finds
Scientists at the University of Bristol have discovered evidence that giraffes are a highly socially complex species.
Skull of 340 million year old animal digitally recreated revealing secrets of ancient amphibian
Researchers from the University of Bristol and University College London have used cutting-edge techniques to digitally reconstruct the skull of one of the earliest limbed animals.
Pandemic may have increased older adults’ fall risk, poll suggests
The COVID-19 pandemic may have increased older adults’ risk of falling and injuring themselves, due to changes in physical activity, conditioning and mobility, a new national poll suggests.
ISPOR Announces Virtual ISPOR Europe 2021 Conference and In-Person Preconference Summit
ISPOR—The Professional Society for Health Economics and Outcomes Research announced that its ISPOR Europe 2021 will include a virtual conference on 30 Nov – 3 Dec and an in-person Preconference Summit on 11 Nov in Copenhagen, Denmark.
De acordo com novo o estudo da Mayo, as variantes genéticas influenciam a resposta ao tratamento da enxaqueca
Enxaquecas atormentam milhões de pessoas em todo o mundo.No entanto, encontrar um medicamento preventivo eficaz, um medicamento mais comumente prescrito para pessoas com diagnóstico de enxaqueca, continua sendo um processo longo e complexo.
دراسة جديدة في مايو تُظهر أن التغييرات الجينية تؤثر على الاستجابة لعلاج الشقيقة
الشقيقة (الصداع النصفي) يصيب الملايين من الناس حول العالم. ومع ذلك، فإن تحديد دواء وقائي فعال- أي الأدوية المتاحة فقط بوصفة طبية والأكثر شيوعًا للمصابين بالشقيقة- يظل عملية طويلة ومعقدة. غالبًا ما يتنقل المرضى بين الأدوية لأسابيع أو شهور حتى تتحقق استجابة علاجية.
Rethinking Remdesivir
UC San Diego researchers modify remdesivir, creating oral version that can be taken earlier in COVID-19 diagnoses. In cell and animal studies, revised drug proved effective and safe.
根据妙佑医疗国际(Mayo Clinic)的新研究，基因变异会影响偏头痛治疗反应
偏头痛困扰着全世界数百万人。然而，确定一种有效的预防药物 ― 偏头痛患者最常用的处方药 ― 仍然是一个漫长而复杂的过程。患者通常连续用药数周或数月，才能出现治疗反应。
Variantes genéticas influyen sobre la reacción al tratamiento contra la migraña, dice nuevo estudio de Mayo
Las migrañas acosan a millones de personas en todo el mundo. Sin embargo, aún es un proceso largo y complejo el identificar con precisión un medicamento profiláctico (o fármaco más frecuentemente recetado a personas diagnosticadas con migrañas) que surta efecto.
Waste to Energy: Biofuel from Kelp Harvesting and Fish
Using existing fish processing plants, kelp and fish waste can be converted to a diesel-like fuel to power generators or fishing boats in remote, coastal Alaska.