Brain Imaging of Neuromelanin May be Key to Understanding Extensive Substance Use

A study that used a specialized type of magnetic resonance imaging (MRI), named neuromelanin-sensitive MRI, showed that this type of MRI signal was increased in regions of the midbrain in young adults ages 20 to 24 who had an extensive alcohol and drug use history. The findings are published early online in the American Journal of Psychiatry.

Mobile-Based Tool to Address Heavy Drinking in Young Adults Passes Pilot Phase

Young adults who drink heavily reported that a specific intervention that provides personalized feedback on daily drinking would be beneficial for people who want to reduce their drinking and would encourage self-reflection among those who are not yet ready to change their drinking habits. The young adults were participants in a pilot study of a first-of-its-kind technology aimed at reducing heavy drinking in young adults through self-selected goal setting and daily personalized feedback based on self-reported behaviors related to drinking. The study is described in Alcohol: Clinical and Experimental Research.

Alcohol Use in Older Adults Doubles Risk of Brain Bleeds from Falls

Little is known about the association between the frequency of alcohol use and the severity of injuries sustained after a fall in older adults. A study of 3,128 older adults who underwent an initial head CT scan in the emergency department after head trauma from a fall shows that occasional alcohol use was associated with double the odds of a brain bleed when compared to patients with no alcohol use. Daily alcohol use was associated with 150% increased odds of a brain bleed.

Adolescent Alcohol Exposure Impairs Behavioral Flexibility and Learning in Adult Rats, Pointing to Persistent Effects on Brain Chemistry

Rats with alcohol exposure in adolescence are less able as adults to adapt their behavior in changing circumstances, according to a study that highlights the possible brain mechanisms involved. The findings may help us better understand ways that alcohol use during the teen years can lead to long-lasting cognitive and behavioral impairments.

A genetic predisposition to alcohol use is not the same as a genetic destiny for alcohol misuse

There is a clear relationship between alcohol and neurodegeneration; for example, an alcohol use disorder correlates with a higher risk of Alzheimer’s disease. It is unclear, however, whether individual differences in brain structure and connectivity are risk factors for, or consequences of, alcohol use. New research exploring this relationship will be shared on Wednesday, 26 June 2024 at the 47th annual scientific meeting of the Research Society on Alcohol (RSA) in Minneapolis, Minnesota.

Using smartwatch sensors to detect, measure, intervene, and prevent alcohol use in the moment

Prevention, intervention, and treatment measures have historically been used to address alcohol use and abuse. New research has explored the use of a smartwatch application to bridge the gap between prevention and intervention, tracking a person’s drinking habits and providing real-time personalized prompts while they are drinking to potentially help them moderate their consumption. These results will be shared at the 47th annual scientific meeting of the Research Society on Alcohol (RSA) in Minneapolis, Minnesota.

Exploring the underlying emotions that lead to alcohol and cannabis use

Theoretical models of alcohol and cannabis use disorders often focus on the idea that people consume alcohol and cannabis use to regulate their negative emotions – in other words, to make themselves feel better. New research does not support this idea, finding instead that people mostly consume alcohol and cannabis in their daily life when they are experiencing positive emotions.

Multiracial individuals face unique challenges that may lead to high rates of alcohol and other drug use

Multiracial or mixed-race individuals – having parents or ancestors of different races – currently comprise more than 10 percent of the U.S. population. There is very little research on Multiracial individuals even though young adults in this group report high rates of alcohol and other drug (AOD) use: binge drinking, illicit drug use other than cannabis, and drug use disorders. New research explores what factors may contribute to high rates of substance use among this population. Results will be shared at the 47th annual scientific meeting of the Research Society on Alcohol (RSA) in Minneapolis, Minnesota.

Heavy Alcohol Use May Increase Type 2 Diabetes Risk in Middle-aged Adults

Heavy alcohol use may increase middle-aged adults’ risk of developing Type 2 diabetes, according to research to be presented this week at the American Physiology Summit in Long Beach, California. The Summit is the flagship annual meeting of the American Physiological Society (APS).

Facilitators of Group Interventions Play a Vital Role in Reducing Drinking Among Young Adults Experiencing Homelessness

Skilled facilitators of an alcohol intervention based on motivational interviewing are key to promoting safer drinking behaviors among young adults experiencing homelessness, a new study suggests. The study is the first to examine the effects of the group process on emerging adults’ drinking outcomes using several different measures of group dynamics. Some young adults experiencing homelessness can access services at drop-in centers, but interventions must be brief and feasible in resource-stretched environments. Previous studies of AWARE, an intervention based on motivational interviewing in a four-session group format, found reductions in drinking in this vulnerable population. It is not well understood, however, which aspects of the group experience—process, structure, and clinician behavior—contribute to these outcomes. Research points to the importance of change talk (e.g., “I’m quitting for the summer”), cohesion (group bonding), climate (group engagement and mutual support), and

Recovery Checkups in Primary Care Settings Linked to Increased Substance Use Treatment and Reduced Alcohol and Cannabis Use in Patients with Complex Needs

Highly vulnerable patients with alcohol use disorder (AUD) or substance use disorder (SUD) who received regular assessments after their initial intervention had substantially better outcomes a year later than those who did not receive the same follow-up, according to a new study. Fewer than one in ten people with SUD receive any form of treatment in a given year; among those who do, relapse and treatment reentry are common. A Screening, Brief Intervention, and Referral to Treatment (SBIRT) protocol is intended to facilitate treatment referrals, especially among patients with more severe SUDs, but research has shown it to be relatively ineffective in that regard. Adding a Recovery Management Checkup (RMC) intervention can improve treatment rates; RMC conceptualizes AUD and SUD as chronic conditions requiring longer-term monitoring via regular check-ins, early re-intervention in cases of relapse, and treatment retention strategies. For the study in Alcohol: Clinical & Experimental Resear

Shared Genetic Factors Influence Risk for Both Disordered Eating and Alcohol Use in Late Adolescence

Certain genetic influences contribute to disordered eating and problematic alcohol use, leaving some people vulnerable to both conditions, according to a large study of late adolescent twins. Previous research has found concurrent eating disorders and risky drinking in younger teens amplify the chance of worse outcomes, including death.

People with Severe Alcohol Use Disorder Have Impaired Ability to Learn From Others’ Painful Experiences, Raising Their Risk for Ongoing Dangerous Drinking, Study Suggests

People with alcohol use disorder (AUD) are less able to learn from others’ negative experiences, potentially rendering them more vulnerable to maintaining their dangerous drinking or relapsing, according to the first study of its type. The study explored social cognition, processes that enable us to understand and interact with others, and specifically social learning, our ability to learn by observing others’ experiences.

Hazardous Drinking in Young Adults: Personal Characteristics Can Help Identify Effective Interventions

Young adults whose drinking lands them in the emergency room respond differently to different interventions to reduce their hazardous drinking, and those differences may be driven by certain personal characteristics.

Alcohol Use, Even at Low Levels, Increases Risk of Developing Disease

Even low levels of alcohol use can increase the likelihood of developing diseases like cancer and heart disease. A systematic review of studies of the relationship between alcohol use and risk of disease published in Alcohol: Clinical and Experimental Research found that disease risk increases as alcohol use increases and high levels of alcohol use have clear detrimental health effects. While lower-level alcohol use can be protective against certain diseases, it can have significant adverse health effects for many other diseases. The authors urge greater awareness that any level of alcohol use can increase a person’s risk of developing serious, even fatal, diseases.

Medicaid Expansion Associated with Increased, But Not High Quality, Screening for Alcohol Use

People living in states with expanded Medicaid access were more likely to be screened by their doctor for alcohol use compared to people who lived in states that did not expand Medicaid access, but they did not necessarily receive effective interventions. A study published in Alcohol: Clinical and Experimental Research found that living in a state with expanded Medicaid access was associated with a higher prevalence of lower-income adults’ receiving some alcohol screening at a recent checkup but not receiving higher quality screening or brief counseling. The authors suggest that expanded Medicaid access may increase screening via increased access to primary care but that policies that target healthcare provider constraints are also needed to increase high-quality, evidence-based screening and counseling around alcohol use.

Emerging adults who experience pain and related anxiety may engage in high-risk drinking

Emerging adults – those aged 18 to 24 years –who experience pain are more likely to engage in high-risk patterns of alcohol use such as binge drinking. Anxiety caused by pain may be what motivates unhealthy coping strategies such as excessive drinking as a form of escape/avoidance. These results and others will be shared at the 46th annual scientific meeting of the Research Society on Alcohol (RSA) in Bellevue, Washington.

Pandemic Alcohol Use Linked to Nervous System Disruption in Pregnant and Postpartum Women, Hinting at Novel Clinical Biomarker and Intervention Potential

Increased alcohol use among pregnant and postpartum women during the COVID-19 pandemic was associated with autonomic nervous system dysregulation, known to negatively affect resilience to change and further exacerbate the risk of stress-related mental health disorders and substance use, a new study suggests. The findings, although preliminary, underline the potential for a new clinical biomarker and novel personalized mobile health apps in facilitating treatment interventions. Previous research linked the pandemic to increased stress levels and drinking, including in pregnant and postpartum women. Alcohol use, and stress-related conditions such as depression and anxiety, are associated with dysregulation in the feedback loop between the body and the brain. This process involves the peripheral autonomic nervous system, which regulates the heartbeat. Healthy, resilient people tend to have higher heart rate variability than people with stress and substance use disorders. Heart rate variab

Neighborhood Access to Alcohol Might be Linked to A Raised Risk of Suicide Attempts

Living in a neighborhood with bars or government-run alcohol outlets may increase suicidal behavior among young adults, especially men and those with elevated genetic liability for attempting suicide, a new study suggests. The paper, in Alcohol: Clinical & Experimental Research, is the latest attempt to clarify the link between alcohol accessibility and suicidal behavior. This complex relationship is proving difficult to unravel. Both acute drinking and alcohol use disorder are associated with increased suicide risk, potentially because of behavioral inhibition, depressed mood, or aggression. The link between heavy drinking and suicidal behavior likely reflects, in part, genetic and environmental influences, including the proximity of alcohol outlets. Research has been inconclusive, however. For the new study, drawing on the experiences of hundreds of thousands of individuals in Sweden, investigators explored the association between neighborhood alcohol outlets and suicide attempts and

A vicious cycle: How alcohol’s impact on the brain makes us more likely to drink

Heavy alcohol use creates a vicious cycle: It changes signaling pathways in the brain, which in turn affects cognitive functions like decision-making and impulse control — and makes the individual more likely to drink. The mechanism behind this may involve the brain’s immune system, according to new research from Binghamton University, State University of New York.

Alcoholic Pancreatitis Patients with Continued Alcohol Intake May Finally Have Therapeutic Options

Researchers at the Miller School are looking for solutions to the continued effects of alcohol use, its harmful impact, and treatment. Understanding the mechanisms of alcohol abuse has gained importance, especially after the COVID-19 pandemic. Higher alcohol consumption led to an increased burden of pancreatic diseases in society.

Why We Want to Drink, What That Has to Do with Genes, and Why it Matters for Our Alcohol Risk

Motives for drinking — to party, to conform, to cope, or to feel good — are consistent through young adulthood, and genes play a role in how those motives influence alcohol use, a new study of college students suggests. Understanding the mechanisms linking genetic variants to differences in drinking behaviors could present opportunities for predicting individuals’ vulnerability to Alcohol Use Disorder (AUD) and intervening to prevent it. Genetic factors are responsible for about 50% of individual risk of AUD. Much of how that heritability functions is unexplained, however. The relationship between genes and drinking behavior is complex, involving thousands of genetic variants that each have small effects. Critical factors known as endophenotypes, or intermediary phenotypes, affect how an individual’s genetic predisposition manifests as a behavioral trait. For the new study in Alcoholism: Clinical & Environmental Research, investigators sought to determine whether drinking motives are o

American Indian Teens Who Anticipate Future Affiliation with their Native Culture Experience Fewer Negative Consequences of Drinking

American Indian (AI) adolescents who expect to relate strongly to their racial culture in the future are less likely than their peers to experience negative alcohol outcomes – like fighting with friends, being arrested, and memory gaps – even if they do not relate strongly to their culture now, a new study suggests. Although AI communities overall have higher rates of abstention from alcohol than other racial groups, AI teens are particularly vulnerable to drinking and its negative consequences. This may be related to cultural identity, which is known to influence substance use.

Family matters: Study shows family support, awareness benefit Latino college students

Research from the Arizona State University Department of Psychology has shown that positive communication among family members contributes to less depressive symptoms and alcohol use in Latino students during their transition to college. The study also found that parent awareness of their child’s daily lives predicted less alcohol use.

People with Certain Personality Traits are Less Likely to Mature Out of Hazardous Substance Use, Study Suggests

The typical rise and fall of alcohol and cannabis consumption from late adolescence into adulthood does not hold for people with certain personality traits, a new study suggests. Among individuals who used both alcohol and cannabis, those with high impulsivity as adolescents showed a different developmental trajectory from their peers, according to a study in Alcoholism: Clinical & Experimental Research — the first to assess co-use of the two substances well into adulthood. Alcohol and cannabis are the two most frequently used psychotropic drugs in the US. High use is associated with negative health outcomes, particularly when the two substances are used concurrently or simultaneously. Little is known about the developmental course of alcohol and cannabis co-use into adulthood and whether it is influenced by sensation seeking and reduced conscientiousness, markers of disinhibition associated with hazardous substance use. Researchers at Arizona State University explored whether those pe

Conversations between teenagers can predict future drug and alcohol abuse

A study from Arizona State University and Radboud University Nijmegen in the Netherlands has shown that conversations between a pair of 17-year-old friends can predict future drug and alcohol abuse. If the teens talked positively about alcohol or cannabis, they were more likely to be diagnosed with an alcohol or cannabis use disorder, respectively, by the time they were 27 years old.

Sleep Disruption Predicts Drinking and Cannabis use in Young People, with Middle and High School Students Potentially Most Vulnerable

A five-year study has highlighted the importance of healthy sleep patterns in relation to future binge-drinking and cannabis use in adolescence and young adulthood, as reported in Alcoholism: Clinical and Experimental Research. The work builds on growing evidence that sleep characteristics are predictive of future substance use and related problems in young people, and could inform strategies for substance use prevention and intervention. Most previous studies assessed only a small range of sleep characteristics, and had limited follow-up. In the new analysis, researchers used six annual assessments from the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) study to examine whether multiple sleep characteristics in any year predict alcohol and cannabis use the following year. Data from over eight hundred NCANDA study participants, aged 12 to 21 at baseline, were included.

Pregnant Women’s Alcohol Use is Linked to Partners’ Drinking

Pregnant women’s alcohol use is correlated with their partners’ drinking, according to a large European study — and partners are unlikely to meaningfully reduce or halt their alcohol consumption while expecting a baby. The findings may offer a new way of identifying women at risk of drinking in pregnancy and potentially intervening to prevent or reduce harm. Alcohol consumption during pregnancy can seriously impair fetal health and development, causing stillbirth and lifelong disabilities. These include fetal alcohol spectrum disorders (FASDs), the primary cause of non-genetic cognitive disability worldwide. Although the drinking patterns of women and their partners are known to be correlated, little attention has been given to partners’ alcohol use during pregnancy and how this may affect women’s drinking and pregnancy outcomes. For the study in Alcoholism: Clinical & Experimental Research, investigators searched for associations between pregnant women’s and their partners’ alcohol us

How Adolescents Used Drugs During the COVID-19 Pandemic

Among adolescents ages 10 to 14 in the U.S, the overall rate of drug use remained relatively stable in the first six months of the COVID-19 pandemic. However, one change was a decreased use of alcohol, but an increased use of nicotine and misuse of prescription drugs.

Young Adults’ Alcohol Use and Cannabis Use Rise and Fall Together Rather than Substituting for Each Other

Young adults’ use of cannabis and alcohol tends to rise and fall together, rather than one substance substituting for the other, according to a new study. Understanding the relationship between cannabis use and alcohol use is critical for informing policy and public health strategies. Legalizing recreational cannabis use has raised the possibility that cannabis may substitute for risky drinking or other substance use, potentially with less severe public health consequences.

Alcohol use among sexual minority adolescents is linked to discrimination and stigmatization

Sexual minority adolescents – lesbian, gay, or bisexual youth – are at an increased risk for substance use, including alcohol. A new study finds that discriminatory and stigmatizing experiences may be to blame. These results and others will be shared at the 44th annual scientific meeting of the Research Society on Alcoholism (RSA), which due to the COVID-19 pandemic will be held virtually this year from the 19th – 23rd of June 2021.

About the cannabis and alcohol relationship: it’s complicated

Not only is cannabis the most commonly used illicit – in a number of states – drug among people who drink alcohol, cannabis is also by far the most commonly used illicit drug in the U.S. overall. New research findings tease out the nuanced relationship between alcohol and cannabis through a survey of regular cannabis users who also report drinking alcohol, as well as heavy drinkers in treatment who also use cannabis. These findings will be shared at the 44th annual scientific meeting of the Research Society on Alcoholism (RSA), which due to the COVID-19 pandemic will be held virtually this year from the 19th – 23rd of June 2021.

Stay-at-home orders tied to an increase in harmful alcohol consumption, study finds

Binge drinkers increased their alcohol consumption by nearly 20% during COVID-19 stay-at-home orders, according to new research by public health experts at The University of Texas Health Science Center at Houston (UTHealth). Their study, published in the American Journal of Drug and Alcohol Abuse, is one of the first to analyze the association of stress caused by the pandemic and dangerous alcohol consumption.

In the Mood for Drinking? Study Tracks College Students’ Emotion Dynamics During Drinking and Non-drinking Days

A study reported in Alcoholism: Clinical and Experimental Research has highlighted the link between emotional functioning and alcohol use. Previous research has shown that mood regulation is a core component of problematic drinking, and that emotions have a role in reinforcing repeated alcohol use – whether via the mood- and social-enhancing effects of alcohol (‘positive reinforcement’), or through drinking as a coping strategy to alleviate negative feelings of stress and anxiety (‘negative reinforcement’). According to theoretical models of addiction, alcohol reinforcement can act as a pathway to development of alcohol misuse and dependence over the longer-term. However, it is also important to understand the daily impact of emotional regulation and alcohol associations. In the latest study, researchers from the University of Central Florida examined snapshots of mood in college students in real time across drinking and non-drinking days, using a technique called ecological momentary

Researchers Unravel the Ways Income and Liquor Stores are Related to Neighborhood Drinking

Residents of wealthier neighborhoods drink alcohol twice as frequently as people in poorer areas, a new study suggests. The neighborhood environment is known to be associated with alcohol use. But the separate effects of various factors — for example, average income and the number of off-sales outlets — are complex, situational, and difficult to unravel. A new study in Alcoholism: Clinical and Experimental Research demonstrates a sampling technique that isolates these influences. It explores how certain individual characteristics interacted with certain neighborhood characteristics among 984 survey respondents.

Untangling the Effects of Past Adversity and Alcohol Use Disorder on Acute Stress Responses

The hypothalamic–pituitary–adrenal (HPA) axis is the body’s key stress response system. By driving production of the stress hormone cortisol, and then ensuring a return to baseline levels, the HPA axis regulates our reaction to stressful events. Chronic alcohol use, however, can lead to persistently elevated cortisol, reducing the body’s capacity to respond appropriately to stress. Among people in treatment for alcohol use disorder (AUD), the blunted stress response predicts risk of relapse and a return to drinking. Longer-term life stress, including childhood adversity, post-traumatic stress disorder (PTSD), and chronic stress, can also dampen HPA axis function, complicating interpretation of the alterations evident in people with AUD. However, it is not known how stress and trauma intereact with AUD to affect HPA-axis reactivity. A new report in Alcoholism: Clinical and Experimental Research by researchers from the universities of Texas, Florida, and Colorado addresses this issue, u

Female college students more affected academically by high alcohol use than men

Female college students appear to be more affected by high alcohol use than men, which may lead to less interest in academics, according to new research including by faculty at Binghamton University, State University of New York.

Students Who Up Their Cannabis Use Face Increased Risk of Alcohol Problems

Cannabis use can worsen some consequences of alcohol use among young adult drinkers over time, according to a new study which tracked the frequency of cannabis use and negative drinking outcomes among college students over three years. More than one in five young drinkers use cannabis, often (but not always) at the same time as drinking alcohol. This is a concern because the effects of cannabis might combine with those of alcohol to increase negative outcomes of drinking, such as impaired driving or developing an alcohol use disorder Although previous research has suggested a link between cannabis use and alcohol consequences, there have been few long-term evaluations of the impact of fluctuations in cannabis use on alcohol consequences over time. The latest study, published in the journal Alcoholism: Clinical and Experimental Research, was conducted by researchers in Toronto, Ontario, and Buffalo, New York.