New evidence suggests the temporomandibular joint is a neurogenic joint: Sympathetic-sensory interaction promotes pain in temporomandibular joint osteoarthritis via bone sensing mechanisms

The temporomandibular joint (TMJ) develops from neural crest cells which originate from the neuroectoderm. Based on the scientific hypothesis that the TMJ, as a “neurogenic joint,” is more susceptible to peripheral nerve regulation and innervation.

Sharks and rays benefit from global warming – but not from CO2 in the Oceans

Sharks and rays have populated the world’s oceans for around 450 million years, but more than a third of the species living today are severely threatened by overfishing and the loss of their habitat. An international research team led by palaeobiologist Manuel A. Staggl from the University of Vienna has now investigated whether and how global warming influences the diversity of sharks based on climate fluctuations between 200 and 66 million years ago. According to the study, higher temperatures and more shallow water areas have a positive effect, while higher CO2 levels have a clearly negative effect. The study was recently published in the scientific journal “Biology”.

AI-based Pregnancy Analysis Discovers Previously Unknown Warning Signs for Stillbirth and Newborn Complications

The analysis of almost 10,000 pregnancies has discovered previously unidentified combinations of risk factors linked to serious negative pregnancy outcomes, finding that there may be up to a tenfold difference in risk for infants who are currently treated identically under clinical guidelines.

Avoiding patient abandonment – ethical approaches to ‘untenable’ patient relationships

Plastic surgeons sometimes face challenging relationships with patients, especially those with underlying psychiatric issues. An ethical framework to managing untenable surgeon-patient relationships is presented in a special Plastic Surgery Focus article in the February issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). The journal is published in the Lippincott portfolio by Wolters Kluwer.

Body weight trends upwards after breast reduction surgery in teens

Many adolescents and young women gain weight in the years after breast reduction surgery – particularly those who were at a healthy body mass index (BMI) before surgery, reports a paper in the February issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). The journal is published in the Lippincott portfolio by Wolters Kluwer.

D-CARE study finds no differences between dementia care approaches on patient behavioral symptoms or caregiver strain

Research comparing different approaches to dementia care for people with Alzheimer’s disease and other dementias found no significant differences in patient behavioral symptoms or caregiver strain, whether delivered through a health system, provided by a community-based organization, or as usual care.

Older People with Alcohol Use Disorder May Underestimate Their Impairment In Visual Processing When Drinking, Raising Their Risk of Accidents

Older adults’ visual functions— eye movement reaction time, speed, and accuracy—are acutely impaired by alcohol, and those with chronic alcohol use disorder (AUD) are not immune to these impairments when imbibing. The study in Alcohol: Clinical & Experimental Research is the first to examine alcohol’s acute effects on eye movements, pupil size, and self-perception of impairment in middle-aged to older adults with AUD versus a control group of those with lifetime light drinking. Alcohol disrupts eye movement and pupil dilation, resulting in delayed visual reactions and reduced accuracy. Many believe that those with longer-term excessive drinking have built up tolerance and are protected against eye movement impairment. While this study showed that older drinkers with chronic AUD (vs. light drinkers) had less impairment in visually tracking an object that moves predictably, they were equally impaired in eye movements that require quick adjustments to randomly appearing objects. The perso

New tool predicts stroke outcome with 93% accuracy, guiding better carotid surgery decisions

Stroke remains a global health challenge, ranking second in worldwide mortality and fifth in U.S. deaths. In response, researchers at Ochsner Health, led by Hernan Bazan, MD, DFSVS, FACS, have developed a predictive model with a 93% accuracy rate in determining whether urgent carotid-intervention patients will regain functional independence.

Q&A: How rate of CO2 rise can affect a global ocean current

How fast the level of atmospheric carbon dioxide — and with it, the temperature — goes up matters for the ability of humans and ecosystems to adjust. A slower increase gives humans time to move away from low-lying coasts and animals time to move to new habitats. It turns out the rate of that increase matters for non-living systems, too.

Artificial intelligence model identifies potential risk genes for Parkinson’s disease

Researchers from the Cleveland Clinic Genome Center have successfully applied advanced artificial intelligence (AI) genetics models to Parkinson’s disease. Researchers identified genetic factors in progression and FDA-approved drugs that can potentially be repurposed for PD treatment.

The npj Parkinson’s Disease report uses an approach called “systems biology,” which uses AI to integrate and analyze multiple different forms of information from genetic, proteomic, pharmaceutical and patient datasets to identify patterns that may not be obvious from analyzing one for of data on its own.

Moffitt Research Advocates for Routine Brain MRI Screening in Asymptomatic Late Stage Breast Cancer Patients

A new study led by researchers at Moffitt Cancer Center shows that asymptomatic brain metastasis is more common in stage 4 breast cancer patients than previously believed. The study, published in Neuro-Oncology, suggests that doctors may need to rethink current screening guidelines for detecting brain metastasis in patients without symptoms.

Novel Lab-on-Chip Platform Promises to Expedite Cancer Diagnoses

In Physics of Fluids, researchers propose a novel system that uses standing surface acoustic waves to separate circulating tumor cells from red blood cells with unprecedented precision and efficiency. The platform integrates advanced computational modeling, experimental analysis, and artificial intelligence algorithms to analyze complex acoustofluidic phenomena.

Investigación muestra que el nuevo tratamiento puede retrasar la progresión del cáncer en pacientes con mieloma múltiple latente de alto riesgo

Un nuevo tratamiento está demostrando ser prometedor para las personas con mieloma múltiple latente (SMM, por sus siglas en inglés) de alto riesgo. Esta afección precancerosa puede progresar a un mieloma múltiple activo, un tipo de cáncer de la sangre. El SMM de alto riesgo tiene una mayor probabilidad de progresión.

Social Network, Social Functioning Associated with Longer Stays in Alcohol Treatment

When seeking treatment for alcohol use disorder, how a person is functioning in society strongly influences how long they will stay in inpatient treatment. According to a study published in Alcohol: Clinical and Experimental Research, people who are dissatisfied in their primary social role—at work or school, for example—and people with a strong social network stay in treatment longer, giving them more opportunities for therapeutic intervention.

Researchers testing antibody to treat drug-resistant bacteria

West Virginia University microbiologists have identified an antibody that can kill one of the most drug-resistant bacteria. Now, supported by a $3.5 million grant from the National Institute of Allergy and Infectious Diseases, they want to determine whether it can be combined with other antibiotics to produce a potent treatment against infection.

Pesquisa mostra que novo tratamento pode atrasar a progressão do câncer em pacientes com mieloma múltiplo latente de alto risco

Um novo tratamento está se mostrando promissor para pessoas com mieloma múltiplo latente (SMM, sigla em inglês) de alto risco. Essa condição pré-cancerosa pode progredir para um mieloma múltiplo ativo, um tipo de câncer no sangue. O SMM de alto risco apresenta uma maior probabilidade de progressão.

Could fecal microbiota transplantation help patients heal after stem cell transplantation?

A new study published in Nature Communications shows that oral fecal microbiota transplantation (FMT) is a feasible and safe addition to preventing graft-versus-host disease in patients undergoing stem cell transplantation for blood cancers.

أظهرت الأبحاث أن علاجًا جديدًا يمكنه تأخير تقدّم المرض لدى مرضى الورم النقوي المتعدد الكامن مرتفع الخطورة

روتشستر، ولاية مينيسوتا — يُظهر علاج جديد أملًا واعدًا لمرضى الورم النقوي المتعدد الكامن مرتفع الخطورة (SMM). يمكن أن تتطور هذه الحالة السابقة للتسرطن وتتحول إلى ورم نقوي متعدد نشط، وهو نوع من سرطانات الدم. الورم النقوي المتعدد الكامن مرتفع الخطورة أكثر عرضة لتقدّم المرض.

New CWRU study targets suicide risk among LGBTQ+ youth in Cleveland’s child welfare, juvenile justice systems

Youth in juvenile detention centers face suicide rates significantly higher than their peers, driven by isolation, untreated mental health conditions and systemic barriers to care, according to the U.S. Office of Justice Programs. But for LGBTQ+ youth involved in child welfare and juvenile justice systems, the outcomes are even worse.

Study reveals biomarker for high risk of metastasis

A team led by UT Southwestern scientists has discovered a mechanism that promotes metastasis in pancreatic, breast, and potentially other cancers along with a new druggable therapeutic target to block it. The findings, published in Science Signaling, represent an important lead in developing new drugs to prevent tumors from spreading, the cause of death among most patients with cancer.

Weight-Loss Surgery Lowers Risk of Developing Complications of Liver Disease in Patients with Cirrhosis and Obesity

A Cleveland Clinic study shows that patients with obesity and fatty liver-related cirrhosis who had bariatric (weight-loss) surgery significantly lowered their future risk of developing serious liver complications compared with patients who received medical therapy alone. The results were published in Nature Medicine journal.