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UrduUC San Diego scientists use lab-grown human brain tissue to identify neural abnormalities in Pitt-Hopkins Syndrome and show gene therapy tools can rescue neural structure and function.
Tag: Pediatrics
Hospitals Can Reduce Antibiotic Overuse by Avoiding Unnecessary Blood Draws in Critically Ill Children, Study Shows
A Johns Hopkins Children’s Center-led national quality improvement collaborative highlights a “less is more” method that may prevent antibiotic overprescribing
Supplement: Life course intervention research optimizes health development and children’s well-being
A new Supplement released today in the journal Pediatrics suggests that although we are starting to connect the dots between events and experiences early in life and later adult health challenges, we are not doing nearly enough to intervene in childhood to optimize later health outcomes.
Tip Sheet: Studies on COVID-19, TV and Toddler Diet Among Johns Hopkins Research to Be Featured at National Pediatrics Meeting
What: Pediatric Academic Societies (PAS) 2022 Meeting
When: April 21 to 25
Where: Colorado Convention Center (700 14th St., Denver, CO 80202)
For Neurons, Where They Begin Isn’t Necessarily Where They End
Scientists at UC San Diego School of Medicine and Rady Children’s Institute of Genomic Medicine describe novel methods for inferring the movement of human brain cells during fetal development by studying healthy adult individuals who have recently passed away from natural causes.
Omicron ‘less severe’ than Delta for children ages 4 and younger, study suggests
New research from the Case Western Reserve University (CWRU) School of Medicine suggests that the children younger than age 5 who are infected with the COVID-19 Omicron variant have less risk of severe health outcomes than those infected with the Delta variant.
Researchers Use Model of Hypothalamus to Implicate Genes Associated with Sleep, BMI, Puberty, and More
A new study has implicated several genes involved in a variety of bodily functions associated with the hypothalamus, a notoriously difficult-to-study region of the brain. The findings could help clinicians identify potential causes of dysfunction for many important traits regulated by the hypothalamus, such as sleep, stress, and reproduction.
UCI and CHOC join new NORD Rare Disease Centers of Excellence Network
University of California, Irvine and Children’s Health of Orange County (CHOC) have been jointly designated a National Organization for Rare Disorders (NORD) Center of Excellence, joining a new and highly select group of 31 medical centers seeking to expand access and advance care and research for rare disease patients in the United States.
Adolescents’ recreational screen time doubled during pandemic, affecting mental health
Many parents fretted over their children’s screen use during the pandemic with good reason, according to a new study in JAMA Pediatrics.
CHOP-led Pediatric Hospital Network Receives Critical Government Support for Genetic Research of Pediatric Tumors
The Center for Data Driven Discovery at CHOP will procure molecular characterization for thousands of these brain tumor samples providing an unprecedented level of insight into devastating cancers and paving the way for future therapeutic interventions.
Same Treatment Tested for Kids with Kawasaki Disease and Rare COVID-19 Reaction
Researchers at University of California San Diego School of Medicine tested the same treatment for kids with Kawasaki disease and rare COVID-19 reaction.
Lower Airways Are Distinct in Cystic Fibrosis Even at Younger Ages
In the largest study of its kind, researchers found that the lower airways in children with cystic fibrosis (CF) have a higher burden of infection, more inflammation and lower diversity of microorganisms, compared to children with other illnesses who also have lung issues. They noted a clear divergence in these bacterial communities in toddlers, which is typically before progressive lung disease takes hold in patients with CF. Their findings, published in the journal PLOS ONE, could help providers target specific pathogens earlier, treat them and potentially prevent more severe lung disease.
New Avenue for Study of Diseases like Multiple Sclerosis
A surprising discovery may offer a promising new direction in the study of multiple sclerosis and other diseases of hypomyelination – when axons of neurons are not covered sufficiently in fatty sheaths (myelin), which disrupts communication between nerve cells.
Pregnant Women Who Receive COVID-19 Vaccination Pass Protection from the Virus to Their Newborns
Women who receive COVID-19 mRNA vaccines during pregnancy pass high levels of antibodies to their babies, a new NYU Langone study finds.
Memorial Sloan Kettering Cancer Center Launches New Center to Expand Commitment to Meeting the Unique Needs of Adolescents and Young Adults with Cancer
While overall cancer cases are declining, they are on the rise in older adolescents and young adults. Today, Memorial Sloan Kettering Cancer Center (MSK) announces the establishment of the Lisa and Scott Stuart Center for Adolescent and Young Adult Cancers (the Stuart Center), dramatically expanding MSK’s already robust efforts to address the very specific, and often unmet, needs of this patient population.
Researchers Show Novel Device Improves Blood Sugar Control in Hyperinsulinism Patients Whose Pancreas Has Been Removed
Researchers at Children’s Hospital of Philadelphia (CHOP) have demonstrated that an experimental device can improve blood sugar control in patients who developed diabetes after their pancreas was removed to treat their hyperinsulinism, a genetic disease in which the pancreas produces too much insulin. Using a combination of continuous glucose monitoring, two hormone pumps, and an algorithm, the device, known as the bihormonal bionic pancreas (BHBP) and developed by researchers at Boston University, helped HI patients with diabetes maintain stable glucose levels over the study period.
Do a Mom’s Medications Affect Her Breast Milk and Baby? New Center Investigates
UC San Diego School of Medicine receives $6.1M to launch a new research center studying the effects of maternal antibiotic use on breast milk and infant health. The center is funded by National Institutes of Health, as part of their new Maternal and Pediatric Precision in Therapeutics (MPRINT) Hub.
Alarming Upward Trend in Black Youth Suicide From 2003 to 2017
In the United States, the rates of suicide and suicidal behavior among youth, children and adolescents 5-17 years of age, have been steadily increasing over the last decade, and Black youth, 5-12 years, are approximately two times more likely to die by suicide than their White counterparts. However, the literature investigating Black youth suicide is extremely limited. For the first time, researchers have examined the trends and precipitating circumstances of suicide in Black youth only by age group and sex.
Study: No Serious COVID-19 Vaccine Side Effects in Breastfeeding Moms, Infants
Researchers found that breastfeeding mothers who received either the Pfizer-BioNTech or Moderna vaccination reported the same local or systemic symptoms as what has been previously reported in non-breastfeeding women, with no serious side effects in the breastfed infants.
Study Shows Contact with Police May Be Detrimental to Health, Well-Being of Black Youth
According to a Johns Hopkins Medicine study published today in JAMA Pediatrics, exposure to police — even in instances in which the officers are providing assistance — may be detrimental to the health and well-being of Black youth, especially males, and can be associated with poor mental health, substance use, risky sexual behaviors and impaired safety.
Children’s Hospital of Philadelphia Researchers Develop Tools to Measure Skeletal Muscle Function in Patients with Mitochondrial Disease
Researchers successfully developed and validated a new outcome measure to monitor disease severity and progression in patients with impaired skeletal muscle function caused by mitochondrial disease. This measure, named ‘Mitochondrial Myopathy-Composite Assessment Tool’ (‘MM-COAST’), is important to identify specific skeletal muscle and neurological problems in both children and adults with mitochondrial disease and may be used to measure response to treatment interventions in future clinical trials.
Every 46 Minutes a Child is Treated in a U.S. Emergency Department for an Injury from a Furniture or TV Tip-Over
Furniture and TV tip-overs are an important source of injury, especially for children younger than 6 years old. A recent study led by researchers at the Center for Injury Research and Policy at Nationwide Children’s Hospital found that an estimated 560,200 children younger than 18 years old were treated in U.S. emergency departments for furniture or TV tip-over injuries from 1990 through 2019. In 2019, there were 11,521 injured children, which is an average of one child every 46 minutes.
Brain Organoids Mimic Head Size Changes Associated with Type of Autism
Stem cell models derived from people with specific genomic variation recapitulate aspects of their autism spectrum disorder, providing a valuable model to study the condition and look for therapeutic interventions.
Families Estimated to Lose $18,000 a Year in Wages When They Have to Cut Work Hours or Leave a Job to Care for Their Child’s Health
A study that identified over 14,000 previously employed American families of children with special healthcare needs found that families who had to reduce work hours or leave a job in order to care for their children’s health lost an estimated average of $18,000 a year in household income in 2016-2017.
Mount Sinai Researchers Find Important Clue to Rare Inflammatory Disease in Children Following COVID-19 Infection
Mount Sinai researchers have found an important clue to a rare but serious aftereffect of COVID-19 in children, known as multisystem inflammatory syndrome in children or MIS-C.
August is National Breastfeeding Month: @UCSDHealth Experts on Health Benefits and Latest in COVID-19 Research
August is National Breastfeeding Month, intended to raise awareness of the health benefits that breast milk provides, including: Reduction in Sudden Infant Death Syndrome Fewer infections: ear, respiratory, diarrhea, bladder, meningitis Decrease in childhood obesity Reduction in diabetes, celiac disease,…
CHOP Researchers Develop Coating for Endotracheal Tubes that Releases Antimicrobial Peptides
In a proof-of-concept study, researchers at Children’s Hospital of Philadelphia (CHOP) have created a coating that can be applied to endotracheal tubes and release antimicrobial peptides that target infectious bacteria with specificity. The innovation could reduce upper-airway bacterial inflammation during intubation, a situation that can lead to chronic inflammation and a condition called subglottic stenosis, the narrowing of the airway by an accumulation of scar tissue. The findings were published recently in the journal The Laryngoscope.
DSW Joins the On Our Sleeves® Movement for Children’s Mental Health
DSW has joined the On Our Sleeves® movement, committing to a national in-store campaign. Between Aug. 1-Oct. 31, DSW customers will have the option to round-up their purchase, or donate $1, $3, $5 or an additional amount of their choice during checkout at approximately 500 stores.
Children’s Hospital of Philadelphia Researchers Identify Approach for Potential Nontypeable Haemophilus Influenzae Vaccine
Scientists at Children’s Hospital of Philadelphia (CHOP) have identified two proteins that could be used for a potential vaccine against nontypeable Haemophilus influenzae (NTHi). Working in a mouse model, the investigators found that administering two bacterial adhesive proteins that play a key role in helping the bacteria to latch on to respiratory cells and initiate respiratory tract infection stimulated protective immunity against diverse NTHi strains, highlighting the vaccine potential.
Half of U.S. Parents May Not Vaccinate Their Youngest Child Against COVID-19
Even as the delta variant of Covid-19 sweeps the globe, leaving those who remain unvaccinated vulnerable, vaccination among adults and teenagers in the United States is stalling, giving rise to concerns over whether parents will vaccinate their young children once vaccines are approved for those under 12 years of age.
New Study Finds Hands-free Cellphone Laws Associated with Fewer Driver Deaths
A recent study led by researchers at the Center for Injury Research and Policy at Nationwide Children’s Hospital looked at drivers, non-drivers (passengers, pedestrians, bicyclists, motorcyclists), and total deaths involved in passenger vehicle crashes from 1999 through 2016 in 50 U.S. states, along with the presence and characteristics of cellphone use laws.
Children’s Hospital of Philadelphia Researchers Develop “Dimmer Switch” to Help Control Gene Therapy
In a major advancement in the field of gene therapy for rare and devastating diseases, researchers at Children’s Hospital of Philadelphia (CHOP) have developed a “dimmer switch” system that can control levels of proteins expressed from gene therapy vectors. The system is based on alternative RNA splicing using an orally available small molecule and works effectively in tissues throughout the body, including the brain. The first research regarding this innovation was published today in the journal Nature.
Anticipate a resurgence of respiratory viruses in young children
Canada should anticipate a resurgence of a childhood respiratory virus as COVID-19 physical distancing measures are relaxed, authors warn in CMAJ ( Canadian Medical Association Journal) . Cases of respiratory syncytial virus (RSV) have risen sharply in Australia and, more…
Experiences, perpetration of identity-based bullying among adolescents
What The Study Did: Using survey responses from students in some Pittsburgh, Pennsylvania, high schools, researchers investigated how experiences of bullying based on race/ethnicity/ national origin and other marginalized identities are associated with outcomes for health, mental health and violence…
Possible link between late-term births and better academic outcomes, study suggests
This release has been removed upon request of the submitting institution. Please contact Jennifer Forbes, 732-788-8301, [email protected] for more information. This part of information is sourced from https://www.eurekalert.org/pub_releases/2021-07/ru-plb072221.php
Precision treatment for severe asthma targets a specific mutation
Drug blocks a cell receptor that is mutated disproportionately in people of color
Study: Wireless radiation exposure for children is set too high
Levels should be hundreds of times lower than current federal limits
Study refutes suspicion that dengue increases risk of microcephaly associated with zika
Researchers compared data for pregnant women in two cities who were infected by zika virus in 2015-16. Factors that influenced the risk of fetal malformation were the high zika attack rate in the area and being infected in the first trimester of pregnan
The Lancet: 1.5 million children worldwide have lost parent, grandparent, caregiver due to COVID-19
Study offers first global estimates of the number of children who experienced the death of a parent, grandparent, or primary caregiver from COVID-19. Researchers estimated figures based on COVID-19 mortality data from March 2020 through April 2021, and national fertility…
Improving access to mental health services in low-income communities
UH researcher: Communication, coordination, collaboration are key
Health care providers missing opportunities to talk about sexual health with young people
Less than one-third of adolescents report conversations about sexual health during annual visits
A small molecule induces readthrough of cystic fibrosis CFTR nonsense mutations
This research suggests that a path to treat currently untreatable cases of cystic fibrosis is clearly achievable.
Transgender young people accessing health care
What The Study Did: The experiences, perspectives and needs of transgender young people in accessing health care are described in this review of 91 studies. Authors: Lauren S. H. Chong, M.D., of the Children’s Hospital at Westmead in Sydney, Australia,…
Sleep twitches facilitate motor cortex development in rats
Sleep twitches enrich coding of sensory information, lay groundwork for later motor functions
Cannabis: sexually diverse youths with depression use more
It’s no secret that studies show that sexually diverse youth – in particular, lesbian, gay and bisexual (LGB) youth – use more cannabis and experience more mental health challenges than their heterosexual peers. But what about the changes that occur…
Co-locating Contraceptive Services & Opioid Treatment Programs May Help Prevent Unintended Pregnancy
More than 75% of women with Opioid Use Disorder report having had an unintended pregnancy, but they are less likely to use effective contraception compared to women who do not use drugs. Results from a multi-year trial found that a two-part intervention featuring co-located contraceptive services in opioid treatment programs and financial incentives could offer an effective solution.
New UK Study Reveals Extent of Brain Complications in Children Hospitalized with COVID-19
Although the risk of a child being admitted to hospital due to COVID-19 is small, a new UK study has found that around 1 in 20 of children hospitalised with COVID-19 develop brain or nerve complications linked to the viral infection.
NIH-funded study finds gene therapy may restore missing enzyme in rare disease
Results provide hope for children with aromatic L-amino acid decarboxylase deficiency
Immune system May Need ‘Continuing Education’ to Protect Pregnancy
Newly Discovered Class of Immune Cells Implicated in Maternal-Fetal Tolerance
Heart problems resolve in majority of kids with COVID inflammatory syndrome
NEW YORK, NY (July 15, 2021)–Heart problems in children hospitalized with multisystem inflammatory syndrome (MIS-C)–an inflammatory condition triggered by COVID–were mostly gone within a few months, a new study by researchers at Columbia University Vagelos College of Physicians and Surgeons…