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UrduThe stem cell pre-treatment approaches at cellular and sub-cellular levels encompass physical manipulation of stem cells to growth factor treatment, genetic manipulation, and chemical and pharmacological treatment, each strategy having adva
Month: June 2024
Gut microbiota modulating intestinal stem cell differentiation
Proliferation and differentiation of intestinal stem cell (ISC) to replace damaged gut mucosal epithelial cells in inflammatory states is a critical step in ameliorating gut inflammation. However, when this disordered proliferation continue
Mesenchymal stem cells-extracellular vesicles alleviate pulmonary fibrosis by regulating immunomodulators
BACKGROUNDPulmonary fibrosis (PF) is a chronic interstitial lung disease characterized by fibroblast proliferation and extracellular matrix formation, causing structural damage and lung failure. Stem cell therapy and mesenchymal stem cells-
Outcomes of combined mitochondria and mesenchymal stem cells-derived exosome therapy in rat acute respiratory distress syndrome and sepsis
BACKGROUNDThe treatment of acute respiratory distress syndrome (ARDS) complicated by sepsis syndrome (SS) remains challenging. AIMTo investigate whether combined adipose-derived mesenchymal-stem-cells (ADMSCs)-derived exosome (EXAD) and ex
Safety and efficiency of Wharton’s Jelly-derived mesenchymal stem cell administration in patients with traumatic brain injury: First results of a phase I study
BACKGROUNDTraumatic brain injury (TBI) is characterized by a disruption in the normal function of the brain due to an injury following a trauma, which can potentially cause severe physical, cognitive, and emotional impairment. Stem cell tra
Exosomes from umbilical cord mesenchymal stromal cells promote the collagen production of fibroblasts from pelvic organ prolapse
BACKGROUNDPelvic organ prolapse (POP) involves pelvic organ herniation into the vagina due to pelvic floor tissue laxity, and vaginal structure is an essential factor. In POP, the vaginal walls exhibit abnormal collagen distribution and dec
RPLP0/TBP are the most stable reference genes for human dental pulp stem cells under osteogenic differentiation
BACKGROUNDValidation of the reference gene (RG) stability during experimental analyses is essential for correct quantitative real-time polymerase chain reaction (RT-qPCR) data normalisation. Commonly, in an unreliable way, several studies u
Searching for the optimal precondition procedure for mesenchymal stem/stromal cell treatment: Facts and perspectives
Mesenchymal stem/stromal cells are potential optimal cell sources for stem cell therapies, and pretreatment has proven to enhance cell vitality and function. In a recent publication, Li et al explored a new combination of pretreatment condi
Overcoming Challenges Encountered by Spanish-Speaking Trauma Patients
Many trauma patients face a myriad of challenges when recovering from a traumatic injury, problems that can be compounded when their English proficiency is limited. An outreach program to Spanish-speaking trauma patients can help improve access to follow-up care and community resources, according to a study published in the Journal of the American College of Surgeons (JACS)
Pillars of Creation Star in New Visualization from NASA’s Hubble and Webb Telescope
Combining data from NASA’s Hubble and James Webb space telescopes, a team from NASA’s Universe of Learning at the Space Telescope Science Institute (STScI) in Baltimore, Maryland has produced a breathtaking new 3D visualization of the towering “Pillars of Creation” in the Eagle Nebula.
Gene-editing nanoparticles correct stem cell mutations in cystic fibrosis models
Researchers at UT Southwestern Medical Center developed nanoparticles that successfully edited the disease-causing gene in the lungs of a mouse model of cystic fibrosis (CF), swapping a mutated form with a healthy one that persisted in stem cells. Their findings, reported in Science, could offer hope for people with CF and other debilitating genetic lung diseases.
JMIR Publications Journals Shine in the 2024 Release of Journal Impact Factors by Clarivate
JMIR Publications is pleased to announce the outstanding performance of its scholarly journals in the 2024 release of Journal Citation Reports (JCR) by Clarivate
Riverview Medical Center Foundation to Host Annual Fireworks on the Navesink on July 3
Riverview Medical Center Foundation to Host Annual Fireworks on the Navesink on July 3
UA Little Rock Professors Receive $50,000 Grant from INBRE to Bring New Centrifuge to Campus
UA Little Rock Chemistry Professors Mohammad Goodarzi and Noureen Siraj have received a $50,000 grant from the Arkansas IDeA Network of Biomedical Research Excellence (INBRE) to acquire an ultra-speed centrifuge for biomedical research. Photo by Ahmed Elkhattabi.
ETRI Creates 3D Shapes from a Flat Surface Using LEDs
A team of South Korean researchers has developed a groundbreaking haptic (tactile) display technology that is attracting global attention.
NFL chooses Case Western Reserve University medical student for immersive experience with Cleveland Browns, University Hospitals to increase diversity in sports medicine
Rachel Gardenhire, a third-year medical student at Case Western Reserve University, has been selected to take part in the 2024 NFL Diversity in Sports Medicine Pipeline Initiative, which aims to inspire medical students from various backgrounds to consider pursuing careers in sports medicine.
Power Generated from Waste Branches and Kudzu Vines
The Korea Institute of Energy Research develops technology to transform discarded forestry and agricultural waste into solid-type biofuel for power generation. Developing technology to upcycle non-edible waste into carbon-neutral fuel is crucial for constructing a circular bioeconomy as well as coping with climate crisis.
New Survey from NCCN Finds Cancer Drug Shortage Management Remains a Moving Target, Impacting Clinical Trials
NCCN shares new data on continued high prevalence for cancer drug shortages in the United States. In the latest survey, carboplatin and cisplatin shortages fell to 11% and 7% respectively, but 89% of centers surveyed continue to report shortages for at least one type of systemic therapy; 75% are experiencing two or more drug shortages.
New research identifies biomarkers that link alcohol use disorder and Alzheimer disease
Researchers agree that alcohol use can produce global and regional tissue volume changes in the brain, and that excessive alcohol use is associated with dementia and cognitive decline. A new study has examined the relationship between Alzheimer disease – the most common type of dementia – and alcohol use disorder (AUD), discovering biomarkers that link the two.
Balancing Act: Novel Wearable Sensors and AI Transform Balance Assessment
Traditional methods to assess balance often suffer from subjectivity, aren’t comprehensive enough and can’t be administered remotely. They also are expensive and require specialized equipment and clinical expertise.
Female heart patients less likely to have additional problems fixed during surgery
Two studies led by Michigan Medicine find that female patients who undergo heart surgery are less likely to have secondary ailments corrected during a procedure — despite guidelines that indicate they should. Researchers say it adds to growing evidence that women are undertreated across the spectrum of cardiovasvular care.
First case of Down syndrome in Neandertals documented in new study
A new study published by an international multidisciplinary team of researchers including faculty at Binghamton University, State University of New York, documents the first case of Down syndrome in Neandertals and reveals that they were capable of providing altruistic care and support for a vulnerable member of their social group.
Leading-Edge Model Predicts Impact of River Plants on Flood Level
The research team at the Korea Institute of Civil Engineering and Building Technology (KICT) has developed a technology for quantifying the effect of river vegetation patches on flood level changes to aid in better decision-making of river management for balancing ecological benefits and flood mitigation.
Some landfill ‘burps’ contain airborne PFAS, study finds
Many municipal landfills “burp” gas from decomposing organic matter rather than letting it build up. And burps from buried waste containing per- and polyfluoroalkyl substances (PFAS) can release these “forever chemicals” into the air, say researchers in ACS’ Environmental Science & Technology Letters.
Small, adsorbent ‘fins’ collect humidity rather than swim through water
To harvest small amounts of humidity, researchers in ACS Energy Letters have developed a compact device with absorbent-coated fins that first trap moisture and then generate potable water when heated.
Using smartwatch sensors to detect, measure, intervene, and prevent alcohol use in the moment
Prevention, intervention, and treatment measures have historically been used to address alcohol use and abuse. New research has explored the use of a smartwatch application to bridge the gap between prevention and intervention, tracking a person’s drinking habits and providing real-time personalized prompts while they are drinking to potentially help them moderate their consumption. These results will be shared at the 47th annual scientific meeting of the Research Society on Alcohol (RSA) in Minneapolis, Minnesota.
A genetic predisposition to alcohol use is not the same as a genetic destiny for alcohol misuse
There is a clear relationship between alcohol and neurodegeneration; for example, an alcohol use disorder correlates with a higher risk of Alzheimer’s disease. It is unclear, however, whether individual differences in brain structure and connectivity are risk factors for, or consequences of, alcohol use. New research exploring this relationship will be shared on Wednesday, 26 June 2024 at the 47th annual scientific meeting of the Research Society on Alcohol (RSA) in Minneapolis, Minnesota.
EventLFM: Event Camera integrated Fourier Light Field Microscopy for Ultrafast 3D imaging
Ultrafast volumetric imaging is essential for visualizing complex and dynamic biological processes. Scientists at Boston University have developed EventLFM, an innovative imaging system that combines event cameras with Fourier light field microscopy to capture rapidly moving and blinking 3D fluorescent samples at kHz speeds.
How consumers evaluate movies on online platforms? Investigating the role of consumer engagement and external engagement
Abstract This study examines how the causal patterns of consumers’ engagement and experts’ external engagement are associated with their online evaluation of movies. To this end, this study identifies the interplay of two dimensions (personal and interactive engagement) of consumers’…
How consumers respond to service failures caused by algorithmic mistakes: The role of algorithmic interpretability
Abstract Despite the advancement of algorithm-based AI transforming business and society, there is growing evidence of service failures caused by algorithmic mistakes. Due to the “black box” nature of algorithmic decisions, consumers are frustrated not only by the mistakes themselves…
Pride in family businesses: Authenticity, hubris, and cultural insights
Abstract Research on family businesses praises the benefits of feeling proud of the family firm. However, pride displayed by next generation family members, who may have (yet) contributed little to the success, can create negative impressions. Building on emotions-as-social-information theory…
Past, present, and future of international joint ventures
Abstract International Joint Ventures (IJVs) are a popular mode for a company to enter a foreign market. Research on IJVs has significantly grown in the past two decades. In this study, we applied several bibliometric analyses (i.e., performance analysis, co-citation…
Intrapreneurs, high performers, or hybrid stars? How individual entrepreneurial orientation affects employee performance
Abstract Recently, scholars have extended the concept of entrepreneurial orientation to the individual level. Yet, how individual entrepreneurial orientation (IEO) contributes to employee performance is not well understood. Building on role theory, we develop a novel typology of employee performance…
Technological and non-technological innovation synergies under the lens of absorptive capacity efficiency
Abstract While extensive research has focused on the role of absorptive capacity on innovation performance, no attention has been paid to the investigation of the relationship between absorptive capacity efficiency -the returns of resources devoted to absorptive capacity development- and…
Unveiling the dimensions of digital transformation: A comprehensive taxonomy and assessment model for business
Abstract Digital transformation (DT) is an adaptive strategy in the evolving tech and business landscape. It helps organizations enhance operations and customer experiences to remain competitive. However, defining digital transformation, creating a universal taxonomy, and developing a practical assessment model…
Absence makes the heart grow fonder: The interactive effect of crowding information and spatial distance on consumers’ patronage intention
Abstract Existing research has examined the influence of crowding on consumer behavior from an environmental cue perspective, with less attention given to its information cue function. To address the gap, based on construal level theory, this study investigated the impact…
Pesquisadores identificam alterações vasculares no cérebro ligadas à doença de Alzheimer
A barreira hematoencefálica — uma rede de vasos sanguíneos e tecidos que nutre e protege o cérebro de substâncias nocivas que circulam no sangue — é interrompida na doença de Alzheimer. No momento, pesquisadores e colaboradores da Mayo Clinic descobriram assinaturas moleculares únicas de disfunção da barreira hematoencefálica que poderiam apontar para novas formas de se diagnosticar e tratar a doença. Os resultados dessa descoberta estão publicados na Nature Communications.
Investigadores identifican cambios vasculares en el cerebro relacionados con la enfermedad de Alzheimer
La barrera hematoencefálica — una red de vasos sanguíneos y tejidos que nutre y protege al cerebro de las sustancias nocivas que circulan en la sangre, se interrumpe en la enfermedad de Alzheimer. En este momento, investigadores y colaboradores de Mayo Clinic han descubierto firmas moleculares únicas de disfunción de la barrera hematoencefálica que podrían apuntar a nuevas formas de diagnosticar y tratar la enfermedad. Los resultados de este hallazgo están publicados en Nature Communications.
يحدد الباحثون التغيرات الوعائية في الدماغ المرتبطة بمرض الزهايمر
جاكسونفيل، فلوريدا — الحاجز الدموي الدماغي — هو شبكة من الأوعية الدموية والأنسجة التي تغذي الدماغ وتحميها من المواد التي قد تسبب الضرر للدماغ في الدم – للخلل ويتعطّل عند الإصابة بمرض الزهايمر. وقد كشف باحثون في مايو كلينك مؤخرًا بالتعاون مع زملاء من جهات أخرى عن بصمات جزيئية فريدة لخلل الحاجز الدموي الدماغي، مما قد ييسر سبلاً جديدة لتشخيص وعلاج مرض الزهايمر. وقد نُشرت النتائج التي توصلوا إليها في مجلة ناتشور كوميونيكاشن.
Survey finds many have misconceptions about sexually transmitted infection risk
Sexually transmitted infections (STIs) are on the rise in the U.S., including an 80% increase in syphilis over a five-year period, according to the Centers for Disease Control and Prevention. A new national survey by The Ohio State University Wexner Medical Center finds many Americans have misconceptions on how STIs are spread and who should be treated.
Why do we cry?
A specialist with Bascom Palmer Eye Institute explains the importance of tears for both physical and emotional health.
Presidential Debate 2024: Biden vs. Trump
This Thursday, President Joe Biden and former President Donald Trump will debate. We are looking for experts to provide insights on the candidates’ strategies, debate performances, and potential influence on voters.
Surgeon general declares firearm violence a public health crisis: U-M experts available
U.S. Surgeon General Vivek Murthy has declared firearm violence a public health crisis, saying it’s time to deploy approaches similar to lifesaving anti-smoking and traffic safety campaigns to decrease deaths and injuries caused by guns. Researchers at the University of…
Infectious Disease Doctor: Flying This Summer? Here’s What You Should Know Before Boarding.
The TSA just reported an all-time high for the number of airline travelers screened, and major U.S. airlines expect to transport 271 million passengers this summer, a 6.3 percent increase from last year. Now, board-certified infectious disease physician Carl Abraham, M.D., assistant…
MSU expert: Taking a public health approach to gun violence prevention
As June is Gun Violence Awareness Month, Aron Sousa, dean of the MSU College of Human Medicine, answers questions on what it means to take a public health approach to prevent gun violence and how the Remembrance Conference promoted this effort.
Vulnerability exposed: Car dealerships grapple with fallout from cybersecurity attacks
Nearly 15,000 car dealerships across North America are still struggling to operate after a massive cyberattack has crippled their software systems. As more vehicles become connected to the Internet and reliant on digital systems, cyberattacks pose a serious risk to businesses and…
Ask the experts: How can we measure our own happiness?
Given the many sources of stress and anxiety individuals encounter each day, its not surprising that people often wonder if they are happy or not. Yet, how do people define happiness and well-being? What are some ways to view and conceptualize happiness? Michigan State University researchers Bill Chopik and Rich Lucas answer this question.
UWF faculty awarded prestigious “Fellow” title by ACCP
UWF faculty member Amanda Dexter has been awarded a highly sought after “Fellow” title with the American College of Chest Physicians.
A fresh set of eyes on next-generation nuclear reactors
Five early and mid-career scientists from Argonne National Laboratory divide and conquer varied challenges to improve nuclear science and technology and help the U.S. meet its future energy goals.
Hackensack Meridian Health Partners with Medically Home Group Inc. to Launch ‘Hospital From Home’ Program
Hospital From Home launched in partnership between Hackensack Meridian Health and Medically Home