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UrduProviding information about dialysis and transplant to a patient in a non-urgent environment leads to better outcomes and improved patient care said Dr. Krissberg. There are a lot of moving parts when…
Tag: Kidney Disease
Prabir Roy-Chaudhury, MD, PhD, FASN, to Become Next President of the American Society of Nephrology
Dr. Roy-Chaudhury will head up an organization—with nearly 21,000 health professionals representing 140 countries—dedicated to leading the fight against kidney diseases.
Preclinical Studies Test Novel Gene Therapy for Treating IgA Nephropathy
IgA nephropathy is an autoimmune kidney disease, and complement, a component of the innate immune system, plays a role in the condition’s pathogenesis. Investigators have developed and tested a novel gene therapy that enters kidney cells and enables them to block complement activation. The research will be presented at ASN Kidney Week 2024 October 23– 27.
Trial Assesses Antibody Therapy for Chronic Active Antibody-Mediated Kidney Transplant Rejection
Chronic active antibody-mediated rejection (caAMR) is a common cause of allograft loss after transplantation, with no approved therapies. Clazakizumab, a monoclonal antibody that targets the inflammatory cytokine interleukin-6 (IL-6), stabilized kidney transplant recipients’ kidney function in a phase 2 trial. Investigators now have data from a phase 3 trial with clazakizumab. The findings from the Phase 3 IMAGINE trial, the largest placebo-controlled study in kidney transplant recipients with caAMR, will be presented at ASN Kidney Week 2024 October 23– 27.
Researchers Test Imlifidase Enzyme Versus Plasma Exchange in Removing Donor-Specific Antibodies in Kidney Transplant Rejection Trial
For kidney transplant recipients experiencing antibody-mediated rejection, the current standard of care involves removing donor-specific antibodies (DSAs) through plasmapheresis (PLEX)—a procedure that removes antibodies from the plasma portion of the blood. Results from a recent clinical trial reveal that an investigational drug called imlifidase, which cleaves and inactivates the type of antibodies that include DSAs, is more effective than PLEX. The research will be presented at ASN Kidney Week 2024 October 23–27.
High-Impact Clinical Trials Generate Promising Results for Improving Kidney Health: Part 2
The results of numerous high-impact phase 3 clinical trials that could affect kidney-related medical care will be presented in-person at ASN Kidney Week 2024 October 23–27.
Kidney Week 2024: Virtual Press Briefings
Kidney Week 2024: Live Event
Do Certain Diabetes Drugs Increase the Risk of Acute Kidney Injury in Patients Taking Anti-Cancer Therapies?
Glucagon-like peptide-1-receptor agonists (GLP-1RA) are medications that are increasingly prescribed for patients with type 2 diabetes and congestive heart failure. Reports of GLP-1RA–associated acute kidney injury (AKI) have emerged, but the risk of GLP-1RA–associated AKI among patients on anti-cancer drugs is unclear. Surprisingly, new research suggests that taking GLP-1RA is not associated with an increased risk of AKI in patients receiving anti-cancer therapies. The findings will be presented at ASN Kidney Week 2024 October 23– 27.
Global, National, and Regional Trends in the Burden of Chronic Kidney Disease among Women
A recent analysis reveals that the number of chronic kidney disease (CKD) cases in women around the globe nearly tripled in the past three decades. Also, type 2 diabetes and hypertension were the leading causes of CKD-related deaths in women. The research will be presented at ASN Kidney Week 2024 October 23– 27.
How the Novel Antibody Felzartamab Impacts IgA Nephropathy
IgA nephropathy (IgAN) is an autoimmune kidney disease driven by immune cells that express a protein called CD38 on their surface. A recent Phase 2 trial revealed that felzartamab, an investigational anti-CD38 monoclonal antibody, helps to reduce proteinuria and maintain patients’ kidney function. Investigators evaluated the molecular mechanisms underlying felzartamab’s potential efficacy in IgAN. The findings will be presented at ASN Kidney Week 2024 October 23– 27.
Heart and Kidney Outcomes After Canagliflozin Treatment in Older Adults
Sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of cardiovascular and kidney outcomes in patients with type 2 diabetes, but it is unclear whether their effects differ based on patients’ age. A recent analysis of clinical trial data reveals that the SGLT2 inhibitor canagliflozin benefited patients across all age categories. The findings will be presented at ASN Kidney Week 2024 October 23 – 27.
Researchers Integrate Multiple Protein Markers to Predict Health Outcomes in Individuals with Chronic Kidney Disease
Prior efforts to identify novel kidney biomarkers as risk factors for chronic kidney disease (CKD) progression have typically evaluated proteins individually, which limits their prognostic power. The National Institute of Diabetes and Digestive and Kidney Diseases’ (NIDDK’s) CKD Biomarkers Consortium of investigators recently developed and tested novel dimensions of kidney health by combining a set of 17 urine and plasma biomarkers that had been individually associated with CKD progression. The research will be presented at ASN Kidney Week 2024 October 23– 27.
High-Impact Clinical Trials Generate Promising Results for Improving Kidney Health: Part 1
The results of numerous high-impact phase 3 clinical trials that could affect kidney-related medical care will be presented in-person at ASN Kidney Week 2024 October 23–27.
The Clinical Significance of Microvascular Inflammation after Kidney Transplantation
Investigators recently uncovered key insights into newly defined rejection entities in kidney transplantation that may offer improved patient risk categorization post-transplant. The research will be presented at ASN Kidney Week 2024 October 23– 27.
AI model predicts patients at most risk of complication during treatment for advanced kidney failure
A study led by the University of Portsmouth in England and Portsmouth Hospitals University NHS Trust (PHUT) has developed an AI model to predict which patients are most at risk of their blood pressure dropping during dialysis; a condition known as intradialytic hypotension (IDH).
Non-invasive eye test for multiple diseases to advance under $4.8M NIH award
Researchers at the IU School of Optometry and IU Luddy School of Informatics, Computing and Engineering will advance next-generation technology that uses a simple eye scan to assist in the early detection of conditions such as Alzheimer’s disease, diabetes and heart disease.
Very few patients with abnormal urine protein dipstick results have recommended follow-up testing for early kidney disease
A study of more than 1 million health records found that very few patients with abnormal urine protein dipstick results had follow-up testing for early kidney disease by albuminuria testing as recommended by clinical guidelines.
Obesity Management and Kidney Health: Live Expert Panel
Reporters are invited to this live event on Obesity Management and Kidney Health. Experts from the American Society of Nephrology will take questions on the inaugural Kidney Health Guidance on managing obesity in kidney disease patients
Joslin Diabetes Center Investigator Rohit N. Kulkarni, MD, PhD, Awarded $10 Million NIH/NIDDK Grant for Pioneering Diabetes and Obesity Research
Rohit N. Kulkarni, MD, PhD, the Diabetes Research and Wellness Foundation Endowed Chair and Co-Head of the Section on Islet & Regenerative Biology at Joslin Diabetes Center, has been awarded $9,920,607 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health (NIH).
Uncontrolled Hypertension: The Old ‘Silent Killer’ is Alive and Well
High blood pressure affects about 45% of U.S. adults. In the 1970s, only about 50% of patients were aware of their hypertension. Today, 54% are aware of their high blood pressure, 40% are actively treated and 21% are actively controlled. As such, researchers alert health care providers that the old “silent killer” is alive and well.
Easy and Fast “Cat Urine Test Kit” for Early Detection of Kidney Disease, Gallstones, and Cystitis
Researchers from Chula Faculty of Science invented an easy-to-use “Cat Urine Test Kit” to screen for the risk of kidney disease, gallstones, and cystitis in cats. The test kit provides fast and accurate results, so cats can be treated promptly.
Virtual reality program shares shopping, cooking advice with dialysis patients
Even with the best intentions, it’s not always easy for dialysis patients to choose low-sodium foods. That’s why University of Illinois and University of Arizona researchers created a virtual reality program focused on shopping and cooking with low-sodium ingredients to educate dialysis patients from the comfort of their treatment chairs.
Men with Chronic Kidney Disease Have Higher Resting Activity in ‘Fight-or-Flight’ System than Women
Article title: Sex differences in sympathetic activity and vascular stiffness in adults with chronic kidney disease (CKD) Authors: Matias G. Zanuzzi, Jinhee Jeong, Dana R. DaCosta, Jeanie Park From the authors: “We show for the first time that males with…
Cleveland Clinic, Tufts University Research Ties Gut Microbial TMAO Pathway to Chronic Kidney Disease
New findings from Cleveland Clinic and Tufts University researchers show high blood levels of TMAO (trimethylamine N-oxide) predicts future risk of developing chronic kidney disease over time.
Resistant Starch Could Help Combat Leading Cause of End-stage Kidney Failure
Combining a low dose of blood pressure medication with a higher intake of dietary-resistant starch might help stave off diabetic kidney disease, according to results from a new animal study. Researchers will present their work this week at the American Physiology Summit.
Transplant doctor discusses how living kidney donors can help those in need of a transplant.
Eric Martinez, MD, at Baylor Scott & White Health, discusses how living kidney donors can help those in need of a transplant. What You Need to Know: Risk factors that could lead to kidney transplant include high blood pressure and…
Trial Tests Intervention to Reduce Sedentary Time in Patients with Chronic Kidney Disease
• Sedentary time decreased, stepping time increased, and number of steps per day increased among patients with chronic kidney disease assigned to the ‘Sit Less, Interact, Move More’ intervention.
• These effects were not sustained after 20 weeks, however.
People with Diabetes Who Live in Rural Areas More Likely to Develop Complications of the Disease, UM School of Medicine Study Finds
It has been well established that people who live in rural areas in the U.S. are more likely to have diabetes and experience barriers to managing their condition compared to those who live in the suburbs and cities.
UT Southwestern study shows glucagon is key for kidney health
Glucagon, a hormone best known for promoting blood sugar production in the liver, also appears to play a key role in maintaining kidney health. When UT Southwestern Medical Center researchers removed receptors for this hormone from mouse kidneys, the animals developed symptoms akin to chronic kidney disease (CKD).
Unveiling uremic toxins linked to itching in hemodialysis patients
Dr. Yamamoto et al. found the several uremic toxins as one of causes of itching in hemodialysis patients.
Hispanics Are Being Impacted By Diabetes and Kidney Disease
Paula Duran, MD, at Baylor Scott & White Health, answers the most common patient questions and reacts to the latest medical research impacting the Hispanic population. Why do Hispanics have a high incidence of diabetes and subsequent kidney disease? Is…
Researchers Explore Proteins’ Roles in Cilia Associated with Polycystic Kidney Disease
Article title: CFTR and PC2, partners in the primary cilia in autosomal dominant polycystic kidney disease Authors: Murali K. Yanda, Cristian Ciobanu, William B. Guggino, Liudmila Cebotaru From the authors: “Here we show that [cystic fibrosis transmembrane conductance regulator (CFTR)]…
Despite social media claims, Borax is not safe to consume
A nephrologist explains the damage that this trend can cause
Gene therapy hope for children with kidney disease
Researchers at the University of Bristol have made a remarkable step forward in finding a potential cure for a type of childhood kidney disease.
Enzyme in T Cells Worsens Salt-sensitive Hypertension and Related Kidney Damage
Article title: Functional NADPH oxidase 2 (NOX2) in T cells amplifies salt-sensitive hypertension and associated renal damage Authors: Samuel D. Walton, John Henry Dasinger, Emily C. Burns, Mary Cherian-Shaw, Justine M. Abais-Battad, David L. Mattson From the authors: “The results…
Study Shows Mitochondrial Transplantation Effective in Reversing Damage to Kidneys and Kidney Cells
According to the National Kidney Foundation, more than 100,000 Americans are waiting for a kidney transplant, and the demand for donated kidneys far exceeds the supply. In fact, only 25,498 kidney transplants were performed in 2022, and kidney disease impacts 37 million people in the U.S. But a new preclinical study, led by scientists at Wake Forest University School of Medicine, shows that a new technology called mitochondrial transplantation holds promise as a potential therapy that could change the kidney transplant landscape.
New algorithm can predict diabetic kidney disease
Researchers from Sanford Burnham Prebys and the Chinese University of Hong Kong have developed a computational approach to predict whether a person with type 2 diabetes will develop kidney disease. The findings could help doctors prevent or better manage kidney disease in people with type 2 diabetes.
Bypassing contrast in patients with kidney disease and contrast allergies may lead to less accurate scans
Upon an arrival to the emergency department for abdominal pain of unknown cause, most non-pregnant adult patients receive a CT scan with IV contrast to diagnose the source of the pain. However, IV contrast can be a risk in patients with severe kidney disease or at risk for an allergic reaction from the dye. When scans are performed without IV contrast, though, they are usually less accurate, which can lead to misdiagnosis.
Researchers find new pathway to prevent kidney failure for thousands
Researchers at the University of Bristol have made a breakthrough that could prevent certain kidney patients progressing towards renal failure.
Diabetes Drug Improves Kidney Function and Inflammation
Article title: Reno-protective effects of empagliflozin are linked to activation of the tubuloglomerular feedback mechanism and blunting of the complement system Authors: Xin Chen, Denis Delić, Yaochen Cao, Linghong Shen, Qin Shao, Zheyu Zhang, Hongwei Wu, Ahmed A. Hasan, Christoph…
Study Finds Certain Substances in Urine, Blood Can Predict Kidney Disease Progression
In a new study looking at the long-term effects of hospitalized patients who have acute kidney injury (AKI), a sudden but temporary loss of kidney function, Johns Hopkins Medicine researchers found that higher levels of certain biomarkers in urine and blood can predict a patient’s risk of developing chronic kidney disease (CKD).
Baltimore PKD Research and Clinical Core Center Receives Prestigious ‘Center of Excellence’ Designation from PKD Foundation
The PKD Foundation recently recognized the University of Maryland School of Medicine’s (UMSOM) clinical center that treats polycystic kidney disease (PKD)with a highly prestigious “Center of Excellence” designation. The designation recognizes the center as a leader in providing multidisciplinary, comprehensive clinical services for families affected by autosomal dominant polycystic kidney disease (ADPKD), a hereditary condition. It is one of just 28 clinical centers in the U.S. to receive this recognition.
Migraine Drug Shows Promise in Treatment of Acute Kidney Injury
The drug lasmiditan, which is used to treat migraines, shows promise as a possible treatment for acute kidney injury, according to a new study from the University of Arizona.
Fatty Acid May Be Useful in Preventing Kidney Fibrosis, Treating Fibrotic Diseases
Article title: Epoxyeicosatrienoic acid administration or soluble epoxide hydrolase inhibition attenuates renal fibrogenesis in obstructive nephropathy Authors: Mi Ra Noh, Hee-Seong Jang, Fadi E. Salem, Fernando A. Ferrer, Jinu Kim, Babu J. Padanilam From the authors: “Our findings provide a…
Researchers Identify How HIV/Hepatitis Drug Harms the Kidneys
A first-of-its-kind study identifies mechanisms that explain how a drug commonly used to treat HIV and hepatitis causes kidney disease and kidney injury. The study is published ahead of print in Function.
UC San Diego Health Named Center of Excellence for Polycystic Kidney Disease
UC San Diego Health has been named a Center of Excellence for polycystic kidney disease (PKD) by the PKD Foundation – the leading advocacy group dedicated to finding treatments and a cure for PKD. UC San Diego Health is one of just 28 institutions nationwide to receive this designation.
Staph infection-induced kidney disease may be linked to bacterial gene mutation
Researchers aiming to predict which staph-infection patients might develop a related kidney disease have found a high frequency of gene mutations in the infecting bacteria of affected patients, which suggests these variants may play a role in the body’s initiation of the renal damage.
Published Real World Evidence Demonstrates KidneyIntelX™ Improved Clinical Decisions and Outcomes in High-Risk Patients with Early-Stage Diabetic Kidney Disease
Renalytix plc (NASDAQ: RNLX) (LSE: RENX) announces the publication of new real-world evidence (RWE) in Primary Care and Community Health demonstrating the Company’s KidneyIntelX bioprognostic™ test resulted in changed clinical decision making for patients in the early-stage of diabetic kidney disease (DKD) being cared for within the Mount Sinai Health System’s Population Health Ambulatory Pharmacy and Condition Management programs.
Podocyte Protectors: NIH Awards CHLA’s GOFARR Laboratory Additional Grants to Combat Chronic Childhood Kidney Disease
CHLA has received a new five-year award of $3.2 million from the National Institutes of Health (NIH) to research the underlying mechanisms that lead to kidney failure and to develop new treatments to protect kidney function.
Researchers Identify Potential New Therapeutic Target for Polycystic Kidney Disease
Article title: The lonidamine derivative H2-gamendazole reduces cyst formation in polycystic kidney disease Authors: Shirin V. Sundar, Julie Xia Zhou, Brenda S. Magenheimer, Gail A. Reif, Darren P. Wallace, Gunda I. Georg, Sudhakar R. Jakkaraj, Joseph S. Tash, Alan S.L.…