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UrduISPOR—The Professional Society for Health Economics and Outcomes Research announced the results of its recent elections. The Society’s membership selected its new president-elect and 4 new board members.
Month: May 2024
Mathematical Model Driven Evolutionary Therapy Dosing Exploiting Cancer Cell Plasticity
A research team led by Dr. Kim Eunjung at the Natural Products Informatics Research Center of the Korea Institute of Science and Technology (KIST) has established a theoretical foundation for cancer treatment strategies following tumor evolution. They have developed a mathematical model to predict tumor evolution, considering the acquisition of resistance by cancer cells and their ability to alter phenotypic behavior (plasticity) during treatment.
Major accidents at production facilities can be detected from a distance in real time through “sounds”
For the first time in the country, KIMM develops “three-dimensional acoustic intensity-based leak detection technology” for detecting pipeline damages. New technology can help to reduce costs by 30 percent, while enhancing safety by allowing prompt response to large-scale accidents at production facilities within the golden hour.
From leaf to cup: decoding the biochemical dance of black tea’s fragrance
Unlocking the biochemical secrets behind a perfect cup of black tea, scientists have identified the CsLOX6 gene as a master regulator in the formation of methyl jasmonate (MeJA), a key compound in tea’s aroma. This breakthrough illuminates the intricate dance of genetics and chemistry that shapes the flavor profile of this globally adored drink.
Brave new virtual world fast becoming a reality in the mining sector
A virtual and robotic revolution in Australia’s mining industry could spell the end of fly-in-fly-out (FIFO) workers within a decade, according to one of the country’s leading geologists and immersive technology experts.
Weight gain is kicked to the curb in antipsychotic drug breakthrough
World first research from the University of South Australia shows that antipsychotics can be reformulated with a strategically engineered coating that not only mitigates unwanted weight gain but also boosts serotonin levels by more than 250%.
ESWL with ERP helpful in short term but not long term for patients with chronic pancreatitis
A randomized trial of persons with chronic pancreatitis found that the use of extracorporeal shockwave lithotripsy (ESWL) endoscopic retrograde pancreatography (ERP) provide modest short-term pain relief. The study is published in Annals of Internal Medicine.
Sepsis covers a broad spectrum of illnesses that vary widely in mortality and cause
An analysis of sepsis presentations and mortality rates observed a 30-fold variation in mortality rates among patients with suspected sepsis depending on infection site, organ dysfunction, and their distinct combinations.
Voluntary circumcision effective for preventing HIV infection among men who have sex with men
A randomized controlled trial comprised of 247 men who have sex with men (MSM) found that voluntary medical male circumcision (VMMC) can prevent incident HIV infection. These findings suggest that MSM should be included in VMMC guidelines. The study is published in Annals of Internal Medicine.
Statins associated with decreased risk for CVD and death, even in very old adults
A study of adults aged 60 years and older found that the use of statin therapy as primary cardiovascular disease (CVD) prevention was effective for preventing CVD and all-cause mortality, even in adults aged 85 years and older. The study is published in Annals of Internal Medicine.
Governments Fail to Reach Consensus on Pandemic Prevention Agreement
Member states of the World Health Organization (WHO) did not reach consensus on a new agreement or treaty on pandemic prevention, preparedness, and response.
Green wheels: new study maps the road to eco-friendly driving
The push for carbon neutrality in the transportation sector is driving significant research and development (R&D) across the globe. A new study provides a comprehensive analysis of the distinct national strategies and R&D organizational paradigms aimed at achieving carbon neutrality in road transport.
Restaurants and Bars Overserve Alcohol, Despite Policy Designed to Deter Them, Study Finds
A strategy aimed at preventing restaurants and bars from serving alcohol to patrons who are already intoxicated does not appear to be effective, according to a study recently published in Alcohol: Clinical and Experimental Research.
ETRI Wins ‘iF Design Award’ for Mobile Collaborative Robot
ETRI research team has won a main prize at the German International Design Competition, one of the top three design award competitions in the world. This signifies global recognition of our research team’s technology.
3rd International Conference on Educational System Management Leadership 2024: Education System Redesign for Creating a Better World for All
The Faculty of Education at Chulalongkorn University, Division of Educational System Management Leadership, in collaboration with Teachers College, Columbia University, cordially invites you to the 3rd International Conference on Educational System Management Leadership (ICESML 2024). The theme of this year’s conference is “Education System Redesign for Creating a Better World for All.” The event will take place on May 31, 2024, 9:30 A.M. – 4:30 P.M. (GMT+7) via an online platform.
Call for Abstracts: CULI TERA ERF International Conference 2024!
The Chulalongkorn University Language Institute (CULI) at Chulalongkorn University cordially invites all to attend the “CULI TERA ERF International Conference 2024” on “Promoting English Reading in the Asian Context and Beyond”, held on August 22-23, 2024 at Arnoma Hotel, Bangkok, Thailand.
Expert pitch: Preventing maritime accidents with autonomous technologies and better systems integration
Recent global events have sparked a need to reassess the risks of shipping navigation. By harnessing the power of autonomous technologies and enusuring better systems integration, the industry could support safer and smoother navigation. Manoeuvring and controlling cargo ships is…
Effects of interleukin-10 treated macrophages on bone marrow mesenchymal stem cells via signal transducer and activator of transcription 3 pathway
BACKGROUNDAlveolar bone defects caused by inflammation are an urgent issue in oral implant surgery that must be solved. Regulating the various phenotypes of macrophages to enhance the inflammatory environment can significantly affect the pr
GATA binding protein 2 mediated ankyrin repeat domain containing 26 high expression in myeloid-derived cell lines
BACKGROUNDThrombocytopenia 2, an autosomal dominant inherited disease characterized by moderate thrombocytopenia, predisposition to myeloid malignancies and normal platelet size and function, can be caused by 5’-untranslated region (UTR)
Hepatocyte growth factor enhances the ability of dental pulp stem cells to ameliorate atherosclerosis in apolipoprotein E-knockout mice
BACKGROUNDAtherosclerosis (AS), a chronic inflammatory disease of blood vessels, is a major contributor to cardiovascular disease. Dental pulp stem cells (DPSCs) are capable of exerting immunomodulatory and anti-inflammatory effects by secr
Single-cell sequencing technology in diabetic wound healing: New insights into the progenitors-based repair strategies
Diabetes mellitus (DM), an increasingly prevalent chronic metabolic disease, is characterised by prolonged hyperglycaemia, which leads to long-term health consequences. Although much effort has been put into understanding the pathogenesis o
Sinomenine increases osteogenesis in mice with ovariectomy-induced bone loss by modulating autophagy
BACKGROUNDA decreased autophagic capacity of bone marrow mesenchymal stromal cells (BMSCs) has been suggested to be an important cause of decreased osteogenic differentiation. A pharmacological increase in autophagy of BMSCs is a potential
Deer antler stem cell niche: An interesting perspective
In recent years, there has been considerable exploration into methods aimed at enhancing the regenerative capacity of transplanted and/or tissue-resident cells. Biomaterials, in particular, have garnered significant interest for their poten
Mesenchymal stem cells’ “garbage bags” at work: Treating radial nerve injury with mesenchymal stem cell-derived exosomes
Unlike central nervous system injuries, peripheral nerve injuries (PNIs) are often characterized by more or less successful axonal regeneration. However, structural and functional recovery is a senile process involving multifaceted cellular
Hydrogel loaded with bone marrow stromal cell-derived exosomes promotes bone regeneration by inhibiting inflammatory responses and angiogenesis
BACKGROUNDBone healing is a complex process involving early inflammatory immune regulation, angiogenesis, osteogenic differentiation, and biomineralization. Fracture repair poses challenges for orthopedic surgeons, necessitating the search
Role of glioma stem cells in promoting tumor chemo- and radioresistance: A systematic review of potential targeted treatments
BACKGROUNDGliomas pose a significant challenge to effective treatment despite advancements in chemotherapy and radiotherapy. Glioma stem cells (GSCs), a subset within tumors, contribute to resistance, tumor heterogeneity, and plasticity. Re
Effect of ginsenoside Rg1 on hematopoietic stem cells in treating aplastic anemia in mice via MAPK pathway
BACKGROUNDAplastic anemia (AA) presents a significant clinical challenge as a life-threatening condition due to failure to produce essential blood cells, with the current therapeutic options being notably limited. AIMTo assess the therapeu
Therapeutic potential of urine-derived stem cells in renal regeneration following acute kidney injury: A comparative analysis with mesenchymal stem cells
BACKGROUNDAcute kidney injury (AKI) is a common clinical syndrome with high morbidity and mortality rates. The use of pluripotent stem cells holds great promise for the treatment of AKI. Urine-derived stem cells (USCs) are a novel and versa
Patient-derived induced pluripotent stem cells with a MERTK mutation exhibit cell junction abnormalities and aberrant cellular differentiation potential
BACKGROUNDHuman induced pluripotent stem cell (hiPSC) technology is a valuable tool for generating patient-specific stem cells, facilitating disease modeling, and investigating disease mechanisms. However, iPSCs carrying specific mutations
Cardiac differentiation is modulated by anti-apoptotic signals in murine embryonic stem cells
BACKGROUNDEmbryonic stem cells (ESCs) serve as a crucial ex vivo model, representing epiblast cells derived from the inner cell mass of blastocyst-stage embryos. ESCs exhibit a unique combination of self-renewal potency, unlimited prolifera
Alcohol Use Disorder Amplifies Suicidal Ideation Severity in Military Personnel with PTSD
Heavy alcohol use may be a key factor contributing to suicide among military personnel with untreated post-traumatic stress disorder. A study of active military personnel found that heavy drinking amplifies the relationship between PTSD symptoms and the severity of suicidal thoughts. The authors of the study, which is published in Alcohol: Clinical and Experimental Research, recommend that the military health system consider requiring screening for suicidal ideation and alcohol use in service members who may have post-traumatic stress disorder and further develop integrated treatment programs that simultaneously treat alcohol use disorder and PTSD.
Young Adult Women’s Alcohol Use is Increasingly Driven by Social Reasons, Narrowing the Binge-Drinking Gap by Gender
The narrowing gap between binge drinking among adult women and men has been driven partly by women’s rising use of alcohol for social reasons—to have fun. In addition, women are increasingly using alcohol to relax or relieve tension, a new study has found. Alcohol use in the USA has increased steadily over the past 20 years, and excessive drinking underlies 1 in 8 deaths of working-age adults. The COVID-19 pandemic contributed to a 25% increase in alcohol-related deaths from 2019 to 2020. Overall, figures like these mask differences by age, however. For over four decades, alcohol use and binge drinking have declined among adolescents and early adults. But by age 30, that effect has plateaued or reversed. Binge drinking has risen more among women than men, narrowing the gender gap for reasons that haven’t been explained by broad societal trends (such as education, family timing, and gender roles). For the study in Alcohol: Clinical & Experimental Research, US researchers considered the
Pathways Study Genotype Data, Alliance A011502 Secondary Analysis Headline Roswell Park ASCO24 Presentations
New insights on improving clinical outcomes and quality of life among breast cancer patients highlight the slate of new research presentations Roswell Park Comprehensive Cancer Center experts will deliver at the American Society of Clinical Oncology (ASCO) Annual Meeting at McCormick Place in Chicago next week.
What to Know About Bird Flu
So far, only two people have been infected with a new strain of H5N1 due to exposure to cows. But the large number of infected cows, their proximity to humans, and flu’s tendency to jump from one host to another have scientists and health officials concerned.
Grainger engineers bring quantum expertise to DOE InterQnet initiative
InterQnet is a three-year initiative to demonstrate that quantum computers separated by large distances and even based on different hardware architectures can work in tandem.
New Research Reveals Differences in the Function of Fine Roots
Using a 26-year-old common garden forest, a multi-institutional team of researchers collected fine root samples from four temperate tree species (three deciduous and one coniferous) that varied in their morphology.
WCS Hosts Diverse/Reverse Vendor Fair at Bronx Zoo
The Wildlife Conservation Society (WCS) recently hosted its first-ever Supplier Diversity event, “Diverse/Reverse Vendor Fair” supported by Columbia University and Ascend NYC on May 23rd, with more than 25 vendors showcasing their products and services to various business units throughout WCS.
Virginia Tech researcher creates “invisible tweezers” to move tiny bioparticles
Undergoing surgery is seldom a pleasant experience, and it can sometimes be highly invasive. Surgical procedures have evolved steadily over the centuries, growing with the knowledge of anatomy and biology.
FDA Approves Assessment Tool to Help Drive Innovation in Premium IOL Cataract Surgery
The U.S. Food and Administration (FDA) last week qualified the American Academy of Ophthalmology’s patient-reported outcome measure for premium intraocular lenses (IOLs) as a Medical Device Development Tool (MDDT).
Loyola Medicine Hosts First Annual Regional Keeley Cup To Benefit Emergency Medicine Education
Loyola Medicine’s Emergency Medicine Residency Program is proud to host the inaugural Regional Keeley Cup on Thursday, May 30th at 12 pm. This pioneering team-based competition is brought to life each year through the support of the Barbara G. & John L. Keeley, Jr. Center for Emergency Medicine Education.
ASCO: Large precision oncology study identifies differences in prostate cancer genomics among a racially and ethnically diverse cohort of U.S. veterans
A new study(Link is external) (Link opens in new window) led by a UCLA-VA collaborative team looking at the landscape of genomic alterations in more than 5,000 veterans with metastatic prostate cancer uncovered differences in the genomic makeup of cancer cells that were associated with race and ethnicity.
Removing Positive Social Features From Alcohol Advertisements and Including Health Warnings May Reduce Consumers’ Drinking
Adults react differently to alcohol advertisements depending on how explicit or implicit the messaging is about the social pleasure of drinking and the possible health effects, a new study shows. Exposure to alcohol marketing is consistently linked to alcohol use. Research also suggests that alcohol advertising influences attitudes around alcohol, such as social norms or reasons for drinking. Policymakers’ options for lowering alcohol consumption and its harms include content controls on advertising. Restricting sales messages to facts about the product is known to reduce how persuasive it is among consumers. Mandating health warnings also increases consumers’ perceptions of risk and reduces the perceived benefits of drinking. No studies, however, have previously examined the effects of such content controls on consumers in the UK. In addition, most research has focused on young adults, yet adults in midlife and beyond may also be vulnerable to the effects of marketing. For the study i
Comprehensive Detection of Light: Dispersion-assisted Photodetector Deciphering High-dimensional Light
The intricate nature of light, characterized by its intensity, polarization, and spectrum composition, holds profound importance across a range of scientific and technological disciplines. From enhancing optical communications to enabling precise chemical and biological characterization, a comprehensive understanding of light’s properties is indispensable.
Carbon Dioxide, the Main Culprit of Global Warming, Reborn as an Antioxidant Substance
The Korea Institute of Energy Research develops a process to convert carbon dioxide into the antioxidant carotenoids using microorganisms. By using a carbon dioxide absorbent, the problem of low solubility is resolved, and the productivity of high-value substances is also improved. Published in the world-renowned journal in the field of chemistry, ‘ChemSusChem
Epigenetic insights: how hybrid poplar regenerates shoots
Hybrid poplar tissue culture regeneration involves intricate changes in DNA methylation, significantly impacting gene expression. This study reveals the dynamic epigenetic landscape during shoot organogenesis, offering crucial insights into allele-specific DNA methylation and its regulatory role in gene expression.
Enhancing tomato salt tolerance: the key role of SlWRKY80 and jasmonic acid pathways
This study explores the mechanism by which exogenous methyl jasmonate (MeJA) enhances tomato resistance to saline-alkali stress. Researchers identified the transcription factor SlWRKY80 as a crucial regulator, which, when overexpressed, significantly improves the plant’s tolerance.
Desert Poplar’s Genetic Blueprint: Insights into Adaptation and Survival Mechanisms
Researchers have sequenced the genome of Populus pruinosa, a plant thriving in extreme deserts. The study reveals key genes for high salinity and drought adaptability. Analysis of individuals from various populations shows genetic differentiation driven by precipitation, offering insights for ecological conservation and genetic enhancement of desert poplars.
Innovative Material for Sustainable Building
Researchers at the Karlsruhe Institute of Technology (KIT) introduce a polymer-based material with unique properties in the latest issue of the journal Nature Communications. This material allows sunlight to enter, maintains a more comfortable indoor climate without additional energy, and cleans itself like a lotus leaf. The new development could replace glass components in walls and roofs in the future
People who hold populist beliefs are more likely to believe misinformation about COVID – new report
Over a fifth of Americans and Poles surveyed believed that COVID-19 vaccines can change people’s DNA.
And more than half of Serbian people believed that natural immunity from COVID was better than being vaccinated.
These figures come from a new report which examines the effects of populism on misinformation and other aspects of crisis communication around the coronavirus pandemic.
Virginia Tech researcher’s breakthrough discovery uses engineered surfaces to shed heat
Splash a few drops of water on a hot pan and if the pan is hot enough, the water will sizzle and the droplets of water seem to roll and float, hovering above the surface.