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UrduMultiple sclerosis (MS) is a debilitating disease of the brain and spinal cord that impacts millions worldwide. In MS, the immune system mistakenly attacks the myelin sheath—a protective layer surrounding nerve cells in the nervous system. The loss of myelin, combined with ongoing inflammation, causes dysfunction and death of nerve cells, making the disability worse, such as difficulties with movement, coordination, and sensation. Treatments now focus on reducing attacks on myelin, but don’t address nerve-cell damage and death. But with $1 million from the National Multiple Sclerosis Society (NMSS), a research team co-led by Paul Tesar, the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics and director of the Institute for Glial Sciences, and Ben Clayton, assistant professor and founding member of the Institute for Glial Sciences, both in the Department of Genetics and Genome Sciences at the Case Western Reserve University School of Medicine, will take a different
Tag: Case Western Reserve University School Of Medicine
New Study Shows that Chronic Neurodegeneration can be Prevented after Traumatic Brain Injury
Violent blows or jolts to the head can cause traumatic brain injury (TBI), and there are currently about five million people in the U.S. living with chronic neurodegeneration and related impairments due to TBI.
Case Western Reserve University receives $1.5M grant from Foundation Fighting Blindness to test possible new treatment for inherited retinal disease
There’s only one U.S. Food and Drug Administration-approved therapy for an inherited retinal disease, and dozens of retinitis pigmentosa (RP) genes for which no therapy is available.
Case Western Reserve University-led research team discovers new method to test for oral cancer
A team of researchers, led by a clinician scientist at the Case Western Reserve University School of Dental Medicine, has discovered a noninvasive, low-cost test to detect oral cancer, monitor precancerous lesions and determine when a biopsy is warranted.
Case Western Reserve University researcher awarded $2 million federal grant to further explore possible new effective treatments for colorectal and other cancers
With a new $2 million federal grant, a researcher with the Case Western Reserve University School of Medicine will lead a team to further explore preliminary findings of an effective treatment for colorectal and possibly other cancers.
Case Western Reserve University School of Medicine launches Institute for Glial Sciences
Case Western Reserve University has established an Institute for Glial Sciences to advance research of glial cells and their critical role in the health and diseases of the nervous systems, including multiple sclerosis, Alzheimer’s, pediatric leukodystrophies, Autism spectrum disorders, Parkinson’s disease and cancer.
Case Western Reserve University and University Hospitals researchers awarded five-year, $11.2 million federal grant to study esophagus cancers
With a new five-year, $11.2 million grant from the National Cancer Institute (NCI), researchers at Case Western Reserve University and University Hospitals hope to learn what causes—and how to reduce and treat—esophagus cancers, an increasingly common and deadly disease.
Case Western Reserve researchers identify inherited gene mutation linked to esophageal cancer
Studying genes in families with a propensity for certain diseases has led to many critical advances in medicine, including the discovery of statins in family members who suffered heart attacks at an early age.
New study finds U.S. military veterans living in discriminatory ‘redlined’ areas suffered higher rates of cardiovascular disease
U.S. military veterans who lived in what were once known as “redlined” areas had a higher risk for heart attacks and other cardiovascular issues, according to a new study by researchers at Case Western Reserve University, University Hospitals and the Cleveland VA Medical Center.
Newly discovered RNA molecules hold promise for detecting and treating esophageal cancer
Irregularities in the body’s genetic coding to make proteins are linked to cancerous tumors. But most genetic material contains elements whose function isn’t clear. Could abnormalities in non-coding material also impact a person’s health, or even be linked to cancers as well? A new study by researchers at the Case Western Reserve University School of Medicine suggests that the non-coding genetic molecules also play a key role in health and disease, including tumor development.
Improving gene therapy with tiny bubbles
Beyond vaccines, mRNA offers immense potential to fight disease, but targeting the genetic material to specific diseased cells is challenging—requiring a new method. To meet this need, researchers at the Case Western Reserve University School of Medicine, with a Global Research Fellowship award from Moderna Inc., are developing a process that essentially uses bubbles to overcome the problem.
New study reveals ketamine could be effective treatment for cocaine-use disorders
As cocaine use continues to climb across the United States, scientists have struggled to develop an effective pharmacological approach to treat the devastating disorder. But by seamlessly combining artificial intelligence (AI), human intelligence, clinical testing and computer analysis, researchers at Case Western Reserve University have unearthed an existing option that appears to hold promise.
Case Western Reserve University awarded $3M grant to advance MRI scan and software to analyze aggressive brain tumors more effectively
With a new five-year, $3.03 million grant from the National Cancer Institute—an agency of the National Institutes of Health—Case Western Reserve University researchers are leading the development and commercialization of a novel MRI and software technology that results in more accurate, consistent brain tumor diagnosis.
Researchers developing treatment for drug-resistant fungus with $3M-plus grant from National Institutes of Health
With a new $3 million-plus grant from the National Institutes of Health (NIH), Case Western Reserve University researchers are examining the next level of treatment for Candida auris (C.auris), a multidrug-resistant yeast that causes serious infection and, in some cases, death.
What if some stress actually protects your body?
Stress has been linked to all sorts of serious health issues, from insomnia to high blood pressure, obesity and even heart disease. But it’s generally acknowledged that some stress can also be helpful, like when someone’s chasing a work deadline. But what if some level of stress can actually protect the body? A new study by researchers at the Case Western Reserve University School of Medicine, with findings published Sept. 26 in Proceedings of the National Academy of Sciences, suggests the immune system may benefit from a measure of stress.
New study reveals mechanism for how disease-spreading prions can jump from one species to another
In a new study, researchers from the Case Western Reserve University School of Medicine have identified the structure of protein fibrils linked to a hereditary form of human prion disease. This insight, they say, reveals the mechanism for how prions can jump between some animal species, while retaining a transmissibility barrier between other species.
Key Mechanisms of Airway Relaxation in Asthma Revealed in New Study
Many therapeutics for asthma and other obstructive lung diseases target the β2-adrenergic receptor (β2AR), a G protein-coupled receptor (GPCR) that rapidly supports airway relaxation when stimulated. Yet, overuse of these agents is associated with adverse health outcomes, including death, which has limited their utility as frontline therapies. Now, a mouse model study published in today’s issue of Molecular Cell, from investigators at University Hospitals (UH) and Case Western Reserve University, identifies a novel strategy to isolate the beneficial effects of β2AR stimulation. This suggests a new therapeutic approach to airway diseases as well as numerous other conditions involving the aberrant function of GPCRs.
2022 AANEM Jun Kimura Outstanding Educator Award Winner Announced
The American Association of Neuromuscular &
Electrodiagnostic Medicine (AANEM), is excited to announce David C. Preston, MD, as the
recipient of the 2022 Jun Kimura Outstanding Educator Award. Each year, AANEM recognizes
members for their significant contributions related to NM and EDX medicine education.
Case Western Reserve University alumna’s $3.5 Million commitment establishes professorship and lab resources to psychiatric discovery and treatment
CWRU alumna Rebecca Barchas commits $3.5M to establish endowed professorship in translational psychiatry.
Researchers Link Pollution to Cardiovascular Disease, Develop Strategies to Reduce Exposure and Encourage Government Intervention
In a new review article, published today in The New England Journal of Medicine, researchers from University Hospitals (UH), Case Western Reserve University and Boston College discuss evidence linking pollution and cardiovascular disease. The research team highlights strategies for reducing individual exposure to pollution, and the importance of government-supported interventions encouraging clean energy.
Harrington Discovery Institute at University Hospitals and Case Western Reserve School of Medicine Open Call for 2022 Harrington-MSTP Scholar Award
Harrington Discovery Institute at University Hospitals and Case Western Reserve University School of Medicine have issued a call for proposals for the 2022 Harrington-MSTP (Medical Scientist Training Program) Scholar Award to help the next generation of physician-scientists advance their discoveries towards clinical application.
Case Western Reserve University receives $16M federal grant to launch major research center on substance use and HIV
Thanks to a new $16 million, five-year grant from the National Institute on Drug Abuse of the National Institutes of Health, Case Western Reserve University is launching a multi-institutional research effort dedicated to deepening understanding of the relationship between substance use and HIV.
First atomic-level imaging of lethal prions provide sharpened focus for potential treatments
The highest-ever resolution imaging of an infectious prion provides the first atomic-level data of how these abnormal proteins are assembled to cause fatal neurodegenerative diseases in people and animals—and how they can be potentially targeted by new therapies.
Unraveling the origin of Alzheimer’s disease
Case Western Reserve University researchers studying prions—misfolded proteins that cause lethal incurable diseases—have identified for the first time surface features of human prions responsible for their replication in the brain.
Case Western Reserve-led research team aims to determine which diabetic individuals can successfully donate corneas for transplant (and which should not)
In a new study, supported by a five-year, $6.4 million grant from the National Eye Institute of the National Institutes of Health, researchers from Case Western Reserve University, University Hospitals and the Jaeb Center for Health Research, aim to finally determine which diabetic individuals can successfully donate their corneas for keratoplasty (and which should not).
Case Western Reserve researchers identify potential new approach to better controlling epileptic seizures
Researchers from Case Western Reserve University have identified a potential new approach to better controlling epileptic seizures. Lin Mei, professor and chair of the Department of Neurosciences at the Case Western Reserve School of Medicine, who led the new study in mouse models, said the team found a new chemical reaction that could help control epileptic seizures.
Ultra-high field MRI detects subtle differences in structure and function of brain’s ‘hippocampus’ in people with Down syndrome
Using ultra-high field magnetic resonance imaging (MRI) to map the brains of people with Down syndrome (DS), researchers from Case Western Reserve University, Cleveland Clinic, University Hospitals and other institutions detected subtle differences in the structure and function of the hippocampus—a region of the brain tied to memory and learning.
Case Western Reserve University biotech startup Rodeo Therapeutics Corp. sold to Amgen Inc.
Rodeo Therapeutics Corp., a drug-development startup founded by two leading researchers from the Case Western Reserve University School of Medicine and a third scientific partner, has been sold to Amgen Inc., a publicly traded international biopharmaceutical company.
Under terms of the agreement, Amgen, based in Thousand Oaks, California, will acquire all outstanding shares of Rodeo for $55 million, plus “future contingent milestone payments potentially worth up to an additional $666 million in cash,” the companies announced today. Total consideration to Rodeo stakeholders could potentially be worth up to $721 million in cash.
New study provides insights into architecture of abnormal protein deposits in brain disorders
Scientists at the Case Western Reserve University School of Medicine have determined the structure of protein “fibrils” linked to Lou Gehrig’s disease and other neurodegenerative disorders—findings that provide clues to how toxic proteins clump and spread between nerve cells in the brain.
International team of bioethicists and scientists suggests revisiting 14-day limit on human embryo research for potential health and fertility benefits
An international team of bioethicists and scientists, led by a researcher at Case Western Reserve University, contends it may be justified to go beyond the standing 14-day limit that restricts how long researchers can study human embryos in a dish. Going beyond this policy limit could lead to potential health and fertility benefits, and the authors provide a process for doing so.
Researchers Identify Muscle Factor that Controls Fat Metabolism
In a recent study, published in The Journal of Clinical Investigation, University Hospitals (UH) Cleveland Medical Center and Case Western Reserve University School of Medicine researchers have found that skeletal muscle significantly affects how the body stores and metabolizes fat.
Case Western Reserve researchers uncover biochemical rules between RNA-protein interactions and expression of thousands of genes
A team of Case Western Reserve University researchers has found a way to measure key characteristics of proteins that bind to RNA in cells—a discovery that could improve our understanding of how gene function is disturbed in cancer, neurodegenerative disorders or infections.
Case Western Reserve University-led team finds that people with dementia at higher risk for COVID-19
A study led by Case Western Reserve University researchers found that patients with dementia were at a significantly increased risk for COVID-19—and the risk was higher still for African Americans with dementia.
Researchers Discover Neuroprotective Treatment for Chronic Traumatic Brain Injury
Traumatic brain injury (TBI) is a leading cause of cognitive impairment that affects millions of people worldwide. Despite growing awareness about the debilitating and lifelong progressive consequences of TBI, there are currently no treatments that slow the deteriorative process. TBI survivors are currently treated with extensive physical and cognitive rehabilitation, accompanied by medications that may mitigate symptoms yet do not halt or slow neurodegeneration. Now, researchers have found for the first time that this process can be pharmacologically reversed in an animal model of this chronic health condition, offering an important proof of principle in the field and a potential path to new therapy.
Global first in mixed-reality education during COVID-19 pandemic
The developers of Case Western Reserve University’s signature HoloAnatomy mixed-reality software for the Microsoft HoloLens knew they were likely achieving a global first this Spring when they quickly pivoted to the first-ever, all-remote anatomy course when the COVID-19 pandemic kept 185 first-year medical students from coming to campus.
Now, they have data reporting that an overwhelming majority of those students across the U.S. and Canada not only preferred the remote course, but believe they can effectively learn anatomy via the mixed-reality application.
NIH Funds Research into Differences in Glioblastoma between Males and Females
A team led by researchers from Case Western Reserve University School of Medicine and Cleveland Clinic Lerner Research Institute has secured $10.4 million over five years from the National Institutes of Health/National Cancer Institute to explore at the molecular level the differences in glioblastoma between males and females.
Study finds racial differences in time it takes to treat melanoma
Black patients with one of the deadliest forms of skin cancer are likely to experience a longer delay from diagnosis to surgery than non-Hispanic white (NHW) patients, according to a new study published in the Journal of the American Academy of Dermatology.
Case Western Reserve researchers to lead Northeast Ohio initiative to prevent, detect and treat lung cancer in underserved communities
With a $2.75 million, three-year grant from the Bristol-Myers Squibb (BMS) Foundation, researchers from Case Western Reserve University will lead a community wide initiative to create and apply innovative methods to prevent and detect lung cancer in underserved residents in Northeast Ohio.
Case Western Reserve University researchers discover critical link to controlling inflammation in Crohn’s disease
Investigators at the Case Western Reserve University School of Medicine discovered that blocking interleukin-1α (IL1α), a protein that controls inflammation in the gut, markedly decreases the severity of intestinal inflammation in a mouse model of Crohn’s disease (CD).
Case Western Reserve University and University Hospitals Infectious Diseases Researcher Awarded NIH Contract to Accelerate TB Vaccine Development
CWRU’s W. Henry Boom, MD, and a team of collaborators nationally received the first installment of a seven-year contract, totaling $30 million in its first year from the National Institute of Allergy and Infectious Diseases of the NIH, to establish three immunology research centers to accelerate TB vaccine development.
Genetic Data Now Available for Bacteria Central to Crohn’s Disease
Scientists have made genetic data publicly available for bacteria that might be lurking inside the gut walls of patients chronically affected with severe Crohn’s disease.
By studying a surgically removed, damaged bowel from a patient, researchers were able to culture bacteria from a special form of microscopic lesions that they earlier discovered and that can be present within the gut wall of the inflamed bowel in Crohn’s disease. After growing the bacteria in their laboratory, they chose one representative species, and performed a complete genome sequence analysis that could hold clues into how the slow and damaging microlesions form.
A New Pathway: Researchers Identify Potential Treatment Target for Crohn’s Disease
There is no cure for the more than 1.6 million people in the United States living with Crohn’s disease (CD) and its symptoms, including abdominal pain, intestinal distress and severe weight-loss. CD is a form of inflammatory bowel disease (IBD) in which the body’s own immune system attacks the gastrointestinal tract, and treatment is focused on controlling the symptoms of the disease in its acute phase and managing it in remission. But recently, researchers at Case Western Reserve University School of Medicine identified a pathway in the immune system activated in CD and which holds promise for investigating new treatments.