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UrduStem cell expansion in vitro and transplantation in the cytokine-rich proinflammatory milieu in the injured tissue generate immense oxidative stress that interferes with the cells’ survival, stemness, and repairability. Stem cell priming
Tag: Oxidative Stress
Anti-Inflammatory and Neuroprotective Polyphenols Derived from the European Olive Tree, Olea europaea L., in Long COVID and Other Conditions Involving Cognitive Impairment
The European olive tree, Olea europaea L., and its polyphenols hold great therapeutic potential to treat neuroinflammation and cognitive impairment. This review examines the evidence for the anti-inflammatory and neuroprotective actions of olive polyphenols and their potential in the treatment of long…
Penny for Your Thoughts? Master Copper Regulator Discovery May Offer Alzheimer’s Clues
A groundbreaking study using a tiny roundworm could pave the way for new treatments for neurodegenerative disorders. Researchers have linked the worm gene swip-10 to copper regulation – a vital element for brain health found in everyday items like wiring and cookware. Understanding the roles of swip-10 and MBLAC1, a protein involved in processing cellular materials, could lead to the development of effective medications and opens new avenues for advancing brain disease treatments.
Current perspectives on mesenchymal stem cells as a potential therapeutic strategy for non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant health challenge, characterized by its widespread prevalence, intricate natural progression and multifaceted pathogenesis. Although NAFLD initially presents as benign fa
Bubbling with benefits: hydrogen nanobubbles boost tomato antioxidants
A pioneering study has unlocked the potential of hydrogen nanobubbles to significantly augment the antioxidant content in tomatoes. This innovative irrigation technique not only fortifies the fruit with higher concentrations of health-boosting compounds but also opens new avenues for enhancing the nutritional value of agricultural produce.
Alcohol misuse can disrupt gut microbiota, causing inflammation that leads to organ damage
Alcohol researchers have long known that excessive drinking can cause damage to the liver, pancreas, heart, muscle, bone, and brain. However, only a subset of patients with alcohol use disorder (AUD) appear to develop organ damage. New research shows that alcohol-induced gut inflammation is the missing link between unhealthy drinking and organ damage among certain AUD patients.
Intermittent Fasting May Help Preserve Intestinal Health as We Age
A study in mice found that intermittent fasting brought benefits beyond weight loss, suggesting it could help the body better process glucose and reduce age-related declines in intestinal function. Researchers will present their work this week at the American Physiology Summit.
Acetaminophen May Be Less Heart-safe than Previously Thought
The common painkiller acetaminophen was found to alter proteins in the heart tissue when used regularly at moderate doses, according to a new study conducted in mice. Researchers will present their work this week at the American Physiology Summit in Long Beach, California.
Study Details Toxic Elements Found in Stranded Whales, Dolphins Over 15 Years
Researchers evaluated the prevalence, concentration and tissue distribution of essential and non-essential trace elements, including heavy metal toxicants in tissue (blubber, kidney, liver, skeletal muscle, skin) and fecal samples. Findings reveal how toxicant levels relate to their sex, breed, age and other demographic factors.
New study reveals why defense against brain corrosion declines in people with Alzheimer’s disease
A new study by researchers at Case Western Reserve University revealed that the progression of Alzheimer’s disease (AD) can be slowed by suppressing a specific protein in the brain that causes corrosion.
Pulmonary and neurological health effects associated with exposure to representative composite manufacturing emissions and corresponding alterations in circulating metabolite profiles
Abstract Cured-in-place pipe (CIPP) technology is increasingly being utilized to repair aging and damaged pipes, however, there are concerns associated with the public health hazards of emissions. CIPP installation involves the manufacture of a new plastic composite pipe at the…
Vaping CBD can increase susceptibility to respiratory infection, says Roswell Park study author
Dr. Thanavala is available for virtual or in-person interviews Monday, Feb. 27 or Tuesday, Feb 28. Press release: https://www.roswellpark.org/newsroom/202302-vaping-cbd-causes-more-severe-lung-damage-vaping-nicotine-roswell-park-study-shows Link to her bio here. Dr. Thanavala has been at the forefront of research on the health effects of vaping cannabinoids.…
Vaping CBD Causes More Severe Lung Damage Than Vaping Nicotine, Roswell Park Study Shows
Vaping cannabidiol (CBD), a compound found in marijuana, leads to more severe lung damage than vaping nicotine, according to a study out of Roswell Park Comprehensive Cancer Center. Until now, research on the health effects of vaping, or using e-cigarettes, has focused almost exclusively on vaping nicotine as opposed to CBD. Previous research has documented the effects of smoking cannabis, but the effects of vaping cannabinoids such as CBD were not previously known.
How COVID-19 Can Impact the Heart
ROCKVILLE, MD – COVID-19 infections can cause potentially life-threatening heart issues. Studies suggest that people with COVID-19 are 55% more likely to suffer a major adverse cardiovascular event, including heart attack, stroke and death, than those without COVID-19. They’re also more likely to have other heart issues, like arrhythmias (abnormal heart rhythms) and myocarditis (inflammation of the heart muscle).
Study Explores Effects of Resistance Training in Older Adults at the Cellular Level
Aging and related diseases are associated with alterations in oxidative status and low-grade inflammation, as well as a decreased endoplasmic reticulum (ER) unfolded protein response (UPR). UPR is a functional mechanism by which cells attempt to protect themselves against ER stress. Researchers analyzed these proteins in peripheral blood mononuclear cells of elderly subjects and used computer simulation to predict the key proteins associated with these biomolecules underlying physiological adaptations to exercise. They collected blood samples about five to six days before and after the training period and analyzed various oxidative stress biomarkers in peripheral blood mononuclear cells. The study takes research one step further in helping to elucidate the benefits of exercise in this population.
Kidney Injury Increases Oxidative Stress, Depletes Energy Production in Lungs
Article title: Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production and ATP depletion Authors: Sophia L. Ambruso, Hyo-Wook Gil, Benjamin Fox, Bryan Park, Christopher Altmann, Rushita A. Bagchi, Peter R. Baker II, Julie A.…
Differences in human, mouse brain cells have important implications for disease research
A UCLA-led study comparing brain cells known as astrocytes in humans and mice found that mouse astrocytes are more resilient to oxidative stress, a damaging imbalance that is a mechanism behind many neurological disorders.
Uncovering a Link Between Inflammation and Heart Disease
In a new study in Circulation, researchers from Tufts University School of Medicine in collaboration with investigators at Vanderbilt University and Tufts Medical Center reveal a mechanism that is activating T cells, a type of immune cell, and causing inflammation in the heart.
UTEP Researchers Develop Nanohybrid Vehicle to Optimally Deliver Drugs Into the Human Body
The researchers discovered that encapsulating ellagic acid in chitosan, a sugar, reduces its inherent cytotoxicity while enhancing its anti-oxidant properties. The chitosan shell, which makes up the hard outer skeleton of shellfish, also permits EA delivery via a rapid burst phase and a relatively slow phase.
Two Rutgers Professors Named Fellows of AAAS
Two Rutgers professors have been named fellows of the American Association for the Advancement of Science (AAAS) this year, an honor awarded to AAAS members by their peers. They join 441 other AAAS members named new fellows because of their scientifically or socially distinguished efforts to advance science or its applications. The fellows will be presented an official certificate and a gold and blue (representing science and engineering, respectively) rosette pin on Feb. 15 at the AAAS Fellows Forum during the 2020 AAAS Annual Meeting in Seattle, Washington.