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UrduResearchers will explore a promising approach for treating degenerative diseases by replacing damaged cells with new ones and will focus on genetically engineering replacement cells from embryonic stem cells, which have the potential to develop into mature cells and tissues.
Tag: Stem Cells
How Healthy Stem Cells Turn Into Oral Cancer
Nearly 60,000 people are diagnosed with oral cancer in the U.S. every year, according to the American Cancer Society, and the rate of new cases continues to rise. Now, researchers at University of California San Diego have discovered how healthy…
Bone marrow mesenchymal stem cells promote uterine healing by activating the PI3K/AKT pathway and modulating inflammation in rat models
BACKGROUNDUterine injury can cause uterine scarring, leading to a series of complications that threaten women’s health. Uterine healing is a complex process, and there are currently no effective treatments. Although our previous studies h
Microvesicles derived from mesenchymal stem cells: A promising therapeutic strategy for acute respiratory distress syndrome-related pulmonary fibrosis?
Pulmonary fibrosis significantly contributes to the pathogenesis of acute respiratory distress syndrome (ARDS), markedly increasing patient mortality. Despite the established anti-fibrotic effects of mesenchymal stem cells (MSCs), numerous
Microvesicles derived from mesenchymal stem cells: A promising therapeutic strategy for acute respiratory distress syndrome-related pulmonary fibrosis?
Pulmonary fibrosis significantly contributes to the pathogenesis of acute respiratory distress syndrome (ARDS), markedly increasing patient mortality. Despite the established anti-fibrotic effects of mesenchymal stem cells (MSCs), numerous
Protective activity of adipose-derived stem cell extracellular vesicles in ischemia and/or reperfusion
Increasing evidence of the significant clinical value of protection against ischemia/reperfusion injury has contributed to the realization of the independent importance of this approach in improving prognosis and reducing cardiovascular mor
Microvesicles derived from mesenchymal stem cells: A promising therapeutic strategy for acute respiratory distress syndrome-related pulmonary fibrosis?
Pulmonary fibrosis significantly contributes to the pathogenesis of acute respiratory distress syndrome (ARDS), markedly increasing patient mortality. Despite the established anti-fibrotic effects of mesenchymal stem cells (MSCs), numerous
Advances in human umbilical cord mesenchymal stem cells-derived extracellular vesicles and biomaterial assemblies for endometrial injury treatment
Endometrial injury caused by repeated uterine procedures, infections, inflammation, or uterine artery dysfunction can deplete endometrial stem/progenitor cells and impair regeneration, thereby diminishing endometrial receptivity and evident
Immortalization of epidural fat-derived mesenchymal stem cells: In vitro characterization and adipocyte differentiation potential
BACKGROUNDMesenchymal stem cells (MSCs) are promising candidates for regenerative therapy due to their self-renewal capability, multilineage differentiation potential, and immunomodulatory effects. The molecular characteristics of MSCs are
UTSW Research: Python guts, emergency room visits, and more
Regeneration insights from snake intestines / Understanding why cancer patients visit the ED / How burr holes affect transcranial direct current stimulation
Two Case Western Reserve University faculty members honored as Fellows of the National Academy of Inventors
Polymer scientist Gary E. Wnek and stem-cell biologist Arnold Caplan have been named Fellows of the National Academy of Inventors (NAI), the highest professional distinction awarded solely to inventors.
Wistar Institute Scientists Identify Important Factor in Neural Development
The Wistar Institute’s Dr. Alessandro Gardini and his lab have published their new paper, “The enhancer module of integrator controls cell identity and early neural fate commitment,” in the journal Nature Cell Biology.
Resilience and challenges: Evaluating the impact of stress conditions on mesenchymal stem cells across different passages
This article discussed a study by Almahasneh et al, which investigated how high glucose and severe hypoxia affected mesenchymal stem cells (MSCs) at different passages. This research provides insights into the resilience of higher-passage M
Effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cells
BACKGROUNDThin endometrium seriously affects endometrial receptivity, resulting in a significant reduction in embryo implantation, and clinical pregnancy and live birth rates, and there is no gold standard for treatment. The main pathophysi
Efficacy of serum-free cultured human umbilical cord mesenchymal stem cells in the treatment of knee osteoarthritis in mice
BACKGROUNDWe investigated the efficacy of intra-articular injection of human umbilical cord mesenchymal stem cells (hUC-MSCs) for the treatment of osteoarthritis (OA) progression in the knee joint. Although many experimental studies of hUC-
Yes-associated protein-mediated melatonin regulates the function of periodontal ligament stem cells under oxidative stress conditions
BACKGROUNDHuman periodontal ligament stem cells (PDLSCs) regenerate oral tissue. In vitro expansion causes replicative senescence in stem cells. This causes intracellular reactive oxygen species (ROS) accumulation, which can impair stem cel
Glutamine metabolic switch is key to red blood cell development and disease
Scientists at St. Jude Children’s Research Hospital identified a link between glutamine metabolism and red blood cell maturation, showing how disruption of the process can drive disease.
Human stem cell-derived heart cells are safe in monkeys, could treat congenital heart disease
Heart muscle cells grown from stem cells show promise in monkeys with a heart problem that typically results from a heart defect sometimes present at birth in humans, according to new research from the University of Wisconsin–Madison and Mayo Clinic.
Key Pathway Leading to Neurodegeneration in Early Stages of ALS Identified
Researchers at UC San Diego identify a key pathway leading to neurodegeneration in early stages of ALS, hinting at the potential for short-circuiting the progression of the fatal disease if diagnosed early.
Espaço: Uma nova fronteira para explorar a terapia com células-tronco
As células-tronco cultivadas em microgravidade a bordo da Estação Espacial Internacional (EEI) possuem qualidades únicas que poderão, um dia, ajudar a potencializar as novas bioterapias e a curar doenças complexas, de acordo com dois pesquisadores da Mayo Clinic. A análise da pesquisa pelo pesquisador Fay Abdul Ghani e pelo Dr. e Ph.D. Abba Zubair, publicada na NPJ Microgravity, descobriu que a microgravidade pode fortalecer o potencial regenerativo das células. O Dr. Zubair é especialista em medicina laboratorial e diretor médico do Centro de Bioterapias Regenerativas na Mayo Clinic, na Flórida. Abdul Ghani é um tecnólogo em pesquisa da Mayo Clinic. A microgravidade é a ausência de peso ou gravidade próxima a zero.
Espacio: Una nueva frontera para explorar la terapia con células madre
Las células madre cultivadas en microgravedad a bordo de la Estación Espacial Internacional (EEI) poseen cualidades únicas que algún día podrán ayudar a potenciar las nuevas bioterapias y curar enfermedades complejas, según dos investigadores de Mayo Clinic. El análisis de la investigación por el investigador Fay Abdul Ghani y por el Dr. y Ph.D. Abba Zubair, publicado en NPJ Microgravity ha hallado que la microgravidad puede fortalecer el potencial regenerativo de las células. El Dr. Zubair es especialista en medicina de laboratorio y director médico del Centro de Bioterapias Regenerativas en Mayo Clinic, Florida. Abdul Ghani es tecnólogo de investigación en Mayo Clinic. La microgravedad es la ausencia o gravedad cercana a cero.
Gamma-aminobutyric acid enhances miR-21-5p loading into adipose-derived stem cell extracellular vesicles to alleviate myocardial ischemia-reperfusion injury via TXNIP regulation
BACKGROUNDMyocardial ischemia-reperfusion injury (MIRI) poses a prevalent challenge in current reperfusion therapies, with an absence of efficacious interventions to address the underlying causes. AIMTo investigate whether the extracellula
Enhancing the functionality of mesenchymal stem cells: An attractive treatment strategy for metabolic dysfunction-associated steatotic liver disease?
The intrinsic heterogeneity of metabolic dysfunction-associated fatty liver disease (MASLD) and the intricate pathogenesis have impeded the advancement and clinical implementation of therapeutic interventions, underscoring the critical dema
Emergence of the stromal vascular fraction and secretome in regenerative medicine
Recently, we read a mini-review published by Jeyaraman et al. The article explored the optimal methods for isolating mesenchymal stromal cells from adipose tissue-derived stromal vascular fraction (SVF). Key factors include tissue source, p
Enhancing the functionality of mesenchymal stem cells: An attractive treatment strategy for metabolic dysfunction-associated steatotic liver disease?
The intrinsic heterogeneity of metabolic dysfunction-associated fatty liver disease (MASLD) and the intricate pathogenesis have impeded the advancement and clinical implementation of therapeutic interventions, underscoring the critical dema
Mechanism of mesenchymal stem cells in liver regeneration: Insights and future directions
Mesenchymal stem cells (MSCs) are a prevalent source for stem cell therapy and play a crucial role in modulating both innate and adaptive immune responses. Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of tr
Mesenchymal stem cells in wound healing: A bibliometric analysis as a powerful research tool
Bibliographic analysis is still very rarely used in experimental basic study papers. The comprehensive bibliometric analysis of scientific literature on research progress and challenges in stem cell therapy for diabetic chronic wounds, whic
Organoids Derived From Gut Stem Cells Reveal Two Distinct Molecular Subtypes of Crohn’s Disease
UC San Diego researchers discover two distinct molecular subtypes of Crohn’s disease using patient-derived organoids, opening the door to personalized treatment for the chronic inflammatory bowel disease.
Pausing biological clock could boost lab-produced blood stem cells
An Iowa State University research team has discovered when and why inflammatory signaling affects the formation of blood stem cells in embryos, which will benefit efforts to develop lab-grown, patient-derived stem cell transfusions to treat blood disorders. The promising advancement in regenerative medicine could eliminate the need for bone marrow transplants.
Breaking the link between obesity and atrial fibrillation with a new cellular target
Blocking oxidative stress enzyme prevents, even reverses, heart condition in lab models
Bone marrow mesenchymal stem cells in treatment of peripheral nerve injury
Peripheral nerve injury (PNI) is a common neurological disorder and complete functional recovery is difficult to achieve. In recent years, bone marrow mesenchymal stem cells (BMSCs) have emerged as ideal seed cells for PNI treatment due to
Microvesicles derived from mesenchymal stem cells inhibit acute respiratory distress syndrome-related pulmonary fibrosis in mouse partly through hepatocyte growth factor
BACKGROUNDPulmonary fibrosis is one of the main reasons for the high mortality rate among acute respiratory distress syndrome (ARDS) patients. Mesenchymal stromal cell-derived microvesicles (MSC-MVs) have been shown to exert antifibrotic ef
Mechanistic basis of lineage restriction
ABSTRACTLineage restriction, the biological phenomenon whereby developing cells progressively lose fate potency for all but their adopted lineages, is foundational to multicellular lifeforms as it secures the functional identities of the myriad cell types in the body. The mechanisms of…
Groundbreaking Study Solves Mystery of Multicellularity
A team of researchers from multiple institutions including the University of Chicago and VectorBuilder, has made a significant breakthrough in the understanding of lineage restriction, a biological phenomenon foundational to multicellular lifeforms as it secures the functional identities of the myriad cell types in the body.
Potential New Approach to Enhancing Stem-Cell Transplants
A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body’s different blood cells.
Wharton’s jelly mesenchymal stem cells: Future regenerative medicine for clinical applications in mitigation of radiation injury
Wharton’s jelly mesenchymal stem cells (WJ-MSCs) are gaining significant attention in regenerative medicine for their potential to treat degenerative diseases and mitigate radiation injuries. WJ-MSCs are more naïve and have a better safe
All Stem Cell Therapies Are Not Created Equal
Researchers from University of California San Diego have found that two of the most frequently administered stem cell therapies, which are often used interchangeably, actually contain completely different types of cells. The results challenge the current “one-cell-cures-all” paradigm in orthopedic…
Revolutionizing Cancer Treatment: Wistar and Accelerated Biosciences Collaborate to Pioneer Transformative Immune Cell Therapies
The Wistar Institute is pleased to announce a research collaboration with Accelerated Biosciences Corp. aimed at creating a platform based on human trophoblast stem cells to explore new immunotherapies that use Accelerated Bio’s proprietary technology.
Priming mesenchymal stem cells to develop “super stem cells”
The stem cell pre-treatment approaches at cellular and sub-cellular levels encompass physical manipulation of stem cells to growth factor treatment, genetic manipulation, and chemical and pharmacological treatment, each strategy having adva
Priming mesenchymal stem cells to develop “super stem cells”
The stem cell pre-treatment approaches at cellular and sub-cellular levels encompass physical manipulation of stem cells to growth factor treatment, genetic manipulation, and chemical and pharmacological treatment, each strategy having adva
RPLP0/TBP are the most stable reference genes for human dental pulp stem cells under osteogenic differentiation
BACKGROUNDValidation of the reference gene (RG) stability during experimental analyses is essential for correct quantitative real-time polymerase chain reaction (RT-qPCR) data normalisation. Commonly, in an unreliable way, several studies u
Human toxicity of Nanomaterials Verified with ‘Organoid,’ an Artificial Organ
The Korea Research Institute of Standards and Science (KRISS) has developed the world’s first organoid culture method capable of accurately assessing human toxicity of nanomaterials.
New research points to ‘stem-like’ T cells as culprits in ulcerative colitis
The researchers hope to one day target this T cell population via drug therapy. “These cells may be a very important target for treating ulcerative colitis and perhaps other autoimmune diseases…”
Q&A: New Frontiers in ALS Research
Clive Svendsen, PhD, executive director of the Board of Governors Regenerative Medicine Institute and professor of Medicine and Biomedical Sciences at Cedars-Sinai, is developing new treatments and models for amyotrophic lateral sclerosis (ALS) using stem cells.
Role of glioma stem cells in promoting tumor chemo- and radioresistance: A systematic review of potential targeted treatments
BACKGROUNDGliomas pose a significant challenge to effective treatment despite advancements in chemotherapy and radiotherapy. Glioma stem cells (GSCs), a subset within tumors, contribute to resistance, tumor heterogeneity, and plasticity. Re
Cedars-Sinai to Join Abu Dhabi Global Healthcare Week
Cedars-Sinai experts are participating in the inaugural Abu Dhabi Global Healthcare Week, May 13-15 in Abu Dhabi, United Arab Emirates, highlighting their dedication to enhancing innovation and medical advances that will have a positive impact on communities worldwide.
Study: Hillocks challenge our understanding of lung biology
A research team from Tufts University School of Medicine and Massachusetts General Hospital is now reporting evidence that hillocks and their stem cells are physiologically distinct from other cells within the lung and consist of a stratified outer layer of scale-like squamous cells that protect an underlying layer of rapidly expanding basal stem cells that are capable of restoring airway tissue after injury.
$2.7 million grant to explore hypoxia’s impact on blood stem cells
Indiana University School of Medicine scientists are on a mission to understand why hematopoietic stem cells, responsible for producing all types of mature blood cells, exhibit better responses in a low-oxygen environment within the bone marrow, also known as hypoxia.
Study documents safety, improvements from stem cell therapy after spinal cord injury
A Mayo Clinic study shows stem cells derived from patients’ own fat are safe and may improve sensation and movement after traumatic spinal cord injuries. The findings from the phase 1 clinical trial appear in Nature Communications.
VX-509 attenuates the stemness characteristics of colorectal cancer stem-like cells by regulating the epithelial-mesenchymal transition through Nodal/Smad2/3 signaling
BACKGROUNDColorectal cancer stem cells (CCSCs) are heterogeneous cells that can self-renew and undergo multidirectional differentiation in colorectal cancer (CRC) patients. CCSCs are generally accepted to be important sources of CRC and are