English
Arabic
Chinese (Simplified)
Dutch
Esperanto
French
German
Greek
Italian
Japanese
Korean
Portuguese
Russian
Spanish
UrduPeople who work the nightshift or odd hours and eat at irregular times are more prone to weight gain and diabetes, likely due to eating patterns not timed with natural daylight and when people typically eat. But is it possible to stave off the ill effects of eating at these “unusual” times despite it not being biologically preferable?
Tag: Perelman School of Medicine at the University of Pennsylvania
Long-Term Antiviral Use is Key to Ocular Shingles Treatment
Year-long use of a typical antiviral treatment for shingles was particularly impactful in reducing complications when the condition eventually affected the eye
Prevention Research Center awarded $6.5 million CDC grant
The University of Pennsylvania Prevention Research Center (UPenn PRC) has been awarded a grant totaling $6.5 million over five years from the Centers for Disease Control and Prevention (CDC) for community-based prevention and public health research, with a particular focus on cancer.
Single-Dose Gene Therapy is Potentially Life-Changing for Adults with Hemophilia B
Adults with hemophilia B saw their number of bleeding episodes drop by an average of 71 percent after a single infusion of gene therapy, according to the results of an international Phase III clinical trial published today in the New England Journal of Medicine by researchers from the University of Pennsylvania Perelman School of Medicine and a multicenter group of investigators.
100x Improvement in Sight Seen After Gene Therapy Trial
The vision of people with a rare inherited condition that causes them to lose much of their sight early in childhood was 100 times better after they received gene therapy to address the genetic mutation causing it. Some patients even experienced a 10,000-fold improvement in their vision after receiving the highest dose of the therapy, according to researchers from the Perelman School of Medicine at the University of Pennsylvania who co-led the clinical trial published in The Lancet.
Combo immunotherapy produces distinct waves of cancer-fighting T cells with each dose
A new tool for monitoring immune health patterns over time reveals how a pair of checkpoint inhibitor therapies works together to recruit new cancer-fighting T cells with every infusion.
Genetic Study Highlights Importance of Diversity in Understanding Health Disparities
The majority of genetic studies focus on people of European descent, which limits the understanding of how genes influence health in other populations.
Penn Study Finds Better Survival Rates for Recipients of Lungs From Hospital-based Donor Care Units Compared to Independent Donor Care Units
A new study by Penn researchers examined, for the first time, the differences in lung transplant graft outcomes from organs recovered from the two types of deceased organ donor care facilities operating in the United States.
Rare Disease’s DNA-Damaging Mutation Could Have Consequences for More Common Conditions
In their pursuit to discover the mechanism behind how RVCL does its damage, researchers found some clues to the DNA damage theory of aging
ASCO: New ‘Armored’ CAR produces significant responses in patients whose cancers don’t respond to current CAR T cell therapies
A new “armored” form of CAR T cell therapy may be able to help patients with non-Hodgkin lymphoma whose cancers do not respond to currently available CAR T cell therapies. The Phase I clinical trial was presented at the 2024 ASCO Annual Meeting.
Offering Both Colonoscopy and At-Home Tests Doubled Colorectal Cancer Screening
In a trial analyzing how messages were framed in an underserved population, offering colorectal cancer screening options resulted in the highest screening rate
Could the liver hold the key to better cancer treatments?
Liver inflammation, a common side-effect of cancers elsewhere in the body, has long been associated with worse cancer outcomes and more recently associated with poor response to immunotherapy. Now, a team led by researchers from the Abramson Cancer Center and Perelman School of Medicine at the University of Pennsylvania has found a big reason why.
Penn Medicine at the AACR Annual Meeting 2024
Researchers from the Abramson Cancer Center (ACC) and Perelman School of Medicine at the University of Pennsylvania will present data on the latest advances in cancer science and medicine at the American Association for Cancer Research (AACR) Annual Meeting 2024, taking place April 5-10 in San Diego, California.
Depression in Black people goes unnoticed by AI models analyzing language in social media posts
Analysis found that models developed to detect depression using language in Facebook posts did not work when applied to Black people’s accounts
Invitation to Cover: Perelman School of Medicine Students Meet Their Match
On Friday, March 15, the Perelman School of Medicine (PSOM) at the University of Pennsylvania will celebrate Match Day, the annual event that reveals where graduating medical students will head for residency programs to further their training.
Penn Medicine Researchers Develop Gene Editing Approaches for Phenylketonuria Treatment
Phenylketonuria (PKU) is a rare newborn genetic disease that impacts between 1 in 10,000 to 1 in 20,000 people, depending on the individuals’ genetic ancestry. PKU causes an amino acid—called phenylalanine (Phe)—to build up in the bloodstream.
Penn Research Projects Increase in U.S. Cardiovascular Deaths Due to Extreme Heat
The number of heat related cardiovascular deaths in the United States will increase over the next four decades, according to a new analysis from the Perelman School of Medicine at the University of Pennsylvania.
High Pregnancy Weight Gain Tied to Higher Risk of Later Death
Findings from 50 years of data highlighted the health risks when more weight is gained in pregnancy than recommended, especially when it comes to heart disease- and diabetes-related mortality
Disparities Persist Across Levels of Surgery Department Leadership in US
Women and those from racial and ethnic groups underrepresented in medicine (URiM) not only occupy few leadership roles in surgical departments but also tend to be clustered into certain leadership roles, according to a new analysis led by researchers from the Perelman School of Medicine at the University of Pennsylvania.
Penn Medicine Researchers Awarded $27.5 Million for Large Palliative Care Study
A Penn Medicine research team has been approved for a $27.5 million funding award from the Patient-Centered Outcomes Research Institute (PCORI) for a large study on effectively and equitably scaling and delivering inpatient palliative care.
Antibody Treatment Prevents Graft Versus Host Disease, a Major Bone Marrow Transplant Complication, in Advanced Preclinical Tests
An experimental antibody treatment largely prevented a bone marrow transplant complication called graft versus host disease (GVHD) in the intestines, without causing broad immune suppression, in a preclinical study led by researchers from Penn Medicine and Dana-Farber/Boston Children’s Cancer and Blood Disorders Center and published today in Science Translational Medicine.
Penn Research Provides Better Understanding into How Genes Make Us Prone To Allergies
New research is bolstering scientific understanding behind why some people are more prone to allergies than others. Researchers in the Perelman School of Medicine at the University of Pennsylvania identified how genetic differences that alter a specific protein called ETS1 can affect our body’s response to allergies. They found that small changes in ETS1 in an animal model can lead to an increased likelihood for allergic reactions that cause inflammation. The findings were published recently in Immunity.
Telemedicine Visits Cut Health System Employee Care Costs by Nearly 25 Percent
Comparing Penn Medicine OnDemand services with in-person care showed that telemedicine visits are significantly less expensive to deliver
Discovering Cell Identity: $6 Million NIH Grant Funds New Penn Medicine Research to Uncover Cardiac Cell Development
Historically, scientists have studied how cells develop and give rise to specialized cells, such as heart, liver, or skin cells, by examining specific proteins.
Penn Medicine to Offer Free Cancer Screenings, including 3D Mammograms with Siemens Healthineers, at June Community Events in and around West Philadelphia
As part of a continued focus on making cancer screenings more accessible to the greater Philadelphia community, Penn Medicine is providing free cancer screenings, no insurance required, including advanced 3D mammograms, in West Philadelphia this June.
Four Penn Medicine Abramson Cancer Center Researchers Receive Top AACR Awards
Four distinguished researchers from the Abramson Cancer Center and Perelman School of Medicine at the University of Pennsylvania will receive 2023 Scientific Achievement Awards from the American Association for Cancer Research (AACR), during the AACR Annual Meeting 2023.
Penn Medicine Awarded $9.7 Million from The Warren Alpert Foundation for Genetic Counselor Continuing Education Efforts
Penn Medicine has received a $9.7 million grant from The Warren Alpert Foundation (WAF) that will fund continuing education efforts for genetic counselors, to ensure opportunities for continued training that will keep them on the leading edge of their profession interpreting genomic data and explaining its implications to patients.
Study Gives Peek of How Ketamine Acts as ‘Switch’ in the Brain
Researchers find that the anesthetic and fast-acting antidepressant switches natural patterns of neuronal activity in the cortex of mice
Study Finds Automated Texts Decrease Odds of Rehospitalization
Text messages sent automatically from patients’ primary care office after hospitalization were tied to decreased odds of needing further emergency care
Stroke, Clot Risk Halved in Heart Disease and Arrhythmia Patients Who Took Blood Thinners Apixaban Versus Rivaroxaban
The new study showed apixaban is superior to rivaroxaban against stroke or systemic embolism in patients with atrial fibrillation and valvular heart disease
Gene Therapy Rapidly Improves Night Vision in Adults with Congenital Blindness
Patients’ low-light sensitivity improved by factors of thousands in a clinical trial
Fast Track to Fertility Program Sharply Cuts Time to Treatment
Telemedicine-driven program cut the time from an initial new patient visit to fertility treatment from more than two months to 41 days
Penn Research Finds Psoriasis Medication Apremilast Leads to Fat Loss in People with Psoriasis
Apremilast (brand name Otezla) has helped psoriasis patients achieve clearer skin and ease the symptoms of their psoriatic arthritis. Now, new data from researchers at the Perelman School of Medicine at the University of Pennsylvania shows it could also help people with psoriasis shed unhealthy body fat and therefore improve cardiovascular health, a well-known vulnerability for those with psoriasis.
Researchers Aim to Use AI to Predict Rare Diseases
Penn Medicine researchers will help lead development of an algorithm to flag patients at risk of rare disease thanks to a $4.7 million NIH grant
Integrating Genetic Testing in Electronic Health Records Saves Time, Study Finds
Ordering and managing genomic testing in electronic health records significantly cut the time Penn Medicine clinicians spent doing it
The Locked Library: Disease Causes Cells to Reorder Their DNA Incorrectly
With super-resolution imaging, Penn Medicine researchers discovered that cells change the physical structure of their genome when they’re affected by disease
Hormone Infusion Improves Pancreatic Insulin Production in Cystic Fibrosis Patients with or at Risk for Diabetes
Medication therapy based on the hormone glucagon-like peptide-1(GLP-1) may help regulate natural insulin production in cystic fibrosis, potentially offering a better way to prevent and ultimately manage diabetes than daily insulin injections
Where and When Violent Crime Rates Fall, Heart Disease Deaths Fall, Too
A new study of data from Chicago found that the neighborhoods where violent crime fell the most, cardiovascular disease mortality fell sharply, too
Both Gun Owners and Non-Gun Owners Trust Kids’ Doctors in Gun Safety Talks
New research shows that parents are open to talking about gun safety measures with their children’s pediatricians and willing to change firearm storage practices
Spinal Anesthesia Linked to Higher Painkiller Use in Hip Fracture Patients
A study examining pain and prescription use among hip fracture patients compared outcomes among those who had spinal anesthesia and those who had general anesthesia
Study: Text Messaging Shows Promise in Reaching Unvaccinated Patients
While automated texting did not get more patients to get their vaccinations against COVID-19, it reached roughly the same amount as manned phone calls
Racial Gap in Completed Doctor Visits Disappeared in 2020 as Telemedicine Adopted
As COVID-19 necessitated the wider adoption of telemedicine, the rate of completed primary care visits for Black patients rose to the same level of non-Black patients, Penn Medicine study finds
Program Issuing Mailed Kits Doubles Rate of Leftover Opioids Disposal
Study finds that patients of orthopaedic and urologic procedures were more likely to dispose of their extra opioid tablets when they received kits in the mail to do so
Penn Medicine, Philadelphia Department of Public Health Partner to Increase Virtual Care for Patients with Opioid Use Disorder
Through a collaboration, a virtual “bridge clinic” will expand access to more extensive and personalized care for patients struggling with opioid use
DNA Analysis Provides Insight into Associations Between Worse COVID and Other Conditions
Through analyzing human DNA samples in a large biobank, Penn Medicine researchers found associations between genetic variants with severe COVID and conditions involving blood clots and respiratory issues
Making a Game of It: Contests Help New Moms Increase Their Steps
Study Used Wearable Tech to Foster Activity in High-Risk, Diverse Populations
Piezo1 Possible Key to Supporting Muscle Regeneration in Duchenne Muscular Dystrophy
Tracing the impact of a single protein, Piezo1, Penn researchers found that restoring it in muscles affected by Duchenne muscular dystrophy could improve their ability to heal efficiently
Online Tool Effective in Triaging Nearly All COVID-19 Patients
The COVID-19 Triage Tool at Penn Medicine categorized almost every patient into a safe classification and took burdens off clinicians during the height of the pandemic
Penn Study Illuminates the Biology of Common Heart Disorder
Dilated cardiomyopathy due to titin gene mutations involves both a shortage of good titin and a buildup of mutant, potentially “bad” titin
A ‘Dented’ Internal Clock Provides Insight Into Shift Workers’ Weight Gain and Diabetes
Weight gain and high blood sugar caused by a damaged internal clock was corrected by researchers, who changed the length of the “day” in mice