Amiodarone used with anticoagulant therapy increases bleeding-related hospitalizations compared with flecainide or sotalol

A cohort study of more than 90,000 older adults diagnosed with atrial fibrillation (Afib) who were treated with anticoagulants found that treatment with amiodarone during apixaban or rivaroxaban use was associated with greater risk for bleeding-related hospitalizations compared to flecainide or sotalol. The findings are published in Annals of Internal Medicine

Apixaban vs. Warfarin in Patients with an On-X Mechanical Aortic Valve

Although the On-X aortic valve and apixaban have been approved for use by the U.S. Food and Drug Administration (FDA), they had not been approved to be used together. Between May 2020 and September 2022, the PROACT Xa randomized, multicenter, open-label trial compared the direct factor Xa inhibitor apixaban (Eliquis) with warfarin in patients with bileaflet carbon aortic valves.

High-Dose Anticoagulation Can Reduce Intubations and Improve Survival for Hospitalized COVID-19 Patients

High-dose anticoagulation can reduce deaths by 30 percent and intubations by 25 percent in hospitalized COVID-19 patients who are not critically ill when compared to the standard treatment, which is low-dose anticoagulation.

Stroke, Clot Risk Halved in Heart Disease and Arrhythmia Patients Who Took Blood Thinners Apixaban Versus Rivaroxaban

The new study showed apixaban is superior to rivaroxaban against stroke or systemic embolism in patients with atrial fibrillation and valvular heart disease