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UrduBy examining which genes were turned on and off in a mix of cell types from breast cancer biopsies, a team led by UT Southwestern Medical Center researchers developed a tool that can accurately predict which patients with breast cancer will respond to immunotherapies.
Tag: Pediatrics
Researchers Publish Final Results of Key Clinical Trial for Gene Therapy for Sickle Cell Disease
An international consortium published the final results of a key clinical trial of the gene therapy CASGEVY (exagamglogene autotemcel) for the treatment of sickle cell disease in patients 12 years and older with recurrent vaso-occlusive crises (VOCs).
CHOP Researchers Discover Underlying Biology Behind Fontan-Associated Liver Disease
As patients with congenital heart diseases live longer, researchers are attempting to understand some of the other complications they may face as they age. In a new study, a team from Children’s Hospital of Philadelphia (CHOP) used state-of-the-art technologies to understand the underlying biology of Fontan-associated liver disease (FALD).
Atlantic Health System Welcomes New System Medical Director of Pediatrics
Beth C. Natt, MD, MPH, MBA a career pediatric hospitalist, was named the new System Medical Director of the Pediatric Service Line for Atlantic Health System and Chairperson of the Department of Pediatrics at Morristown and Overlook Medical Centers.
Researchers Find No Link Between COVID-19 Virus and Development of Asthma in Children
In the wake of the COVID-19 pandemic, many families worried about the long-term effects posed by the SARS-COV-2 virus. Now, researchers found that a SARS-COV-2 infection likely does not increase the risk of asthma development in pediatric patients. The findings were published today in the journal Pediatrics.
CHOP, Stanford Researchers Identify Protein That Controls CAR T Cell Longevity
CAR T cell therapy has revolutionized the way certain types of cancer are treated, and the longer those CAR T cells live in a patient’s body, the more effectively they respond to cancer. Now, researchers have found that a protein called FOXO1 improves the survival and function of CAR T cells, which may lead to more effective CAR T cell therapies and could potentially expand its use in difficult-to-treat cancers.
Youths with Mood Disorders 30 Percent Less Likely to Acquire Driver’s License Than Peers
Researchers found that teens and young adults with mood disorders, such as depression and bipolar disorder, were 30% less likely to obtain their driver’s license than peers without such disorders. Additionally, those youths with mood disorders experienced a slightly elevated risk of crashing.
UTSW discovers protective ‘acid wall’ formed by cancer cells
Cancer cells release a significantly more concentrated level of acid than previously known, forming an “acid wall” that could deter immune cells from attacking tumors, UT Southwestern Medical Center scientists show in a new study.
Gene therapy offers hope for giant axonal neuropathy patients
A gene therapy developed by researchers at UT Southwestern Medical Center for a rare disease called giant axonal neuropathy (GAN) was well tolerated in pediatric patients and showed clear benefits, a new study reports. Findings from the phase one clinical trial, published in the New England Journal of Medicine, could offer hope for patients with this rare condition and a host of other neurological diseases.
Researchers at Phoenix Children’s First in the World to Produce Mouse Lungs in Rats
Research conducted at the Phoenix Children’s Research Institute at the University of Arizona College of Medicine — Phoenix reports the successful generation of a mouse lung in a rat, according to a paper published in the American Journal of Respiratory and Critical Care Medicine.
CHOP Researchers Find Branched Chain Amino Acid Supplementation May Aid in Concussion Recovery
In the first clinical trial of a targeted pharmacologic therapeutic for mild traumatic brain injury in pediatric patients, scientists have found preliminary evidence that adolescents and young adults with concussion who take a specific formulation of branched chain amino acid (BCAA) supplements after injury experience faster symptom reduction and return to physical activity.
Match Day magic: UTSW students earn top residency spots
Future physicians persevere through pandemic to reach milestone moment
CHOP Researchers Discover Key Metabolic Process Responsible for Rapid Immune Responses
Researchers identified a key metabolite in cells that helps direct immune responses and explains at a single cell level why immune cells that most efficiently recognize pathogens, vaccines, or diseased cells grow and divide faster than other cells.
Researchers Find That Length of Opioid Treatment for Hospitalized Infants Differs by Institution and Geography
Los Angeles (March 12, 2024) – Opioids such as fentanyl and morphine can provide effective pain relief for infants with complex medical conditions when used carefully. But who decides what careful actually means? In a study published in JAMA Network…
This Injectable Hydrogel Mitigates Damage to the Right Ventricle of the Heart
An injectable hydrogel can mitigate damage to the right ventricle of the heart with chronic pressure overload, according to a new study published March 6 in Journals of the American College of Cardiology: Basic to Translational Science. The study, by a research team from the University of California San Diego, Georgia Institute of Technology and Emory University, was conducted in rodents.
Gold nanoparticles reverse brain deficits in multiple sclerosis, Parkinson’s
Results from phase two clinical trials at UT Southwestern Medical Center showed that a suspension of gold nanocrystals taken daily by patients with multiple sclerosis (MS) and Parkinson’s disease (PD) significantly reversed deficits of metabolites linked to energy activity in the brain and resulted in functional improvements.
Children’s Hospital Los Angeles RECOVER Study Collaborators Publish Comprehensive Report on Long COVID Symptoms in Children
Children’s Hospital Los Angeles is one of 10 pediatric sites involved in the nationwide Researching COVID to Enhance Recovery (RECOVER) Initiative, sponsored by the National Institutes of Health to improve the diagnosis, treatment and prevention of long COVID in children.
Study Finds Adolescents with Concussion May Benefit from More Activity Earlier
Researchers at Nationwide Children’s Hospital have found that when it comes to concussion recovery, activity type matters.
Which Antibiotics Best Prevent Infections for Children With Vesicoureteral Reflux?
Children with vesicoureteral reflux often need to take continuous antibiotics to reduce the risk of urinary tract infections (UTIs). But which antibiotics do the best job at preventing these infections?
A Noninvasive Way to Measure Placental Health
A healthy placenta is critical for a healthy baby. But unfortunately, there’s no direct way to measure how well this important organ is working.
What’s on Your Plate?
The Food Pyramid that many of us learned about in school is now ancient history. That old guideline on food groups and servings has been replaced by MyPlate.
Inaugural class of Damon Runyon–St. Jude Pediatric Cancer Research Fellows announced
The initiative aims to provide support for early-career scientists to study pediatric cancer, addressing a funding gap that drives top talent to seek more prevalent opportunities in adult cancer research or the pharmaceutical sector.
Device keeps brain alive, functioning separate from body
Researchers led by a team at UT Southwestern Medical Center have developed a device that can isolate blood flow to the brain, keeping the organ alive and functioning independent from the rest of the body for several hours.
Risk of serious infection even in low-active IBD
IBD patients with low disease activity are still at increased risk of serious infections. Aiming for full intestinal healing may reduce this risk.
Earlier detection of cardiometabolic risk factors for kids may be possible through next generation biomarkers
American Heart Association statement finds potential future measures, reiterates importance of heart-healthy lifestyle from birth through adulthood
Hospital Care for Children Has Shifted from General Hospitals to Children’s Hospitals Over Last 20 Years
Children’s hospital care is now concentrated in fewer locations, because of a shift in children’s care from general hospitals to higher volume children’s specialty centers, and this has important implications for hospital planning and readiness, according to a new study led Michael Steiner, MD, MPH, of UNC Health.
Study reveals how estrogen exerts its anti-diabetic effects
The quintessential female sex hormone estrogen stimulates cells that line blood vessels to deliver insulin to muscles, lowering blood sugar and protecting against Type 2 diabetes, UT Southwestern Medical Center researchers report. The findings, published in Nature Communications, could eventually lead to new therapies for Type 2 diabetes, a disease that affects hundreds of millions of people around the globe and continues to grow more prevalent.
Nationwide Children’s Hospital to Expand Mental and Behavioral Health Research
Nationwide Children’s Hospital has created a new Institute for Mental and Behavioral Health Research, significantly expanding opportunities to seek a better understanding of mental and behavioral health in children and to develop better diagnostics, treatment and preventative strategies.
HMH Physician Awarded $5.6 Million NIH Grant as part of National ECHO Study To Assess Environmental Influences on Health and Development of Children with Disabilities
Dr. Judy Aschner continues her investigations into childhood development
Iron supplements provided in prenatal visits improved outcomes
Giving free prenatal iron supplements to medically underserved pregnant patients rather than only recommending them significantly reduced anemia and postpartum blood transfusions, researchers at UT Southwestern Medical Center and Parkland Health report in a study published in JAMA Network Open.
The Latest in Science and Medical Advancement in Otolaryngology-Head and Neck Surgery to be Presented at AAO-HNSF Annual Meeting
The latest research and advances in otolaryngology-head and neck surgery will be presented in Nashville, Tennessee, during the AAO-HNSF 2023 Annual Meeting & OTO Experience, September 30 – October 4.
Study Shows Nearly 300% Increase in ADHD Medication Errors
In a new study, published in Pediatrics, researchers at the Center for Injury Research and Policy and Central Ohio Poison Center at Nationwide Children’s Hospital investigated the characteristics and trends of out-of-hospital ADHD medication errors among people younger than 20 years old reported to U.S. poison centers from 2000 through 2021.
Children’s Hospital Los Angeles Names Alan S. Wayne, MD, as Pediatrician-in-Chief and Senior Vice President of Academic Affairs
A nationally renowned medical leader, clinician and researcher in cancer and blood diseases, Alan S. Wayne, MD, has been appointed as the Senior Vice President of Academic Affairs and Pediatrician-in-Chief at Children’s Hospital Los Angeles (CHLA), and Chair of the Department of Pediatrics at the Keck School of Medicine of the University of Southern California (USC).
Medical Care publishes article collection on integrating evidence-based programs into clinical practice
As part of its partnership with the Patient-Centered Outcomes Research Institute (PCORI), Medical Care has published its first PCORI-sponsored article collection, which provides specific information about the costs that healthcare systems can expect to incur in promoting the uptake of specific evidence-based programs.
Study tracks Texas youths being treated for depression
Nearly half of Texas youths being treated for depression or suicidal thoughts reported at least one suicide attempt, and 90% had experienced suicidal ideation, according to a study led by UT Southwestern Medical Center researchers.
Study: health equity an important aspect of improving quality of care provided to children in emergency departments
A new multi-site study led by Indiana University School of Medicine found increasing pediatric readiness in emergency departments reduces, but does not eliminate, racial and ethnic disparities in children and adolescents with acute medical emergencies.
Firearm Injuries and the Pandemic: Lower Opportunity Neighborhoods are Disproportionately Affected
In a new study, investigators at Children’s Hospital Los Angeles reveal that children from lower opportunity neighborhoods had a significantly higher rate of firearm-related injury during the pandemic.
New primary care model created to dispense nutrition advice
Expert advice on nutrition delivered to patients electronically saved physicians time, improved patient satisfaction, and was reimbursable by insurance, UT Southwestern Medical Center researchers report.
Obesity plays key role in children’s sleep apnea
Obesity and older age are significant predictors of the severity of obstructive sleep apnea (OSA) in children, researchers at UT Southwestern Medical Center and Children’s Health found. The study is published in Laryngoscope Investigative Otolaryngology.
Medical experts available: Backpack safety, Child Eye Health & Safety Month, preventing injuries in young athletes, and National Breastfeeding Month
As you plan your health coverage for this week and next, Ochsner Health has medical experts on standby to discuss backpack safety as kids head back to school, Child Eye Health & Safety Month, preventing injuries in young athletes, and…
Research pinpoints inflammation source behind atherosclerosis
Scientists at UT Southwestern Medical Center and Children’s Medical Center Dallas have discovered in mice how high cholesterol causes blood vessels to become inflamed, a necessary prerequisite for atherosclerosis – the “hardening of the arteries” responsible for most heart attacks and strokes. The findings, published in Nature Communications, could lead to new interventions to protect against cardiovascular diseases (CVD), the leading cause of death globally.
Wake Forest University School of Medicine Approved for $4.4 Million PCORI Funding Award to Study Telehealth
A team of researchers at Wake Forest University School of Medicine has been approved for a $4.4 million funding award from the Patient-Centered Outcomes Research Institute (PCORI) to assess the benefits of expanding telehealth by primary care physicians to children with complex chronic conditions and their caregivers. The project is a collaboration with Atrium Health Wake Forest Baptist Brenner Children’s in Winston-Salem and Atrium Health Levine Children’s in Charlotte.
Juvenile Arthritis Awareness Month — 10-Year-Old Johns Hopkins Children’s Center Patient’s Journey Living with Juvenile Arthritis
In December 2021, 9-year-old Bryce Lampe of Edgewater, Maryland, began experiencing serious symptoms — a fever, vomiting, diarrhea, and body aches so intense he could barely move, causing him to sleep like a corpse, recalls his mother, Alexandra.
CRI’s Sean Morrison elected to European Molecular Biology Organization
Stem cell biologist Sean J. Morrison, Ph.D., Howard Hughes Medical Institute Investigator and founding Director and Professor of the Children’s Medical Center Research Institute at UT Southwestern (CRI), has been elected by his peers as an associate member of the European Molecular Biology Organization (EMBO).
Public-private consortium will fund three gene therapy clinical trials at UT Southwestern and Children’s Health
A consortium of government, industry, and nonprofit partners will fund gene therapy clinical trials for three different rare diseases at UT Southwestern Medical Center and Children’s Health, where scientists are working on gene therapies to treat neurodevelopmental disorders in children.
As Summer Heats Up, CHOP Researchers Study Caregiver Attitudes Toward Pediatric Vehicular Heatstroke
Despite prevention efforts, a child dies of heatstroke in a vehicle approximately once every 10 days. According to a new survey, most caregivers report they never leave children in their vehicles for any length of time. However, the attitudes toward those who were thought to put their children at risk for pediatric vehicular heatstroke are largely negative, which may cause some caregivers not to adopt important mitigation efforts to prevent these tragic deaths.
Public-private consortium will fund three gene therapy clinical trials at UT Southwestern
A consortium of government, industry, and nonprofit partners will fund gene therapy clinical trials for three rare diseases at UT Southwestern Medical Center, where scientists are working on gene therapies to treat neurodevelopmental disorders in children.
Nationwide Children’s Hospital Marks A Decade as One of the Nation’s Best
Nationwide Children’s Hospital has been named to U.S. News & World Report’s Best Children’s Hospitals Honor Roll for the 10th consecutive year. The Honor Roll is a top distinction awarded to only 10 children’s hospitals nationwide recognized by U.S. News as the “Best of the Best.” Nationwide Children’s is ranked sixth on the 2023-24 Honor Roll list.
Debriefing After Critical Events Combines Review, Reflection
The PICU bereavement/wellness committee at Lurie Children’s Hospital of Chicago developed a tailored debriefing process to allow time for reflection and communication after critical patient events. The process was designed as a hot debriefing to be completed during the current shift, with all staff members who were involved in the event invited to participate.
Mortality high for children whose caregivers decline tracheostomies, UTSW study shows
Forty percent of critically ill children whose parents or other caregivers declined tracheostomies died within 24 months, and half of all deaths occurred within six weeks, researchers at UT Southwestern Medical Center and Children’s Medical Center Dallas found.