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UrduA study led by scientists at Rutgers University-New Brunswick has shown that specialized cells involved in how the body responds to insulin are activated in the brain after exercise, suggesting that physical activity may directly improve brain function. A recent study, published in Aging Cell, a journal focused on the biology of aging, indicates that therapies targeting this insulin action may be developed to offset or even prevent dementia progression.
Tag: Insulin
Precision diabetes management: glucose-triggered insulin delivery membrane
Scientists have developed an innovative glucose-responsive membrane capable of self-regulating insulin release, offering a potential revolution in diabetes management. This cutting-edge material responds to glucose levels by contracting, functioning as an automatic chemical valve that controls insulin delivery.
A new injectable to prevent and treat hypoglycemia
To prevent and treat hypoglycemia, researchers in ACS Central Science report encapsulating the hormone glucagon. In mouse trials, the nanocapsules activated when blood sugar levels dropped dangerously low and quickly restored glucose levels.
Mount Sinai and City of Hope Scientists First to Demonstrate a Combination Treatment Can Increase Human Insulin-Producing Cells in Vivo
Research published in Science Translational Medicine advances therapies to regenerate beta cells as a potential new treatment for diabetes
Algorithm Improves Blood Sugar Control in Hospitalized Patients
Hospitalized patients with complex dietary restrictions often develop hyperglycemia (high blood sugar), leading to serious complications particularly in those with preexisting diabetes. UCSF endocrinologist Robert J. Rushakoff, MD, and his team developed a self-adjusting subcutaneous insulin algorithm (SQIA) for automatically adjusted dosing.
Metformin may be as safe as insulin during pregnancy, 11-year data shows
Metformin is safe to use during pregnancy to manage diabetes, with no long-term adverse effects on the children born and their mothers for at least 11 years after childbirth, according to research presented Sunday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass. This is the first study to look at longer term effects of metformin use during pregnancy.
High insulin levels contribute to worse outcomes for Black women with aggressive form of breast cancer
High insulin levels contribute to worse outcomes for Black women compared to white women who have an aggressive form of breast cancer called triple-negative breast cancer, according to a study presented Sunday at ENDO 2024, the Endocrine Society’s annual meeting in Boston, Mass.
This Outdated Diabetes Drug Still Has Something to Offer
Researchers from UC San Diego have discovered the biochemical workings of an old-fashioned diabetes drug, and it’s helping them develop new, safer alternatives.
Expert available to discuss transgenic cow capable of producing human insulin in milk
A new study in Biotechnology Journal describing a transgenic cow capable of producing human proinsulin and insulin in her milk could have wide-reaching implications for millions of diabetics worldwide. The advancement provides proof-of-concept for a system that would require refinement…
Obesity linked to neurodegeneration through insulin resistance
Researchers led by Mroj Alassaf at the Fred Hutchinson Cancer Research Center in the United States have discovered a link between obesity and neurodegenerative disorders like Alzheimer’s disease.
Study provides preliminary evidence in favor of a new type 1 diabetes treatment
A new study led by researchers at UChicago Medicine and Indiana University suggests that an existing drug could be repurposed to treat type 1 diabetes, potentially reducing dependence on insulin.
High insulin levels directly linked to pancreatic cancer
First detailed explanation of why people with obesity and Type 2 diabetes are at an increased risk of pancreatic cancer
Once-weekly insulin icodec with dosing guide app showed superior HbA1c reduction versus once-daily insulin in phase 3a trial
In the Phase 3a ONWARDS 5 randomized trial, once-weekly insulin icodec titrated with a dosing guide app demonstrated superior reduction in HbA1c levels and similarly low hypoglycemia rates compared with once-daily insulin. The findings are published in Annals of Internal Medicine.
Is Snacking Bad for Your Health? It Depends on What and When You Eat
In a new study involving more than 1,000 people, researchers examined whether snacking affects health and if the quality of snack foods matters.
Too Much Insulin Can Be as Dangerous as Too Little
UC San Diego researchers describe a key player in the defense mechanism that safeguards against excessive insulin in the body, which can be as harmful as too little.
Wonder drug-capsule may one day replace insulin injection for diabetics
Scientists in Melbourne have designed a new type of oral capsule that could mean pain-free delivery of insulin and other protein drugs.
The new insulin price cap: What you need to know
In early March, Eli Lilly made headlines after announcing a new $35 price cap on insulin for individuals with private insurance. Novo Nordisk and Sanofi made their own price reduction announcements shortly after Eli Lilly’s move.
Endocrine Society applauds Eli Lilly’s efforts to lower insulin costs
The Endocrine Society commends Eli Lilly and Company for taking steps to reduce insulin prices and make insulin affordable for more people with diabetes.
Eli Lilly ‘just the first shoe to drop’ in drug cost changes
Drugmaker Eli Lilly and Company announced it would significantly reduce the prices of several of its insulin products and cap patient insulin out-of-pocket costs at $35 per month. Nick Fabrizio, professor of health policy at Cornell University, says this is…
Endocrine Society praises State of the Union attention to insulin affordability
The Endocrine Society applauds President Biden’s call to rein in soaring insulin prices for those with private insurance and urges Congress to take immediate action.
CUVET Successfully Developed the First Stem Cell Transplantation Technology to Treat Pet Diabetes
For the first time in Thailand, a research team from Chula’s Faculty of Veterinary Science (CUVET) is the first to have successfully developed a method to culture dog pancreatic cells from stem cells and cell transplantation technology. They aim to test the method in the lab and sick animals suffering from diabetes.
People with diabetes may benefit more from a pancreas transplant than other treatments
Results of pancreas transplantation continue to improve and up to 90% of recipients with diabetes enjoy freedom from both insulin therapy and the need for close glucose monitoring following the procedure, according to a new paper published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
Alzheimer’s Association Awards Grant to Wake Forest University School of Medicine for Alzheimer’s Research
The Alzheimer’s Association, through its Part the Cloud global research grant program, has awarded Wake Forest University School of Medicine $795,000 over two years to study potential treatments for Alzheimer’s disease.
UCI-led study shows Rhodiola rosea root might be beneficial for managing type 2 diabetes
A team of researchers led by the University of California, Irvine has discovered that treatment with an extract from the roots of the Rhodiola rosea plant might be effective for helping manage type 2 diabetes, showing promise as a safe and effective non-pharmaceutical alternative. The study, recently published online in Scientific Reports, found that in a mouse model of human type 2 diabetes, Rhodiola rosea lowered fasting blood sugar levels, improved response to insulin injections, modulated the composition of bacteria in the gastrointestinal tract and decreased several biomarkers of inflammation.
Endocrine Society celebrates passage of historic insulin affordability measure
The Endocrine Society cheered the Senate’s passage of the Inflation Reduction Act, including meaningful measures to make insulin more affordable.
Study Reverses Long-Held Ideas About Relationship Among Diabetes, Fat and Cardiovascular Disease
In a paper published in Circulation Research, scientists describe a series of studies designed to determine the relationship among insulin, fats and the vascular system.
Vitamin B5 May Help Weight Loss by Turning on Brown Fat
Pantothenate acid, also known as vitamin B5, stimulated the production of brown fat in both cell cultures and mice, a new study finds. “[B5] has therapeutic potential for treating obesity and type II diabetes,” researchers conclude. The study was chosen as an APSselect article for July.
Gut microbe peptide implicated in triggering type 1 diabetes
Researchers have identified a species of human gut bacterium that makes a protein containing a sequence of amino acids that mimics the insulin peptide targeted by the immune system in type 1 diabetes.
Hormone Infusion Improves Pancreatic Insulin Production in Cystic Fibrosis Patients with or at Risk for Diabetes
Medication therapy based on the hormone glucagon-like peptide-1(GLP-1) may help regulate natural insulin production in cystic fibrosis, potentially offering a better way to prevent and ultimately manage diabetes than daily insulin injections
Cold temps may help to combat obesity and related metabolic diseases by reducing inflammation, researchers find
Researchers report that exposure to cold temperatures resolved obesity-induced inflammation while improving insulin sensitivity and glucose tolerance in diet-induced obese mice.
Endocrine Society urges Congress to pass bill to make insulin more affordable for people with diabetes
The Endocrine Society announces its endorsement of the bipartisan insulin bill introduced by Sens. Jeanne Shaheen (D-NH) and Susan Collins (R-ME) that would take steps to reduce out-of-pocket costs of insulin, the escalating price of insulin, and formulary management for people with diabetes.
Helping the body make more insulin
Aresearch team is testing a protein block to suppress specific cells of the body’s immune system contribute to developing type 1 diabetes. If successful, the drug would diminish autoimmunity, preserving the body’s ability to naturally produce more insulin, the researchers said.
Increased fracture risk in patients using insulin compared to metformin
Patients with type 2 diabetes have an increased risk for fractures, despite their normal-to-high bone mineral density, according to research being presented Saturday, June 11 at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga.
Key Protein Identified for Brain Stem Cell Longevity
A receptor that was first identified as necessary for insulin action, that also is located on the neural stem cells found deep in the brains of mice, is pivotal for brain stem cell longevity, according to a Rutgers study, a finding that has important implications for brain health and future therapies for brain disorders.
High Blood Insulin Levels Lead to More Nervous System Activity in Muscles
Article title: Role of the arterial baroreflex in the sympathetic response to hyperinsulinemia in adult humans Authors: Neil J. McMillan, Rogerio N. Soares, Jennifer L. Harper, Brian Shariffi, Alfonso Moreno-Cabañas, Timothy B. Curry, Camila Manrique-Acevedo, Jaume Padilla, Jacqueline K. Limberg…
Insulin spray improved gait, cognitive function in patients with and without type 2 diabetes, clinical trial shows
Scientists have assessed the long-term effects of intranasal insulin on cognition and on gait in people with and without type 2 diabetes mellitus.
Endocrine Society celebrates House passage of Build Back Better Act
The Endocrine Society hailed the House of Representatives for including provisions to improve insulin affordability in its version of the Build Back Better Act.
Physiologists Celebrate 100 Years of Insulin
This year marks 100 years since physiologists discovered insulin. The lifesaving drug has given millions of people with diabetes worldwide a second chance at life.
Physiologists Celebrate 100 Years of Insulin
This year marks 100 years since physiologists discovered insulin. The lifesaving drug has given millions of people with diabetes worldwide a second chance at life. APS is making available several of the leading experts in the field of endocrinology to…
Lowering blood insulin levels could lower your risk of getting COVID-19
Keeping blood insulin levels within strict, healthy parameters is a daily goal for people with diabetes.
A Cure for Diabetes?
Technion researchers are working on a novel treatment approach for treating type 2 diabetes using an autograft of muscle cells engineered to take in sugar at increased rates. Mice treated in this manner displayed normal blood sugar levels for months after a single procedure.
$6M NIH Grant Launches UC San Diego Consortium to Study Insulin-Producing Cells
UC San Diego School of Medicine researchers will receive $6.4 million in National Institutes of Health grant funding to study how external signals and genetic variations influence the behavior of one cell type in particular: insulin-producing beta cells in the pancreas.
Diabetes experts available to discuss 100 years of insulin
2021 marks the centennial of the discovery of insulin at the University of Toronto. Drs. William Rostène and Pierre De Meyts just published an article that explores the history of insulin, and they are both available to discuss the importance of…
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Wednesday.
Lifestyle Interventions to Reduce Blood Sugar: Don’t Forget Resistance Exercise
In the past 30 years, prediabetes (elevated fasting or post-meal blood sugar below the levels required for diagnosis of type 2 diabetes) has grown into a major epidemic affecting nearly one in three adults. Previous studies have shown that combining…
Endocrine Society calls on Congress to pass legislation to lower the price of insulin
The Endocrine Society is calling on Congress to pass legislation to lower the price of insulin and applauds the efforts of Energy and Commerce Committee Chairman Frank Pallone Jr. (D-NJ), Ways and Means Committee Chairman Richard E. Neal (D-MA), and Education and Labor Committee Chairman Robert C. “Bobby” Scott (D-VA) to reintroduce H.R. 3, the Elijah E. Cummings Lower Drug Costs Now Act to improve access to affordable medications. In January, the Society published a position statement on insulin access and affordability, which recommends policymakers include government negotiation as part of an overall strategy to reduce insulin prices.
Once-A-Week Insulin Treatment Could Be Game-Changing For Patients With Diabetes
DALLAS – April 19, 2021 – Treating people with Type 2 diabetes with a new once-a-week injectable insulin therapy proved to be safe and as effective as daily insulin injections, according to the results of two international clinical trials published online today in Diabetes Care. The studies suggest that the once-weekly treatment could provide a convenient alternative to the burden of daily insulin shots for diabetes patients.
Experts mark the centennial anniversary of the discovery of insulin by highlighting the critical role adipose tissue has played in understanding insulin’s control of metabolism.
2021 marks 100 years since researchers identified insulin, a hormone produced by the pancreas that regulates the amount of glucose, or sugar, in the blood. Soon after, insulin was shown to be effective in lowering blood glucose in humans with…
Weekly insulin helps patients with type 2 diabetes achieve similar blood sugar control to daily insulin
A new once-weekly basal insulin injection demonstrated similar efficacy and safety and a lower rate of low blood sugar episodes compared with a daily basal insulin, according to a phase 2 clinical trial. The study results, which will be presented at ENDO 2021, the Endocrine Society’s annual meeting, compared an investigational drug called basal insulin Fc (BIF) with insulin degludec, a commercially available long-lasting daily insulin, in patients with type 2 diabetes.
USDA grant seeks to enhance milk production and cow health
An animal scientist studying relationships between insulin and milk production in dairy cows has received a three-year, $500,000 grant from the U.S. Department of Agriculture National Institute of Food and Agriculture.