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UrduBACKGROUNDWe investigated the efficacy of intra-articular injection of human umbilical cord mesenchymal stem cells (hUC-MSCs) for the treatment of osteoarthritis (OA) progression in the knee joint. Although many experimental studies of hUC-
Tag: Osteoarthritis
Tool Listens in on Early Osteoarthritis Biochemical Communication in Joints
New research in FASEB BioAdvances reveals that a fluorescent dye could help scientists listen to biochemical conversations between cartilage and bone during the earliest stages of osteoarthritis—even before the disease causes pain.
Spinning artificial spider silk into next-generation medical materials
Scientists reporting in ACS Nano have made their own version of fake spider silk, but this one consists of proteins and heals wounds instead of haunting hallways. The artificial silk is strong enough to be woven into bandages that helped treat joint injuries and skin lesions in mice.
Adding oral methotrexate to care reduces pain in knee osteoarthritis
A randomized, placebo-controlled trial found that oral methotrexate added to usual analgesia care showed statistically significant reduction in knee osteoarthritis pain at 6 months, with improvements also noted in some secondary outcomes.
College of Medicine launching $6 million study of physical function in seniors
Penn State College of Medicine has been awarded nearly $6 million from the Patient-Centered Outcomes Research Institute to study approaches to encourage the use of the SilverSneakers benefits by seniors with osteoarthritis.
Additional comments on extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis
Recently, we read an article published by the Yang et al. The results of this study indicated that engineered exosomes loaded with microRNA-29a (miR-29a) alleviate knee inflammation and maintain extracellular matrix stability in Sprague Daw
UCLA Health awarded up to $12.3 million as part of a federally funded moonshot effort to develop new treatments for osteoarthritis
UCLA Health is part of a multi-institution research team to receive a contract for up to $33 million from the federal Advanced Research Projects Agency for Health (ARPA-H) for the development of new treatments specifically focused on joint regeneration for osteoarthritis.
Lipogems Announces Last Patient Enrolled in the U.S FDA IDE Arise Study for the Treatment of Knee Osteoarthritis
Lipogems Announces Last Patient Enrolled in the U.S FDA IDE Arise Study for the Treatment of Knee Osteoarthritis
Case Western Reserve University awarded federal contract to develop and commercialize ‘live’ replacement joints
A research team led by Case Western Reserve University will begin work on engineering, growing and commercializing “live” replacement joints to treat degenerative joint disease knowns as osteoarthritis (OA).
Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a
BACKGROUNDKnee osteoarthritis (KOA) is a common orthopedic condition with an uncertain etiology, possibly involving genetics and biomechanics. Factors like changes in chondrocyte microenvironment, oxidative stress, inflammation, and immune
Nonsurgical treatment of thumb arthritis shows lasting benefits
Initial nonsurgical treatment, including the use of orthotics and exercise therapy, provides satisfactory long-term outcomes for patients with osteoarthritis of the thumb carpometacarpal joint (CMC-1 OA)– with a low rate of conversion to surgery, reports a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.
Common blood pressure medications linked to lower risk of total knee replacement
Among patients with knee pain, those who take a widely used class of blood pressure-lowering medications called beta-blockers appear to have a lower risk of total knee arthroplasty (TKA) for the treatment of advanced osteoarthritis (OA), suggests a study in The Journal of Bone & Joint Surgery.
MEDIA ADVISORY: Cedars-Sinai Experts Available to Discuss Safety, Benefits of Using Medications to Lose Weight
The science is unclear on exactly why an increasingly popular new class of federally approved diabetes and obesity medications work, but they do know that they are effective at helping people lose weight.
NHS policies on patient’s weight and access to hip replacement surgery are inappropriate, study finds
Weight and body mass index (BMI) policies introduced by NHS commissioning groups in England are inappropriate and worsening health inequalities, according to a new study published in BMC Medicine today [13 June] that analysed nearly 490,000 hip surgeries. With one in ten people likely to need a joint replacement in their lifetime, many thousands of patients are directly affected by these policies.
Composition of Joint Lubricant Potential Culprit Behind Osteoarthritis
The exact mechanism of cartilage breakdown in osteoarthritis is unknown, but damage from mechanical stress with insufficient self-repair is believed to be the main culprit. The composition of synovial fluid, or joint lubricant, changes significantly: The concentration and molecular weight of hyaluronic acid tends to decrease. In Biointerphases, researchers explore the disease-driven breakdown of hyaluronan and the mechanistic implications of these changes on the lubrication and subsequent wear of joints.
New Guideline Introduces Recommendations for Optimal Timing of Elective Hip or Knee Arthroplasty
The ACR and the American Association of Hip and Knee Surgeons (AAHKS) released a summary of its new guideline titled “the Optimal Timing of Elective Hip or Knee Arthroplasty for Patients with Symptomatic Moderate to Severe Osteoarthritis or Osteonecrosis Who Have Failed Nonoperative Therapy.”
New drug offers hope for people with hand osteoarthritis
Tonia Vincent, Professor of Musculoskeletal Biology & Honorary Rheumatologist at Oxford’s Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), said: ‘Hand osteoarthritis is a common and debilitating medical condition that affects mainly women, especially around the time of the menopause.
Quarter of former Olympians suffer from osteoarthritis, study says
One in four retired Olympians reported a diagnosis of osteoarthritis, the form of arthritis that causes changes in the joint and can lead to discomfort, pain and disability, the research found.
Poll: Aching joints make older adults reach for many forms of pain relief – but health risks could follow
Popping a pill may bring short-term relief for arthritis-related joint pain, but many older adults may not realize that what they swallow could raise their risk of other health problems, or that other non-drug options could help them, a new poll suggests.
MECHANISM OF ACTION OF A MULTI-HERBAL EXTRACT BLEND (KARALLIEF ® EASY CLIMB ®) IN SUPPORTING JOINT HEALTH
A new herbal extract blend, Karallief ® Easy Climb ® (KEC) showed promising results in addressing Osteoarthritis (OA) by helping rebuild the joint connective tissue. The product goes beyond just addressing the symptoms of OA – reducing pain and inflammation.…
Lipofilling procedure improves pain and function in finger osteoarthritis
For patients with painful finger osteoarthritis, a nonsurgical procedure called lipofilling – in which fat obtained from another part of the body is transferred into the arthritic joints – produces lasting improvements in hand function and especially pain, suggests a study in the May issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
AMSSM Releases Position Statement on Regenerative Medicine in Sports Medicine
The American Medical Society for Sports Medicine (AMSSM) has released a position statement on Principles for the Responsible Use of Regenerative Medicine in Sports Medicine.
Corticosteroid injections of hip linked to ‘rapidly destructive hip disease’
Corticosteroid injections are a common treatment option for pain and inflammation in patients with osteoarthritis of the hip. But a new study adds to concerns that hip steroid injections may lead to increased rates of a serious complication called rapidly destructive hip disease (RDHD), according to a paper in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.
Cartilage Resurfacing Implant Reduces Pain, Restores Hip Joint Function in Dogs
A textile-based implant containing cartilage derived from stem cells reduced pain and restored hip joint function to baseline levels in a study of dogs with symptoms of moderate osteoarthritis.
Balance between sleep and exercise may be key to help osteoarthritis patients manage pain
Researchers at Michigan Medicine are creating a hybrid sleep-exercise intervention to mitigate osteoarthritis-related pain.
Modified Nanoparticles Can Stop Osteoarthritis Development
After a team of researchers showed that a certain enzyme’s presence in cartilage increased significantly in people with osteoarthritis, they targeted it with specially-loaded nanoparticles that stopped the disease’s progression in its tracks.
Good sleep is just what doctor ordered
In a study released Feb. 22 in JAMA Internal Medicine researchers found that six 20-minute telephone calls over eight weeks coaching participants on how to get better sleep improved their sleep, pain, and daytime function. The improvements in sleep and daytime function persisted 12 months after treatment. One of the lead investigators who has been researching age and sleeping for 40 years offers great tips on getting better sleep. Just because you are aging, does NOT mean your sleep needs to get worse.
Lin Han, PhD, receives 2021 Kappa Delta Young Investigator Award for the study of cartilage function, regeneration and disease intervention in osteoarthritis
The 2021 Kappa Delta Young Investigator Award was presented to Lin Han, PhD, for research on the structure and function of cartilage extracellular matrix (ECM) and its impact on tissue regeneration and disease evolution in osteoarthritis (OA).
Common anti-depressant may be first-ever treatment for osteoarthritis
In a new study, scientists have discovered the cellular pathway that leads to osteoarthritis and have identified a commonly used anti-depressant — paroxetine — that inhibits this pathway.
Do antidepressants help back pain and osteoarthritis?
Antidepressants are commonly used worldwide to treat pain, however new research from the University of Sydney shows they offer little to no help for people suffering chronic back pain and osteoarthritis and may even cause harm.
Target Discovered That Halts Osteoarthritis-Like Knee Cartilage Degeneration
In a mouse study, researchers used nanotechnology and previous knowledge of a protein pathway to significantly reduce knee cartilage degeneration and pain
What’s the ‘true’ rate of dislocation after total hip replacement?
The cumulative incidence of hip dislocation following total hip replacement is about 50 percent higher than suggested by simple analysis of hospital data, reports a study in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.
Warfarin Use Significantly Increases Risk of Knee and Hip Replacement in People with OA
New research presented at ACR Convergence, the American College of Rheumatology’s annual meeting, shows that use of warfarin, a vitamin K drug widely prescribed to prevent blood clots, is associated with a significantly greater risk of knee and hip replacements in patients with osteoarthritis.
Steroid Injections Do Not Hasten the Need for Knee Replacement When Compared to Hyaluronic Acid Treatments for Adults with Knee OA
New research shows that corticosteroid injections for knee OA treatment do not hasten a patient’s progression to a total knee replacement when compared with hyaluronic acid injections. Details of this study was presented at ACR Convergence, the American College of Rheumatology’s annual meeting.
Osteoarthritis biomarker could help 300 million people worldwide
University of South Australia researchers are a step closer to finding a new biomarker for osteoarthritis, a painful condition which affects more than 300 million people worldwide.
‘Incredibly generous’ $25 million donation to create the Schroeder Arthritis Institute at UHN, consolidating research, education and patient care under one global brand
One in five Canadian adults is currently living with arthritis, a disease causing inflammation of the joints, which can result in chronic, debilitating pain, reduced mobility and premature disability. Arthritis is the leading cause of disability globally. To address this growing crisis, the Schroeder Arthritis Institute, launched with a $25 million donation by philanthropists Walter and Maria Schroeder, will help UHN’s innovative arthritis program become a world-class hub for innovation in research, education and patient care.
Artificial Intelligence Detects Osteoarthritis Years Before it Develops
Researchers have created a machine-learning algorithm that can pick up on subtle signs of osteoarthritis – too abstract to register in the eye of a trained radiologist – on an MRI scan taken years before symptom onset.
NEW APPROACH TO TREATING OSTEOARTHRITIS ADVANCES
Injections of a natural “energy” molecule prompted regrowth of almost half of the cartilage lost with aging in knees, a new study in rodents shows.
Excess coffee consumption a culprit for poor health
Cappuccino, latte or short black, coffee is one of the most commonly consumed drinks in the world. But whether it’s good or bad for your health can be clarified by genetics, as a world-first study from the University of South Australia’s Australian Centre for Precision Health shows that excess coffee consumption can cause poor health.
CAREER Award Supports Research to Deepen Understanding of Osteoarthritis
Deva Chan, an assistant professor of biomedical engineering at Rensselaer Polytechnic Institute, is leading a team that will study the role that biomechanics plays in the production and function of hyaluronan in an effort to learn more about the factors that affect joint health and osteoarthritis. This research is being supported by a National Science Foundation Faculty Early Career Development (CAREER) Program Award.
Osteoarthritis: How running actually can help
Not running or jogging because you think it worsens or increases your risk for osteoarthritis?
Collaboration reveals potential new therapy for osteoarthritis
Osteoarthritis affects 240 million people worldwide and is one of the most common causes of disability in both humans and animals. Currently, no therapeutics exist to prevent this disease, but recent multidisciplinary research at Cornell reveals that the application of a proprietary peptide known as SS-31 may protect cartilage from the injury that leads to arthritis.
Better Biosensor Technology Created for Stem Cells
A Rutgers-led team has created better biosensor technology that may help lead to safe stem cell therapies for treating Alzheimer’s and Parkinson’s diseases and other neurological disorders. The technology, which features a unique graphene and gold-based platform and high-tech imaging, monitors the fate of stem cells by detecting genetic material (RNA) involved in turning such cells into brain cells (neurons), according to a study in the journal Nano Letters.
While there’s no cure for osteoarthritis, its symptoms can be managed
Osteoarthritis can produce joint pain and stiffness sufficient to limit and even prohibit the performance of everyday tasks. It becomes more common with age, once it starts it typically gets worse and there’s no known cure. But there are therapies that can relieve pain and maintain joint function.