The Search for a Biological Link between Reactivated HSV and Neurological Disease

New research data in the journal PLoS Pathogens suggests that reactivated HSV in trigeminal nerves of laboratory mice kills off at least a portion of sensory neurons. The findings provide additional evidence that as humans get older, the long-term consequences of HSV infection in the nervous system can accumulate and cause neurological damage.

Multi-sensor Band Quickly and Simply Records Subtle Changes in Patients with MS

An international team of scientists, led by UC San Diego researchers, has developed a new, multi-sensor tool that measures subtle changes in multiple sclerosis patients, allowing physicians to more frequently and more quickly respond to changes in symptoms or patient condition.

Validating NIH Toolbox to help evaluate cognitive processing in people with intellectual disability

Cognitive processing in people with intellectual disability can now be accurately assessed thanks to UC Davis Health researchers who updated and validated series of tests, part of the NIH Toolbox Cognitive Battery.

New Research Links Genetics and MS Severity, Offers Innovative Treatment Ideas to Combat MS and Other Neurodegenerative Diseases

Dr. Peter Calabresi, professor of Neurology and Neuroscience at the Johns Hopkins School of Medicine and Director of the Johns Hopkins Multiple Sclerosis (MS) Center, will present his team’s discovery of a possible link between severe damage and C3 and C1q gene variants, and how this information could lead to improvements in the ways MS and other neurodegenerative diseases are treated, during his keynote Kenneth P. Johnson Memorial Lecture on the opening day of the Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum 2020.

Bridging the gap between AI and the clinic Rapprocher l’IA de la pratique clinique

Researchers trained machine learning algorithms on data from more than 62,000 patients with a meningioma. Their goal was to find statistical associations between malignancy, survival, and a series of basic clinical variables including tumour size, tumour location, and surgical procedure.

Des chercheurs ont entraîné des algorithmes d’apprentissage automatique à partir des données de plus de 62 000 patients ayant un méningiome. L’objectif était de déceler des associations statistiques entre la malignité, le temps de survie et d’autres variables cliniques de base telles que la taille de la tumeur, son emplacement et la nature de l’intervention chirurgicale effectuée.

AI-analyzed blood test can predict the progression of neurodegenerative disease

Evaluating the effectiveness of therapies for neurodegenerative diseases is often difficult because each patient’s progression is different. A new study shows artificial intelligence (AI) analysis of blood samples can predict and explain disease progression, which could one day help doctors choose more appropriate and effective treatments for patients.

Opioid Dependence Found to Permanently Change Brains of Rats

Approximately one-quarter of patients who are prescribed opioids for chronic pain misuse them, with five to 10 percent developing an opioid use disorder or addiction. In a new study, UC San Diego researchers found that opioid dependence produced permanent changes in the brains of rats.

Objective Subtle Cognitive Difficulties Predict Amyloid Accumulation and Neurodegeneration

Researchers report that accumulating amyloid protein occurred faster among persons deemed to have “objectively-defined subtle cognitive difficulties” (Obj-SCD) than among persons considered to be “cognitively normal,” offering a potential new early biomarker for Alzheimer’s disease.

What Comes First, Beta-Amyloid Plaques or Thinking and Memory Problems?

The scientific community has long believed that beta-amyloid, a protein that can clump together and form sticky plaques in the brain, is the first sign of Alzheimer’s disease. Beta-amyloid then leads to other brain changes including neurodegeneration and eventually to thinking and memory problems. But a new study challenges that theory. The study suggests that subtle thinking and memory differences may come before, or happen alongside, the development of amyloid plaques that can be detected in the brain. The study is published in the December 30, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Mount Sinai Researchers Uncover New Molecular Drivers of Parkinson’s Disease

New Approach Will Lead to a Better Understanding of Most Cases

ICU Survivors Commonly Experience Job Loss after Critical Illness, Study Confirms

National attention has been drawn to the plight of patients who have experienced the unintended side effects of prolonged ICU care such as memory loss and muscle weakness. Now, a research team led by UC San Diego have evaluated the employment impacts to ICU patients, with concerning findings.

A Rare Diagnosis Leads to a Successful Surgery and Recovery

Drew, a 65-year-old man from Connecticut, was diagnosed with a spinal dural arteriovenous fistula (SDAVF), which is a rare vascular malformation of the spinal cord that only affects 1 in every 200,000 people.

SDAVFs are underdiagnosed because symptoms can be vague and mirror many other types of medical problems. If left untreated, SDAVFs can result in permanent spinal cord injury.

Despite the uncommon diagnosis, a multidisciplinary care team from Nuvance Health, including primary care, neurology, radiology, and neurosurgery correctly and expeditiously identified and surgically treated Drew’s SDAVF.

Dial In to the Cutting-edge Neuroscience at ANA2019 during the October 15 Media Roundtable

In a media roundtable at 11 a.m. U.S. Central on Tuesday, October 15, leading neuroscientists will summarize key science being presented at the American Neurological Association’s 2019 Annual Meeting (ANA2019). Reporters may attend in person or dial in.

Kim Campbell, Alzheimer’s disease advocate and widow of music legend Glen Campbell, to keynote ANA2019 October 13

WHO: Kim Campbell, Alzheimer’s disease advocate and widow of Grammy Hall of Fame and Award-winning music legend Glen Campbell; and ANA President David Holtzman, MD, ANA President, Professor and Chairman of the Department of Neurology at the Washington University School…

Researchers Identify Metabolic Cycles in Baby Teeth Linked to ADHD and Autism in Children

Mount Sinai researchers have identified elemental signatures in baby teeth that are unique to attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, and cases when both neurodevelopment conditions are present, which suggests that the metabolic regulation of nutrients and toxins play a role in these diseases, according to a study published in Translational Psychiatry in September.

Multi-institutional team to study effects of age, gender on brain injury mechanics

A team of researchers, led by Philip V. Bayly in the McKelvey School of Engineering at Washington University, plans to use MRI to study the brains of healthy, uninjured individuals to create models of brain motion to enable the researchers to predict the chronic effects of repeated head impacts in both men and women.

Single protein plays important dual transport roles in the brain

Edwin Chapman of the Howard Hughes Medical Institute and the University of Wisconsin–Madison reports that halting production of synaptotagmin 17 (syt-17) blocks growth of axons. Equally significant, when cells made more syt-17, axon growth accelerated. A wide range of neurological conditions could benefit from the growth of axons, including spinal cord injuries and some neurodegenerative diseases.

Carroll, Kalanithi, Kearns Goodwin, Skloot, Stephens, Vedantam, and Zimmer Headline the 2019 CNS Annual Meeting

An inspiring lineup of guest speakers will address thousands of leading neurosurgeons from around the world at the Congress of Neurological Surgeons 2019 Annual Meeting in San Francisco, California on October 19–23. The chosen speakers are known for their leadership and expertise in healthcare, science, and journalism.

Mount Sinai Ranked Among the Top in the Nation by U.S. News & World Report

The Hospital was ranked No. 14 nationally, up four spots from last year. Eight departments within the Hospital were ranked among the top 20 nationally in their specialties, up from five last year

Infectious Diseases Society of America (IDSA)

Public Comment Period for IDSA/AAN/ACR Draft Lyme Disease Guidelines Open Through Aug. 10

The Infectious Diseases Society of America (IDSA), the American Academy of Neurology (AAN), and the American College of Rheumatology (ACR) have opened a public comment period for the draft of their joint guidelines for the prevention, diagnosis, and treatment of Lyme disease.…