English
Arabic
Chinese (Simplified)
Dutch
Esperanto
French
German
Greek
Italian
Japanese
Korean
Portuguese
Russian
Spanish
UrduPatients with metastatic colorectal cancer (mCRC) harboring BRAF V600E mutations benefitted from first-line treatment with the targeted therapies encorafenib and cetuximab plus a mFOLFOX6 chemotherapy regimen, according to results from the Phase III BREAKWATER trial led by researchers at The University of Texas MD Anderson Cancer Center.
Tag: Colorectal Cancer
Blood test could guide use of anti-inflammatory drug celecoxib to reduce risk of colon cancer recurrence
A data analysis from a randomized clinical trial for stage 3 colon cancer patients by investigators at Dana-Farber Brigham Cancer Center found that patients with evidence of residual cancer in their blood after surgery to remove the cancer, may benefit from adding of celecoxib, to post surgery treatment.
Sylvester Cancer Tip Sheet for Dec. 2024
Coping with grief and holiday sadness; “biological age” as a tool to predict early colorectal cancer, genetic mutations accumulate in smokers with MDS, two clinical trials show promise for an antibody to treat high-risk form of lymphoma, and more.
Social Risks Impede Cancer Screening, Even with Access to Care
Researchers at UC San Diego and collaborating organizations have revealed disparities in cancer screening rates for individuals with social risks, even when patients have regular access to care through a community health center.
ACS Study Finds Early-Onset Colorectal Cancer Cases Surge Globally
A new study led by American Cancer Society (ACS) researchers shows that early-onset colorectal cancer (CRC) incidence rates are rising in 27 of 50 countries/territories worldwide, 20 of which have either exclusive or faster increases for early-onset disease. In 14 countries, including the United States, rates are increasing in young adults while stabilizing in those 50 years and older. The research is published today in the journal The Lancet Oncology.
Using ‘Biological Age’ to Predict Early Colorectal Cancer Risk
New research suggests that one’s biological age, which can be higher than his or her chronological age may predict who’s at risk for developing colon polyps, a known risk factor for colorectal cancer.
MD Anderson and AmMax Bio announce agreements to advance development of AMB-066 in colorectal cancer patients with minimal residual disease
MD Anderson and AmMax Bio announced agreements to develop and advance AmMax’s AMB-066 monoclonal antibody therapy for colorectal cancer with minimal residual disease.
Tackling tough cancers: the dual-targeted attack on metastatic colorectal cancer
Scientists are making waves with a novel therapy for metastatic colorectal cancer (mCRC) that combines two powerful antibodies—one targeting epidermal growth factor receptor (EGFR), the other programmed cell death 1 (PD-1). This dual treatment aims to supercharge the immune system, showing early signs of improving survival and response rates. For patients with no other treatment options, this breakthrough offers a glimmer of hope, potentially changing the trajectory of their fight against cancer.
More Cancers Are Being Treated with Personalized Therapies Before Surgery
The first-ever annual report from the American College of Surgeons National Cancer Database includes in-depth data on adult cancer diagnoses and treatment trends.
ASTRO issues update to clinical guideline on radiation therapy for rectal cancer
The American Society for Radiation Oncology (ASTRO) issued today an updated clinical guideline for physicians who use radiation therapy to treat patients with locally advanced rectal cancer. This update incorporates new data on patient selection and best practices from several practice-changing clinical trials published since the prior guideline was issued in 2020.
Tips to make colonoscopy bowel prep easier
For many people, one of the most uncomfortable parts of a colonoscopy is the preparation for the procedure.
Novel blood-based screening for colorectal cancer less effective, less cost-effective compared to colonoscopies or stool tests
A projected impact and cost-effectiveness analysis estimated reductions in colorectal cancer (CRC) incidence and mortality with novel blood-based and stool-based CRC screening tests versus established alternatives.
For Younger Adults, a Colorectal Cancer Diagnosis Impacts Their Lives Much Differently Than Older Adults
Younger adults with colon cancer tend to be diagnosed at a later stage and have more aggressive types of tumors. Additionally, young patients living with colorectal cancer have long-term, adverse consequences on their lives, which are different from the impact the disease* has on older adults, according to two studies being presented at the American College of Surgeons (ACS) Clinical Congress 2024 in San Francisco, California.
Researchers receive grant to boost colorectal cancer screening follow-up in underserved communities
Researchers from the UCLA Health Jonsson Comprehensive Cancer Center were awarded a $3 million grant from the National Institutes of Health to improve follow-up care for colorectal cancer screening in underserved populations.
MD Anderson Research Highlights for October 2, 2024
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
MD Anderson Research Highlights for September 19, 2024
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Researchers awarded $1.14M to use artificial intelligence to determine best rectal cancer treatment strategy
Case Western Reserve University and the Louis Stokes Cleveland VA Medical Center have been awarded a $1.14M grant from the U.S. Department of Veterans Affairs to use artificial intelligence (AI) to determine the best personalized treatment for Veterans with rectal cancer.
New study links ‘forever chemical’ PFOS with colorectal cancer
A recent University of Kentucky Markey Cancer Center study sheds light on how the environmental pollutant perfluorooctanesulfonic acid (PFOS) may affect our intestines and possibly increase the risk of developing colorectal cancer.
Researchers find substantial variations in performance characteristics between fecal immunochemical tests
A comparative performance study of 5 commonly used fecal immunochemical tests (FIT) found substantial variations in performance characteristics between tests.
Targeting the uncommon: advances in detecting and treating rare genetic variants of colorectal cancer
Recent research highlights the importance of targeted therapies for treating advanced colorectal cancer (CRC) with rare genetic variants. These mutations, often linked to poor prognosis and limited response to conventional treatments, are being addressed through advanced sequencing technologies and new targeted drugs. This study explores the clinical diagnosis and treatment strategies tailored to these unique genetic profiles.
MD Anderson Research Highlights for August 21, 2024
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Cleveland Clinic study reveals diet as main risk factor for colon cancer in younger adults
A new Cleveland Clinic study has identified diet-derived molecules called metabolites as main drivers of young-onset colorectal cancer risk, especially those associated with red and processed meat. The NPJ Precision Oncology report, which analyzed metabolite and microbiome datasets, highlighted that one of the best ways a younger (<60 years) adult can prevent colorectal cancer is to discuss their diet with their doctor.
Cleveland Clinic-led Research Identifies Priority Zones That May Help Improve Colorectal Cancer Screening Among Hispanic/Latino Individuals
Cleveland Clinic-led research has identified geographic areas in the United States where strategic efforts to promote colorectal cancer screening could help reduce healthcare gaps affecting Hispanic/Latino communities. The study, published in the American Journal of Public Health, marks a first step toward conducting larger neighborhood-level studies addressing disparities in colorectal cancer screening.
MD Anderson and Summit Therapeutics announce strategic collaboration to accelerate development of ivonescimab
MD Anderson and Summit Therapeutics announced a strategic five-year collaboration to accelerate the development of ivonescimab, a novel PD-1/VEGF bispecific antibody.
Researchers report first effective use of immunotherapy for most common subtype of colorectal cancer
These clinical trial results point to the first safe and effective use of immunotherapy for patients with microsatellite stable colorectal cancer, the most common subtype of the disease. The encouraging results of this phase I trial have prompted Dana-Farber investigators to move forward with a phase III trial of this immunotherapy combination.
The Harvey L. Neiman Health Policy Institute Launches Cancer Equity Compass
The Harvey L. Neiman Health Policy Institute announces the public launch of a new online tool that reveals the overlap between cancer disparities and social determinants of health (SDOH) using advanced heat maps of U.S. counties. The Cancer Equity Compass can identify high-opportunity targets for policies and programs to achieve equitable health outcomes in underserved populations.
Offering Both Colonoscopy and At-Home Tests Doubled Colorectal Cancer Screening
In a trial analyzing how messages were framed in an underserved population, offering colorectal cancer screening options resulted in the highest screening rate
Researchers Engineer Yeast to Transport Medicines and Lower Inflammation for Potential Treatment of Inflammatory Bowel Disease
Researchers at the UNC Eshelman School of Pharmacy and the UNC School of Medicine have engineered a probiotic yeast that enhances probiotic absorption in the gut and has the ability to suppress and even reverse inflammation in animals.
Tip Sheet: Funding awarded to two ovarian cancer research projects, progress towards liquid biopsies for lung cancer — and cannabis and alcohol use in patients
Below are summaries of recent Fred Hutch Cancer Center research findings, patient stories and other news.
MD Anderson Research Highlights for April 24, 2024
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
New research from Case Western Reserve University aims to block tumor growth in colorectal cancer patients
Researchers at Case Western Reserve University’s School of Medicine believe they have found information that could lead to developing new treatment options for people with metastatic colorectal cancer.
AACR: Combination treatment is well-tolerated, shows antitumor effects in KRAS G12C-mutated metastatic colorectal cancer
Combining the KRAS G12C inhibitor adagrasib with the anti-EGFR antibody cetuximab demonstrated promising anti-tumor effects in patients with KRAS G12C-mutated metastatic colorectal cancer (CRC), according to pooled results from the Phase I/II KRYSTAL-1 trial reported by researchers from The University of Texas MD Anderson Cancer Center.
Tip Sheet: Weight loss drugs and cancer prevention, Fred Hutch at AACR, lymphedema Q&A — and new vice president and chief nursing officer
SEATTLE — April 3, 2024 — Below are summaries of recent Fred Hutchinson Cancer Center research findings, patient stories and other news. If you’re covering the American Association for Cancer Research (AACR) Annual Meeting, please see our list of and contact to set up interviews.
Yale Cancer Center Experts, Scientists to Share Vision and Research at Leading Conference
The five-day session (April 5-10), themed as “Inspiring Science. Fueling Progress. Revolutionizing Care,” will include new findings from Yale Cancer Center researchers.
Combining epigenetic cancer medications may have benefit for colorectal cancers and other tumor types
A pair of medications that make malignant cells act as if they have a virus could hold new promise for treating colorectal cancers and other solid tumors, reports a study published today in Science Advances.
Musicians Colbie Caillat, Lisa Loeb, Rufus Wainwright, Hilary Hahn, and More Support Colorectal Cancer Awareness in Free Webcast Concert
The American College of Gastroenterology Free Virtual Event on March 28, 2024, at 8:00 pm ET, “Tune It Up: A Concert To Raise Colorectal Cancer Awareness”
Blood Test Shows Promise for Early Detection of Colorectal Cancer
A recent study published in the New England Journal of Medicine reports a DNA blood-based test that identified 83% of patients with colorectal cancer. This test is showing promise as a new option for colorectal cancer screening. Samir Gupta, MD,…
Hackensack Meridian Jersey Shore University Medical Center Welcomes Dr. Lee Peng as Chief of Gastroenterology
Hackensack Meridian Jersey Shore University Medical Center welcomed Lee F. Peng, M.D., PhD, as section chief of gastroenterology, department of medicine.
New Research in March: Colorectal Cancer, Kidney Health, OR Supply Costs, and More
The March issue of the Journal of the American College of Surgeons (JACS) features new research on topics ranging from colorectal cancer and social vulnerability to operating room supply costs, the rise in school shootings since 1970, and the impact of permitless open carry laws on suicide rates, among others.
Colorectal cancer ‘not an old people’s disease anymore’
Dr. Issaka’s comments follow the January release of the American Cancer Society’s Cancer statistical report for 2024. Among people under 50 in the U.S., the report said, colorectal cancer is currently the No. 1 cause of cancer death among men and the No. 2 cause of death among women.
Grand Prize Winner: The Southwest Coalition for Colorectal Cancer Screening (SuCCCeS) program
According to the American Cancer Society, the number of colorectal cancers in the US for 2024 are estimated to be about 106,590 new cases of colon cancer (54,210 in men and 52,380 in women) and about 46,220 new cases of rectal cancer (27,330 in men and 18,890 in women).
NCCN Updates Treatment Recommendations for Breast, Colorectal, Lung, and other Cancer Types Based on Emerging Evidence
Recent NCCN Guidelines updates—along with the supporting evidence—will be presented during the NCCN 2024 Annual Conference held in Orlando, Florida April 5-7, and simultaneously online. Visit NCCN.org/conference to learn more and register.
Baylor Scott & White doctor discusses why cancer is impacting more young people
David Winter, MD, at Baylor Scott & White Health, discusses why cancer is impacting more young people. What You Need to Know: People aged 50 and older are living longer because of better cancer detection and treatments. Cancer diagnosis in…
Five Signs of Colorectal Cancer You Shouldn’t Ignore – Even if You’re a Younger Adult
The recent Cancer Facts & Figures 2024 report from American Cancer Society (ACS) researchers revealed a stark increase in colorectal cancer (CRC) incidence among Americans under the age of 55. In just two decades, CRC has moved up from being the fourth leading cause of cancer death in both younger men and women, to first in men and second in women.
VX-509 attenuates the stemness characteristics of colorectal cancer stem-like cells by regulating the epithelial-mesenchymal transition through Nodal/Smad2/3 signaling
BACKGROUNDColorectal cancer stem cells (CCSCs) are heterogeneous cells that can self-renew and undergo multidirectional differentiation in colorectal cancer (CRC) patients. CCSCs are generally accepted to be important sources of CRC and are
Stemming colorectal cancer in Latin America
Little is known about colorectal cancer screening strategies throughout the Western Hemisphere, with the exception of the U.S. and Canada.
Clues to early onset colorectal cancer found in microbiome of Hispanic patients
Nina Sanford, M.D., Chief of Gastrointestinal Radiation Oncology Service, UT Southwestern Medical Center Most people have a screening colonoscropy around age 50, however recent research has uncovered a rise in early onset colorectal cancer in patients younger than 50. What can…
Drug used for cocaine addiction may pave way for new treatment of advanced colon cancer
New research from the University of Ottawa proposes using vanoxerine as a safe method for potentially eliminating cancer stem cells in colorectal tumors.
Case Western Reserve University researcher awarded $2 million federal grant to further explore possible new effective treatments for colorectal and other cancers
With a new $2 million federal grant, a researcher with the Case Western Reserve University School of Medicine will lead a team to further explore preliminary findings of an effective treatment for colorectal and possibly other cancers.
Can personalized care prevent over screening for colorectal cancer in older adults?
Study reveals presenting adults between 76 and 85 with personalized information about the benefits and harms of colon cancer screening decreases excess screening