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UrduNew research presented during the 2024 San Antonio Breast Cancer Symposium (SABCS) reveals a new machine learning model that could change the way metastatic breast cancer is treated in the future. By combining clinical and genomic data, physician-scientists from Memorial Sloan Kettering Cancer Center (MSK) developed a tool that could help improve predictions of how people with hormone receptor-positive, HER2-negative (HR+/HER2-) metastatic breast cancer respond to CDK4/6 inhibitors, a class of oral medications that control cell division and are often prescribed in combination with hormone therapy to treat this subset of patients.
Tag: Breast Cancer
AI shaping the future of breast cancer risk prediction
A new publication by a national collective of researchers has highlighted the potential for the use of artificial intelligence (AI) in identifying women with increased breast cancer risk. The piece, published in Trends in Cancer, explores how AI can help clinicians to better identify features on a mammogram that indicate a high risk of developing breast cancer.
New Study Shows Mobile Mammography Reach is Highest in Underserved Groups with Low Breast Cancer Screening Adherence
A recent study by the Harvey L. Neiman Health Policy Institute demonstrates that mobile mammography is generally used by women otherwise unlikely to be screened, and thus is complementary to facility-based mammography rather than a substitute for it. Hence, mobile mammography could feasibly increase breast cancer screening rates, especially in traditionally underserved communities. This study, published in Clinical Breast Cancer, was based on 2.6 million women with Medicare fee-for-service insurance during the 2004-2021 period.
Breast cancer alert: study finds post-35 weight gain raises risk
A new study has unveiled a striking connection between weight gain after the age of 35 and an increased risk of breast cancer, highlighting the urgent need for proactive weight monitoring in women’s health as they age. The research, which delves into the relationship between body mass index (BMI) changes and cancer risk, underscores how weight gain during key hormonal transitions could significantly influence breast cancer susceptibility.
Battling breast cancer: new insights into angiogenesis and drug resistance
Breast cancer’s resistance to treatment is a major hurdle in improving patient outcomes. A recent study explores how tumor angiogenesis—the formation of abnormal blood vessels in tumors—plays a pivotal role in fostering drug resistance. The research highlights how these blood vessels hinder drug delivery and create a hostile tumor environment, reducing the effectiveness of therapies. It also investigates the potential of anti-angiogenic treatments to normalize these vessels, enhancing drug efficacy and offering new hope for patients.
Analyzing multiple mammograms improves breast cancer risk prediction
A new method of analyzing mammograms — developed by researchers at WashU Medicine — identified individuals at high risk of developing breast cancer more accurately than the standard, questionnaire-based method did. The new method, powered by artificial intelligence, could help diagnose cancer earlier and guide recommendations for earlier screening, additional imaging or risk-reducing medications.
Advances in the Molecular Diagnostic Methods for Circular RNA
The author summarized the traditional and emerging methods for circRNA detection as well as the advantages and limitations, and look forward to future research directions.
More Cancers Are Being Treated with Personalized Therapies Before Surgery
The first-ever annual report from the American College of Surgeons National Cancer Database includes in-depth data on adult cancer diagnoses and treatment trends.
Advancing Breast Cancer Research: Yale Cancer Center to Share Insights at International Conference
Yale Cancer Center (YCC) researchers at Yale School of Medicine will present new research at the 47th annual San Antonio Breast Cancer Symposium (SABCS) at the Henry B. Gonzalez Convention Center from December 10 to 13.
Vaccine shows promise against aggressive breast cancer
A small clinical trial shows promising results for patients with triple-negative breast cancer who received an investigational vaccine designed to prevent recurrence of tumors. Conducted at Washington University School of Medicine in St. Louis with a therapy designed by WashU Medicine researchers, the trial is the first to report results for this type of vaccine — known as a neoantigen DNA vaccine — for breast cancer patients.
Cleveland Clinic Announces Updated Findings in Preventive Breast Cancer Vaccine Study
Cleveland Clinic researchers are presenting updated findings from their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.
The study team found that the investigational vaccine was generally well tolerated and produced an immune response in most patients. The team described the side effects of the vaccine, showed the highest tolerated dose to date, and presented the immunologic effects of the vaccine. Findings are being presented at the Society for Immunotherapy of Cancer Annual Meeting.
How Hypoxia Helps Cancer Spread
Scientists at the Johns Hopkins Kimmel Cancer Center have identified 16 genes that breast cancer cells use to survive in the bloodstream after they’ve escaped the low-oxygen regions of a tumor. Each is a potential therapeutic target to stop cancer recurrence, and one – MUC1 – is already in clinical trials.
Living Flat: Study sheds light on challenges for women of color after breast cancer surgery
A new study led by Yale Cancer Center researchers at Yale School of Medicine titled, “Living Flat: Stories from Women of Color After Mastectomy,” explains how cultural factors, spirituality, and personal beliefs play an important role in the lives of women of color after mastectomies.
New JNCCN Study Suggests Medicaid Expansion Improves Cancer Care and Survival for People with Aggressive Type of Breast Cancer
New study in JNCCN-Journal of the National Comprehensive Cancer Network that finds that people diagnosed with an aggressive breast cancer subtype (HR-negative, HER2-positive) are more likely to live longer in states that participate in Medicaid expansion under the Affordable Care Act (ACA).
Surgical innovations help personalize breast cancer treatment, improve quality of life
There are two surgical options to treat breast cancer: lumpectomy and mastectomy. But there are many more reasons why women choose one over another, says Sarah McLaughlin, M.D., a breast surgical oncologist and chair of the Department of Surgery at Mayo Clinic in Jacksonville, Florida.
Emotional and Financial Concerns of Breast Cancer Patients Are Often Unmet
Although breast cancer is the most common non-skin
cancer diagnosed in women, finding support during treatment and through survivorship can be incredibly challenging. An analysis of posts from breast cancer patients on the popular online forum Reddit found that many breast cancer patients often struggle with several unmet emotional and financial concerns during treatment and long after.
Study seeks rapid, paper-based test to detect cancer cells in cerebrospinal fluid
With time being of the essence for patients facing one of cancer’s most dire complications, UCLA researchers are working to create a new test to detect cancer’s spread to the central nervous system on the same day as the doctor’s visit.
Experimental Cancer Drug Eliminates Bone Metastases Caused by Breast Cancer in Lab Models
In a new study led by Johns Hopkins Medicine, the drug RK-33 has demonstrated promise in treating breast cancer that has spread to the bone (breast cancer bone metastasis). RK-33 was previously shown to help treat other types of cancer and viral illnesses.
Nipple-Sparing Mastectomy: A Modern Approach to Breast Cancer Surgery
Nipple-Sparing Mastectomy (NSM) is a surgical option for patients requiring a mastectomy, in which the breast tissue is removed while the skin, nipple, and areola remain intact. This procedure allows for immediate reconstruction and offers a more natural post-surgery result, giving patients both peace of mind and a sense of body confidence. M. Michele Blackwood, MD, FACS, director of Breast Surgery and director of Women’s Oncologic Health, RWJBarnabas Health and Rutgers Cancer Institute shares more on this surgical technique.
Am I too Young for a Mammogram?
While routine mammograms are generally recommended starting at age 40, there are certain factors that may make it necessary to get screened at a younger age. Learn more about these factors that may prompt younger women to consider getting screened earlier.
Assessment and Management of Lymphatic Pain in Breast Cancer Survivors
Lymphatic pain refers to co-occurring pain, or sensations of aching, soreness, tenderness, and swelling due to fluid accumulation. Lymphatic pain impairs breast cancer survivors’ physical function, emotional and overall health. Lymphatic pain usually occurs in the ipsilateral body or upper limb following breast cancer treatment. Precision assessment to distinguish lymphatic pain from other different types of pain is essential.
Advancements in fighting an aggressive type of breast cancer
Triple-negative breast cancer is an aggressive and difficult to treat form of breast cancer, which grows rapidly, spreads to other parts of the body faster, and recurs more frequently than other types of breast cancer. It is most prevalent in…
Study finds common breast cancer treatments may speed aging process
The findings, published in the Journal of the National Cancer Institute, show that markers of cellular aging—such as DNA damage response, cellular senescence, and inflammatory pathways—significantly increased in all breast cancer survivors, regardless of the type of treatment received.
MD Anderson and UICC collaborate to improve women’s cancer care
The University of Texas MD Anderson Cancer Center today announced an agreement to become a Women’s Cancer Partner with the Union for International Cancer Control (UICC), marking a significant collaboration to improve breast and cervical cancer care worldwide.
Tip Sheet: 4 NCI-designated cancer centers form AI alliance, new database of Hispanic/Latinx scientists — and Fred Hutch volunteer stories
Below are summaries of recent Fred Hutch Cancer Center research findings, patient stories and other news.
Cedars-Sinai to Participate in Largest AAPI Cancer Initiative
Cedars-Sinai Cancer is advancing its commitment to diversity in research by participating in the largest-ever national study of cancer risk factors in Asian Americans. Investigators are hoping to learn why Asian Americans have disproportionately high rates of many types of cancer.
5 Things I Learned About Cancer From My Diagnosis
“5 Things I Learned About Cancer From My Diagnosis” – Journalist Rochelle Broder-Singer offers tips learned from her experience as a breast cancer survivor.
Yale Cancer Center Expert Available to Discuss New American Cancer Society Report Revealing Higher Rates of Early Onset Breast Cancer and Disparities in Underserved Populations
Dr. Eric Winer, director of Yale Cancer Center and president and physician-in-chief of Smilow Cancer Hospital, can provide expert insight on the new American Cancer Society report which revealed a three-decade decline in breast cancer mortality, but higher rates of breast…
MD Anderson Research Highlights for October 2, 2024
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
3 Things to Know After Receiving a Breast Cancer Diagnosis
For Breast Cancer Awareness Month, breast surgeons Katharine A. Yao, MD, FACS, and Daniela A. Ochoa, MD, FACS, of the American College of Surgeons (ACS) share tips on coping with a breast cancer diagnosis.
Precision Breast Cancer Trial Shows Improved Treatment by Tumor Subtype
Recent results from one of the I-SPY 2.2 study arms, published September 14, 2024 in Nature Medicine, showed that neoadjuvant treatment with the antibody-drug conjugate datopotamab–deruxtecan (Dato-DXd) in combination with the immune checkpoint inhibitor, durvalumab (Imfinzi), produced high rates of pCR in patients who have an immune breast cancer subtype as well as a subtype of triple negative cancer that would ordinarily have a high risk of recurrence.
New ACS Report: Breast Cancer Mortality Continues Three Decade Decline Overall, but Steeper Increases in Incidence for Women <50 & Asian American, Pacific Islanders of all Ages
The American Cancer Society (ACS) today released Breast Cancer Statistics, 2024, the organization’s biennial update on breast cancer occurrence and trends in the United States. The new report finds breast cancer mortality rates overall have dropped by 44% since 1989, averting approximately 517,900 breast cancer deaths. However, not all women have benefited from this progress, notably American Indian and Alaska Native (AIAN) women, whose rates have remained unchanged over the past three decades
UNLV Receives Federal Funding to Study Effects of Low Dose Radiation Exposure on Breast Cancer Risk
Three-year grant from U.S. Dept. of Energy will highlight AI-based and experimental learning to understand effects of occupational and medical radiation.
Breast cancer experts & story ideas
Sylvester Comprehensive Cancer Center experts attack breast cancer on multiple fronts to advance cures, reduce racial disparities and save lives. New imaging and surgical techniques help.
Post-mastectomy radiation therapy can be shortened by nearly half for patients planning breast reconstruction
An accelerated course of radiation therapy does not increase complications for patients who undergo breast reconstruction following a mastectomy, new research shows. Findings of the large, phase III RT CHARM trial (Alliance A221505) will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
Trastuzumab deruxtecan significantly outperforms chemotherapy for the treatment of advanced breast cancer
A new study published in NEJM and led by global principal investigator Aditya Bardia, MD, director of Translational Research Integration at the UCLA Health Jonsson Comprehensive Cancer Center, found trastuzumab deruxtecan (T-DXd), an antibody-drug conjugate, significantly improves progression-free survival compared to…
FDA approval of new drug regimen helps reduce risk of breast cancer recurrence for patients with early-stage disease
Teri Boudreaux was one of more than 5,000 women who joined a clinical trial that was looking at the benefit of adding the targeted therapy drug ribociclib to conventional hormonal therapy for the adjuvant treatment of HR-positive, HER2-negative early-stage breast cancer. I
False-positive mammograms discourage women from breast cancer screening, study finds. Why it happens — and what to do.
Every year, millions of women get mammograms to screen for breast cancer. About 10% of them are called back for further testing. And 7% to 12% of those women receive a false-positive result, meaning that the mammogram detects something that looks like cancer, but turns out not to be.
Elle Macpherson says she refused chemotherapy after breast cancer diagnosis. Here’s what oncologists think.
After being diagnosed with breast cancer seven years ago, Elle Macpherson made a controversial choice: She refused chemotherapy, the model has revealed in her new memoir, Elle: Life, Lessons, and Learning to Trust Yourself. Macpherson did undergo a lumpectomy — surgery to remove…
MD Anderson Research Highlights Special Edition: ESMO 2024
The University of Texas MD Anderson Cancer Center’s Research Highlights provides a glimpse into recent basic, translational and clinical cancer research from MD Anderson experts.
ASTRO 2024 Tip Sheet From Sylvester Comprehensive Cancer Center
Research findings from Sylvester Comprehensive Cancer Center and the Miller School of Medicine at the University of Miami will be presented at ASTRO 2024 – the American Society for Radiation Oncology’s annual meeting Sept. 29 – Oct. 2 in Washington D.C. Below are titles for oral presentations, posters and special sessions in which our researchers will be involved.
Statement on Passage of Diagnostic and Supplemental Imaging Legislation in Alaska
A new law in Alaska removes out-of-pocket costs for diagnostic and supplemental breast imaging for people with state-regulated insurance plans.
False-positive mammogram results discourage some women from future screenings
A false-positive mammogram may deter women from future screenings, according to a new study. But staying on schedule remains key to early detection of cancer.
False-positive mammography result may discourage women from subsequent screening
A large, multi-center cohort study of more than 3 million screening mammograms in over 1 million patients aged 40 to 73 found that women were less likely to return for subsequent mammography screenings if they had a false positive recall for additional imaging or biopsy.
Preliminary study shows potential of Manuka honey as a nutraceutical for breast cancer
A new study led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center found that Manuka honey could potentially be an alternative, natural option for breast cancer prevention and treatment— particularly for estrogen receptor (ER)-positive breast cancer, the most common subtype of breast cancer that accounts for about 70–80% of all breast cancer cases.
Comprehensive atlas of normal breast cells offers new tool for understanding breast cancer origin
Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have completed the most extensive mapping of healthy breast cells to date. These findings offer an important tool for researchers at IU and beyond to understand how breast cancer develops and the differences in breast tissue among genetic ancestries.
Several RWJBarnabas Health Facilities Earn National Accreditation from the Commission on Cancer of the American College of Surgeons
Cancer programs at several RWJBarnabas Health facilities, in partnership with Rutgers Cancer Institute, the state’s only National Cancer Institute-designated Comprehensive Cancer Center, were recently granted Three-Year Accreditation from the American College of Surgeons Commission on Cancer (CoC).
Tip Sheet: BRCA cancer risks for men, a new way to classify brain tumors, funding for bile duct cancer — and cancer care in LGBTQ+ communities
Below are summaries of recent Fred Hutch Cancer Center research findings, patient stories and other news.
Precision Oncology via Artificial Intelligence on Cancer Biopsies
An artificial intelligence method to detect biomarkers in tumor biopsies promises to cut weeks and thousands of dollars from cancer detection, extending the benefits of precision oncology to underserved and under-resourced patients.
MD Anderson and Summit Therapeutics announce strategic collaboration to accelerate development of ivonescimab
MD Anderson and Summit Therapeutics announced a strategic five-year collaboration to accelerate the development of ivonescimab, a novel PD-1/VEGF bispecific antibody.