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UrduThe National Institutes of Health awarded a four-year, $2.6 million grant to researchers at Case Western Reserve University to study how high blood-pressure drugs affect patients with chronic kidney disease (CKD).
Tag: Chronic Kidney Disease
High-Impact Clinical Trials Generate Promising Results for Improving Kidney Health: Part 1
The results of numerous high-impact phase 3 clinical trials that could affect kidney-related medical care will be presented in-person at ASN Kidney Week 2024 October 23–27.
AI model predicts patients at most risk of complication during treatment for advanced kidney failure
A study led by the University of Portsmouth in England and Portsmouth Hospitals University NHS Trust (PHUT) has developed an AI model to predict which patients are most at risk of their blood pressure dropping during dialysis; a condition known as intradialytic hypotension (IDH).
AMERICAN SOCIETY OF NEPHROLOGY LAUNCHES THE GLOMERULAR DISEASES COLLABORATIVE (GD-C) TO ADDRESS GAPS IN KNOWLEDGE AND BARRIERS IN THE CARE OF PEOPLE WITH GLOMERULAR DISEASES
Chronic kidney disease is a progressive condition that affects more than 10% of the general population worldwide, amounting to 800 million individuals.1 Glomerular diseases (GD), excluding diabetic nephropathy, account for approximately 25% of the cases of kidney diseases worldwide.2 Given the magnitude of long-term morbidity from GD— particularly the frequent manifestation in younger patients—diagnosing it efficiently and optimizing management to control diseases and prevent progressive kidney diseases is paramount.
Chronic Kidney Disease Linked to Key Cardiovascular Risk Precursor
Rockville, Md. (September 17, 2024)—Overactivation of the sympathetic nervous system is a hallmark sign of chronic kidney disease (CKD) that increases the risk of cardiovascular disease. People with CKD often have impaired sympathetic baroreflex sensitivity—a measure of how well the…
Researchers Identify How Kidneys Protect Themselves from Too Much Phosphate
Article title: Endogenous activation of peroxisome proliferator-activated receptor alpha in proximal tubule cells in counteracting phosphate toxicity Authors: Yusuke Katsuma, Isao Matsui, Ayumi Matsumoto, Hiroki Okushima, Atsuhiro Imai, Yusuke Sakaguchi, Takeshi Yamamoto, Masayuki Mizui, Shohei Uchinomiya, Hisakazu Kato, Akio Ojida,…
Either ACEi or ARB therapy protect against kidney failure in those with advanced CKD
A systematic review and retrospective individual participant-level meta-analysis of 18 trials comprised of more than 1,700 participants found that initiating treatment with an angiotensin-converting enzyme inhibitor (ACEi) or angiotensin-receptor blocker (ARB) protects against kidney failure in patients with advanced chronic kidney disease (CKD).
Chulalongkorn Unveils “Microalbuminuria Rapid Test”: Easy, Accurate, Ready for Commercial Use
Ms. Supamas Isarabhakdi, Minister of Higher Education, Science, Research and Innovation, attended the launching of the innovative Microalbuminuria Rapid Test developed by a team of experts and researchers from the Faculty of Medicine, Chulalongkorn University. The test, which is convenient and easy to use and offers high accuracy, allows users to self-screen for kidney damage, giving it commercial potential in order to enhance Thailand’s healthcare system. It is expected for distribution in mid-2024.
Physicians debate best management strategy for patient with type 2 diabetes and CKD
In a new Annals ‘Beyond the Guidelines’ feature, an endocrinologist and a nephrologist discuss controversies regarding the care of patients with type 2 diabetes (T2D) and chronic kidney disease (CKD) and how they would apply the consensus statement to the care of an individual patient with T2D who is unaware that he has CKD.
Men with Chronic Kidney Disease Have Higher Resting Activity in ‘Fight-or-Flight’ System than Women
Article title: Sex differences in sympathetic activity and vascular stiffness in adults with chronic kidney disease (CKD) Authors: Matias G. Zanuzzi, Jinhee Jeong, Dana R. DaCosta, Jeanie Park From the authors: “We show for the first time that males with…
CHLA Researchers Uncover Underlying Mechanism Driving Membranous Nephropathy, Offering Insights Into Chronic Kidney Disease in Children
No therapies currently exist that can halt the progression of chronic kidney disease in children or restore the ability of kidney cells to filter blood.
Even lower levels of albuminuria associated with increased risk for CKD progression and kidney failure
A study of patients with chronic kidney disease (CKD) found substantial excess risk for CKD progression and kidney failure as albuminuria (protein in the urine) increased even at levels below 30 mg/g.
UT Southwestern study shows glucagon is key for kidney health
Glucagon, a hormone best known for promoting blood sugar production in the liver, also appears to play a key role in maintaining kidney health. When UT Southwestern Medical Center researchers removed receptors for this hormone from mouse kidneys, the animals developed symptoms akin to chronic kidney disease (CKD).
Measuring eGFR based on cystatin C levels may be a more accurate assessment of kidney function in older adults
A study of more than 82,000 older adults receiving outpatient measurements of estimated glomerular filtration rate (eGFR) found that measuring eGFR based on creatinine and cystatin C levels (eGFRcr-cys) was more strongly associated with adverse outcomes than measuring eGFR with only creatinine levels (eGFRcr).
Cardiac Arrest: Hispanics, Latinos With Kidney Disease at High Risk
Hispanics and Latinos with chronic kidney disease are at significant risk for suffering from sudden cardiac arrest, according to a new study from the Smidt Heart Institute at Cedars-Sinai.
Acute kidney injury not associated with worsening kidney function in persons with CKD
A study of hospitalized persons with chronic kidney disease (CKD) fournd that acute kidney injury (AKI) did not predict worsening of kidney function trajectory once difference in pre-hospitalization characteristically were fully accounted for. Instead, the authors suggest that much of determinants of faster kidney disease decline observed after AKI may already be present before AKI. The findings are published in Annals of Internal Medicine.
AACC and National Kidney Foundation Release Guidance to Combat Racial and Gender Inequalities in Chronic Kidney Disease Care
Today, AACC—in collaboration with the National Kidney Foundation (NKF)—released guidance to reduce racial and gender disparities in the care of patients with chronic kidney disease (CKD). The document gives members of the healthcare team actionable, evidence-based tools to improve equity in kidney health, including recommendations for using an updated algorithm that does not disproportionately affect any one group of individuals.
Screening all U.S. adults aged 35 and older for chronic kidney disease could be cost effective
A cost-effectiveness analysis of screening for chronic kidney disease (CKD) has found that screening all adults in the United States starting at age 35 could be cost-effective for the quality of life-years (QALY) gained. The analysis is published in Annals of Internal Medicine.
Study Finds Certain Substances in Urine, Blood Can Predict Kidney Disease Progression
In a new study looking at the long-term effects of hospitalized patients who have acute kidney injury (AKI), a sudden but temporary loss of kidney function, Johns Hopkins Medicine researchers found that higher levels of certain biomarkers in urine and blood can predict a patient’s risk of developing chronic kidney disease (CKD).
Three Kidney Transplants, Weight Gain and a Journey Back to Wellness
Rowena Roque, 46, was having a problem that many people can relate to: doing everything in her power to lose weight and get healthy but never succeeding.
Large Study Identifies Risk Factors in Children with Chronic Kidney Disease
In a new study led by Children’s Hospital of Philadelphia (CHOP) and Nemours Children’s Health, researchers have overcome the obstacle of scale by analyzing electronic health record data from PEDSnet, a national multicenter pediatric network, to identify a large cohort of children with CKD, evaluate CKD progression, and examine clinical risk factors for kidney function decline. The findings were published in the Clinical Journal of the American Society of Nephrology.
Digital decision aid may help older adults with CKD make better quality treatment decisions
A randomized controlled trial of 400 adults aged 70 years or older with chronic kidney disease (CKD) found that use of the decision-making aid DART (Decision-Aid for Renal Therapy) improved decision quality and clarified treatment preferences among older adults with advanced CKD for 6 months after the DART intervention. The findings are published in Annals of Internal Medicine.
Dapagliflozin reduces risk for hospitalization in patients with CKD with or without diabetes
Dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, reduced the risk for hospitalization for any cause in patients with chronic kidney disease (CKD) with and without type 2 diabetes.
New onset chronic kidney disease in people with diabetes highest among ethnic, racial minorities
New onset chronic kidney disease (CKD) in people with diabetes is highest among racial and ethnic minority groups compared with white persons, a UCLA-Providence study finds. The study, published as a letter to the editor in the New England Journal of Medicine, found that new onset CKD rates were higher by approximately 60%, 40%, 33%, and 25% in the Native Hawaiian/Pacific Islander, Black, American Indian/Alaska Native, and Hispanic/Latino populations, respectively, compared to white persons with diabetes.
Inhaling Silica Particles May Cause Kidney Disease
New research in rats demonstrates that inhaling amorphous silica particles—of the size released from burning sugarcane—could damage the kidneys. The study, chosen as an APSselect for August, is published ahead of print in the American Journal of Physiology-Renal Physiology.
Tip Sheet: Studies on COVID-19, TV and Toddler Diet Among Johns Hopkins Research to Be Featured at National Pediatrics Meeting
What: Pediatric Academic Societies (PAS) 2022 Meeting
When: April 21 to 25
Where: Colorado Convention Center (700 14th St., Denver, CO 80202)
Chronic Kidney Disease is Curable if Detected Early – Chula’s User-friendly CKD Screening Strips with Results in 15 minutes!
A Chula research team has developed a screening strip kit to detect the early stage of chronic kidney disease (CKD) that’s easy to use, yields quick results, increasing the chance of being cured for patients, and helping to cut over 10 billion baht of the ever-increasing annual healthcare costs for CKD patients. The CKD screening strip kits are expected to be released early next year.
The enzyme that could help 700 million people worldwide
University of South Australia researchers have identified an enzyme that may help to curb chronic kidney disease, which affects approximately 700 million people worldwide.
Surprise Discovery Shows Chronic Heart Dysfunction Protects against Acute Kidney Injury
Article title: Activation of hypoxia-sensing pathways promotes renal ischemic preconditioning following myocardial infarction Authors: Andrew S. Terker, Kensuke Sasaki, Juan Pablo Arroyo, Aolei Niu, Suwan Wang, Xiaofeng Fan, Yahua Zhang, Sochinwechi Nwosisi, Ming-Zhi Zhang, Raymond C. Harris From the authors:…
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Wednesday.
Blood-flow Restriction Training Delay the Progression of Chronic Kidney Disease
Chronic kidney disease (CKD) is recognized as a public health problem, affecting more than 15% of the population. Although CKD can drastically impair health, it is rarely diagnosed early due to its silent revelation. Identifying and proposing treatments to attenuate…
New Blood Pressure-Lowering Guidelines Could Benefit 25 Million Americans with Chronic Kidney Disease
A recommendation for more intensive blood pressure management from an influential global nonprofit that publishes clinical practice guidelines in kidney disease could, if followed, benefit nearly 25 million Americans.
Blocking Calcium Channel May Prevent Calcification in Kidney Disease
Inhibiting the Kv1.3 channel, a potassium channel expressed in tissues around the body, including vascular smooth muscle cells, may help prevent uremia-induced calcification in people with chronic kidney disease. The study is published ahead of print in the journal Function.…
Kidney Disease Affects Men’s Blood Vessel Health More
Men who suffer from chronic kidney disease (CKD) have greater rates of reduced blood vessel function compared to women with the same disorder.
Sugary Soda Consumption Linked to Reduced Kidney Blood Flow
Regular consumption of sugary soda sweetened with high-fructose corn syrup (HFCS) reduces kidney blood flow, which could be linked to a greater risk of developing chronic kidney disease (CKD), according to a recently published paper in the American Journal of Physiology-Renal Physiology.
Sugary Sodas Linked to Increased Risk of Chronic Kidney Disease
Article title: High-fructose corn syrup-sweetened soft drink consumption increases vascular resistance in the kidneys at rest and during sympathetic activation Authors: Christopher L. Chapman, Tigran Grigoryan, Nicole T. Vargas, Emma L. Reed, Paul J. Kueck, Leonard D. Pietrafesa, Adam C. Bloomfield,…
Link between chronic kidney disease and heart failure is identified in patients
People with chronic kidney disease have a higher risk for heart disease and heart-disease death. Now, for the first time in humans, researchers have identified a pathological change that appears to link kidney disease to progressive heart disease.
Nicotine Boosts Production of Inflammation-causing Hormones, Worsens Kidney Disease
Article title: COX-2 derived prostaglandins as mediators of the deleterious effects of nicotine in chronic kidney disease Authors: Sunil Rangarajan, Gabriel Rezonzew, Phillip Chumley, Huma Fatima, Mikhail Golovko, Wenguang Feng, Ping Hua, Edgar A. Jaimes From the authors: “In these studies,…
Chronic kidney disease patients at increased risk of adverse cardiovascular outcomes, Mayo Clinic study finds
Chronic kidney disease, which afflicts an estimated 6.4% of U.S. adults 45 and older, is associated with an increased risk of heart attack and other adverse cardiovascular outcomes, according to new research from Mayo Clinic.
Common Clinical Estimates of Kidney Function May Not Accurately Assess Indian Patients
Pilot study finds that considering body composition rather than weight could improve patient management Charlottesville, Va. (June 25, 2019)—A common metric for monitoring kidney health may not accurately represent the kidney function of Indian patients. However, tweaks to an older…