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UrduNew research conducted with Washington, DC, residents who experienced homelessness during pregnancy sheds light on the intersection of homelessness, pregnancy, and racial inequities. The findings underscore the urgent need for policy and practice changes to support vulnerable populations.
Month: May 2024
Both high performance and stability were achieved with multifunctional materials!
The Korean joint research team has developed a 4-Amino-TEMPO derivative with photocatalytic properties and successfully used it to produce high-performance and stable fiber-shaped dye-sensitized solar cells (FDSSCs) and fiber-shaped organic light-emitting diodes (FOLEDs).
Safety and efficacy of osimertinib plus consolidative stereotactic ablative radiation (SABR) in advanced EGFR mutant non-small cell lung cancer (NSCLC): results from a multi-center Phase II trial
BackgroundDespite high response rates to EGFR inhibitors, patients with advanced EGFR mutant NSCLC generally experience disease progression within two years (osimertinib median PFS 18.9 months, median OS 38.6 months). We sought to determine whether administration of SABR to residual sites…
ARC-9: A randomized study to evaluate etrumadenant based treatment combinations in previously treated metastatic colorectal cancer (mCRC).
For this presentation at ASCO 2024, please email the media contact for more information.
A phase 1 dose expansion study of a first-in-class KAT6 inhibitor (PF-07248144) in patients with advanced or metastatic ER+ HER2− breast cancer.
For this presentation at ASCO 2024, please email the media contact for more information.
ARV-766, a proteolysis targeting chimera (PROTAC) androgen receptor (AR) degrader, in metastatic castration-resistant prostate cancer (mCRPC): Initial results of a phase 1/2 study.
For this presentation at ASCO 2024, please email the media contact for more information.
Phase 1/2 trial of the XPO1 inhibitor selinexor in combination with docetaxel in previously treated, advanced KRAS mutant non-small cell lung cancer (NSCLC)
Background: KRAS mutant NSCLC remains a therapeutic challenge. Although KRAS G12C inhibitors are now approved for cases harboring that specific mutation, their efficacy is modest and the G12C variant accounts for only 40% of KRAS mutations in NSCLC. To date,…
American Association of Neurological Surgeons Names E. Antonio Chiocca, MD, PhD, FAANS, as the Organization’s Vice President
Dr. Chiocca assumes the role of vice president of the American Association of Neurological Surgeons (AANS) for 2024-25.
American Association of Neurological Surgeons Names E. Sander Connolly MD, FAANS, as the Organization’s President-Elect
Dr. Connolly assumes the role of president-elect of the American Association of Neurological Surgeons (AANS) for 2024-25. His term will culminate with the prestigious 2025 AANS Annual Scientific Meeting scheduled to convene in Boston on April 25-28, 2025.
American Association of Neurological Surgeons Names Aviva Abosch, MD, PhD, FAANS, as the Organization’s Secretary
Dr. Abosch assumes the role of secretary of the American Association of Neurological Surgeons (AANS) for 2024-25.
Fibrolamellar hepatocellular carcinoma (FL-HCC) epidemiology, survival characteristics, and outcomes: Surveillance, epidemiology, and end results database (SEER) study
Background:Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare and distinctive form of liver cancer that primarily affects adolescents and young adults without underlying liver disease. Unlike conventional HCC, it exhibits unique clinical and histological features and poses a diagnostic and therapeutic…
Association between congenital heart disease and cancer: A meta-analysis of 30 million patients
Background: Birth defects have been associated with increased cancer risk; however, the association between congenital heart disease (CHD) and cancer risk has not been well established with limited and conflicting literature till date. Children afflicted with CHD possess multiple risk factors…
Clinically significant variant classification resulting from the addition of RNA sequencing: Experience at high-volume cancer genetics center
Background: Germline cancer genetic testing plays an important role in prevention, early detection, and targeted therapy1. The increasing use of multi-gene panel testing (MGPT) underscores the importance of accurate variant classification. We report on the significant contribution of RNA analysis…
Cancer screening in sexual and gender minority populations: A systematic review and meta-analysis
Background: The sexual and gender minority (SGM) populations experience a greater cancer burden than their heterosexual or cisgender counterparts. Screening rates for cancer within this cohort are frequently suboptimal, highlighting notable deficiencies in screening recommendations. Inadequate culturally competent care and screening…
Non-Hodgkin lymphoma mortality disparities across different sexes, races, and geographic locations
Background: Non-Hodgkin lymphoma (NHL) is one of the common hematological cancers in the United States (U.S.), accounting for 4% of new cancer cases in 2023. The mortality rate of NHL is the sixth highest among all cancers in the U.S. Our…
A meta-analysis of models for predicting the incidence of brain metastasis in patients with lung cancer
Background: Brain metastasis (BM) represents a significant clinical challenge in the management of lung cancer, impacting patient prognosis and treatment decisions. While various predictive models have been developed to assess the risk of BM development, their performance and applicability remain under…
Evaluating the impact of socioeconomic status on patient satisfaction in radiation oncology
Background: Patient satisfaction (PS) is a critical indicator in evaluating healthcare quality. While the impact of socioeconomic status (SES), on healthcare outcomes is well-documented, its specific connection to PS in the context of radiation oncology remains unclear. This study aims to…
Impact of race and ethnicity on financial toxicity in patients with genitourinary cancers
For this presentation at ASCO 2024, please email the media contact for more information.
Trilaciclib use for prevention of hematological adverse events in chemotherapy: A meta-analysis of real-world studies and clinical trials
Background: Trilaciclib, a cyclin-dependent kinase (CDK)-4 and -6 inhibitor, is the only FDA-approved agent that preemptively protects hematopoietic stem cells from chemotherapy-induced myelosuppression (CIM) without compromising efficacy. It transiently arrests hematopoietic stem cells in the G1 phase, thus temporarily blocking progression…
The effect of resting dendritic cells on overall survival in the hepatocellular carcinoma tumor microenvironment
Background: Hepatocellular carcinoma (HCC) continues to have a poor prognosis even in the advent of new immunotherapy regimens. An area of growing interest in HCC is its tumor immune microenvironment. Classifying the immune microenvironment based on available genomics can lead to…
The AI paradox: Building creativity to protect against AI
A new machine-learning model developed by the University of South Australia is providing teachers with access to high-quality, fit-for-purpose creativity tests, that can score assessments in a fraction of the time and a fraction of the cost.
Epidemiology, symptomatology, diagnosis and clinical implications of cystic tumors of atrioventricular node (CTAVN): A systematic review
Background: Primary cardiac tumors have an incidence of 0.0017% to 0.03% of all autopsies. CTAVN is a rare tumor associated with sudden cardiac death, and its incidence cannot be accurately determined as the diagnosis has been historically made on incidental or…
Socioeconomic disparities in survival outcomes of patients with SCLC with brain metastases: A nationwide analysis
Background:Despite advances in the management of cancer, socioeconomic disparities have been reported to impact survival outcomes. However, recent state of disparities in SCLC patients with brain metastases (BM) remains unknown. We explored socioeconomic disparities in survival outcomes of SCLC BM…
Trend and burden of cancer related hospitalizations in the US: Insights from a National Inpatient Sample Database analysis
Background: Cancer-related hospitalizations constitute one of the primary drivers of cancer-related healthcare expenses. Understanding the burden and characteristics of these hospitalizations is essential to appropriately direct resources, improve outcomes, and avoid unnecessary hospitalizations. Our study sought to evaluate the national…
RNA Inhibitor Is Shown Safe and Effective in Reducing a Wide Range of Cholesterol and Triglyceride Levels in the Blood in Mount Sinai-Led Clinical Trial
A small interfering RNA (siRNA) investigational therapy that inhibits a gene involved in lipoprotein metabolism has been shown in a clinical trial led by Mount Sinai researchers to significantly reduce levels of different types of cholesterol and triglycerides in individuals with mixed hyperlipidemia, a condition in which fats build up in the blood.
Biobased building materials less sustainable than concrete in South Africa, experts find
Scientists at the University of Bristol have discovered that mycelium composites, biobased materials made from fungi and agricultural residues, can have a greater environmental impact than conventional fossil-fuel-based materials due to the high amount of electricity involved in their production.
Altering cancer treatment dosing could reduce climate impact, study finds
Changing how often a popular cancer therapy is delivered would reduce greenhouse gas emissions and improve environmental impact without decreasing cancer survival, according to a new analysis from researchers at the University of Michigan Health Rogel Cancer Center.
Mindfulness Meditation: A Promising Remedy for Addiction and Chronic Pain
A particular form of mindfulness emphasizing pleasure works as well as a starting dose of a narcotic for pain and better than traditional psychotherapy for substance abuse.
Scientists identify gene that could lead to resilient ‘pixie’ corn
A widely found gene in plants has been newly identified as a key transporter of a hormone that influences the size of corn. The discovery offers plant breeders a new tool to develop desirable dwarf varieties that could enhance the crop’s resilience and profitability.
Scientists Share the Genomic Research Transforming Healthcare at 2024 CGM Symposium
The 120 attendees are using Utah’s uniquely strong genetics resources to answer fundamental biological questions and develop solutions to urgent issues in human health.
Rutgers Researchers Examine Black Men’s Perceptions of Labeling After a Violent Firearm Injury
The way Black men see themselves after a firearm injury – whether as a survivor or victim – could change over time and have implications on their mental health, according to a Rutgers Health study.
Summer Camp Ready: Tips From Hackensack Meridian Health Pediatricians On Preparing Your Child For A Healthy Summer Camp Season
Pediatrician tips to prepare your child for a healthy happy time at summer camp.
AANA Issues Updated Practice Considerations for Ketamine Therapy for Psychiatric Disorders and Chronic Pain Management
The American Association of Nurse Anesthesiology (AANA) recently updated its practice considerations addressing ketamine therapy to cite the most current studies, as AANA continues to support a patient-centered, interdisciplinary approach to providing care and treatment to persons with psychiatric disorders or chronic pain.
Kitt Peak National Observatory Hosts Open Night for the Tohono O’odham Nation
More than 70 NOIRLab staff volunteers welcomed hundreds of visitors from the Tohono O’odham Nation to Kitt Peak National Observatory to enjoy a night of telescope viewings, cultural performances, and educational activities.
Penn Medicine Brings Free 3D Mammograms and Health Screenings Back to West Philly
Penn Medicine will once again join with community partners and Siemens Healthineers to host a free mammogram clinic and community health fair in June, giving the West Philadelphia and Upper Darby communities convenient access to health screenings right in their neighborhoods.
U of I-Led Team Receives $15 Million to Study the Effects of Drought and Fires on Forests
A multidisciplinary team led by University of Idaho researchers has received a $15 million grant to study the long-term impact of drought and fire on forest ecosystems.
Overlooked lipid connected to ancient cellular pathway with links to cancer
Brooke Emerling, Ph.D., co-director of, and associate professor in, the Cancer Metabolism and Microenvironment Program at Sanford Burnham Prebys, is contributing to a revival of interest in an underappreciated set of enzymes called phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks).
Mercy Medical Center & Zinnia Film’s “Medoscopy” Program Wins 2024 Telly Award Talk show receives Bronze Telly for Public Awareness, Interest Online
Mercy Medical Center in conjunction with Zinnia Films has received a Bronze Telly Award for excellence for its ongoing talk show series, “Medoscopy”, in the “Public Awareness & Interest – ONLINE” category.
Monitoring diseases through sweat becomes accessible to everyone
Dr. Kim Joohee from the Bionics Research Center at the Korea Institute of Science and Technology (KIST) and Professor John A. Rogers from Northwestern University jointly announced the development of a convenient sweat monitoring device that does not require physical activity but delivers drug stimulation through the skin.
Prenatal exposure to air pollution associated with increased mental health risks
A baby’s exposure to air pollution while in the womb is associated with the development of certain mental health problems once the infant reaches adolescence, new research has found.
Harnessing Green Energy from Plants Depends on Their Circadian Rhythms
Plant hydraulics drive the biological process that moves fluids from roots to plant stems and leaves, creating streaming electric potential, or voltage, in the process.
A Cleaner Way to Produce Ammonia
Ammonia is the starting point for the fertilizers that have secured the world’s food supply for the last century. It’s also a main component of cleaning products, and is even considered as a future carbon-free replacement for fossil fuels in vehicles.
Internet of Waste: SLU Researcher Tackles the Recycling Problem with GeoAI and Sensor-Powered Waste, Recycling Bins
Orhun Aydin, Ph.D., assistant professor in Earth and Atmospheric Science at SLU’s School for Science and Engineering, received a $149,791 planning grant from the National Science Foundation for a program to put sensors in garbage and recycling bins around the City of St. Louis.
New Research Supports Expansion of Kidney Donation to Include Organs from Deceased Patients Who Once Had Dialysis
Researchers from Johns Hopkins Medicine propose a novel approach to addressing the pressing issue of a kidney donor shortage through findings that suggest a promising method to expand the pool of available kidney donors by utilizing deceased donors on dialysis for kidney transplants.
Shielding our heroes: Dermatologists deploy to provide free skin cancer checks to 425 NYC firefighters
The American Academy of Dermatology (AAD), in conjunction with the Firefighter Cancer Support Network, will host a free Skin Cancer Check event for an estimated 425 New York City firefighters on Saturday, June 1 at the New York City Firefighter Training Facility on Randall’s Island. The inaugural event kicks off the Academy’s Firefighter Skin Cancer Checks Initiative, a nationwide effort designed to provide free skin cancer checks to 10,000 firefighters by 2026.
Fentanyl Fueling an Increase in Overdose Deaths among Teens
An analysis by The Washington Post shows that across the country fentanyl has fueled a more than doubling of overdose deaths for children and teens since the start of the pandemic. The analysis, which is based on CDC data, shows…
Image sensor: Better cameras with perovskite
Capturing three times more light: Empa and ETH researchers are developing an image sensor made of perovskite that could deliver true-color photos even in poor lighting conditions. Unlike conventional image sensors, where the pixels for red, green and blue lie next to each other in a grid, perovskite pixels can be stacked thus greatly increasing the amount of light each individual pixel can capture.
Factor Bioscience Successfully Defends Three U.S. Patents Covering Foundational Methods for Therapeutic Gene Editing
Factor Bioscience Inc., a Cambridge, Massachusetts-based biotechnology company pioneering mRNA-based cell engineering, today announced that the United States Patent and Trademark Office (USPTO) has terminated three separate ex parte reexaminations of three U.S. patents owned by Factor.
Apple versus doughnut: How the shape of a tokamak impacts the limits of the edge of the plasma
PPPL scientists have developed a new theoretical model about the edge of a plasma, which can become unstable and potentially damage a fusion reactor. The model refines ideas about a critical obstacle on the path to harnessing clean energy from this fourth state of matter.
Psilera to Unveil New Data on Lead Clinical Asset at the BIO International Conference on June 5th
Ground-breaking preclinical data on next-generation psychedelic, PSIL-006, reveals therapeutic benefits in depression, anxiety, cognition, and sleep cycle restoration while eliminating hallucinations.