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UrduA new study from researchers at Wilmer Eye Institute, Johns Hopkins Medicine explains not only why some patients with wet age-related macular degeneration (or “wet” AMD) fail to have vision improvement with treatment, but also how an experimental drug could be used with existing wet AMD treatments to save vision.
Tag: Johns Hopkins Medicine
Media Advisory: Johns Hopkins to Host Henrietta Lacks Building Groundbreaking Event
Johns Hopkins University and Johns Hopkins Medicine, in collaboration with descendants of Henrietta Lacks, will honor the legacy of Mrs. Lacks and celebrate Hopkins’ newest multidisciplinary space in East Baltimore with a groundbreaking ceremony for the building to be named in Henrietta Lacks’ honor.
Two Johns Hopkins Faculty Members Elected to National Academy of Medicine
Two faculty members at the Johns Hopkins University School of Medicine and the Johns Hopkins Bloomberg School of Public Health have been elected to the National Academy of Medicine (NAM). Christopher Chute, M.D., Dr.P.H., and Jeffrey Rothstein, M.D., Ph.D., join 100 new members of NAM.
Study Suggests a Healthy Diet May Help Keep Low Grade Prostate Cancer from Progressing to More Dangerous States During Active Surveillance
In a peer-reviewed study believed to be the first of its kind published, a research team led by Johns Hopkins Medicine provides scientific evidence that a healthy diet may reduce the chance of low risk prostate cancer progressing to a more aggressive state in men undergoing active surveillance — a clinical option in which men with lower risk cancer are carefully monitored for progression in lieu of treatments that could have undesired side effects or complications.
Study Finds HIV-To-HIV Kidney Transplants Are as Safe and Effective as Those Using Organs From Donors Without HIV
According to findings from a multicenter study led by Johns Hopkins Medicine and released today in The New England Journal of Medicine (NEJM), transplanting kidneys from deceased donors who had the human immunodeficiency virus (HIV) to recipients with HIV is safe. Perhaps more importantly, the study authors also found that HIV-to-HIV kidney transplants are comparable in effectiveness to those using organs from donors without HIV.
Experimental Cancer Drug Eliminates Bone Metastases Caused by Breast Cancer in Lab Models
In a new study led by Johns Hopkins Medicine, the drug RK-33 has demonstrated promise in treating breast cancer that has spread to the bone (breast cancer bone metastasis). RK-33 was previously shown to help treat other types of cancer and viral illnesses.
Clinical Trial Shows Synthetic Cannabis Reduces Agitation in Alzheimer’s Disease
In a study led by the Johns Hopkins University School of Medicine and Tufts University School of Medicine, researchers show that a pill form of the drug dronabinol, an FDA-approved synthetic version of marijuana’s main ingredient, THC, reduces agitation in patients with Alzheimer’s by an average of 30%.
‘Synthetic’ Cell Shown to Follow Chemical Directions and Change Shape, A Vital Biological Function
In a feat aimed at understanding how cells move and creating new ways to shuttle drugs through the body, scientists at Johns Hopkins Medicine say they have built a minimal synthetic cell that follows an external chemical cue and demonstrates a governing principle of biology called “symmetry breaking.”
Study Suggests High-Frequency Electrical ‘Noise’ Results in Congenital Night Blindness
In what they believe is a solution to a 30-year biological mystery, neuroscientists at Johns Hopkins Medicine say they have used genetically engineered mice to address how one mutation in the gene for the light-sensing protein rhodopsin results in congenital stationary night blindness.
Study Suggests Adolescent Stress May Raise Risk of Postpartum Depression in Adults
In a new study, a Johns Hopkins Medicine-led research team reports that social stress during adolescence in female mice later results in prolonged elevation of the hormone cortisol after they give birth.
Wilmer Eye Institute Awarded More Than $20 Million for Clinical Trial Investigating Genetic Eye Condition
The Wilmer Eye Institute, Johns Hopkins Medicine has received two awards totaling more than $20 million from the National Eye Institute at the National Institutes of Health, both of which will be used for a six-year clinical trial investigating a potential treatment for the most common inherited retinal disease, retinitis pigmentosa.
Johns Hopkins Medicine-Led Study Shows Rapid COVID-19 Tests Done at Home are Reliable
In a study involving nearly 1,000 patients seen at the Baltimore Convention Center Field Hospital (BCCFH) during a five-month period in 2022 — researchers at Johns Hopkins Medicine, the University of Maryland School of Medicine and five other collaborators report that a rapid antigen test (RAT) for detecting SARS-CoV-2, the virus that causes COVID-19, can be used at home with accuracy comparable to the same test being administered by a health care professional.
Study Suggests Marijuana Use Damages Brain Immune Cells Vital to Adolescent Development
In a mouse study designed to explore the impact of marijuana’s major psychoactive compound, THC, on teenage brains, Johns Hopkins Medicine researchers say they found changes to the structure of microglia, which are specialized brain immune cells, that may worsen a genetic predisposition to schizophrenia. The
Three Johns Hopkins Medicine Faculty Members Elected to National Academy of Medicine
Three faculty members at the Johns Hopkins University School of Medicine have been elected to the National Academy of Medicine (NAM), an independent organization made up of leading professionals from multiple fields, such as public health, medicine, and natural, social and behavioral sciences
Does Form Follow Function? Johns Hopkins Medicine Researchers Advance Understanding of Why Cell Parts Look the Way They Do
Scientists have long understood that parts of cells, called organelles, evolved to have certain shapes and sizes because their forms are closely related to how they function.
Long-Term Study Reaffirms Benefits of Covid-19 Vaccination for Organ Transplant Recipients
A two-year study found that spikes of post-vaccination SARS-CoV-2 viral infections (commonly known as COVID-19 breakthrough cases) remain common, yet hospitalization rates have dramatically dropped following the first wave of the virus’ omicron subvariant.
Study Shows Positive Outcomes for First Three U.S. Living HIV-To-HIV Kidney Transplant Donors
Based on findings from a study published today in the journal, The Lancet Regional Health – Americas, researchers at Johns Hopkins Medicine and three collaborating medical institutions suggest that people living with the human immunodeficiency virus (HIV) who donate a kidney to other people living with HIV (PLWH) have a low risk of developing end-stage kidney disease (ESKD) or other kidney problems in the years following the donation.
‘Tipping The Balance’ Of Immune Cells from Bad to Good Reverses Multiple Sclerosis Symptoms in Mice
According to the federal government’s National Institute of Neurological Disorders and Stroke, nearly 3 million people worldwide — with almost a third in the United States — are living with multiple sclerosis (MS), a disabling neurological disease in which the body’s immune system mistakenly attacks nerves feeding information to the central nervous system (the brain and spinal cord). Although rarely fatal, MS can lead to long-term disabilities, and impair movement, muscle control, vision and cognition.
AI Used to Advance Drug Delivery System for Glaucoma and Other Chronic Diseases
Wilmer Eye Institute, Johns Hopkins Medicine researchers say they have used artificial intelligence models and machine-learning algorithms to successfully predict which components of amino acids that make up therapeutic proteins are most likely to safely deliver therapeutic drugs to animal eye cells.
Research Team Creates Statistical Model to Predict Covid-19 Resistance
Researchers from Johns Hopkins Medicine and The Johns Hopkins University have created and preliminarily tested what they believe may be one of the first models for predicting who has the highest probability of being resistant to COVID-19 in spite of exposure to SARS-CoV-2, the virus that causes it.
U.S. Study of Intravenous Mistletoe Extract to Treat Advanced Cancer
Researchers at the Johns Hopkins Kimmel Cancer Center completed what is believed to be the first phase I trial of intravenous Helixor M in the U.S. aimed at determining dosing for subsequent clinical trials and to evaluate safety.
Four Johns Hopkins Medicine Researchers Named Fellows of the American Association for the Advancement of Science
Four researchers from the Johns Hopkins University School of Medicine were elected as 2022 fellows of the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society and a publisher of numerous journals, including Science.
New Studies Suggest Social Isolation Is a Risk Factor for Dementia in Older Adults, Point to Ways to Reduce Risk
In two studies using nationally representative data from the National Health and Aging Trends Study gathered on thousands of Americans, researchers from the Johns Hopkins University School of Medicine and Bloomberg School of Public Health have significantly added to evidence that social isolation is a substantial risk factor for dementia in community-dwelling (noninstitutionalized) older adults, and identified technology as an effective way to intervene.
Key Change in Genetics of SARS-CoV-2 Evolved to Counter Weakness Caused by the Virus’ Initial Mutation that Enabled Its Spread
Researchers at Johns Hopkins Medicine say their new studies suggest that the first pandemic-accelerating mutation in the SARS-CoV-2 virus, which causes COVID-19, evolved as a way to correct vulnerabilities caused by the mutation that started the SARS-CoV-2 pandemic.
New Computer Model Tracks Origin of Cell Changes That Drive Development
Scientists at Johns Hopkins Medicine say they have developed a computer model — dubbed quantitative fate mapping — that looks back in the developmental timeline to trace the origin of cells in a fully grown organism.
Study Shows Paxlovid Can Safely Be Used to Reduce Risk of Severe COVID in People Who Are Pregnant
Findings from a Johns Hopkins Medicine research study published today in JAMA Network Open provide strong evidence that people who are pregnant and have been infected with SARS-CoV-2 (the virus that causes COVID-19) can safely take the antiviral drug Paxlovid to reduce the possibility of severe disease.
‘You can always make a change’: 15-Year-Old Johns Hopkins Patient with Type 2 Diabetes Thrives Almost 2 Years After Diagnosis
November is National Diabetes Awareness Month. Youth onset type 2 diabetes is rising worldwide, and a recent study by researchers at Johns Hopkins Children’s Center, published in the Journal of Pediatrics, documented a steep rise in new diagnoses of type 2 diabetes among children during the early part of the COVID-19 pandemic
Wearable Activity Trackers Can Be Used to Determine Health Metrics That Could Support Clinical Care
A new Johns Hopkins study shows that data gathered from wearable activity trackers can be used to obtain several metrics associated with the user’s general physical health and cardiovascular health status.
Johns Hopkins Researchers Design ‘Prodrug’ That Targets Cancer Cells’ Big Appetite for Glutamine, Leaving Healthy Cells Unharmed
Newly published study in mice show augmented drug eliminates cancer cells without causing toxicity.
Extracellular Viscosity Linked to Cancer Spread
New research findings show how higher viscosity, or resistance to flow, of the extracellular fluid that surrounds cells enables cancer cells to migrate more rapidly from a primary tumor to other sites in the body.
Proof-of-Concept Study Advances Potential New Way to Deliver Gene Therapy
Johns Hopkins Medicine researchers say they have successfully used a cell’s natural process for making proteins to “slide” genetic instructions into a cell and produce critical proteins missing from those cells.
Trick-Or-Treat Tips — Johns Hopkins Children’s Center Experts Available to Talk About Halloween Safety
It’s that time of year: costumes, candy and trick-or-treating. As families celebrate this season, Johns Hopkins Children’s Center experts are available for interviews on a variety of tips to help ensure a safe and fun Halloween.
Researchers Find Link Between Immune Cells’ Closest Neighbors and Survival Time in Patients with Pancreatic Cancer
Researchers from Johns Hopkins Medicine have discovered that the organization of different types of immune cells within pancreatic tumors is associated with how well patients with pancreatic cancer respond to treatment and how long they survive.
Patient Education and Feedback to Nurses Help Improve Administration Of Clot-Busting Drugs
Johns Hopkins Medicine study suggests strategies may prevent dangerous post-surgery condition
Study Finds Genetic Method for Identifying Hundreds of Disease Agents ‘Promising’
In the pursuit of accurate diagnoses for illnesses, doctors have traditionally used multiple methods to try to identify the bacterium, virus, fungus or other pathogen responsible for an infection.
Scientists Identify Novel Molecular Biomarkers in Cells That Spread a Deadly Form of Breast Cancer
Studying a deadly type of breast cancer called triple negative, Johns Hopkins Medicine scientists say they have identified key molecular differences between cancer cells that cling to an initial tumor and those that venture off to form distant tumors.
Johns Hopkins Medicine Scientists Create Nanobody That Can Punch Through Tough Brain Cells and Potentially Treat Parkinson’s Disease
Johns Hopkins Medicine researchers have helped develop a nanobody capable of getting through the tough exterior of brain cells and untangling misshapen proteins that lead to Parkinson’s disease, Lewy body dementia, and other neurocognitive disorders caused by the damaging protein.
Protein Parts Must Indeed Wiggle and Jiggle to Work Right, New Research Suggests
Johns Hopkins Medicine scientists report they have probed the atomic structure of proteins to add to evidence that the wobbles, shakes and quivers of proteins play a critical role in their ability to function. The findings of the research may help scientists design new drugs that can modify or disrupt the intricate “dances” of proteins to alter their functions.
Duration of Preoperative Pain Linked to Chronic Opioid Use After Adult Spinal Deformity Surgery
In a Johns Hopkins Medicine study of patients who underwent adult spinal deformity (ASD) surgery, preoperative opioid use and pain duration of four or more years were independently associated with higher odds of chronic post-surgery opioid use.
Johns Hopkins Medicine Study: Abnormal Heart Metabolism May Predict Future Sudden Cardiac Death
Adults with abnormal heart metabolism are up to three times more likely to experience life-threatening arrhythmias (an irregular heart rhythm), and MRI techniques could be used to detect the condition and predict future sudden cardiac death (SCD), according to a small, but rigorous study led by Johns Hopkins Medicine researchers.
Johns Hopkins Researchers Call for Closing Gap in Collecting Racial and Ethnic Data in Studies of Rare Genetic Condition
In a review of published research papers, investigators from the Johns Hopkins Medicine Hereditary Hemorrhagic Telangiectasia (HHT) Center have identified a substantial lack of racial and ethnic data that may be negatively impacting the treatment and diagnosis of this rare disorder in diverse patients.
Measuring Levels of Proteins in Eye Fluid May Accurately Predict Need for Lifelong Macular Degeneration Therapy
In a study of eye fluid from 38 patients, Johns Hopkins Medicine researchers say they have found that levels of a specific protein appears to help accurately predict whether people with the wet form of age-related macular degeneration may need lifelong, frequent eye injections to preserve vision or if they can be safely weaned off the treatments.
Adult Cancer Survivors Have Higher Risk of Cardiovascular Disease Than Those Without Cancer, Study Shows
Adult survivors of cancer have a higher risk of heart failure and other cardiovascular diseases (CVD) later in life than adults without cancer, according to results of a large study led by Johns Hopkins Medicine researchers.
Breast Duct Treatment For Early Breast Cancer Eliminates All Signs Of Disease In Laboratory Experiments
Delivering a targeted immunotoxin into breast ducts via openings in the nipple wiped out all visible and invisible precancerous lesions in laboratory studies, led by researchers at the Johns Hopkins Kimmel Cancer Center, of very early stage breast cancers
COVID-19 Pandemic Curtailed Young Adults’ Access to Addiction Treatment
A study analyzing prescription claims for a drug used to treat opioid addictions found that adolescents and young adults were less likely than usual to get treatment during the COVID-19 pandemic, especially if they were covered by private, commercial health insurance.
Uncontrolled Diabetes Can Advance Heart Failure from Early Stage to Late Stage
Among older adults with early stage — also known as preclinical — heart failure, uncontrolled diabetes can substantially increase the risk of heart failure progression, according to a new Johns Hopkins-led study.
Coffee consumption linked to reduced risk of acute kidney injury, study finds
A recent study by Johns Hopkins Medicine researchers has revealed that consuming at least one cup of coffee a day may reduce the risk of acute kidney injury (AKI) when compared to those who do not drink coffee.
Common Medical Tool May Delay Treatment of Nonwhite Patients with COVID-19
A retrospective analysis of over 7,000 patients with COVID-19 found that pulse oximeter devices — tools that measure oxygen levels in the blood and that are used in virtually every U.S. hospital — overestimated blood oxygen levels in non-White patients.
Johns Hopkins Medicine Researchers Link Sugar-Studded Protein to Alzheimer’s Disease
Johns Hopkins Medicine researchers say they discovered that a special sugar molecule could play a key role in the development of Alzheimer’s disease. If further research confirms the finding, the molecule, known as a glycan, could serve as a new target for early diagnostic tests, treatments and perhaps prevention of Alzheimer’s disease, say the researchers.
Johns Hopkins Medicine Experts Available to Discuss Importance of Mental Well-Being
Nearly 20% of adults — about 50 million American people — are experiencing a mental illness, and about one in five children are affected by a mental disorder each year. There are many types of mental illness, including mood, anxiety and personality disorders.