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UrduA new paper in the Journal of Neuropathology & Experimental Neurology finds a gene that may help explain a large part of the genetic risk for developing Alzheimer disease. Late-onset Alzheimer disease, the most common form of the illness, is…
Tag: genes
Mount Sinai Researchers Uncover New Molecular Drivers of Parkinson’s Disease
New Approach Will Lead to a Better Understanding of Most Cases
Melanin-producing Streptomyces are more likely to colonize plants
Plant growth-promoting Streptomyces assemble into the internal, root endophytic compartments of a wide variety of plants around the world. These bacteria are well-known for their ability to produce a huge array of secondary metabolites and also protect against pests. Recent…
New fossils shed light on how snakes got their bite and lost their legs
New fossils of an ancient legged snake, called Najash, shed light on the origin of the slithering reptiles.
Scientists find promising drug combination against lethal childhood brain cancers
Studies in cell and animal models reveal insights into cancer cells’ vulnerability that could lead to new strategies against brain cancers
Team led by institute for basic research scientist publishes findings on TAF1 syndrome
An international, multidisciplinary research team from more than 50 institutions, led by geneticist and psychiatrist Gholson Lyon, MD, PhD, of the New York State Office for People With Developmental Disabilities’ (OPWDD) Institute for Basic Research in Developmental Disabilities (IBR), today…
Researchers find striking variation in mechanisms that drive sex selection in frogs
Researchers from McMaster University have discovered striking variation in the underlying genetic machinery that orchestrates sexual differentiation in frogs, demonstrating that evolution of this crucial biological system has moved at a dramatic pace. A team of biologists examined more than…
Researchers find striking variation in mechanisms that drive sex selection in frogs
Researchers from McMaster University have discovered striking variation in the underlying genetic machinery that orchestrates sexual differentiation in frogs, demonstrating that evolution of this crucial biological system has moved at a dramatic pace. A team of biologists examined more than…
Researchers clear the path for ‘designer’ plants
New targets for gene editing could lead to more resilient crops
Climate change could double greenhouse gas emissions from freshwater lakes
Every drop of fresh water contains thousands of different organic molecules that have previously gone unnoticed. By measuring the diversity of these molecules and how they interact with the environment around them, research has revealed an invisible world that affects…
How maternal Zika virus infection results in newborn microcephaly
A new study led by researchers at Baylor College of Medicine revealed how in utero Zika virus infection can lead to microcephaly in newborns. The team discovered that the Zika virus protein NS4A disrupts brain growth by hijacking a pathway…
DNA data offers scientific look at 500 years of extramarital sex in Western Europe
These days it’s easy to resolve questions about paternity with over-the-counter test kits. Now, researchers have put DNA evidence together with long-term genealogical data to explore similar questions of biological fatherhood on a broad scale among people living in parts…
Researchers find new role for dopamine in gene transcription and cell proliferation
Researchers at the George Washington University and the University of Pittsburgh have found a previously unobserved role for the dopamine D2 receptor in gene transcription and cell proliferation, which may have implications for development of therapeutics
New method described for quantifying antisense oligonucleotides in nuclei
New Rochelle, NY, November 14, 2019–A novel method uses subcellular fractionation to quantify label-free antisense oligonucleotides (AONs)- designed to silence targeted genes – that have crossed into the nucleus of a cell, where they can exert their effects. Researchers used…
MicroRNA comprehensively analyzed
Messenger RNA transmits genetic information to the proteins, and microRNA plays a key role in the regulation of gene expression. Scientists from the Moscow Institute of Physics and Technology and the Research Centre for Medical Genetics have described the complex…
Is evolution predictable?
An international team of scientists working with Heliconius butterflies at the Smithsonian Tropical Research Institute (STRI) in Panama was faced with a mystery: How do pairs of unrelated butterflies from Peru to Costa Rica evolve nearly the same wing-color patterns…
How maternal Zika virus infection results in newborn microcephaly
A new study led by researchers at Baylor College of Medicine revealed how in utero Zika virus infection can lead to microcephaly in newborns. The team discovered that the Zika virus protein NS4A disrupts brain growth by hijacking a pathway…
DNA data offers scientific look at 500 years of extramarital sex in Western Europe
These days it’s easy to resolve questions about paternity with over-the-counter test kits. Now, researchers have put DNA evidence together with long-term genealogical data to explore similar questions of biological fatherhood on a broad scale among people living in parts…
Researchers find new role for dopamine in gene transcription and cell proliferation
Researchers at the George Washington University and the University of Pittsburgh have found a previously unobserved role for the dopamine D2 receptor in gene transcription and cell proliferation, which may have implications for development of therapeutics
New method described for quantifying antisense oligonucleotides in nuclei
New Rochelle, NY, November 14, 2019–A novel method uses subcellular fractionation to quantify label-free antisense oligonucleotides (AONs)- designed to silence targeted genes – that have crossed into the nucleus of a cell, where they can exert their effects. Researchers used…
MicroRNA comprehensively analyzed
Messenger RNA transmits genetic information to the proteins, and microRNA plays a key role in the regulation of gene expression. Scientists from the Moscow Institute of Physics and Technology and the Research Centre for Medical Genetics have described the complex…
Is evolution predictable?
An international team of scientists working with Heliconius butterflies at the Smithsonian Tropical Research Institute (STRI) in Panama was faced with a mystery: How do pairs of unrelated butterflies from Peru to Costa Rica evolve nearly the same wing-color patterns…
System by which plants have formed secondary buds since ancient times illuminated
A collaborative research group has succeeded in identifying an important transcription factor, GCAM1, which allows liverwort plants to asexually reproduce through creating clonal progenies (vegetative reproduction). Furthermore, this transcription factor was revealed to have the same origin as those which…
System by which plants have formed secondary buds since ancient times illuminated
A collaborative research group has succeeded in identifying an important transcription factor, GCAM1, which allows liverwort plants to asexually reproduce through creating clonal progenies (vegetative reproduction). Furthermore, this transcription factor was revealed to have the same origin as those which…
Scientists crack rabies virus weaponry
Researchers from have found a way to stop the rabies virus shutting down the body’s immune defence against it.
University of Florida scientists advance citrus greening research efforts
Citrus greening, a devastating disease, has reduced Florida citrus production by 70%, according to most accounts. Efforts to develop disease control methods have been stymied because scientists have been unable to culture and experimentally manipulate the causal bacterial pathogen, Candidatus…
Epigenetic switch found that turns warrior ants into forager ants
In 2016, researchers observed that they could reprogram the behavior of the Florida carpenter ant Camponotus floridanus . This species has two distinct castes with nearly identical genetic makeup: smaller Minor workers who forage and nurse the ant brood and…
Delivering large genes to the retina is problematic
New Rochelle, NY, November 12, 2019–A new study has shown that a commonly used vector for large gene transfer can successfully deliver genes to retinal cells in the laboratory, but when injected subretinally into rats it provokes a robust and…
Songbirds sing species-specific songs
The generation of species-specific singing in songbirds is associated with species-specific patterns of gene activity in brain regions called song nuclei, according to a study published November 12 in the open-access journal PLOS Biology by Kazuhiro Wada of Hokkaido University…
Widespread misinterpretation of gene expression data
Reproducibility is a major challenge in experimental biology, and with the increasing complexity of data generated by genomic-scale techniques this concern is immensely amplified. RNA-seq, one of the most widely used methods in modern molecular biology, allows in a single…
University of Florida scientists advance citrus greening research efforts
Citrus greening, a devastating disease, has reduced Florida citrus production by 70%, according to most accounts. Efforts to develop disease control methods have been stymied because scientists have been unable to culture and experimentally manipulate the causal bacterial pathogen, Candidatus…
Epigenetic switch found that turns warrior ants into forager ants
In 2016, researchers observed that they could reprogram the behavior of the Florida carpenter ant Camponotus floridanus . This species has two distinct castes with nearly identical genetic makeup: smaller Minor workers who forage and nurse the ant brood and…
Scientists crack rabies virus weaponry
Researchers from have found a way to stop the rabies virus shutting down the body’s immune defence against it.
Delivering large genes to the retina is problematic
New Rochelle, NY, November 12, 2019–A new study has shown that a commonly used vector for large gene transfer can successfully deliver genes to retinal cells in the laboratory, but when injected subretinally into rats it provokes a robust and…
Songbirds sing species-specific songs
The generation of species-specific singing in songbirds is associated with species-specific patterns of gene activity in brain regions called song nuclei, according to a study published November 12 in the open-access journal PLOS Biology by Kazuhiro Wada of Hokkaido University…
Widespread misinterpretation of gene expression data
Reproducibility is a major challenge in experimental biology, and with the increasing complexity of data generated by genomic-scale techniques this concern is immensely amplified. RNA-seq, one of the most widely used methods in modern molecular biology, allows in a single…
Better Biosensor Technology Created for Stem Cells
A Rutgers-led team has created better biosensor technology that may help lead to safe stem cell therapies for treating Alzheimer’s and Parkinson’s diseases and other neurological disorders. The technology, which features a unique graphene and gold-based platform and high-tech imaging, monitors the fate of stem cells by detecting genetic material (RNA) involved in turning such cells into brain cells (neurons), according to a study in the journal Nano Letters.
CRISPR: More than just for gene editing?
researcher finds new use for revolutionary gene-splicing tool; Electrochemical CRISPR platform could lead to quick blood test for disease identification through detection of important nucleic acids, HPV or Parvo
New research explains how HIV avoids getting ZAPped
ANN ARBOR–Humans have evolved dynamic defense mechanisms against the viruses that seek to infect our bodies–proteins that specialize in identifying, capturing and destroying the genetic material that viruses try to sneak into our cells. A new study, scheduled to publish…
Finding Nemo’s cousins
Meet the little fish that can see UV light
Team plucks needle from genomic haystack, finding essential transcription factor binding sites
Using CRISPR/Cas9 knockout screens a multi-institutional research team systematically interrogated the essentiality of more than 10,000 forkhead box protein A1 (FOXA1) and CTCF binding sites in breast and prostate cancer cells, plucking useful needles from a massive genomic haystack that…
New research explains how HIV avoids getting ZAPped
ANN ARBOR–Humans have evolved dynamic defense mechanisms against the viruses that seek to infect our bodies–proteins that specialize in identifying, capturing and destroying the genetic material that viruses try to sneak into our cells. A new study, scheduled to publish…
CRISPR: More than just for gene editing?
researcher finds new use for revolutionary gene-splicing tool; Electrochemical CRISPR platform could lead to quick blood test for disease identification through detection of important nucleic acids, HPV or Parvo
Finding Nemo’s cousins
Meet the little fish that can see UV light
Team plucks needle from genomic haystack, finding essential transcription factor binding sites
Using CRISPR/Cas9 knockout screens a multi-institutional research team systematically interrogated the essentiality of more than 10,000 forkhead box protein A1 (FOXA1) and CTCF binding sites in breast and prostate cancer cells, plucking useful needles from a massive genomic haystack that…
Scientists develop method to standardize genetic data analysis
MIPT researchers have collaborated with Atlas Biomedical Holding and developed a new bioinformatics data analysis method. The developed program, EphaGen, can be used for quality control when diagnosing genetic diseases. The team published the article in Nucleic Acid Research .…
Chimera formation could favor the expansion of invasive species in the marine environment
Didemnum vexillum: A global invader
From Plants, UVA Extracts a Better Way to Determine What Our Genes Do
The improved technique will help explore genetic diseases and benefit drug development. It could also lead to better, safer weed killers.
Learning to stop cancer at its roots
Why do some cancers come back? Sometimes, a treatment can effectively eliminate cancer cells to undetectable levels, but, if the treatment stops, cancer may return. This is the case of chronic myeloid leukemia treated with drugs known as tyrosine kinase…
Human heart cells are altered by spaceflight, but return to (mostly) normal on Earth
Heart muscle cells derived from stem cells show remarkable adaptability to their environment during and after spaceflight, according to a study publishing November 7 in the journal Stem Cell Reports . The researchers examined cell-level cardiac function and gene expression…