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UrduA new editorial – published in Nature – suggests that frequent fluctuations in diet, commonly known as “yo-yo dieting,” can significantly increase the risk of cardiovascular disease. The authors, from the University of Pennsylvania Schools of Nursing and Medicine, describe how cycling between high-fat and low-fat diets in mice led to a substantial acceleration of atherosclerosis, a condition characterized by the buildup of plaque in arteries.
Tag: Atherosclerosis
New discovery may lead to more effective treatment for cardiovascular disease
Researchers at Case Western Reserve University have identified a new target to treat atherosclerosis, a condition where plaque clogs arteries and causes major cardiac issues, including stroke and heart attack.
Antibody Shows Promise Against Obesity-related Liver Disease and Atherosclerosis in Mice
Latest research in the FASEB Journal reveals an antibody called bFKB1 improves liver disease and atherosclerosis in a mouse model of metabolic dysfunction-associated steatohepatitis (MASH), which is associated with obesity.
Hackensack Meridian Pascack Valley Medical Center Among First in New Jersey to Offer Innovative TCAR Procedure to Treat Carotid Artery Disease
Hackensack Meridian Pascack Valley Medical Center is among first in New Jersey to treat carotid artery disease and prevent future strokes using an innovative procedure called TransCarotid Artery Revascularization (TCAR). TCAR (tee-kahr) is a clinically proven and minimally invasive approach for patients who need carotid artery treatment.
RNA Inhibitor Is Shown Safe and Effective in Reducing a Wide Range of Cholesterol and Triglyceride Levels in the Blood in Mount Sinai-Led Clinical Trial
A small interfering RNA (siRNA) investigational therapy that inhibits a gene involved in lipoprotein metabolism has been shown in a clinical trial led by Mount Sinai researchers to significantly reduce levels of different types of cholesterol and triglycerides in individuals with mixed hyperlipidemia, a condition in which fats build up in the blood.
Hepatocyte growth factor enhances the ability of dental pulp stem cells to ameliorate atherosclerosis in apolipoprotein E-knockout mice
BACKGROUNDAtherosclerosis (AS), a chronic inflammatory disease of blood vessels, is a major contributor to cardiovascular disease. Dental pulp stem cells (DPSCs) are capable of exerting immunomodulatory and anti-inflammatory effects by secr
Common hair loss and prostate drug may also cut heart disease risk in men and mice
The drug finasteride, also known as Propecia or Proscar, treats male pattern baldness and enlarged prostate in millions of men worldwide. But a new University of Illinois Urbana-Champaign study suggests the drug may also provide a surprising and life-saving benefit: lowering cholesterol and cutting the overall risk of cardiovascular disease.
Oxidized phospholipid oxPAPC induces a dysfunctional Th1-like phenotype in regulatory T cells
Regulatory T cells (Tregs) are protective in atherosclerosis but numbers are reduced during disease progression due to cell death and loss of stability. Oxidized lipids are abundant in atherosclerotic lesions and can activate innate immune cells, but there is limited…
Researchers discover way to reverse infertility by reducing HDL cholesterol
Houston Methodist scientists reversed infertility in sterile mice by reducing HDL cholesterol with a bacterial protein in a promising development that shows further evidence linking high cholesterol to female infertility. The researchers worked with a protein called serum opacity factor that lowered cholesterol levels by over 40% in three hours.
Study Finds Chronically Disrupted Sleep May Increase the Risk for Heart Disease
Sleep irregularity — chronically disrupted sleep and highly variable sleep durations night after night — may increase the risk for atherosclerosis, according to a study led by Kelsie Full, PhD, MPH, of Vanderbilt University Medical Center.
Malfunctioning Mitochondria at the Heart of Many Cardiovascular Diseases
Many cardiovascular diseases, such as atherosclerosis, or ‘hardening of the arteries,’ correlate to mitochondrial dysfunction and endothelial impairment in the tissues of the heart and blood vessels.
Artificial Intelligence Shown to More Rapidly and Objectively Determine Calcium Scores Than Physicians
A study published today in the Journal of the American College of Cardiology (JACC): Cardiovascular Imaging shows that artificial intelligence tools can more rapidly, and objectively, determine calcium scores in computed tomographic (CT) and positron emission tomographic (PET) images than physicians, even when obtained from very-low-radiation CT attenuation scans.
Blacks Found Twice as Likely to Have Atherosclerosis as Hispanics in Young Adult Populations in Underserved Communities
A unique Mount Sinai study focused on a multi-ethnic, underserved community in New York City shows that young Black adults are twice as likely to have atherosclerosis as similarly situated young Hispanic adults.
Ultrasound-Assisted Laser Technique Vaporizes Artery Plaque #ASA182
Atherosclerosis, a buildup of plaque, can lead to heart disease, artery disease, and chronic kidney disease and is traditionally treated by inserting and inflating a balloon to expand the artery. During the 182nd ASA Meeting, Rohit Singh, of the University of Kansas, will present a method that combines a low-power laser with ultrasound to remove arterial plaque safely and efficiently.
Haywire T cells attack protein in “bad” cholesterol
Detecting these T cells may lead to diagnostics to better detect heart disease—and disease severity.
Researchers Explore How Lack of Cadherin-11 Protein Drives Immune Response in Atherosclerosis
Article title: Impaired macrophage trafficking and increased helper T-cell recruitment with loss of cadherin-11 in atherosclerotic immune response Authors: Camryn L. Johnson, Lance Riley, Matthew Bersi, MacRae F. Linton, W. David Merryman From the authors: “The results from this study…
Lower- and higher-dose aspirin achieve similar protection and safety for people with cardiovascular disease
People with cardiovascular disease (CVD) taking aspirin to lower their chances of suffering a heart attack or stroke experienced similar health benefits, including reduced death and hospitalization for heart attack and stroke, whether they took a high or low dose of aspirin, according to a study presented today at ACC.21, the American College of Cardiology’s 70th Annual Scientific Session and published in the New England Journal of Medicine.
Scientists find genetic link to clogged arteries
High cholesterol is the most commonly understood cause of atherosclerosis, a hardening of the arteries that raises the risk of heart attack and stroke. But now, scientists at Washington University School of Medicine in St. Louis have identified a gene that likely plays a causal role in coronary artery disease independent of cholesterol levels. The gene also likely has roles in related cardiovascular diseases, including high blood pressure and diabetes.
Heavier smoking linked to skyrocketing health risks
Each cigarette smoked a day by heavier smokers increases the risk of contracting some diseases by more than 30 per cent, according to a new international study published today.
T cells can shift from helping to harming in atherosclerosis
At La Jolla Institute for Immunology (LJI) researchers are dedicated to finding a way to stop plaques from forming in the first place. In a new study, LJI scientists show that certain T lymphocytes, a type of white blood cell, that start out trying to fight the disease can end up increasing inflammation and making atherosclerosis cases even worse.
How good gut bacteria help reduce the risk for heart disease
Scientists have discovered that one of the good bacteria found in the human gut has a benefit that has remained unrecognized until now: the potential to reduce the risk for heart disease.
Could This Plaque Identifying Toothpaste Prevent a Heart Attack or Stroke?
For decades, researchers have suggested a link between oral health and inflammatory diseases affecting the entire body – in particular, heart attacks and strokes. Results of a randomized pilot trial of Plaque HD®, the first toothpaste that identifies plaque so that it can be removed with directed brushing, showed that it produced a statistically significant reduction in C-reactive protein, a sensitive marker for future risks of heart attacks and strokes, among those with elevations at baseline.
Earlier detection of women’s vascular health issues can affect heart disease risk, Mayo Clinic study advises
Men and women differ in the way their vascular systems age and the rate at which atherosclerosis ― the hardening of artery walls or buildup of arterial blockage ― progresses over time. These sex- and age-related differences have a direct bearing on a woman’s risk factors for cardiovascular disease.
High-protein diets boost artery-clogging plaque, mouse study shows
A new study from Washington University School of Medicine in St. Louis reveals how high-protein diets increase atherosclerosis, especially unstable plaque that increases the risk of a heart attack.
Teaching Preschool Caregivers about Healthy Behaviors May Promote Healthier Lifestyle in Some High-Risk Groups
Study Shows Vascular Ultrasounds and Adhering to Interventional Education in Underserved Communities can Improve Health among Parents and School Staff