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UrduA multi-disciplinary, “One Health” approach to cancer research is necessary to guide society in reduction of toxic substances, as well as regulation of chemical impacts on the environment and public health, according to an editorial published recently in Issue II of Annals of Research in Oncology.
Category: Research Alert
Women earn less than men overall, but the gender pay gap is smaller in occupations with a higher ratio of male employees, according to study of over 6,000 Germans
Women earn less than men overall, but the gender pay gap is smaller in occupations with a higher ratio of male employees, according to study of over 6,000 Germans Press-only preview: https://plos.io/3Of0cIM Article URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0270343 Article Title: The gender pay gap is smaller…
Leading Causes of Death in US During Pandemic
About The Study: Heart disease, cancer, COVID-19, accidents and stroke were the most common causes of death in the United States from March 2020 to October 2021 during the pandemic, with COVID-19 accounting for 1 in 8 deaths, according to this…
Researchers Suggest Continued Heart and Lung Monitoring after COVID-19 for People with Highly Physical Jobs
Article title: The effect of medium-term recovery status after COVID-19 illness on cardiopulmonary exercise capacity in a physically active adult population Authors: Peter Ladlow, Oliver O’Sullivan, Alexander N. Bennett, Robert Barker-Davies, Andrew Houston, Rebecca Chamley, Samantha May, Daniel Mills, Dominic…
Omicron Variant of COVID-19 Does Not Cause Long-term Vascular Damage in Vaccinated Young Adults
Article title: Impact of breakthrough COVID-19 cases during the Omicron wave on vascular health and cardiac autonomic function in young adults Authors: Rachel J. Skow, Damsara Nandadeva, Ann-Katrin Grotle, Brandi Y. Stephens, Alexis N. Wright Paul J. Fadel From the…
Metabolomic Profiles Differ in Children Born to People with and without Obesity
Article title: Metabolomic signatures of low- and high-adiposity neonates differ based on maternal BMI Authors: Begum Aydogan Mathyk, Brian D. Piccolo, Fernanda Alvarado, Kartik Shankar, Perrie O’Tierney-Ginn From the authors: “Using untargeted metabolomics in 100 newborns, we found that cord…
Study of Body Weight-associated Genes in Rats May Inform Regulation of Obesity in Humans
Article title: Transcriptome-wide analyses of adipose tissue in outbred rats reveal genetic regulatory mechanisms relevant for human obesity Authors: Wesley L. Crouse, Swapan K. Das, Thu Le, Gregory Keele, Katie Holl, Osborne Seshie, Ann L. Craddock, Neeraj K. Sharma, Mary…
Selective Autophagy Process Protects Heart Muscle Cells from Death
Article title: Chaperone-mediated autophagy protects cardiomyocytes against hypoxic cell death Authors: Rajeshwary Ghosh, Jennifer Jason Gillaspie, Kenneth S. Campbell, J. David Symons, Sihem Boudina, James Scott Pattison From the authors: “In summary, the present study demonstrated the importance of [chaperone-mediated…
Flozin Drugs Lower Salt-Induced Hypertension, Maintain Circadian Rhythm in Rats
Article title: SGLT2 inhibition effect on salt-induced hypertension, RAAS and Na+ transport in Dahl SS rats Authors: Olha Kravtsova, Ruslan Bohovyk, Vladislav Levchenko, Oleg Palygin, Christine A. Klemens, Timo Rieg, Alexander Staruschenko From the authors: “The main findings of the…
Skin and Oral Microbiota Contribute to Blood Pressure Regulation
Article title: Beyond the gastrointestinal tract: oral and sex-specific skin microbiota are associated with hypertension in rats with genetic disparities Authors: Xue Mei, Blair Mell, Xi Cheng, Ji-Youn Yeo, Tao Yang, Nathaline Chiu, Bina Joe From the authors: “In conclusion,…
Large numbers cause magnitude neglect: The case of government expenditures
AbstractFour studies demonstrate that the public’s understanding of government budgetary expenditures is hampered by difficulty in representing large numerical magnitudes. Despite orders of magnitude difference between millions and billions, study participants struggle with the budgetary magnitudes of government programs. When…
Cannabinoid Vaping Products, Genomic Biomarkers, a Novel In Vitro Testing System, and More in New Toxicological Sciences
Cannabinoid vaping products, genomic biomarkers to determine tumorigenic potential, and analyses of various testing assays are just a few of the article topics in the July 2022 issue of Toxicological Sciences.
Application and prospects of high-throughput screening for in vitro neurogenesis
Adipose tissue (AT) is recognized as a complex organ involved in major home-ostatic body functions, such as food intake, energy balance, immunomodulation, development and growth, and functioning of the reproductive organs. The role of AT in tis
Long noncoding RNAs in mesenchymal stromal/stem cells osteogenic differentiation: Implications in osteoarthritis pathogenesis
This letter focuses on a recently published article that provided an exceptional description of the effect of epigenetic modifications on gene expression patterns related to skeletal system remodeling. Specifically, it discusses a novel modalit
Adipose tissue in bone regeneration – stem cell source and beyond
Adipose tissue (AT) is recognized as a complex organ involved in major home-ostatic body functions, such as food intake, energy balance, immunomodulation, development and growth, and functioning of the reproductive organs. The role of AT in tis
Role of stem cells-based in facial nerve reanimation: A meta-analysis of histological and neurophysiological outcomes
BACKGROUNDTreatments involving stem cell (SC) usage represent novel and potentially interesting alternatives in facial nerve reanimation. Current literature includes the use of SC in animal model studies to promote graft survival by enhancing n
Medication Use and Clinical Outcomes by the Dutch Institute for Clinical Auditing Medicines Program: Quantitative Analysis
Background: The Dutch Institute for Clinical Auditing (DICA) Medicines Program was set up in September 2018 to evaluate expensive medicine use in daily practice in terms of real-world effectiveness using only existing data sources. Objective: The aim of this study…
College towns saw fewer COVID-19 cases when classes were held online and/or on-campus testing was conducted – suggesting regular tests could reduce future community infections
In your coverage, please use this URL to provide access to the freely available article in PLOS Digital Health: https://journals.plos.org/digitalhealth/article?id=10.1371/journal.pdig.0000065 Press-only preview: https://plos.io/3zFkE0I Article Title: Higher education responses to COVID-19 in the United States:Evidence for the impacts of university policy Author Countries: United States Funding: A.V.…
Mount Sinai Researchers Learn That ALS May Be Linked to Both the Immune and Central Nervous Systems
New York, NY (June 22, 2022) – The immune system may play a fundamental role along with the central nervous system in amyotrophic lateral sclerosis (ALS), also known as “Lou Gehrig’s disease,” Mount Sinai researchers report. Their study, published…
In the 2020 U.S. House of Representatives Elections, Democrats supporting the Green New Deal increased their vote share.
Press-only preview: https://plos.io/3HckDmQ Article URL: https://journals.plos.org/climate/article?id=10.1371/journal.pclm.0000043 Article Title: Electoral appeal of climate policies: The Green New Deal and the 2020 U.S. House of Representatives elections Author Countries: U.S.A. Funding: The authors received no specific funding for this work. Competing Interests: The authors have declared that…
Getting Tough on Tuft Cell Lung Cancer
Cold Spring Harbor Laboratory (CSHL) Professor Christopher Vakoc’s team discovered in 2018 a new type of small-cell lung cancer. The cancer originates from cells known as tuft cells.
Novel Treatment for Rare Form of Kidney Cancer Uncovered
Chromophobe renal cell carcinoma (ChRCC) is a rare form of kidney cancer for which there are currently no proven treatments for metastatic or unresectable disease. In a study led by investigators from Brigham and Women’s Hospital, researchers report the first…
The Lancet Publishes Sylvester-Led Study Defining New Standard of Care for Prostate Cancer Recurrence After Prostatectomy
Adding short-term hormone therapy and pelvic lymph node radiotherapy to standard of care prostatectomy surgical bed treatment benefits prostate cancer patients whose prostate-specific antigen (PSA) levels are rising post prostatectomy, according to an international study led by Alan Pollack, M.D.,…
SEIR Model to Address the Impact of Face Masks amid COVID-19 Pandemic
When vaccines are not available, alternative strategies are required to decrease SARS-CoV-2 transmission. Behavior of the population and government regulations, such as hand hygiene, quarantine of exposed persons, isolation of symptomatic persons, and travel restriction, play an essential role in…
Sylvester Researchers Study Vaginal Microbiome’s Role in Screening for Endometrial Cancer
The vaginal microbiome differentiates benign disease from endometrial cancer and can even provide insight about the specific endometrial cancer type and disease severity, according to a study by investigators at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of…
Racial Disparities in Health Care Spending, Use Among Medicaid Enrollees
About The Study: In this analysis of nearly 2 million Medicaid enrollees in 2016, compared with white enrollees, Black enrollees generated lower spending and used fewer services, including primary care and recommended care for acute and chronic conditions, but had substantially…
The Effect of Fear of Infection and Sufficient Vaccine Reservation Information on Rapid COVID-19 Vaccination in Japan: Evidence From a Retrospective Twitter Analysis
Background: The global public health and socioeconomic impacts of the COVID-19 pandemic have been substantial, rendering herd immunity by COVID-19 vaccination an important factor for protecting people and retrieving the economy. Amon…
Video Relay Interpretation and Overcoming Barriers in Health Care for Deaf Users: Scoping Review
Background: Persons who are deaf are more likely to avoid health care providers than those who can hear, partially because of the lack of means of communication with these providers and the dearth of available interpreters. The use o…
mHealth Research for Weight Loss, Physical Activity, and Sedentary Behavior: Bibliometric Analysis
Background: Research into mobile health (mHealth) technologies on weight loss, physical activity, and sedentary behavior has increased substantially over the last decade; however, no research has been published showing the research t…
Novel Immunotherapy Mechanism Suppresses Breast Cancer Development
METHOD OF RESEARCH Experimental study SUBJECT OF RESEARCH Animals ARTICLE TITLE CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation ARTICLE PUBLICATION DATE 3-Jun-2022 COI STATEMENT Disclosures: M. Boieri is an employee of Zelluna Immunotherapy.…
Artificial Intelligence Analyzes Gut Microbiota of Fish to Detect Waters Compromised by Climate Change
Article title: Gut microbiota of wild fish as reporters of compromised aquatic environments sleuthed through machine learning Authors: John W. Turner Jr., Xi Cheng, Nilanjana Saferin, Ji-Youn Yeo, Tao Yang Bina Joe From the authors: “Overall, this study represents the…
Researchers Find New Microvascular Regulation Role for Protein-coupled Receptor
Article title: Control of coronary vascular resistance by eicosanoids via a novel GPCR Authors: Nabil J. Alkayed, Zhiping Cao, Zu Yuan Qian, Shanthi Nagarajan, Xuehong Liu, Jonathan W. Nelson, Fuchun Xie, Bingbing Li, Wei Fan, Lijuan Liu, Marjorie R. Grafe,…
Acid Reflux in People with Barrett’s Esophagus May Change Cells to Cause Cancer
Article title: A human Barrett’s esophagus organoid system reveals epithelial-mesenchymal plasticity induced by acid and bile salts Authors: Qiuyang Zhang, Ajay Bansal, Kerry B. Dunbar, Yan Chang, Jianning Zhang, Uthra Balaji, Jinghua Gu, Xi Zhang, Eitan Podgaetz, Zui Pan, Stuart…
Calcium Signaling Plays Important Role in Regulating Bone Formation
Article title: Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation Authors: Abu Shufian Ishtiaq Ahmed, Matilda H. C. Sheng, Kin-Hing William Lau, Sean M. Wilson, Daniel Wongwarawat, Xiaolei Tang, Mahdis Ghahramanpouri,…
Anxiety Drug Increases Blood Pressure Variability in Young Adults
Article title: Potentiation of GABAergic synaptic transmission by diazepam acutely increases resting beat-to-beat blood pressure variability in young adults Authors: André L. Teixeira, Massimo Nardone, Milena Samora, Igor A. Fernandes, Plinio S. Ramos, Jeann L. Sabino-Carvalho, Djalma R. Ricardo, Philip…
Kidney Stone Formation Linked to Polycystic Kidney Disease in Mice
Article title: Kidney stone formation in a novel murine model of polycystic kidney disease Authors: Heather A.L. Riddle, Shiqin Zhang, Feng Qian, James C. Williams Jr., Jason R. Stubbs, Peter Stanley N. Rowe, Stephen C. Parnell From the authors: “Our…
Blocking Endothelin Receptors May Help People with Obesity Burn Calories, Reduce Heart Disease Risk
Article title: Dual endothelin receptor antagonism increases resting energy expenditure in people with increased adiposity Authors: Cassandra C. Derella, Anson M. Blanks, Andy Nguyen, Jacob Looney, Matthew A. Tucker, Jinhee Jeong, Paula Rodriguez-Miguelez, Jeffrey Thomas, Matthew Lyon, David M. Pollock,…
Temperature Plays a Role in Brain Activity Related to Episodic Memory and Planning
Article title: Brain temperature affects quantitative features of hippocampal sharp wave ripples Authors: Peter C. Petersen, Mihály Vöröslakos, György Buzsáki From the authors: “Here, we show that features of hippocampal ripples, including the rate of occurrence, peak frequency, and duration…
New Exercise Technique Improves Muscle Responsiveness in Aging Mice
Rockville, Md. (June 1, 2022)—Combined modality exercise such as aerobic and resistance exercise is highly beneficial for an aging population, according to a new mouse study published ahead of print in the journal Function. Researchers also discovered the calf muscle…
Compared to COVID-19 PCR testing, dogs can detect infections with high sensitivity (97%), though lower specificity (91%) – even when patients are asymptomatic
Press-only preview: https://plos.io/3lvCafy Article URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0268382 Article Title: Diagnostic accuracy of non-invasive detection of SARS-CoV-2 infection by canine olfaction Author Countries: France, U.A.E. Funding: The trial was supported by a grant from the French Ministry of Health, Region Ile de France and Assistance Publique-Hôpitaux de…
MECHANISM OF ACTION OF A MULTI-HERBAL EXTRACT BLEND (KARALLIEF ® EASY CLIMB ®) IN SUPPORTING JOINT HEALTH
A new herbal extract blend, Karallief ® Easy Climb ® (KEC) showed promising results in addressing Osteoarthritis (OA) by helping rebuild the joint connective tissue. The product goes beyond just addressing the symptoms of OA – reducing pain and inflammation.…
Brain Activity May Play Role in Childhood Trauma Victims’ Heart Disease Risk
Rockville, Md. (June 1, 2022)—Research published ahead of print in the journal Function suggests that reduced activity in one area of the brain may play in role in how adults who experienced adverse childhood events (ACEs) have a greater risk…
Blood Protein Levels and Birth Control Pills May Increase Blood Clot Risk in Female Astronauts
Article title: Albumin, oral contraceptives and venous thromboembolism risk in astronauts Authors: Sara R. Zwart, Serena M. Auñón-Chancellor, Martina Heer, M. Mark Melin, Scott M. Smith From the authors: “We report here evidence of an association between oral contraceptive use…
Durability of the Treatment Effects of an 8-Week Self-administered Home-Based Virtual Reality Program for Chronic Low Back Pain: Follow-up Study of a Randomized Clinical Trial
Background: We previously reported the efficacy of an 8-week home-based therapeutic immersive virtual reality (VR) program in a double-blind randomized placebo-controlled study. Community-based adults with self-reported chronic low b…
Factors Influencing Adherence to mHealth Apps for Prevention or Management of Noncommunicable Diseases: Systematic Review
Background: Mobile health (mHealth) apps show vast potential in supporting patients and health care systems with the increasing prevalence and economic costs of noncommunicable diseases (NCDs) worldwide. However, despite the availabi…
Scandium–microorganism interactions in new biotechnologies
Highlights Microorganisms can effectively extract scandium (Sc) from ore and waste. Microbial biomass can be used for Sc concentration and separation from other elements. Sc stimulates cryptic genes and the metabolism of microbes. Sc-based microbial technologies have great potential in…
High Social Vulnerability Predicts Worse Long-Term Outcomes After Traumatic Injury
Traumatic injuries — such as physical injuries resulting from a car accident, fall, gunshot or stabbing — are one of the most common causes of impairment and disability worldwide. A team of investigators led by Juan P. Herrera-Escobar, MD, MPH,…
Continuity of Primary Care Reduces Hospitalizations in People with Chronic Kidney Disease
People with chronic kidney disease (CKD) require three- to eight-times higher levels of acute care than the general population for comorbidities such as hypertension, diabetes and cardiovascular disease. It is unclear how regular access to primary care influences subsequent acute…
Study finds higher excess deaths during Omicron period compared to Delta period in Massachusetts
WHO: Jeremy Faust, MD, Department of Emergency Medicine, Brigham and Women’s Hospital, corresponding author of JAMA paper WHAT: The COVID-19 pandemic has led to excess deaths — a higher number of fatalities than would be expected over a given period. A new study compares…
Researchers uncover how tumors circumvent prostate cancer therapy, identify promising treatment strategy
A Cleveland Clinic-led research team uncovered how tumors circumvent prostate cancer therapy and identified a promising new strategy for treatment. Findings were published in Proceedings of the National Academy of Sciences (PNAS). Antiandrogen strategies remain the backbone for advanced prostate…