English
Arabic
Chinese (Simplified)
Dutch
Esperanto
French
German
Greek
Italian
Japanese
Korean
Portuguese
Russian
Spanish
UrduDespite advances in the understanding of the pathophysiology of cytomegalovirus (CMV)
infection, it remains as one of the most common infectious complications after
allogeneic hematopoietic stem cell transplantation (allo-HSCT). The aim of this study …
Category: Research Alert
Treatment Efficacy Score a Better Way to Predict Long-Term Survival in Breast Cancer Trials
In a study led by Dr. Lajos Pusztai, Professor of Medicine (Medical Oncology) at Yale Cancer Center, researchers across various institutions, and on behalf of the I-SPY consortium, developed a novel continuous residual cancer based metric to compare neoadjuvant chemotherapy efficacy between randomized trial arms in preoperative breast cancer trials.
The Effect of Dissemination Pathways on Uptake and Relative Costs for a Transdiagnostic, Self-guided Internet Intervention for Reducing Depression, Anxiety, and Suicidal Ideation: Comparative Implementation Study
Background: Self-guided web-based programs are effective; however, inadequate implementation of these programs limits their potential to provide effective and low-cost treatment for common mental health problems at scale. There is a …
A Virtual Community of Practice to Support Physician Uptake of a Novel Abortion Practice: Mixed Methods Case Study
Background: Virtual communities of practice (VCoPs) have been used to support innovation and quality in clinical care. The drug mifepristone was introduced in Canada in 2017 for medical abortion. We created a VCoP to support implemen…
Health Care Professionals’ Experiences of Web-Based Symptom Checkers for Triage: Cross-sectional Survey Study
Background: Web-based symptom checkers are promising tools that provide help to patients seeking guidance on health problems. Many health organizations have started using them to enhance triage. Patients use the symptom checker to re…
Direct measurement of optical properties of glacier ice using a photon-counting diffuse LiDAR
Physicists from the University of Oregon’s Oregon Center for Optical Molecular and Quantum Science along with glaciologists from the Department of Geography as well as the Oregon Glacier Institute spent the last year developing a new measurement technique to investigate…
Disturbance of calcium homeostasis and myogenesis caused by TET2 deletion in muscle stem cells
… In this study, we demonstrated that TET2 deficiency impaired muscle stem cell
proliferation and differentiation, leading to notable changes in mouse body weight
and muscle morphology during development. We further assayed the genome-wide …
New UM Study Adds New Perspective on Latino Health in the U.S.
Dr. Olveen Carrasquillo, a principal investigator with the NIH’s All of Us research program at the University of Miami, just today published a new study that tests the Latino Epidemiological Paradox–a heavily debated finding that despite having more risk factors…
Reversal of Heart Enlargement Differs in the Sexes; Doesn’t Use Universal Signaling Pathways
Article title: Regression from pathological hypertrophy in mice is sexually dimorphic and stimulus-specific Authors: Deanna L. Muehleman, Claudia Crocini, Alison R. Swearingen, Christopher D. Ozeroff, Leslie A. Leinwand From the authors: “This work highlights that the reversal of pathological hypertrophy…
Sex Differences in Rat Heart Ventricle Function Aren’t Caused Only by Hormones
Article title: Female rats are less prone to clinical heart failure than male rats in a juvenile rat model of right ventricular pressure load Authors: Guido P.L. Bossers, Quint A.J. Hagdorn, Anne Marie C. Koop, Diederik E. van der Feen,…
Researchers Explore Manipulation of Proteins as Way to Leverage Changes in Extracellular Matrix
Article title: PDIA3/ERp57 promotes a matrix-rich secretome that stimulates fibroblast adhesion through CCN2 Authors: Andrew L. Hellewell, Kate J. Heesom, Mark A. Jepson, Josephine C. Adams From the authors: “Thus, manipulation of PDIA3 or other relevant resident proteins within the…
High Blood Insulin Levels Lead to More Nervous System Activity in Muscles
Article title: Role of the arterial baroreflex in the sympathetic response to hyperinsulinemia in adult humans Authors: Neil J. McMillan, Rogerio N. Soares, Jennifer L. Harper, Brian Shariffi, Alfonso Moreno-Cabañas, Timothy B. Curry, Camila Manrique-Acevedo, Jaume Padilla, Jacqueline K. Limberg…
Researchers ID Post-exercise Changes in MicroRNA as Potential Markers for Coronary Artery Disease
Article title: Associations between circulating microRNAs and coronary plaque characteristics: potential impact from physical exercise Authors: Maria Dalen Taraldsen, Rune Wiseth, Vibeke Videm, Anja Bye, Erik Madssen From the authors: “This exploratory study demonstrated six miRs associated with coronary necrotic…
Extracellular Vesicles in Lung Fluid May Point to Acute Respiratory Distress Syndrome Severity
Article title: CD14-positive extracellular vesicles in bronchoalveolar lavage fluid as a new biomarker of acute respiratory distress syndrome Authors: Rahul Y. Mahida, Joshua Price, Sebastian T. Lugg, Hui Li, Dhruv Parekh, Aaron Scott, Paul Harrison, Michael A. Matthay, David R.…
Study Explores Function and Characteristics of Enteric Nervous System Cells in Context of Injury
Article title: Adult enteric Dclk1-positive glial and neuronal cells reveal distinct responses to acute intestinal injury Authors: Moritz Middelhoff, Giovanni Valenti, Lorenzo Tomassoni, Yosuke Ochiai, Bryana Belin, Ryota Takahashi, Ermanno Malagola, Henrik Nienhüser, Michael Finlayson, Yoku Hayakawa, Leah B. Zamechek,…
Calorie Count More Important than Nutrient Composition in Development of Obesity-related Kidney Disease
Article title: High-calorie diet results in reversible obesity-related glomerulopathy in adult zebrafish regardless of dietary fat Authors: Evan M. Zeitler, J. Charles Jennette, Jennifer E. Flythe, Ronald J. Falk, John S. Poulton From the authors: “This work suggests that macronutrient…
Light Exposure Enhances Circadian Rhythm Protein, Protects against Bacterial Lung Injury in Mice
Article title: Intense light elicited alveolar type 2 specific circadian PER2 protects from bacterial lung injury via BPIFB1 Authors: Yoshimasa Oyama, Sydney R. Shuff, Nana Burns, Christine U. Vohwinkel, Tobias Eckle From the authors: “Our studies indicate that light-elicited [alveolar…
Public Beware: Study Finds Potential for Massive Cancer Nutrition Misinformation on Pinterest
A multi-center team including researchers from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine claims that the social media site Pinterest is rife with cancer misinformation. Their study found that about a third of posts…
Association of raising US-Mexico wall with migrant deaths, trauma center admissions, injury severity
About The Study: This retrospective trauma registry study of the University of California, San Diego level 1 trauma center, which receives patients with border wall injuries from San Diego and Imperial counties, examined deaths, injuries and hospital costs after construction of…
A Framework for Femtech: Guiding Principles for Developing Digital Reproductive Health Tools in the United States
The United States has abysmal reproductive health indices that, in part, reflect stark inequities experienced by people of color and those with preexisting medical conditions. The growth of “femtech,” or technology-based solutions to women’s he…
Wonder of Wonders, Miracle of Miracles: The Unprecedented Speed of COVID-19 Science
Article title: Wonder of Wonders, Miracle of Miracles: The Unprecedented Speed of COVID-19 Science Author: Michael Saag From the author: “Although a wide variety of scientific disciplines established the platform upon which the remarkable response to COVID-19 was based, the study…
Oncology specialists’ perspective on caring for patients with cancer during the early days of war in Kyiv, Ukraine
Recently, members of The Institute for Cancer Care at Mercy Medical Center oncology research team, working in conjunction with two oncologists in war-torn Ukraine, developed a report now appearing in THE LANCET/Oncology, describing the challenges faced in cancer care delivery under…
Hype up fitness to support kids’ health post-lockdowns
As COVID-19 reaches record levels in the UK, health experts are calling for a focus on children’s physical fitness as new research reveals concerning changes to children’s health and physical fitness following the pandemic.
Female Mice More Susceptible to Salt-induced Hypertension and Kidney Dysfunction
Rockville, Md. (April 27, 2022)—A new study finds male and female mice with a novel mutation in the protein cullin3 that causes deletion of the coding region exon-9 developed salt-induced high blood pressure and renal injury. The effect of salt…
The significance of all life can be left in traceable way: Freshwater pearl mussels
Freshwater pearl mussels are found in rivers in Japan.
Extremely rapid up-and-down motions of island arc crust during arc-continent collision
Mountain building and the rock cycle often involve large vertical crustal motions, but theirrates and timescales in unmetamorphosed rocks remain poorly understood.We utilize high-resolution magneto-biostratigraphy and backstripping analysis of marine deposits in an activearc-continent suture zone of eastern Taiwan to…
Study finds markups in prices of cancer therapies, lack of price transparency across cancer centers
U.S. spending on cancer therapies has risen sharply in recent years. Researchers from Brigham and Women’s Hospital analyzed data on drug pricing from 61 National Cancer Institute-designated cancer centers to determine how much U.S. hospitals mark up the price of…
Egr1 is a 3D matrix–specific mediator of mechanosensitive stem cell lineage commitment
… stem cell commitment, the field’s mechanistic understanding of this phenomenon
largely derives from simplified two-dimensional (2D) culture substrates. Here, we
found a 3D matrix–specific mechanoresponsive mechanism for neural stem cell (NSC …
Auxilin regulates intestinal stem cell proliferation through EGFR
… Importantly, we demonstrate that Aux interacts with EGFR and safeguards the
activation of EGFR to maintain a proper stem cell proliferation rate. Thus, our data
uncover the underlying mechanism of Aux in stem cell proliferation control and …
Moderate solar flare erupts from sun
The Sun emitted a moderate solar flare on April 20, 2022, peaking at 9:59 p.m. EST. NASA’s Solar Dynamics Observatory, which watches the Sun constantly, captured an image of the event.
Publicly Available, Interactive Web-Based Tools to Support Advance Care Planning: Systematic Review
Background: There is an increasing number of interactive web-based advance care planning (ACP) support tools, which are web-based aids in any format encouraging reflection, communication, and processing of publicly available informat…
Prior poor mental health is associated with higher COVID-19 infection rates
Introduction Limited evidence exists about the association between prior prevalence of poor mental health at the area level and subsequent rates of COVID-19 infections. This association was tested using area-level nationwide population data in the U.S. Methods A nationwide study…
Assessing risk of myocarditis following SARS-CoV-2 vaccination
What The Study Did: The risks of myocarditis and pericarditis after SARS-CoV-2 mRNA vaccinations were assessed by vaccine, dose number, sex and age among 23.1 million residents of Denmark, Finland, Norway and Sweden. Authors: Rickard Ljung, M.D., Ph.D., M.P.H., of the Swedish…
The effects of embodying wildlife in virtual reality on conservation behaviors
AbstractEfforts to mitigate environmental threats are often inversely related to the magnitude of casualty, human or otherwise. This “compassion fade” can be explained, in part, by differential processing of large- versus small-scale threats: it is difficult to form empathic connections…
Optimization of adipose tissue-derived mesenchymal stromal cells transplantation for bone marrow repopulation following irradiation
BACKGROUNDBone marrow (BM) suppression is one of the most common side effects of radiotherapy and the primary cause of death following exposure to irradiation. Despite concerted efforts, there is no definitive treatment method available. Recent
In vitro induced pluripotency from urine-derived cells in porcine
BACKGROUNDThe generation of induced pluripotent stem cells (iPSC) has been a game-changer in translational and regenerative medicine; however, their large-scale applicability is still hampered by the scarcity of accessible, safe, and reproducib
Novel Surgical Device Can Potentially Improve Outcomes of Coronary Bypass Grafting That Uses Leg Veins
(New York, NY – November 13, 2021) –A novel device called venous external support (VEST) may lead to increased longevity and durability of saphenous (leg) vein grafting during coronary artery bypass surgery, according to a new trial done in collaboration…
Art, horticulture team creates North American alternative to Japanese washi
An interdisciplinary team of artists and horticulture students at Iowa State University have created an alternative to the Japanese handmade paper washi (used in printmaking and paper arts like origami). Their research has been published in the Journal of Visual…
Improved Diet and Exercise Needed to Lower Cardiovascular Risks in Older Ugandans with HIV
November 8, 2021 – For people living with HIV (PLWH), a healthy lifestyle is important to lower risk factors for cardiovascular disease. However, little is known about physical activity, exercise, and diet among PLWH in sub-Saharan Africa. This study assessed interpersonal,…
Researchers Explore How Urea Relates to Total Osmolality in ICU Patients
Research published ahead of print in the journal Function examines the concentration of urea in relation to the total level of osmolality (ratio of substances to fluids) in the blood of people hospitalized in intensive care (ICU). Increased osmolality in…
Researchers Unexpectedly Identify Potential Causes of Asthma, COPD
Rockville, Md. (November 8, 2021)—The activation of muscarinic acetylcholine (M2) receptors could be one of the causes of diseases like asthma and chronic obstructive pulmonary disease (COPD), according to the findings of a new study in the journal Function. The…
Dosing Patterns In Treatment of Disabling Spasticity With Intrathecal Baclofen
Abstract Purpose The aim of this study was to describe and analyze dosing patterns for patients with ITB treatment over time and to identify possible subgroups demonstrating diversity in patterns. Design A retrospective design. Methods For 81 patients from six…
Older Persons and Nursing Staff’s Perspectives on Continence Care in Rehabilitation
Abstract Purpose The aim of the study was to understand continence care in geriatric rehabilitation from the perspectives of older persons and nursing staff. Design This is a qualitative descriptive study. Methods Ten patients and 10 nursing staff participated in semistructured interviews. Observations…
Physical and Cognitive Training to Enhance Intensive Care Unit Survivors’ Cognition
Abstract Purpose The aim of this study was to examine current literature regarding effects of physical or cognitive training and simultaneous (dual-task) physical and cognitive training on cognition in adults surviving an intensive care unit (ICU) stay. Design Systematic mapping.…
Scientists Study Changes in Kids’ Brains after Epilepsy Surgery
Article title: Spectral changes following resective epilepsy surgery and neurocognitive function in children with epilepsy Authors: Olivia N. Arski, Simeon Wong, Nebras M. Warsi, Daniel J. Martire, Ayako Ochi, Hiroshi Otsubo, Elizabeth Donner, Puneet Jain, Elizabeth N. Kerr, Mary Lou…
E-cigarette Exposure during Pregnancy Changes Autophagy Signaling, Leads to Brain Defects in Rats
Article title: Fetal e-cigarette exposure programs a neonatal brain hypoxic-ischemic sensitive phenotype via altering DNA methylation patterns and autophagy signaling pathway Authors: Andrew Walayat, Yong Li, Yanyan Zhang, Yingjie Fu, Bailin Liu, Xuesi M. Shao, Lubo Zhang, Daliao Xiao From…
Single-cell RNA Sequencing IDs Cell Clusters, Genes, Pathways in Pancreas
Article title: Single-cell analyses of human pancreas: characteristics of two populations of acinar cells in chronic pancreatitis Authors: Brandon M. Blobner, Jami L. Saloman, Celeste A. Shelton Ohlsen, Randall Brand, Robert Lafyatis, Rita Bottino, Martin Wijkstrom, Amer H. Zureikat, Kenneth…
Metabolic Syndrome during Pregnancy Leads to Abnormal Development of Fat Tissue in Mouse Offspring
Article title: Accelerated developmental adipogenesis programs adipose tissue dysfunction and cardiometabolic risk in offspring born to dams with metabolic dysfunction Authors: Anna Mikolajczak, Nada A. Sallam, Radha D. Singh, Taylor B. Scheidl, Emma J. Walsh, Sebastian Larion, Carol Huang, Jennifer…
Study Is First to Examine Fibrocyte Levels in People Hospitalized with COVID-19 Pneumonia
Article title: Blood fibrocytes are associated with severity and prognosis in COVID-19 pneumonia Authors: Mada Ghanem, Méline Homps-Legrand, Marc Garnier, Lise Morer, Tiphaine Goletto, Justine Frija-Masson, Paul-Henri Wicky, Pierre Jaquet, Catherine Bancal, Margarita Hurtado-Nedelec, Luc de Chaisemartin, Madeleine Jaillet, Arnaud…
Exercise May Correct Leakage of Blood-brain Barrier Caused by High Blood Pressure
Article title: Transcytosis within PVN capillaries: a mechanism determining both hypertension-induced blood-brain barrier dysfunction and exercise-induced correction Authors: Matheus Garcia Fragas, Vanessa Brito Cândido, Gustavo Gastão Davanzo, Carla Rocha-Santos, Alexandre Ceroni, Lisete C. Michelini From the authors: “The present set…