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UrduAbstract Knowledge transfer office (KTO) personnel play a crucial role in the success of knowledge transfer processes through their motivation and other individual-level dimensions. Individual-level dimensions have been mostly overlooked when exploring the performance of KTOs. In this paper, we…
Category: Research Alert
Children’s Hospital Los Angeles Experts to Present at 2024 American Society of Hematology Meeting
Children’s Hospital Los Angeles faculty will present their latest research on pediatric blood cancers and diseases at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition in San Diego.The annual conference—billed as the world’s largest and most comprehensive hematology event—will take place Dec. 7-10. In 2023, ASH attracted more than 32,000 attendees from over 100 countries.
Methods Used in Co-Creation Within the Health CASCADE Co-Creation Database and Gray Literature: Systematic Methods Overview
Background: Co-creation is increasingly recognized for its potential to generate innovative solutions, particularly in addressing complex and wicked problems in public health. Despite this growing recognition, there are no standards or recommendations for method use in co-creation, leading to confusion and…
RankMHC: Learning to Rank Class-I Peptide-MHC Structural Models
The binding of peptides to class-I Major Histocompability Complex (MHC) receptors and their subsequent recognition downstream by T-cell receptors are crucial processes for most multicellular organisms to be able to fight various diseases. Thus, the identification of peptide antigens that…
The fate of airborne microfibers in the human respiratory tract in different microenvironments
Αirborne microplastics (MPs) are considered an important exposure hazard to humans, especially in the indoor environment. Deposition and clearance of MPs in the human respiratory tract (HRT) was investigated using the ExDoM2 dosimetry model, modified to incorporate the deposition and…
Yale Study: CHIP is an independent risk factor for ICI myocarditis
Clonal hematopoiesis of indeterminate potential (CHIP)is an independent risk factor for myocarditis after ICI therapy, a new Yale-led study finds. CHIP involves mutations in hematopoietic stem cells that can increase the risk of cardiovascular disease and worsen cancer outcomes. The condition is…
The moderating effect of national culture on board interlocks’ impact on firm performance: A meta-analysis
Abstract Globalization has made it essential to examine the effectiveness of management practices in different cultural contexts. This study employs a meta-analysis method to explore the effects of board interlocks across cultures. Based on 56 empirical studies with 121 correlations…
‘Smart’ Choice? Evaluating AI-Based mobile decision bots for in-store decision-making
Abstract To address a research gap on how AI can be leveraged to enhance customers’ in-store journeys, this study evaluates the effectiveness of an AI-powered conversational decision bot (mobile messaging app) employing two laboratory experiments in a simulated store. Study…
A cross-sector exploration of the barriers to customer satisfaction in the sharing economy
Abstract The relevance of the sharing economy model has attracted the academic interest, leading to distinct lines of inquiry. However, an empirical examination of the factors influencing customer satisfaction in the sharing economy context – regarded as the degree to…
Energy Performance of Building Refurbishments: Predictive and Prescriptive AI-based Machine Learning Approaches
Abstract The energy performance (EP) of buildings is critical for European governments to meet their decarbonization targets by 2050. In the context of European Union (EU) policies, which subsidize citizen-led building renovations, it is imperative to ascertain the efficacy of…
How Artificial Intelligence Could Automate Genomics Research
Researchers at University of California San Diego School of Medicine have demonstrated that large language models (LLMs), such as GPT-4, could help automate functional genomics research, which seeks to determine what genes do and how they interact. The most frequently-used…
Prescriptive multi-group networks: Humanoid service robots’ value co-creation and co-destruction potentials in apparel stores
Abstract Drawing upon a theoretical foundation within service-dominant logic, this study analyzed multi-group networks of humanoid service robots (HSRs) and investigated the differences in the structures and relations between groups that adopted and rejected HSRs. Moreover, it explored the most…
Family involvement in management and risk-taking of family firms: The moderating role of kinship composition
Abstract Corporate risk-taking is a crucial factor that influences firm growth, performance, and survival. Based on the socioemotional wealth and agency theories, we investigate the effect of family involvement in management on risk-taking by considering the moderating role of kinship…
How Disinformation Affects Sales: Examining the Advertising Campaign of a Socially Responsible Brand
Abstract This study explores the effect of disinformation on sales performance in the context of socially responsible brands. Using a case study methodological approach, we examine the advertising campaign of an socially responsible beauty brand, introducing its newest sustainable packaging and its…
The Business of (Im)migration: Bodies Across Borders
Abstract Irrespective of length of stay or voluntariness, (im)migration is the movement of individuals across borders. From national identity to labor markets, (im)migration affects various dimensions and spheres of social life. Currently, 3.6% of the global population are international (im)migrants,…
Potential of ginsenoside Rg1 to treat aplastic anemia via mitogen activated protein kinase pathway in cyclophosphamide-induced myelosuppression mouse model
Aplastic anemia (AA) is a rare but serious condition in which the bone marrow fails to produce sufficient new blood cells, leading to fatigue, increased susceptibility to infection, and uncontrolled bleeding. In this editorial, we review an
Refining adipose-derived stem cell isolation for optimal regenerative therapy
This article highlights the importance of optimizing the techniques used for isolating stromal vascular fraction cells from adipose tissue. Furthermore, by presenting key findings from the literature, it clarifies the effects of refined tec
Resilience and challenges: Evaluating the impact of stress conditions on mesenchymal stem cells across different passages
This article discussed a study by Almahasneh et al, which investigated how high glucose and severe hypoxia affected mesenchymal stem cells (MSCs) at different passages. This research provides insights into the resilience of higher-passage M
Melatonin-based priming of stem cells to alleviate oxidative stress
Stem cell expansion in vitro and transplantation in the cytokine-rich proinflammatory milieu in the injured tissue generate immense oxidative stress that interferes with the cells’ survival, stemness, and repairability. Stem cell priming
Effects of miR-214-5p and miR-21-5p in hypoxic endometrial epithelial-cell-derived exosomes on human umbilical cord mesenchymal stem cells
BACKGROUNDThin endometrium seriously affects endometrial receptivity, resulting in a significant reduction in embryo implantation, and clinical pregnancy and live birth rates, and there is no gold standard for treatment. The main pathophysi
Efficacy of serum-free cultured human umbilical cord mesenchymal stem cells in the treatment of knee osteoarthritis in mice
BACKGROUNDWe investigated the efficacy of intra-articular injection of human umbilical cord mesenchymal stem cells (hUC-MSCs) for the treatment of osteoarthritis (OA) progression in the knee joint. Although many experimental studies of hUC-
Exosome-based strategy against colon cancer using small interfering RNA-loaded vesicles targeting soluble a proliferation-inducing ligand
BACKGROUNDRecent advancements in nanomedicine have highlighted the potential of exosome (Ex)-based therapies, utilizing naturally derived nanoparticles, as a novel approach to targeted cancer treatment. AIMTo explore the targetability and
Yes-associated protein-mediated melatonin regulates the function of periodontal ligament stem cells under oxidative stress conditions
BACKGROUNDHuman periodontal ligament stem cells (PDLSCs) regenerate oral tissue. In vitro expansion causes replicative senescence in stem cells. This causes intracellular reactive oxygen species (ROS) accumulation, which can impair stem cel
Embedding Owner-Manager Values in the Small and Medium Sized Enterprise Context: A Lockean Conceptualisation
Abstract The salience of owner-manager values to small and medium sized enterprise (SME) engagement with ethics and social responsibility is well documented. Despite this, understanding of how these values are transposed into and become embedded within the culture, norms and…
Refugee Entrepreneurship: Resolving Multi-contextuality and Differential Exclusion
Abstract This study examines the multi-contextual dynamics of refugee entrepreneurship through the lens of embeddedness. It attempts to explain the interplay of inclusion and exclusion within a host society. For this purpose, the study qualitatively analyses the narratives of 39…
Systems Perspectives on Business and Peace: The Contingent Nature of Business-Related Action with Respect to Peace Positive Impacts
Abstract We examine three business-related initiatives designed to achieve peace positive impacts in the Cape Town township of Langa. Each was seemingly straightforward in its purpose, logic, and implementation. However, their positive intent was frustrated and their impacts ultimately harmful…
At the Roots of Business Ethics: A New Reading of the Merchant of Venice
Abstract This paper discusses The Merchant of Venice from an economic and Biblical perspective in an attempt to corroborate the view that the work epitomizes the spirit of the early capitalism of Shakespeare’s London. The main goal of the paper…
Don’t Rock the Boat: The Social-symbolic Work to Confront Ethnic Discrimination in Branches of Professional Service Firms
Abstract In Western societies and organizations, episodes of discrimination based on individual demographic and social characteristics still occur. Relevant questions, such as why ethnic discrimination is perpetuated and how people confront it in the workplace, remain open. In this study,…
Why and When Do Employees Feel Guilty About Observing Supervisor Ostracism? The Critical Roles of Observers’ Silence Behavior and Leader–Member Exchange Quality
Abstract This study investigates why and when employees’ observations of supervisors’ ostracism of coworkers elicit their own feelings of guilt. In this connection, observers’ silence might function as a mediator, and leader–member exchange quality could moderate the process. The tests…
Universal Design for the Workplace: Ethical Considerations Regarding the Inclusion of Workers with Disabilities
Abstract This paper examines the ethical issues of the inclusion of workers with disabilities in the workplace with a cross-fertilization approach between organization studies, the ethics of care, and a movement from the field of architecture and design that is…
Study: Coronary Function Testing Improves Diagnosis of Heart Disease in Women
A Yale School of Medicine team finds that women who underwent a common procedure called coronary angiography (CA) were more likely to receive an accurate diagnosis with the use of coronary function testing (CFT), in a recent study published in the Journal…
How Does Legal Status Inform Immigrant Agency During Encounters of Workplace Incivility?
Abstract Workplace incivility is experienced ubiquitously by immigrants. While a growing body of literature has sought to identify the causes and the outcomes of this phenomenon, what remains largely underexplored is the role of legal status in configuring how workplace…
Virtue Signaling in the Sharing Economy: The Effect of Airbnb Entrepreneurs’ Virtue Language on Airbnb Price Premiums
Abstract Drawing from costless signaling research, we examine the role of virtue language in Airbnb listings. We propose that virtue language espoused by entrepreneurs is beneficial for Airbnb price premiums—but only to a certain extent. Specifically, we argue that virtue…
The Lean Startup as an Actionable Theory of Entrepreneurship
Abstract Academic theories of entrepreneurship and applied theories of entrepreneurship have historically been siloed. In this article, we connect the Lean Startup, a widely used and applied approach toward entrepreneurship, with selected academic theories of entrepreneurship. In doing so, we…
New research highlights potential role of the thalamus in complex reasoning
By recording neural activity of the prefrontal cortex, the part of the brain that drives executive functions such as making complex decisions, and the thalamus, which is classically considered a relay, researchers provide an updated view of the thalamus in…
UC San Diego Health Study Sheds Light on Nurse Suicide Rates During COVID-19 Pandemic
Using data from the National Violent Death Reporting System, a study published in The Journal of Nursing Administration found risk of suicide highest in female nurses as opposed to their male counterparts. Led by Judy E. Davidson, DNP, RN, nurse…
The Dismissal of New Female CEOs: A Role Congruity Perspective
Abstract Gender role congruity theory emphasizes the ubiquity of male-typed leadership schemas as barriers to female leaders’ career development (i.e., descriptive stereotypes); however, the expectation of female leaders’ fulfilling their gender role (i.e., prescriptive stereotypes) has received limited attention. Extending…
When There’s No One Else to Blame: The Impact of Coworkers’ Perceived Competence and Warmth on the Relations between Ostracism, Shame, and Ingratiation
Abstract Workplace ostracism is a prevalent and painful experience. The majority of studies focus on negative outcomes of ostracism, with less work examining employees’ potential adaptive responses to it. Further, scholars have suggested that such responses depend on employee attributions,…
Lean Hypotheses and Effectual Commitments: An Integrative Framework Delineating the Methods of Science and Entrepreneurship
Abstract Recently, there is increasing interest in building theories that offer actionable guidance to the practice of entrepreneurship. Here I present a general theoretical framework, called CAVE, for understanding, assessing, and enhancing existing tools that offer such guidance. The framework…
Conceptualizing international new ventures as the nexus of entrepreneurship and international business
Abstract We propose a typology that captures the heterogeneity of international new ventures’ (INVs’) entrepreneurial behavior and their commitment to foreign markets. The typology identifies four types of INVs, highlighting the dynamic interplay between the degree of radicalness of their…
Family ties and corporate tax avoidance
Abstract A well-established body of international business research examines how the institutional environment influences corporate decisions. We add to this literature by investigating the unexplored link between family, a fundamental institution in human society, and corporate tax decisions. Applying theories…
The Enactment of a Corporate Entrepreneurial Role: A Double-Edged Sword Forged by Heart and Context
Abstract Enacting a corporate entrepreneurial role requires cognitive, behavioral, and emotional qualities. While scholarly work has focused on the cognitive and behavioral aspects of this role, its emotional aspect—how corporate entrepreneurs feel when enacting their role—remains relatively unexplored. Our qualitative…
Anti-Inflammatory and Neuroprotective Polyphenols Derived from the European Olive Tree, Olea europaea L., in Long COVID and Other Conditions Involving Cognitive Impairment
The European olive tree, Olea europaea L., and its polyphenols hold great therapeutic potential to treat neuroinflammation and cognitive impairment. This review examines the evidence for the anti-inflammatory and neuroprotective actions of olive polyphenols and their potential in the treatment of long…
Cohesin RAD21 Gene Promoter Methylation in Patients with Acute Myeloid Leukemia
Aberrant gene promoter methylation is one of the hallmarks of Acute Myeloid Leukemia (AML). RAD21 is an important gene, implicated in sister chromatids cohesion, DNA repair, the regulation of gene transcription, apoptosis and hematopoiesis. Methods: In this study, we investigate the possible…
PIM-1L Kinase Binds to and Inactivates SRPK1: A Biochemical and Molecular Dynamics Study
SR/RS dipeptide repeats vary in both length and position, and are phosphorylated by SR protein kinases (SRPKs). PIM-1L, the long isoform of PIM-1 kinase, the splicing of which has been implicated in acute myeloid leukemia, contains a domain that consists largely of repeating SR/RS and SH/HS dipeptides (SR/SH-rich).
Natural volatiles preventing mosquito biting: an integrated screening platform for accelerated discovery of ORco antagonists
Insect olfactory receptors are heteromeric ligand-gated cation channels composed of an obligatory receptor subunit, ORco, and one of many variable subunits, ORx, in as yet undefined molar ratios. When expressed alone ex vivo, ORco forms homotetrameric channels gated by ORco-specific ligands…
Polymorphic positions 349 and 725 of the autoimmunity-protective allotype 10 of ER aminopeptidase 1 are key in determining its unique enzymatic properties
ER aminopeptidase 1 (ERAP1) is a polymorphic intracellular aminopeptidase with key roles in antigen presentation and adaptive immune responses. ERAP1 allotype 10 is highly protective toward developing some forms of autoimmunity and displays unusual functional properties, including very low activity versus some substrates.
Maintaining “Good” Care: An Articulation Work Perspective on Organizational Ethics in the Healthcare Sector
Abstract The literature on organizational ethics has paved the way for a situated and intersubjective understanding of ethics through caring practices. In this article, we try to extend this perspective by looking beyond the interactions of caregivers among themselves or…
Turning a Blind Eye to Team Members’ Unethical Behavior: The Role of Reward Systems
Abstract Organizations have increasingly relied on team-based reward systems to boost productivity and foster collaboration. Drawing on the literature on ethics and justice as well as appraisal theories of emotion, we examine how team-based reward systems can have an insidious…
Religion in Family Firms: A Socioemotional Wealth Perspective on Top-Level Executives with Perceived Religiosity
Abstract The extent and mechanisms through which religion intertwines with decision-making processes in family firms remain inadequately understood. Family firm owners, driven by their commitment to ethical business practices and the safeguarding of their socioemotional wealth, actively seek cues to…