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UrduOAK BROOK, Ill. – A technique that delivers high-intensity focused ultrasound to targeted tissue under MRI guidance effectively treats intermediate-risk prostate cancer with minimal side effects, according to a study published in Radiology . Prostate cancer is the most common…
Tag: prostate cancer
Oncotarget: Neuroendocrine carcinoma of uterine cervix findings shown by MRI
“The Oncotarget author’s findings show that MRI is reliable for T staging of cervical NEC”
Oncotarget: Simvastatin is a potential candidate drug in ovarian clear cell carcinomas
“Simvastatin efficiently controlled OCCC proliferation and migration, thus showing potential as a candidate drug for the treatment of OCCC.”
Oncotarget: The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer
The objective of this Oncotarget study was to elucidate the molecular mechanism of actions of 2MeOE2, a known microtubule disrupting agent, in inducing apoptosis in ovarian tumors
Leading cancer organizations warn cancer doesn’t stop for COVID-19 and neither should you
National Comprehensive Cancer Network and American Cancer Society are leading nationwide effort to resume appropriate cancer screening and treatment to prevent excess deaths
Study finds shorter radiation regimen safe, effective for men with advanced prostate cancer
A study led by researchers at the UCLA Jonsson Comprehensive Cancer Center found shortening a traditional 45-day course of radiation to a five-day course delivered in larger doses is safe and as effective as conventional radiation for men with high-risk forms of prostate cancer.
Oncotarget: Drug-resistant cells grow exponentially in metastatic prostate cancer
The Oncotarget authors show that the drug-resistant, metastasis-causing cells are capable of producing drug-resistant, exponentially growing tumors, responsible for tumor growth as a patient receives different treatments
Oncotarget: Improved therapeutic efficacy of unmodified anti-tumor antibodies
The Oncotarget findings suggest that MEKi induced an increased expression of tumor-associated antigens, which in combination with anti-tumor antibodies, generated a robust adaptive anti-tumor response that was sustained by immune checkpoint inhibition the
Oncotarget: Prognostic biomarker for patients with hepatocellular carcinoma
Reduced expression of TBX15 in tumor tissue represents a potential biomarker for predicting poor survival of patients with HCC
Robin Roberts, Charles Barkley and TNT’s Ernie Johnson Jr. team up to #EndCancer on Feb. 4
An all-star lineup of basketball greats, several of whom are courageous cancer survivors, will share their stories Feb. 4 at The University of Texas MD Anderson Cancer Center’s A Conversation with a Living Legend event. Robin Roberts, an anchor of “Good Morning America,” will join Emmy Award-winning sportscaster Ernie Johnson Jr. for a virtual fireside chat with a special guest appearance by 11-time NBA All-Star Charles Barkley.
Researchers Help Pioneer New Era in Prostate Cancer Active Surveillance
Sylvester Comprehensive Cancer Center researchers are looking at ways to combine imaging and biomarkers to predict prostate cancer progression more accurately.
An Unexpected, and Novel, Target for Prostate Cancer – Our Biological Clock
Researchers find that CRY-1, a regulator of circadian rhythms, promotes tumor progression by altering DNA repair.
Artificial intelligence tool for reading MRI scans could transform prostate cancer surgery and treatment
Researchers at the Center for Computational Imaging and Personalized Diagnostics (CCIPD) at Case Western Reserve University have preliminarily validated an artificial intelligence (AI) tool to predict how likely the disease is to recur following surgical treatment for prostate cancer.
Scientists study use of abundant enzyme in tumor cells to monitor cancer treatment
After 14 years studying the action of the enzyme LMWPTP in tumor cells, Brazilian researchers conclude that the molecule is associated with chemotherapy resistance and metastasis.
Oncotarget: HIV +/- patients with lymphoma as a predictor of outcome & tumor proliferation
The Oncotarget author’s hypothesis is that ADC values will inversely correlate with Ki-67 expression and that tumors with higher ADC values above the median will have improved OS and PFS
Oncotarget: PD-1/PD-L1 expression in anal squamous intraepithelial lesions
Dr. Margot Bucau from The Hôpital Bichat-Claude Bernard said, ‘Anal intraepithelial neoplasia (AIN) is the precursor lesion for anal squamous cell carcinomas (ASCC)’
Oncotarget: Targeted lymphodepletion with a CD45-directed antibody radioconjugate
“Here the Oncotarget authors describe the results of preclinical studies with an anti-mouse CD45 antibody 30F11”
MRI frequently underestimates tumor size in prostate cancer
Improving imaging processes will lead to more successful treatments and help reduce morbidity in men with the disease.
Mediterranean diet may decrease risk of prostate cancer progression for men on active surveillance
In a study to examine a Mediterranean diet in relation to prostate cancer progression in men on active surveillance, researchers from The University of Texas MD Anderson Cancer Center found that men with localized prostate cancer who reported a baseline dietary pattern that more closely follows the key principles of a Mediterranean-style diet fared better over the course of their disease.
Research News Tip Sheet: Story Ideas from Johns Hopkins Medicine
During the COVID-19 pandemic, Johns Hopkins Medicine Media Relations is focused on disseminating current, accurate and useful information to the public via the media. As part of that effort, we are distributing our “COVID-19 Tip Sheet: Story Ideas from Johns Hopkins” every other Tuesday.
New clues to prostate cancer
Why aggressive subtype can resist treatment
Inflammation from ADT may cause fatigue in prostate cancer patients
Moffitt Cancer Center study suggests elevation in inflammation marker IL-6 linked to higher levels of fatigue
Largest, most diverse ever study of prostate cancer genetics brings disparities into focus
Eighty-six new risk factors identified in research co-led by USC Norris Comprehensive Cancer Center
Prostate cancer regulator plays role in COVID-19, providing a promising treatment lead
By taking a lesson from prostate cancer, researchers now have a promising lead on a treatment for COVID-19. They found that, just like in prostate cancer, TMPRSS2 is regulated by the androgen receptor in the lungs. And notably, blocking the androgen receptor led to lower expression of TMPRSS2, which led to decreased coronavirus infection in mice and cellular models.
Moffitt Researchers Identify Genomic and Immune Indicators That Predict Lethal Outcomes in High-Grade Prostate Cancer
Moffitt Cancer Center researchers conducted studies to determine if genomic heterogeneity in tumors from grade 4/5 prostate cancer patients can be exploited to identify patient subsets that are at higher risk for lethal outcomes and that may benefit from targeted treatment strategies. Their results were published in the journal European Urology.
Moffitt identifies genomic and immune indicators that predict lethal outcomes in prostate cancer
Together, immune content and Decipher scores can help determine which patients could benefit from targeted therapies
Scientists Recruit New Atomic Heavyweights in Targeted Fight Against Cancer
Researchers from Berkeley Lab and Los Alamos National Laboratory have developed new methods for the large-scale production, purification, and use of the radioisotope cerium-134, which could serve as a PET imaging radiotracer for a highly targeted cancer treatment known as alpha-particle therapy.
Exploring how prostate cancer cells resist treatment
Research by a University of Georgia scientist sheds light on how two genes factor into prostate cancer cells becoming resistant to treatment, providing a potential new target for therapeutics.
Glyphosate can create biomarkers predicting disease in future generations
PULLMAN, Wash. – Exposure to the widely used weed-killer glyphosate makes genetic changes to rats that can be linked to increased disease in their grandchildren and great-grandchildren, a new study has found. The study provides evidence that glyphosate-induced changes to…
Uniquely human gene may drive numerous cancers
Humans are more prone to develop carcinomas compared with our closest evolutionary cousins, the great apes. These cancers begin in the epithelial cells of the skin or the tissue that covers the surface of internal organs and glands, and they…
Safety of delaying surgery for high-risk prostate cancer
What The Study Did: Considering when health care resources need to be prioritized during special times, such as the COVID-19 pandemic, researchers in this observational study looked at whether delaying radical prostatectomy surgery for up to six months for high-risk prostate cancer…
Researchers create framework to help determine timing of cancer mutations
UCLA researchers studying cancer evolution have created a framework to help determine which tool combinations are best for pinpointing the exact timing of DNA mutations in cancer genomes.
Researchers create framework to help determine timing of cancer mutations
UCLA RESEARCH ALERT FINDINGS UCLA Jonsson Comprehensive Cancer Center researchers studying cancer evolution have created a framework to help determine which tool combinations are best for pinpointing the exact timing of DNA mutations in cancer genomes. There are currently many…
Bluestar Genomics, UChicago publish whole genome map of key biomarker for detecting cancer
Nature Communications publication of the 5hmC profiles across multiple human tissue types lays foundation for future diagnostics
UCLA, UCSF gain FDA approval for prostate cancer imaging technique
The University of California’s two nationally ranked medical centers, UCSF and UCLA, and their nuclear medicine teams have obtained approval from the U.S. Food and Drug Administration to offer a new imaging technique for prostate cancer that locates cancer lesions in the pelvic area and other parts of the body to which the tumors have migrated.
Baylor Scott & White Medical Center – Temple Performs 1000th HoLEP Procedure That Improves Men’s Quality of Life
In mid-October, Baylor Scott & White Medical Center – Temple conducted its 1000th holmium laser enucleation of the prostate (HoLEP), a minimally invasive procedure that can address benign prostatic hyperplasia (BPH). BPH can prevent the bladder from emptying properly and could lead to kidney damage or failure. It also impacts quality of life in about one third of men older than 50 years old.
Yale Cancer Center Study Shows Regional Variation in Genomic Testing for Men with Prostate Cancer
In a new study by Yale Cancer Center, researchers found substantial regional variation in use of genomic testing for prostate cancer, raising questions about access and other factors that might promote rapid adoption of new cancer technologies.
New findings speed progress towards affordable gene therapy
Researchers used metal-organic frameworks (MOFs) enhanced with a green tea phytochemical coating to target human prostate cancer cells for the first time. The new method for deploying the genetic snipping tool directly into target cells is a big step towards…
Henry Ford Health System is the First in Michigan to offer da Vinci Single Port Robotic Surgery System
Henry Ford Health System is the first in Michigan to offer the da Vinci SP® robotic surgery system, which requires only a single small incision for its surgical instruments and allows for greater control and access in narrow surgical spaces.
Vitamin D supplements may reduce risk of developing advanced cancer
For many years, investigators have been trying to pin down the tantalizing connection between vitamin D and cancer.
What Drives Painful Bone Metastasis in Prostate Cancer, and Can it Be Prevented?
While prostate cancer originates within the prostate, metastasis, or the spread of a tumor from the site of origin to other organs, remains a leading cause of death among people with the disease. Prostate tumors can metastasize to a number of different organs, including the liver, lymph nodes and bone.
Prostate cancer: CRYM protein inhibits tumour growth
Diagnostic marker opens up possible target for new forms of treatment
Common prostate cancer treatment may impair cardiorespiratory fitness, raise risk of CV death
Study finds prolonged androgen deprivation therapy treatment in some high-CV risk patients associated with higher CV mortality risk, reduced cardiorespiratory fitness
‘Vanished’ or ‘hidden’ prostate cancer? Men with negative biopsies during active surveillance have good outcomes
November 17, 2020 – Can early-stage prostate cancer “vanish” during follow-up? More likely the cancer is just “hidden”–either way, negative biopsies during active surveillance for prostate cancer are associated with excellent long-term outcomes, reports a study in The Journal of…
Sylvester Comprehensive Cancer Center Researchers Report Positive Results for New Treatment Strategy for Localized Prostate Cancer
A Sylvester Comprehensive Cancer Center research team has found that focal high intensity focused ultrasound (HIFU) is an effective strategy for treating localized prostate cancer while minimizing side effects.
Gene signature predicts whether localized prostate cancer is likely to spread
NEW YORK, NY (Nov. 10, 2020)–Researchers have identified a genetic signature in localized prostate cancer that can predict whether the cancer is likely to spread, or metastasize, early in the course of the disease and whether it will respond to…
Oncotarget: IGF2 expression in breast cancer tumors and in breast cancer cells
The Oncotarget authors propose that methylation of DVDMR represents a novel epigenetic biomarker that determines the levels of IGF2 protein expression in breast cancer.
Exercise Slowed Tumor Growth in Mouse Model of Prostate Cancer
Kai Zou, PhD, and his doctoral student, Benjamin Kugler, MS, of the University of Massachusetts Boston, examined the link between physical activity and tumor growth in a mouse model.
Exercise May Improve Effects of Radiation Therapy in Prostate Cancer
Cancer is the second leading cause of death around the world after heart disease. This week, researchers exploring the effects of exercise as a natural preventive tool and noninvasive treatment for cancer will present their work at the American Physiological Society (APS) Integrative Physiology of Exercise conference.
New cancer drugs saved over 1.2 million people in the US over 16 years, new study shows
More than 1.2 million people in the US prevented facing death following a cancer diagnosis, between the year 2000 and 2016, thanks to ever improving treatment options – a large new national study shows. Published in the peer-reviewed Journal of…