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UrduBreast cancer’s resistance to treatment is a major hurdle in improving patient outcomes. A recent study explores how tumor angiogenesis—the formation of abnormal blood vessels in tumors—plays a pivotal role in fostering drug resistance. The research highlights how these blood vessels hinder drug delivery and create a hostile tumor environment, reducing the effectiveness of therapies. It also investigates the potential of anti-angiogenic treatments to normalize these vessels, enhancing drug efficacy and offering new hope for patients.
Tag: Drug Resistance
A New Approach to Predicting Malaria Drug Resistance
Researchers at UC San Diego analyzed the genomes of hundreds of malaria parasites to determine which genetic variants are most likely to confer drug resistance.
Study uncovers first evidence of resistance to standard malaria treatment in African children with severe malaria
An international team of researchers has uncovered evidence of partial resistance to artemisinin derivatives — the primary treatment for malaria — in young children with severe malaria.
New addition to standard-of-care treatments for non-small-cell lung cancer patients has potential to increase progression-free survival
Houston Methodist researchers have developed an advanced mathematical model that predicts how novel treatment combinations could significantly extend progression-free survival for patients with non-small-cell lung cancer (NSCLC), the most common type of lung cancer.
Leading Computational Scientist and Oncology Researcher Elana Fertig, PhD, Appointed as New Director of the Institute for Genome Sciences at the University of Maryland School of Medicine
University of Maryland School of Medicine (UMSOM) Dean Mark T. Gladwin, MD, announced today the appointment of Elana J. Fertig, PhD, FAIMBE, as the new Director of the School’s Institute for Genome Sciences (IGS).
What Enables Herpes Simplex Virus To Become Impervious to Drugs?
At a glance: New research explains how herpes simplex virus can develop resistance to antiviral medicines.
Study shows that movements in specific parts of a protein that enable viral replication can alter susceptibility to drugs
The findings answer long-standing questions about viral drug resistance and can inform new approaches to designing more effective therapies.
Multidrug-resistant fungi found in commercial soil, compost, flower bulbs
That pile of soil you bought at the home improvement store may contain more than just dirt, according to new research from the University of Georgia. A new UGA study found high levels of multidrug-resistant fungi in commercially available compost, soil and flower bulbs. Aspergillus fumigatus is a widespread fungus that thrives in soil. But it also poses a serious risk to human health if inhaled. People with compromised immune systems are particularly vulnerable to the opportunistic fungus, facing a near 100% fatality rate if infected with a multidrug-resistant strain.
Some lymphomas become resistant to treatment. Gene discovery may offer path to overcome it.
Patients with some types of lymphoma that become resistant to standard treatments may benefit from a therapy that University of Wisconsin–Madison researchers are evaluating after they discovered a key process that fuels the blood cancers’ resistance to current drugs.
RUDN pharmacists proposed ways to increase the activity of levofloxacin and overcome bacterial resistance to antimicrobial agents
RUDN University pharmacists modeled derivative molecules of the antibacterial levofloxacin to find out what biological functions its individual structural fragments – pharmacophores – are responsible for. This is necessary to increase the effectiveness of the drug, as bacteria become increasingly resistant to antibiotics.
Resistant bacteria can remain in the body for years
Fighting disease-causing bacteria becomes more difficult when antibiotics stop working.
A step toward treating chemotherapy-resistant prostate cancer
Prostate cancer is resistant to one of the most powerful chemotherapy medications — cisplatin. Now, researchers in ACS Central Science have developed the first therapy of its kind that disrupts prostate cancer cells’ metabolism and releases cisplatin into the weakened cells, causing them to die.
A new tactic to take on leprosy
Though antibiotics can treat leprosy, researchers are concerned about the increase in drug-resistant strains. Now, a team reporting in ACS Central Science has begun to understand the role certain immune receptors play in leprosy, which could lead to new types of treatments for this disease.
Researchers discover drug-resistant, often deadly pathogen living in dogs’ ears, creating concern it may jump to humans
Scientists at McMaster University and India’s University of Delhi have discovered and isolated the first live culture of the drug-resistant pathogen Candida auris from an animal, specifically from the ear canals of stray dogs.
Drug-resistant fungi are thriving in even the most remote regions of Earth
New McMaster research has found that a disease-causing fungus — collected from one of the most remote regions in the world — is resistant to a common antifungal medicine used to treat infections.
Neglected 80-year-old antibiotic is effective against multi-drug resistant bacteria
An old antibiotic may provide much-needed protection against multi-drug resistant bacterial infections, according to a new study publishing May 16th in the open access journal PLOS Biology by James Kirby of Harvard Medical School, US, and colleagues.
Second gene implicated in malaria parasite resistance evolution to chloroquine
How malaria parasites evolved to evade a major antimalarial drug has long been thought to involve only one key gene. Now, thanks to a combination of field and lab studies, an international research team has shown a second key gene is also involved in malaria’s resistance to the drug chloroquine.
UNLV, SNWA Study Makes Case for Candida Auris Wastewater Surveillance
A rapid spike in cases of a potentially deadly, drug-resistant fungus has concerned public health officials across the nation. But a team of Southern Nevada researchers hope their new study applying wastewater surveillance can help health officials get a step ahead of this emerging global public health threat.
Research Scientist: Naturally occurring compound could be latest weapon in antibiotic resistance battle
Researchers at the University of Portsmouth have discovered that a naturally-occurring compound found in trees is effective in combating superbugs. Dr Robert Baldock and his team from the School of Pharmacy & Biomedical Sciences found that hydroquinine, which can be used…
St. Jude approach prevents drug resistance and toxicity
Scientists at St. Jude Children’s Research Hospital showed an effective method to avoid activating a major cellular detoxification receptor to overcome drug resistance and toxicity.
Study: New tool twice as accurate at predicting antibody resistance among U.S. children with Kawasaki disease
A new tool under development by University at Buffalo researchers could one day help clinicians better predict resistance to immunoglobulin therapy among children with Kawasaki disease in the United States.
Don’t give up the fight. Read the latest news about drug and antibiotic resistance
Here are some of the latest articles that have been added to the Drug Resistance channel on Newswise, a free source for journalists.
Cleveland Clinic Researchers Shed New Light on Importance of Ecological Cellular Interactions in Targeted Therapy Resistance in Lung Cancer
New Cleveland Clinic research has uncovered key information about cellular interaction between tumor cells and normal tissue, providing better understanding of how therapeutic resistance develops. Findings published in Science Advances.
National Researcher of the Year 2022 Decodes Drug Resistance in Animals – A Step towards Sustainable Solutions
Chula Veterinary Lecturer and “National Outstanding Researcher 2022” has revealed the genetic code that causes drug resistance in animals that affects human health, animals, and the environment, and suggests comprehensive solutions under the concept “One Health”.
Computer Simulations of Proteins Help Unravel Why Chemotherapy Resistance Occurs
Understanding why and how chemotherapy resistance occurs is a major step toward optimizing treatments for cancer. A team of scientists including Markus Seeliger, PhD, of the Renaissance School of Medicine at Stony Brook University, believe they have found a new process through which drug resistance happens.
Gut bacteria can make blood pressure medication less effective
A new study from The University of Toledo College of Medicine and Life Sciences has shown gut bacteria can reduce the effectiveness of certain blood pressure drugs.
Researchers uncover how tumors circumvent prostate cancer therapy, identify promising treatment strategy
A Cleveland Clinic-led research team uncovered how tumors circumvent prostate cancer therapy and identified a promising new strategy for treatment. Findings were published in Proceedings of the National Academy of Sciences (PNAS). Antiandrogen strategies remain the backbone for advanced prostate…
Dog parasite is developing resistance to treatments
Right now, U.S. veterinarians rely on three types of drugs to kill the hookworms, but the parasites appear to becoming resistant to all of them.
Avoiding Drug Resistance by Understanding Evolution of Viruses
During ACA’s 71st annual meeting, Celia Schiffer, from the University of Massachusetts, will talk about her lab’s work with virus substrate recognition as a method to avoid drug resistance. Schiffer and her team expanded their work on HIV and the hepatitis C virus to include human T-cell lymphotropic virus type 1 and SARS-CoV-2, the virus that causes COVID-19, and discovered that designing robust inhibitors to fit within the substrate envelope tips this balance toward decreasing the probability of resistance.
Drug-Resistant Germ Packs Punch to US Travelers
One type of the salmonella bacteria is much more likely to cause disease and fend off frontline antibiotics when acquired in Europe, Asia, and parts of Africa rather than domestically in the United States.
Hackensack Meridian CDI Scientists Discover New Tuberculosis Treatment Pathway
The compound TA-C is metabolized by TB bacteria – weakening the germ from within like a ‘Trojan horse’ attack
CU Cancer Researcher Wins Two Awards to Study Drug-Resistant Cancer Cells
Sabrina L. Spencer, PhD, is a CU Boulder researcher and CU Cancer Center member. Spencer recently won the Damon Runyon-Rachleff Innovation Award and the Emerging Leader Award. She will use the grants to continue her research on drug resistance in cancer cells.
Building bridges: PARP enzymes bring broken DNA together
St. Jude researchers capture the structure of PARP enzymes at work, leading to a new understanding of DNA repair that may aid cancer treatments targeting the process.
Adult stem cell study shows fish oil may help with depression
A study published in Molecular Psychiatry shows that patient-derived adult stem cells can be used to model major depressive disorder and test how a patient may respond to medication and that fish oil, when tested in the model, created an antidepressant response.
Computer model IDs drug-resistant mutations
To counter drug resistance Penn State engineers have developed a new approach for predicting which mutation has expanded the most in a population and should be targeted to design the most effective new drug.
Long-Lasting, Low Toxicity Antimicrobial Peptide Fights ‘Superbug’ Lung Infections
Through serendipity, researchers at the University of Pittsburgh Graduate School of Public Health considerably reduced the toxicity of a potential antibiotic against the most feared drug-resistant bacteria, while also improving its stability in fighting infections.
St. Jude finds cancer drug resistance genes and possibly how to limit their effects
Drug resistance is a leading cause of cancer death in children and adults with leukemia. St. Jude Children’s Research Hospital scientists have developed a novel strategy to find the genes responsible.
Why It Matters: Prescription for Disaster
Bacteria are becoming increasingly resistant to antibiotics. A major cause is their overuse in both humans and animals. At the same time, a lack of financial incentives is setting back efforts to discover new classes of antibiotics. The problem is both global and local, and without new initiatives, many common medical conditions could become deadly once again.
Calcium Signaling Identified as Exploitable Target in Addressing Drug Resistance to Non-Hodgkin Lymphoma Treatment
Gene expression profiling and other analyses conducted by Rutgers Cancer Institute of New Jersey researchers and colleagues examining drug resistance to a common antibody therapy for non-Hodgkin lymphoma have identified calcium signaling as a novel and exploitable target in overcoming this treatment obstacle. Results are being presented at the American Society of Hematology Annual Meeting.
Strength in numbers: Crowdsourcing challenge seeks new methods to combat drug-resistant malaria
A team of researchers at Notre Dame put out a call to the masses, enlisting researchers, data scientists and health professionals to analyze genomic data from emerging drug-resistant malaria parasites and gain a better understanding of the mechanisms of resistance.
Single Mutation Dramatically Changes Structure and Function of Bacteria’s Transporter Proteins
Swapping a single amino acid in a simple bacterial protein changes its structure and function, revealing the effects of complex gene evolution, finds a new study published in the journal eLife. The study—conducted using E. coli bacteria—can help researchers to better understand the evolution of transporter proteins and their role in drug resistance.
UC San Diego Researchers Convert Pro-Tumor Macrophages into Cancer Killers
University of California San Diego School of Medicine researchers identified a new therapeutic approach in mouse models that halts drug resistance and cancer progression by using an antibody that induces the immune system via macrophages to seek and kill cancer cells.
Engineered Cell Evolution May Provide Pathway to Halting Cancer Drug Resistance
STONY BROOK, NY, June 24,, 2019 — A significant problem when treating cancer patients remains drug resistance, which often causes chemotherapy treatments to ultimately fail. Scientists in recent years have hypothesized that cell-cell differences, also known as cell heterogeneity, aides…