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UrduIn a preliminary study with a small number of humans, rabbits and mice, researchers at Johns Hopkins Children’s Center say they have developed four new regimens that have the potential to treat and save the lives of people with multidrug-resistant (MDR) tuberculous (TB) meningitis.
Tag: blood-brain barrier
MD Anderson Research Highlights for May 21, 2024
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Magnetic resonance-guided focused ultrasound in intracranial diseases.
This paper focus on the latest clinical applications of Magnetic resonance-guided focused ultrasound (MRgFUS) in intracranial diseases, and we discuss current challenges and future directions.
Research offers hope for preventing post-COVID ‘brain fog’ by targeting brain’s blood vessels
In a study of mice, researchers identified a mechanism that causes post-infection neurological problems
UTHealth Houston awarded nearly $13M in grants to study treatments for traumatic brain injury
Nearly $13 million in federal grant funds to study treatments for traumatic brain injury, which kills an average of 190 people and hospitalizes another 600 in the U.S. every day, has been awarded to UTHealth Houston by the Department of Defense’s Office of Congressionally Directed Medical Research Programs (CDMRP).
FAU and Insightec Partner to Use Focused Ultrasound to Treat Neurological Disorders
This agreement will enable FAU and Insightec to collaborate to advance scientific knowledge about the use of focused ultrasound to treat brain diseases, including Parkinson’s disease and Alzheimer’s disease. By harnessing acoustic energy, Insightec’s innovative technology uses focused ultrasound to treat diseases in different ways.
Mothers’ Obesity Damages Blood-brain Barrier in Offspring, Lean Foster Mothers’ Milk May Be Preventive Tool
Article title: Maternal obesity damages the median eminence blood-brain barrier structure and function in the progeny: the beneficial impact of cross-fostering by lean mothers Authors: Roberta Haddad-Tóvolli, Joseane Morari, Roberta Barbizan, Vanessa C. Bóbbo, Rodrigo S. Carraro, Carina Solon, Nathalia…
Exposure to World Trade Center Dust Exacerbates Cognitive Impairment in an Animal Model of Alzheimer’s
Also evokes central and peripheral pro-inflammatory responses
Alzheimer’s Disease: Making Connections between Air Pollution and Neurodegeneration
Exposure to urban air pollutants such as ozone (O3) is increasingly linked with Alzheimer’s disease; yet because ozone cannot travel from the lungs to the brain, the mechanism by which it contributes to development of Alzheimer’s has been poorly understood.…
Stem Cell-Gene Therapy Shows Promise in ALS Safety Trial
Cedars-Sinai investigators have developed an investigational therapy using support cells and a protective protein that can be delivered past the blood-brain barrier. This combined stem cell and gene therapy can potentially protect diseased motor neurons in the spinal cord of patients with amyotrophic lateral sclerosis, a fatal neurological disorder known as ALS or Lou Gehrig’s disease.
Iron Buildup in Brain Linked to Higher Risk for Movement Disorders
UC San Diego researchers report that individuals with two copies of a gene mutation show evidence of substantial iron buildup in regions of the brain, raising risk for movement disorders like Parkinson’s disease.
Whole blood exchange could offer disease-modifying therapy for Alzheimer’s disease, study finds
A novel, disease-modifying therapy for Alzheimer’s disease may involve the whole exchange of blood, which effectively decreased the formation of amyloid plaque in the brains of mice, according to a new study from UTHealth Houston.
Exercise May Correct Leakage of Blood-brain Barrier Caused by High Blood Pressure
Article title: Transcytosis within PVN capillaries: a mechanism determining both hypertension-induced blood-brain barrier dysfunction and exercise-induced correction Authors: Matheus Garcia Fragas, Vanessa Brito Cândido, Gustavo Gastão Davanzo, Carla Rocha-Santos, Alexandre Ceroni, Lisete C. Michelini From the authors: “The present set…
Breaching the Blood-Brain Barrier to Deliver Precious Payloads
RNA-based drugs may change the standard of care for many diseases, making personalized medicine a reality. So far these cost-effective, easy-to-manufacture drugs haven’t been very useful in treating brain tumors and other brain disease. But a team of researchers at Georgia Tech and Emory University has shown that a combination of ultrasound and RNA-loaded nanoparticles can temporarily open the protective blood-brain barrier, allowing the delivery of potent medicine to brain tumors.
Leaky Blood-Brain Barrier Linked to Brain Tissue Damage in Brain Aging Disease
As people age, changes in the tiniest blood vessels in the brain, a condition called cerebral small vessel disease, can lead to thinking and memory problems and stroke. These changes can also affect the blood-brain barrier, a layer of cells that protect the brain from toxins circulating in the blood. Now a new study has found that people with cerebral small vessel disease who have blood-brain barrier leakage had more brain tissue damage over two years than people with less blood-brain barrier leakage. The study is published in the March 24, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Could leak in blood-brain barrier cause poor memory?
One of the keys to having a healthy brain at any age is having a healthy blood-brain barrier, a complex interface of blood vessels that run through the brain. Research shows the blood-brain barrier leaks as we age, and we lose cells called pericytes. But could this leak and the difficulties in recall be the early stages of Alzheimer’s disease?
Brain Disease Research Reveals Differences Between Sexes
In APL Bioengineering, University of Maryland scientists highlight a growing body of research suggesting sex differences play roles in how patients respond to brain diseases, as well as multiple sclerosis, motor neuron disease, and other brain ailments. They are urging their colleagues to remember those differences when researching treatments and cures.
Virginia Tech scientists advance understanding of blood-brain barrier health
in a study with potential impacts on a variety of neurological diseases, Virginia Tech researchers have provided the first experimental evidence from a living organism to show that an abundant, star-shaped brain cell known as an astrocyte is essential for blood-brain barrier health.
Poison control: Chasing the antidote
A fast-acting antidote to mitigate the effects of organophosphate poisoning requires a reactivator that can effectively and efficiently cross the blood-brain barrier, bind loosely to the enzyme, chemically snatch the poison and then leave quickly. Oak Ridge National Laboratory is using neutron diffraction data towards improving a novel reactivator design.
The Human Brain’s Meticulous Interface with the Bloodstream now on a Precision Chip
It can be the bain of brain drug developers: The interface between the human brain and the bloodstream, the blood-brain-barrier, is so meticulous that animal models often fail to represent it. This improved chip represents important features more accurately.
LLNL researchers mimic blood-brain barrier on chip-based device
With a recent publication in the journal Annals of Biomedical Engineering (ABME), a team of LLNL researchers are one step closer to recapitulating the brain’s response to both biochemical and mechanical cues in a chip-based platform.
Brain Guard
Israeli researchers have developed new technology for transporting drugs within silicon nanostructures to the brain. These nanostructures release an essential protein, which can inhibit the development of Alzheimer’s disease, and provide targeted delivery in the brain with the use of a “gene gun.”