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UrduA multi-national team of evolutionary biologists shows that diversity exists even when expecting oth
Tag: Genetics
$2M from NIH to extract meaningful data from CRISPR screens
Protein-coding genes comprise a mere 1% of DNA. While the other 99% of DNA was once derided as “junk,” it has become increasingly apparent that some non-coding genes enable essential cellular functions. Wei Li, Ph.D., a principal investigator in the…
Discovery paves the way for earlier detection of type 1 diabetes
Using single-cell analysis of immune cells involved in the onset of disease, a new study provides am
NSF Awards ‘Dream Team’ $1.1 Million for Blind Mexican Cavefish Research
How is it that a fish that lived in difficult to access caves in rural Mexico is becoming a leading model to study diabetes, insomnia, and obesity? It’s all about this tiny, translucent, cave-dwelling fish that lost its eyes to…
Inflammation triggers silent mutation to cause deadly lung disease, Stanford study shows
Researchers at the Stanford University School of Medicine have found that inflammation in the lungs of rats, triggered by something as simple as the flu, may wake up a silent genetic defect that causes sudden onset cases of pulmonary hypertension,…
Blocking specific protein could provide new treatment for deadly form of prostate cancer
Study provides rationale for clinical trial evaluating CDK7 inhibitors
Maleness-on-the-Y: A novel male sex determiner in major fruit fly pests
Becoming a male Mediterranean fruit fly relies on the newly identified Y-chromosome linked gene – Maleness-on-the-Y (MoY) – which encodes the small protein required to signal male sex determination during development, a new study shows. According to the report, the…
No genome signature predicts same-sex sexual behavior, GWAS study finds
According to a genome-wide association study involving more than 470,000 people, a person’s genetic variants do not meaningfully predict whether they will engage in same-sex sexual behavior. The findings suggest same-sex sexual behavior is influenced by a complex mix of…
Study of bile acids links individual’s genetics and microbial gut community
Gene identified in mice affects both size of a bacterial population and bile acid levels in blood
Narrowing risk of preeclampsia to a specific phenotype
By studying lipoproteins in pregnant women with type 1 diabetes, MUSC researchers aim to understand
New sequencing study provides insight into HIV vaccine protection
RNA-sequencing reveals B cell gene signature associated with protective efficacy of SIV and HIV vacc
The making of ‘Fancy Mouse’
Study reveals true cause of colorful hair on popular East Asian pet mice
These albino lizards are the world’s first gene-edited reptiles
Meet the world’s first gene-edited reptiles: albino lizards roughly the size of your index finger. Researchers used CRISPR-Cas9 to make the lizards, providing a technique for gene editing outside of major animal models. In their study, publishing August 27 in…
How to tell if you’ve found Mr. or Mrs. Right? For lemurs, it’s in their B.O.
Lemurs can smell whether a mate’s immune genes are a good match
Gene mutations coordinate to drive malignancy in lung cancer
The identification of a molecular mechanism that causes lung cells to lose their identity, thereby p
Mediating the trade-off — How plants decide between growth or defense
Grow or defend yourself – a decision plants need to make on a daily basis, due to their inability to do both simultaneously. For a long time, it was thought that the reason for the growth-defence trade-off might be a…
NIH announces six inaugural genomic innovator awards
Supporting early career investigators at the cutting edge of genomics
BRAIN grant will fund new tools to study astrocytes
In the brain, cells called astrocytes are at least as abundant as neurons, but are much less understood. While neuroscientists have begun to appreciate how closely astrocytes support the development and function of the neural circuit connections, or synapses, we…
BRAIN grant will fund new tools to study astrocytes
In the brain, cells called astrocytes are at least as abundant as neurons, but are much less understood. While neuroscientists have begun to appreciate how closely astrocytes support the development and function of the neural circuit connections, or synapses, we…
$3 million grant will fund search for biological basis of major depressive disorder
Researchers will study chemical modifications on RNA in postmortem brains
$3 million grant will fund search for biological basis of major depressive disorder
Researchers will study chemical modifications on RNA in postmortem brains
The genealogy of important broiler ancestor revealed
A new study examines the historical and genetic origins of the White Plymouth Rock chicken, an important contributor to today’s meat chickens (broilers). Researchers at Uppsala University in Sweden, The Livestock Conservancy and Virginia Tech in the USA have used…
Oncologists echo findings that suggest a reduced risk of breast cancer recurrence
Oncologists at VCU Massey Cancer Center were invited to co-author an editorial published in the Journal of Clinical Oncology providing expert commentary on findings from a large study conducted by German investigators that a modified drug combination may lead to…
Grant awarded to MDI Biological Laboratory scientist James A. Coffman, Ph.D.
Will support research on genes governing the health effects of chronic stress
Identification of all types of germ cells tumors
Germ cell tumors constitute a diverse group of rare tumors, which occur in the testes, ovaries and also in other places. Some germ cell tumors exist prenatally, while others present during or after puberty. The majority is benign. Malignant germ…
New technique isolates placental cells for non-invasive genetic testing
PROVIDENCE, R.I. [Brown University] — Brown University researchers have developed a simple method for isolating placental cells from cervical swabs. The technique, described in the journal Scientific Reports , could aid in developing less invasive ways of diagnosing genetic disorders…
New research predicts stability of mosquito-borne disease prevention
UNIVERSITY PARK, Pa.–To reduce transmission of dengue to humans, scientists have introduced Wolbachia bacteria to A. aegypti mosquitoes. Now a team of international researchers has found that Wolbachia’s ability to block virus transmission may be maintained by natural selection, alleviating…
Breath! Respiring microbes generate more energy
Researchers have now shed light on how bacteria and baker’s yeast generate and use their energy to g
Study shows frying oil consumption worsened colon cancer and colitis in mice
Research by UMass Amherst food scientists compared effects of fresh and thermally processed oil
Biophysicists discovered how ‘Australian’ mutation leads to Alzheimer’s disease
A team of scientists from the Moscow Institute of Physics and Technology (MIPT) and Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry (IBCh RAS) studied one hereditary genetic mutation to discover general molecular mechanisms that may lead both to early onset of Alzheimer’s…
Grant to develop drought-tolerant poplars for bioenergy
Bioenergy — growing crops that can be used to generate energy (and possibly refined into chemicals) could be an important tool for mitigating climate change. But bioenergy can be controversial if it takes land out of food production or affects…
A novel technology for genome-editing a broad range of mutations in live organisms
Salk scientists develop a new gene-editing tool that could help treat many disorders caused by gene
How our genes and environment influence BMI and height
Environmental conditions influence our body mass index (BMI) by increasing or decreasing the effect
‘Malaria cell atlas’ reveals gene clusters, possible drug targets
After performing single-cell RNA sequencing on thousands of malaria parasites – the genomes of which have historically encoded many uncharacterized genes – researchers report the first high-resolution atlas of malaria parasite gene expression across the entirety of these organisms’ complex…
Moderate to Heavy Drinking During Pregnancy Alters Genes in Newborns, Mothers
Mothers who drink moderate to high levels of alcohol during pregnancy may be changing their babies’ DNA, according to a Rutgers-led study.
Tweaked CRISPR in neurons gives scientists new power to probe brain diseases
A team of scientists at UC San Francisco and the National Institutes of Health have achieved another CRISPR first, one which may fundamentally alter the way scientists study brain diseases. In a paper published August 15 in the journal Neuron…
Extinct Caribbean bird yields DNA after 2,500 years in watery grave
GAINESVILLE, Fla. — Scientists have recovered the first genetic data from an extinct bird in the Caribbean, thanks to the remarkably preserved bones of a Creighton’s caracara from a flooded sinkhole on Great Abaco Island. Studies of ancient DNA from…
Genetic redundancy aids competition among bacteria in symbiosis with squid
The molecular mechanism used by many bacteria to kill neighboring cells has redundancy built into its genetic makeup, which could allow for the mechanism to be expressed in different environments. Some strains of luminescent bacteria that compete to colonize the…
TGen team links gene to children with physical and intellectual disabilities
DDX6 among a growing list of genes identified by TGen’s Center for Rare Childhood Disorders
WPI biologist’s discovery gives evolution clues and may affect drug interaction research
Worcester, Mass. – August 15, 2019 – A biologist at Worcester Polytechnic Institute (WPI) has shown that a key biological component in a worm’s communication system can be repurposed to take on a different job, a critical finding about the…
Numbers count in the genetics of moles and melanomas
University of Queensland scientists have identified a way to help dermatologists determine a patient
Uric acid pathologies shorten fly lifespan, highlighting need for screening in humans
Backed by human genetics, research in flies provides potential drug targets for gout, metabolic synd
Immune cells drive gallstone formation
Sticky meshworks of DNA and proteins extruded by white blood cells called neutrophils act as the glue that binds together calcium and cholesterol crystals during gallstone formation, researchers in Germany report August 15 in the journal Immunity . Both genetic…
Princeton scientists awarded grant to boost crop yields by adding algal organelle to plant
Goal is to increase efficiency of photosynthesis
Bloodsucker discovered: First North American medicinal leech described in over 40 years
Museum collections reveal the new leech has hidden in plain sight for decades
AAV9 gene therapy vector dramatically increases life span in krabbe disease mouse model
New Rochelle, NY, August 12, 2019–An optimized and newly engineered form of the adeno-associated vector 9 (AAV9) vector used to deliver the galactosylceramidase gene to a mouse model of the inherited neurogenerative and rapidly fatal form of Krabbe dis-ease improved…
Simple protocol for assessing maturation of HPCs from induced pluripotent stem cells
New Rochelle, NY, August 13, 2019-Researchers have developed a guide to help labs standardize the production of mature hepatic-like cells (HPCs) from stem cells and easily compare gene expression of HPCs to actual human liver tissue. This moderately high throughput…
NIH’s All of Us Research Program recaps progress and next steps
WHAT: The All of Us Research Program at the National Institutes of Health has made strong progress in its efforts to advance precision medicine, according to program leadership in a forthcoming paper in the New England Journal of Medicine .…
AI used to test evolution’s oldest mathematical model
Researchers have used artificial intelligence to make new discoveries, and confirm old ones, about one of nature’s best-known mimics, opening up whole new directions of research in evolutionary biology. The researchers, from the University of Cambridge, the University of Essex,…
Rapid evolution: New findings on its molecular mechanisms
The mechanisms by which new species arise are still not fully understood. What are the evolutionary processes that drive the evolution of new species? Evolutionary biologists traditionally assumed that geographical barriers between animal populations play a decisive role (allopatric speciation):…