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UrduDietary fructose promotes tumor growth in animal models of melanoma, breast cancer and cervical cancer. However, fructose does not directly fuel tumors, according to the study published Dec. 4 in the journal Nature. Instead, WashU scientists discovered that the liver converts fructose into usable nutrients for cancer cells, a compelling finding that could open up new avenues for care and treatment of many different types of cancer.
Tag: Metabolomics
Study reveals link between microbiome and aggression in mice
A new study led by Prof. Omry Koren and graduate student Atara Uzan-Yuzari from the Azrieli Faculty of Medicine at Bar-Ilan University has unveiled significant evidence connecting the gut microbiome to aggressive behavior in mice.
Published in the journal Brain, Behavior, and Immunity, the research explores how disruptions in the microbiome, particularly due to antibiotic use in early life, can lead to increased aggression.
Type 2 Diabetes Medication Improves Liver Health in Mice Fed High Fat Diet
Article title: SGLT2 inhibition leads to a restoration of hepatic and circulating metabolites involved in the folate cycle and pyrimidine biosynthesis Authors: Ileana Mendez Espinoza, Elijah N. D. Choos, Carolyn M. Ecelbarger, Blythe D. Shepard From the authors: “Here, we…
New Research Reveals Differences in the Function of Fine Roots
Using a 26-year-old common garden forest, a multi-institutional team of researchers collected fine root samples from four temperate tree species (three deciduous and one coniferous) that varied in their morphology.
Metabolism of Autism Reveals Developmental Origins
New insights into the metabolism of autism from researchers at UC San Diego could help inform early detection and prevention strategies for the disorder.
First Steps Toward a Whole-Body Map of Molecular Responses to Exercise
PNNL contributes to a nationwide research consortium investigating the molecular mechanisms triggered by endurance training.
New Technology Unscrambles the Chatter of Microbes
Researchers from University of California San Diego have developed a new search tool to that can match microbes to the metabolites they produce with no prior knowledge, an innovation that could transform our understanding of both human health and the environment.
‘You Are What You Eat,’ and Now Researchers Know Exactly What You’re Eating
UC San Diego researchers describe a new method to identify all of the unidentified molecules derived from food, providing a direct way to link molecules in diet to health outcomes.
Metabolomic Profiles Differ in Children Born to People with and without Obesity
Article title: Metabolomic signatures of low- and high-adiposity neonates differ based on maternal BMI Authors: Begum Aydogan Mathyk, Brian D. Piccolo, Fernanda Alvarado, Kartik Shankar, Perrie O’Tierney-Ginn From the authors: “Using untargeted metabolomics in 100 newborns, we found that cord…
Getting to the core of a more nutritious apple
A new platform housing data from over 100 apple varieties could shave years off of the breeding process and enable data-driven assessments of how to boost the health benefits of America’s favorite fruit.
Memory Biomarkers Confirm Aerobic Exercise Helps Cognitive Function in Older Adults
Until now, systemic biomarkers to measure exercise effects on brain function and that link to relevant metabolic responses were lacking. A study shows a memory biomarker, myokine Cathepsin B (CTSB), increased in older adults following a 26-week structured aerobic exercise training. The positive association between CTSB and cognition, and the substantial modulation of lipid metabolites implicated in dementia, support the beneficial effects of exercise training on brain function and brain health in asymptomatic individuals at risk for Alzheimer’s.
Cancer has ripple effect on distant tissues
A new study with zebrafish shows that a deadly form of skin cancer — melanoma — alters the metabolism of healthy tissues elsewhere in the body. The research from Washington University in St. Louis suggests that these other tissues could potentially be targeted to help treat cancer.“Tumors rely on a constant supply of nutrients to grow.
The Future of Precision Medicine
Precision medicine is a rapidly growing approach to health care that focuses on finding treatments and interventions that work for people based on their genetic makeup, rather than their symptoms.
Zeeshan Ahmed, director of the new Ahmed Lab at Rutgers Institute for Health, Health Care Policy and Aging Research, discusses the future of precision medicine, what needs to be done to successfully analyze the data necessary to develop individualized treatments and the role genetics play during the COVID-19 pandemic.
Study looks at smoking in pre-colonization North America
For the first time, researchers use a metabolomics approach to find more detailed information about how tobacco use and smoking practices changed after colonization in North America.
Identifying the Dark Matter of the Molecular World
Scientists have deployed artificial intelligence to identify more of the billions of metabolites that are currently unknown. The small molecules underlie and inform every aspect of our lives, including energy production, the fate of the planet, and our health. “Beast Mode” helps explain how they did it.
Read-Across of Chemical Hepatotoxicants; Exposure-Based Cholinergic Synaptic Functional Deficits; and More Featured in April 2020 Toxicological Sciences
The April 2020 issue of the Society of Toxicology’s official journal, Toxicological Sciences, features leading research in toxicology, including several manuscripts covering emerging technologies, methods, and models.
Exercise, Weight Loss May Induce Metabolism-related Changes to Molecules in Gut
New research finds that exercise causes changes to some of the body’s metabolites—small molecules the body produces during metabolism—and also triggers change in blood levels of unique “foreign” molecules not thought to stem from our own metabolism. These changes to the global metabolome—the entire group of metabolites found throughout the body in the blood, tissues or urine—may help scientists better understand the body’s response to exercise.
Blood Metabolite Levels May Help Identify Diabetic Kidney Disease
Noninvasive measurement may provide alternative to diagnostic kidney biopsy Charlottesville, Va. (June 24, 2019)—Metabolomics, the study of small molecules the body produces during metabolism (metabolites) may be a future key to identifying diabetes-related kidney disease. The finding will be presented…