Tag: Glioblastoma

Chemo for glioblastoma may work better in morning than evening

sarah JonasResearch Results

An aggressive type of brain cancer, glioblastoma has no cure. Patients survive an average of 15 months after diagnosis, with fewer than 10% of patients surviving longer than five years. While researchers are investigating potential new therapies via ongoing clinical trials, a new study from Washington University in St. Louis suggests that a minor adjustment to the current standard treatment — giving chemotherapy in the morning rather than the evening — could add a few months to patients’ survival.

New immunotherapy target discovered for malignant brain tumors

sarah JonasResearch Results

Scientists say they have discovered a potential new target for immunotherapy of malignant brain tumors, which so far have resisted the ground-breaking cancer treatment based on harnessing the body’s immune system. The discovery, reported in the journal CELL, emerged from laboratory experiments and has no immediate implications for treating patients.

Henry Ford Cancer Institute is First in the World to Activate Two New Treatments in GBM AGILE Trial for Glioblastoma

sarah JonasFeature

Henry Ford Cancer Institute is the first site in the world to activate two new treatments for glioblastoma (GBM), the deadliest form of brain cancer, as part of a patient-centered adaptive platform trial known as GBM AGILE (Glioblastoma Adaptive Global Innovative Learning Environment).

Researchers link cellular transport pathway to aggressive brain cancer

sarah JonasResearch Results

Researchers at McGill University have identified a new cellular pathway that limits the growth and spread of brain tumors by controlling the recycling of cell surface receptor proteins. The study, which will be published January 14 in the Journal of Cell Biology (JCB), suggests that the pathway, which involves a protein called Rab35, is defective in many patients with glioblastoma and that restoring Rab35’s activity could be a new therapeutic strategy for this deadly form of brain cancer.

Researchers identify mechanism underlying cancer cells’ immune evasion

sarah JonasResearch Results

Researchers in China have discovered how brain cancer cells increase production of a key protein that allows them to evade the body’s immune system. The study, which will be published August 27 in the Journal of Experimental Medicine (JEM), suggests that targeting this cellular pathway could help treat the deadly brain cancer glioblastoma, as well as other cancers that are resistant to current forms of immunotherapy.

Brain Cancer: UVA IDs Gene Responsible for Deadly Glioblastoma

sarah JonasResearch Results

The discovery of the oncogene responsible for glioblastoma could be the brain tumor’s Achilles’ heel, one researcher says.

Treatment shows promise in treating deadly brain cancer

sarah JonasResearch Results

In this study, researchers investigated if specific targeting of CD133+ glioblastoma with cutting-edge immunotherapy drugs could eradicate the most aggressive subpopulation of cells in the tumour. They also looked at the safety of CD133-targeting therapies on normal, non-cancerous human stem cells including hematopoietic stem cells which create blood cells and progenitor cells which can form one or more kinds of cells.

International Research Team Confirms Potential Glioblastoma Inhibitors

sarah JonasResearch Results

However, San Diego Supercomputer Center (SDSC) Research Scientist Igor Tsigelny recently collaborated Researchers from the San Diego Supercomputer at UC San Diego and colleagues from Sweden’s Karolinska Institute and the Pasteur Institute in France released a study focused on improving the prognosis for glioblastoma patients.

Zika Virus’ Key into Brain Cells ID’d, Leveraged to Block Infection and Kill Cancer Cells

sarah JonasResearch Results

Two different UC San Diego research teams identified the same molecule — αvβ5 integrin — as Zika virus’ key to brain cell entry. They found ways to take advantage of the integrin to both block Zika virus from infecting cells and turn it into something good: a way to shrink brain cancer stem cells.

Surgery May Add Months or Years of Survival For Adults With Rare And Deadly Brain Cancers

sarah JonasResearch Results

For adult patients with brainstem high-grade gliomas — one of the rarest and deadliest forms of brain cancer — surgically removing the entire tumor may add many months or potentially years of survival beyond that offered by radiation and chemotherapy, according to results of a medical records study led by researchers at the Johns Hopkins Kimmel Cancer Center.

Brain Organoids Reveal Glioblastoma Origins

sarah JonasResearch Results

Glioblastomas are the most aggressive form of brain cancer – they grow and spread rapidly through the brain and are virtually impossible to eradicate, typically leading to death within one or two years of diagnosis. Scientists are constantly seeking more powerful targeted therapies, but so far without success — in part because glioblastomas are challenging to study in a laboratory setting.

Researchers identify immune-suppressing target in glioblastoma

sarah JonasResearch Results

Researchers at The University of Texas MD Anderson Cancer Center have identified a tenacious subset of immune macrophages that thwart treatment of glioblastoma with anti-PD-1 checkpoint blockade, elevating a new potential target for treating the almost uniformly lethal brain tumor.

Tulane University student spends summer conducting brain tumor research in Switzerland

sarah JonasFeature

Tulane University senior James Rogers has been charting a course in the name of research since he arrived on campus in the fall of 2016. Rogers’ journey has led him from New Orleans to Bethesda, Md., across the Atlantic to Scotland and, most recently, Switzerland, where he spent the summer as a visiting research scholar in the Brain Tumor Center at the University Hospital Zürich (USZ).

Adding MS Drug to Targeted Cancer Therapy May Improve Glioblastoma Outcomes

sarah JonasResearch Results

The multiple sclerosis drug teriflunomide, paired with targeted cancer therapy, markedly shrinks patient-derived glioblastomas grown in mice by reaching stem cells at the tumor’s root, according to a new UC San Diego School of Medicine study published in Science Translational Medicine.